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    • 21. 发明授权
    • Twister fiber optic systems and their use in medical applications
    • 扭转光纤系统及其在医疗应用中的应用
    • US08721631B2
    • 2014-05-13
    • US12714155
    • 2010-02-26
    • Wolfgang Neuberger
    • Wolfgang Neuberger
    • A61B18/16
    • A61B18/22A61B2018/0019A61B2018/1861A61B2018/2211A61B2018/2272A61B2018/2288
    • An improved device and method for safe, accurate and efficient surgical procedures are disclosed. The disclosed device is an optical fiber set with an asymmetric distal end configuration, comprising a bent tip fiber with a fused sleeve as an integral part of it, placed at the fiber's distal (output) end and with a rotatable connector at the proximal (input) side. Fiber tip and tissue-contacting surface located at the distal end of the tip may be constructed with different shape configurations, such as convex tip to improve focusing characteristics, concave tip to achieve diverging irradiation or an expanded beam tip to achieve an effect similar to that obtained by electrosurgical tools. A grip guarantees and enhances the ability to twist and rotate it easily. In another preferred embodiment, twisting maneuvers are enhanced through a special configuration. Both special features (bent tip and rotatable connector), allow for improved and enhanced treatment of diverse pathologies, making possible to efficiently and easily reach and treat specific tissues. Optical fiber's steerability, twistability and rotation lead to a more precise and improved effect on tissues.
    • 公开了一种用于安全,准确和有效的外科手术的改进的装置和方法。 所公开的装置是具有不对称远端构造的光纤组件,其包括具有作为其整体部分的熔融套筒的弯曲尖端纤维,放置在光纤的远端(输出端)处并且在近端(输入端)处具有可旋转连接器 )侧。 位于尖端远端处的纤维尖端和组织接触表面可以被构造成具有不同的形状构造,例如凸尖以改善聚焦特性,凹形尖端以实现发散照射或扩张的束尖以实现类似于 通过电外科手术获得。 抓地力保证并增强扭曲和旋转的能力。 在另一优选实施例中,通过特殊配置来增强扭转机动。 两个特殊功能(弯尖和可旋转连接器),可以改善和增强各种病态的治疗,使得有效和容易地达到和治疗特定组织成为可能。 光纤的可操纵性,扭曲性和旋转性导致对组织的更精确和改善的影响。
    • 22. 发明授权
    • Device and method for vessel treatment
    • 血管治疗的装置和方法
    • US08685072B2
    • 2014-04-01
    • US12877721
    • 2010-09-08
    • Wolfgang Neuberger
    • Wolfgang Neuberger
    • A61N5/06
    • A61N5/0601A61B90/36A61N2005/063A61N2005/0659
    • A device and method for restoring functionality of blood vessels are disclosed. Laser energy is accurately and precisely applied in order to restore vessel functionality. This is accomplished by a controlled, reliable and specific shrinkage and/or strengthening of the vessel structure by controlled transport of laser radiation via an optical fiber to the treatment site. Laser wavelength is chosen according to the required penetration depth in tissue. In a preferred embodiment, wavelength of approximately 1470 nm is used. A mini-endoscope is preferably used to control the process by visual inspection from the inside of the vessel but other means may also be combined to control the procedure. Full 360° radial emission, i.e., delivery of laser radiation perpendicularly or fairly inclined relative to the veins axis, is beneficial, and is accomplished by means of a radial emitting fiber. In another preferred embodiment, a 360 degree radiation pattern can be achieved by using a twister or side-emitting fiber, along with rotational and sweeping movements to apply energy in an even, more-controlled, and guided manner. Valve function is restored to recover whole vein functionality, avoiding the need of closing it. In a preferred embodiment, energy is applied from the outside of the vessel, by inserting a device through the skin and tissue. In another preferred embodiment, specific radiation absorbers are located at suitable positions inside the vessel wall, to selectively target radiation to tagged locations. Vessel function is restored preserving its structure. A wide range of vessel diameters are effectively treated. Vessels include veins, arteries and fistulas.
    • 公开了恢复血管功能的装置和方法。 激光能量准确而精确地应用于恢复血管功能。 这是通过受控的,可靠的和具体的收缩和/或通过经由光纤将激光辐射控制传输到处理部位来加强容器结构来实现的。 根据组织中所需的穿透深度选择激光波长。 在优选实施例中,使用约1470nm的波长。 微型内窥镜优选地用于通过目视检查从容器的内部控制过程,但也可以组合其它装置来控制该过程。 完全360°径向辐射,即相对于静脉轴线垂直或相当倾斜的激光辐射的传送是有益的,并且通过径向发射光纤实现。 在另一个优选实施例中,360度辐射图可以通过使用捻线机或侧发射光纤以及旋转和扫掠运动来实现,以以均匀,更受控制和引导的方式施加能量。 阀功能恢复恢复整个静脉功能,避免了关闭它。 在优选实施例中,通过将装置插入皮肤和组织,从容器的外部施加能量。 在另一优选实施例中,特定的辐射吸收器位于血管壁内的适当位置,以选择性地将辐射靶向到标记位置。 船舶功能恢复保存其结构。 有效处理各种血管直径。 血管包括静脉,动脉和瘘管。
    • 23. 发明申请
    • METHOD AND DEVICE FOR VALVE REPAIR
    • 阀门维修的方法和装置
    • US20110213348A1
    • 2011-09-01
    • US13102830
    • 2011-05-06
    • Enrique FerracaniWolfgang Neuberger
    • Enrique FerracaniWolfgang Neuberger
    • A61B18/20A61B17/00
    • A61B18/24A61B2018/00029A61B2018/00982
    • A method and a device for minimally invasive treatment of diseased deep and superficial venous valves are disclosed. Treatment seeks to repair/rejuvenate dysfunctional valve by reducing the circumference of dilated valve rings and by restoring their original shape and function using laser energy to make physical suture points and shrink collagen in selected points. Real time monitoring is by angioscopic view and endovenous echographic control. In a preferred embodiment, system comprises a specific catheter-like device for endovenous insertion that allows for real time view of energy emission and venous surface to be corrected. Catheter flexibility is such that viewing angle and direct energy emission can be oriented properly. Catheter can comprise channels for irrigation or for interchange of laser fibers according to desired irradiation pattern. A preferred embodiment of catheter device also comprises cuffs for temporary occlusion, by inflation and deflation. In preferred embodiments, 1470 nm, 1550 nm or 1900 nm laser energy is applied. This treatment can be applied to venous valves of the deep venous system, as well as valves of the sapheno-femoral junction, terminal valve and pre-terminal valve.
    • 公开了用于微创治疗患病深部和浅静脉瓣的方法和装置。 治疗旨在通过减小扩张瓣环的周长并通过使用激光能量恢复其原始形状和功能来修复/恢复功能失调的瓣膜,以在选定的点产生物理缝合点和收缩胶原蛋白。 实时监测是通过血管镜观察和静态回波控制。 在优选实施例中,系统包括用于静脉内插入的特定导管状装置,其允许实时观察要校正的能量排出和静脉表面。 导管的灵活性使得视角和直接能量发射可以适当地定向。 导管可以包括根据所需照射模式进行冲洗或激光纤维交换的通道。 导管装置的优选实施例还包括用于暂时闭塞的袖口,通过充气和放气。 在优选实施例中,施加1470nm,1550nm或1900nm的激光能量。 这种治疗可以应用于深静脉系统的静脉瓣膜,以及隐静脉股关节,终端阀和前端阀的阀门。
    • 24. 发明申请
    • METHOD AND DEVICE FOR LASER LITHOTRIPSY
    • 激光雷达的方法和装置
    • US20100137847A1
    • 2010-06-03
    • US12628634
    • 2009-12-01
    • Walter CecchettiWolfgang NeubergerLeonardo Cecchetti
    • Walter CecchettiWolfgang NeubergerLeonardo Cecchetti
    • A61B17/225
    • A61B18/26A61B18/24A61B2017/2215A61B2018/00029A61B2018/263
    • A system and method for the destruction/ablation of stones, calculi or other hard substances by means of laser energy is disclosed. As a consequence, several important medical treatments can be performed, especially lithotripsy. The system comprises a diode laser source emitting at least at one wavelength, one or more optical fibers which convey laser radiation to the treatment site and a liquid delivery system used for creating a liquid environment around the stones (calculi). The laser device emits at least one wavelength which is highly absorbed in the surrounding/covering medium, thus causing evaporation and cavitation effects that lead to stone/calculi destruction. Different radiation configurations may be used. In one embodiment continuous radiation is used to create sparkler-less plasma bubbles able to destroy hard substances. In another embodiment high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally it can be applied in combination with another wavelength with medium absorption in water such as 980 nm. In another embodiment a concentric double core fiber is used, in which the ignition radiation is guided in near single mode, inner core and the radiation used to maintain and enhance the pulse is guided into the surrounding second outer core. In another preferred embodiment, the use of multiple optical fibers allows for treating larger stones in a shorter time period. In another preferred embodiment, cooling liquid is supplied to the impact site to further reduce thermal heating of the stone, thus diminishing risks of tissue damage caused by stone fragment anchorage and thermal energy. With these safer and improved methods and system, enhanced lithotripsy treatments can be performed in a shorter treatment time, destroying a wider range of stones with less risk of tissue damage, and less patient and physician stress.
    • 公开了一种用于通过激光能量破坏/消融石头,结石或其它硬物质的系统和方法。 因此,可以进行若干重要的医疗治疗,特别是碎石术。 该系统包括发射至少一个波长的二极管激光源,将激光辐射传送到治疗部位的一个或多个光纤和用于在石头周围产生液体环境(结石)的液体输送系统。 激光装置发射至少一种在周围/覆盖介质中被高度吸收的波长,从而导致导致石头/结石破坏的蒸发和气蚀效应。 可以使用不同的辐射配置。 在一个实施例中,使用连续辐射来产生能够破坏硬物质的无闪蒸的等离子体气泡。 在另一个实施例中,使用高峰值功率脉冲辐射。 优选1470nm,1940nm或1550nm的波长。 此外,它可以与另外一种在水中具有介质吸收的波长(例如980nm)结合使用。 在另一个实施例中,使用同心双芯纤维,其中点火辐射在近单模模式内引导,并且用于维持和增强脉冲的辐射被引导到周围的第二外核中。 在另一个优选实施例中,使用多根光纤允许在更短的时间段内处理较大的石头。 在另一个优选实施例中,将冷却液供应到冲击部位以进一步减少石头的热加热,从而降低由石块碎片锚固和热能引起的组织损伤的风险。 使用这些更安全和改进的方法和系统,可以在更短的治疗时间内进行增强的碎石治疗,破坏更广泛的石块,同时组织损伤的风险较小,患者和医生的压力较小。
    • 25. 发明申请
    • Microbe Reductions with Photosensitizers
    • 微生物减少与光敏剂
    • US20100100030A1
    • 2010-04-22
    • US12643467
    • 2009-12-21
    • Tim DriscollVerónica Inés MegaWolfgang Neuberger
    • Tim DriscollVerónica Inés MegaWolfgang Neuberger
    • A61M37/00A61K9/14A61K31/195A61N5/06
    • A61K8/494A61K8/0241A61K8/19A61K41/0038A61K2800/413A61K2800/81A61Q3/00A61Q11/00A61Q17/005B82Y5/00
    • Methods, devices and composition are disclosed for treating oral, skin and nail diseases, including inflammatory periodontal disease, onychomycosis and dermatophytosis. In a preferred embodiment a method for treating oral, skin and nail infections comprises administering a photosensitizing compound in long term effect or timed release formulations, including local highly concentrated formulations, and activating the photosensitizer with radiation to selectively destroy bacteria, fungi and other microbial bodies. In another preferred embodiment, photosensitizers are housed within nanoparticles, and can be gradually released through biodegradation or periodically released by such processes as brushing, irradiation and chemically induced release. The diffusion speed of the photosensitizers can be accelerated by brushing. In another embodiment, the photosensitizer molecule is also modified to more effectively target the molecule to the unwanted oral bacterial and fungal species. In another embodiment devices for treating oral, skin and nail infections includes a laser radiation source and delivery apparatuses such as brush or teethed comb for nail and scalp infections respectively.
    • 公开了用于治疗口腔,皮肤和指甲疾病的方法,装置和组合物,包括炎症性牙周病,甲真菌病和皮肤癣菌病。 在优选的实施方案中,用于治疗口腔,皮肤和指甲感染的方法包括长期作用或定时释放制剂(包括局部高度浓缩的制剂)施用光敏化合物,并用放射线激活光敏剂以选择性地破坏细菌,真菌和其它微生物体 。 在另一个优选的实施方案中,光敏剂容纳在纳米颗粒内,并且可以通过生物降解逐渐释放或通过诸如刷洗,照射和化学诱导释放的过程周期性释放。 通过刷涂可以加速光敏剂的扩散速度。 在另一个实施方案中,光敏剂分子也被修饰以更有效地将分子靶向不需要的口腔细菌和真菌物种。 在另一个实施方案中,用于治疗口腔,皮肤和指甲感染的装置分别包括激光辐射源和递送装置,例如用于指甲和头皮感染的刷子或牙齿梳。
    • 26. 发明申请
    • Medical Light Diffusers for High Power Applications and their Manufacture
    • 用于大功率应用的医用光扩散器及其制造
    • US20090210038A1
    • 2009-08-20
    • US12227078
    • 2007-08-22
    • Wolfgang NeubergerStefan Spaniol
    • Wolfgang NeubergerStefan Spaniol
    • A61N5/067
    • G02B6/262A61B2018/2261A61N5/0601A61N5/062
    • A high power density light delivery device is presented that uses an optical fiber with a diffuser attached at a distal end for use in, for example, photodynamic therapy (PDT) and laser induced thermotherapy (LITT). Uniform scattering in the diffuser section is obtained by either inducing differences in refractive index profiles of the core or in the core-cladding interface with the use of scattering centers or nano-voids. Nano-voids are created in the core or core-cladding interface by focusing high power laser energy or picosecond/femtosecond laser pulses on the quartz fiber material to induce defects. A special method is used that writes defects into or near to the core/cladding boundary through the jacket, without the necessity to first remove the jacket and then recoat the fiber. The method uses a wavelength that is highly transmissive in the jacket and fiber but absorbed in the fiber at very short laser pulses with high peak power. These processes allow the use of high power laser energy and the emission of the resulting high power densities in quartz fibers. The disclosed optical fiber delivery system is suitable for high power applications that require optical fibers with high flexibility and strength and core diameters from about 50 to about 400 microns.
    • 提出了一种高功率密度光输送装置,其使用具有连接在远端的扩散器的光纤用于例如光动力疗法(PDT)和激光诱导热疗法(LITT)。 通过使用散射中心或纳米空隙,通过诱导芯的折射率分布或芯 - 包层界面的差异来获得扩散器部分中的均匀散射。 通过将高功率激光能量或皮秒/飞秒激光脉冲聚焦在石英纤维材料上以引起缺陷,在芯或芯 - 包层界面中产生纳米空隙。 使用一种特殊的方法,其通过夹套将缺陷写入芯/包层边界或靠近芯/包层边界,而不需要首先除去护套然后再覆盖光纤。 该方法使用在护套和光纤中高度透射的波长,但是以非常短的具有高峰值功率的激光脉冲吸收在光纤中。 这些过程允许使用高功率激光能量并且在石英纤维中发射所得到的高功率密度。 所公开的光纤传送系统适用于需要高柔性和强度以及约50至约400微米的芯直径的光纤的高功率应用。
    • 27. 发明申请
    • Benign prostatic hyperplasia treatment method and device
    • 良性前列腺增生治疗方法及装置
    • US20070219601A1
    • 2007-09-20
    • US11714370
    • 2007-03-06
    • Wolfgang Neuberger
    • Wolfgang Neuberger
    • A61N5/06
    • A61B18/24A61B2017/00274A61B2018/00547A61B2018/2005A61B2018/207A61B2018/2272A61N2005/0659
    • A device and method are provided which achieve tissue ablation as well as tissue coagulation substantially simultaneously during the treatment of BPH by utilizing at least two wavelengths of light. The device and method improve urinary flow and minimize post-treatment blood loss and edema while maintaining a nearly blood-free operating field during treatment by irradiating substantially simultaneously with at least two different wavelengths of light. According to the present invention, tissue ablation is affected by having one wavelength that is highly absorbed in the prostatic tissue while another less highly absorbed wavelength coagulates surrounding tissues while maintaining minimal thermal damage to surrounding tissue. In a preferred embodiment the highly absorbed wavelength is about 1460 nm and the less absorbed by water but with some significant hemoglobin absorption is about 980 nm. This combination aids the patient by reducing blood loss and edema. It can aid the practitioner, especially where imaging is employed, by maintaining a substantially blood-free area during treatment. The present device and method is used in conjunction with optical fibers including side emitting optical fibers to provide a practical, minimally invasive treatment of enlarged prostates.
    • 提供了一种通过利用至少两个波长的光来在BPH治疗期间基本上同时实现组织消融以及组织凝固的装置和方法。 该装置和方法改善尿流量并且使治疗后的失血和水肿最小化,同时通过基本同时照射至少两种不同波长的光而在治疗期间保持几乎无血液的操作区域。 根据本发明,组织消融受到在前列腺组织中高度吸收的一种波长的影响,而另一较低吸收波长使周围组织凝结,同时保持对周围组织的最小热损伤。 在优选的实施方案中,高吸收波长为约1460nm,并且较少被水吸收,但具有一些显着的血红蛋白吸收约为980nm。 该组合通过减少失血和水肿来帮助患者。 它可以帮助医生,特别是在使用成像的地方,通过在治疗期间维持基本上无血液的区域。 本发明的装置和方法与包括侧向发射光纤的光纤结合使用以提供对扩大的前列腺的实用的,微创的治疗。
    • 28. 发明申请
    • Side fire optical fiber for high power applications
    • 侧火光纤适用于大功率应用
    • US20070106286A1
    • 2007-05-10
    • US11592598
    • 2006-11-03
    • Alexander HarschackWolfgang NeubergerKelly Moran
    • Alexander HarschackWolfgang NeubergerKelly Moran
    • A61B18/18G02B6/028G02B6/02G02F1/295
    • An optical fiber treatment system is provided for high power laser transmission to an area of medical treatment. A side fire optical fiber tip for use in high power laser applications having outputs of greater than or equal to 50 Watts is a key to the system. Embodiments are particularly appropriate for the medical treatment of benign prostate hyperplasia (BPH) with a side fire optical fiber tip using a Holmium:YAG laser or a high power diode laser. Such procedures can be done with only local anesthesia A predetermined length of an output tip on the distal end of the optical fiber of the present invention is formed with an optical fiber core and cladding layer of preselected thickness wherein the cladding to core diameter ratio is at least as great as 1.2. A side fire surface is formed on the distal end of the core/clad output end. Over this optical fiber output end, a pure silica capillary tube is fused to the predetermined length of exposed cladding where the outermost cladding is also pure silica to reduce thermal mismatch during the fusion process. By having the refractive index at the fusing interface of the tube to the cladding matched, and bubbles or gaps eliminated or prevented, it is possible to substantially eliminate Fresnel reflection losses at this interface. Further, the outer surface area where the laser energy is exiting from the tube may be heat treated with a laser to increase durability for high power laser energy transmission in fluid environments. Germanium-doped silica as well as pure silica can be used as fiber core material.
    • 提供了一种用于大功率激光传输到医疗领域的光纤处理系统。 用于具有大于或等于50瓦的输出的大功率激光应用的侧面火光光纤尖端是系统的关键。 实施例特别适用于使用钬:YAG激光器或高功率二极管激光器的侧消光光纤尖端治疗良性前列腺增生(BPH)。 这样的程序可以仅进行局部麻醉。本发明的光纤的远端上的输出端的预定长度形成有预定厚度的光纤芯和包层,其中包层与芯直径之比为 至少高达1.2。 侧面火表面形成在芯/包层输出端的远端。 在该光纤输出端上,纯二氧化硅毛细管被熔化到预定长度的暴露的包层,其中最外包层也是纯二氧化硅,以减少融合过程中的热失配。 通过使管的熔融界面处的折射率与包层匹配,并且消除或防止气泡或间隙,可以基本上消除该界面处的菲涅尔反射损失。 此外,激光能量从管出射的外表面区域可以用激光进行热处理,以提高在流体环境中的高功率激光能量传输的耐久性。 锗掺杂二氧化硅以及纯二氧化硅可用作纤维芯材料。
    • 29. 发明申请
    • Medical device recognition system with write-back feature
    • 具有回写功能的医疗器械识别系统
    • US20060111699A1
    • 2006-05-25
    • US11320389
    • 2005-12-28
    • Wolfgang Neuberger
    • Wolfgang Neuberger
    • A61B18/18
    • A61B18/22A61B90/90A61B2017/00482A61B2017/00725A61B2018/00988A61B2090/0803
    • A medical radiation treatment system is disclosed for identifying and monitoring the use of disposable or reusable optical fibers or other optical accessories. The treatment system comprises a radiation source unit connected to a recognition/control unit, and a medical radiation delivery system connected to an identification/recordation unit. This forms a read-write system to ensure that radiation parameters conform to delivery device characteristics, and to prevent the use of overused or incompatible delivery devices. This is achieved by reading previously encoded information in the identification/recordation unit that provides all usage history, including number of uses or total duration of use. The encoded information is updated after use, and preferably frequently or continuously during use, to guarantee a complete usage history even after an incomplete treatment. Additionally, the treatment system can differentiate between completed treatments, incomplete treatments and calibration, to retain an accurate record of all the stresses on a fiber. A transponder sends information to the source unit, and also receives and writes information to a non-volatile memory chip or other storage means. The identification/recordation unit, including the transponder and memory, is powered by sending/receiving means in the recognition/control unit without physical, optical or electrical connection between the source unit and delivery system.
    • 公开了用于识别和监测一次性或可重复使用的光纤或其他光学附件的使用的医疗辐射治疗系统。 治疗系统包括连接到识别/控制单元的辐射源单元和连接到识别/记录单元的医疗辐射传送系统。 这形成一个读写系统,以确保辐射参数符合传送设备特性,并防止使用过度使用或不兼容的传送设备。 这是通过读取提供所有使用历史的识别/记录单元中的先前编码的信息来实现的,包括使用次数或使用总时间。 编码信息在使用后被更新,并且优选地在使用期间经常或连续地更新,以保证即使在不完全处理之后的完整使用历史。 此外,治疗系统可以区分完成的治疗,不完全的治疗和校准,以保持光纤上所有应力的准确记录。 应答器向源单元发送信息,并且还向非易失性存储器芯片或其他存储装置接收和写入信息。 识别/记录单元(包括应答器和存储器)由识别/控制单元中的发送/接收装置供电,而不需要源单元和传送系统之间的物理,光学或电气连接。
    • 30. 发明授权
    • Laser safety contact lenses
    • 激光安全隐形眼镜
    • US06948815B2
    • 2005-09-27
    • US10628522
    • 2003-07-28
    • Wolfgang Neuberger
    • Wolfgang Neuberger
    • A61F9/02G02C7/04
    • G02C7/021A61F9/022G02C7/04
    • Individually marked contact lenses for protection of one's eyes from harmful radiation are provided. Contact lenses are coated or treated to be absorptive or reflective to a preselected wavelength or wavelengths. The lenses contain one or more identification areas on each lens to demonstrate that the lenses are being worn and to indicate the proper applications with which the lenses should be used and/or the wavelengths for which the lens is protective. The identification area, which should be visible when worn to third parties and/or the person wearing the lenses, consists of markings such as colored bands or shaded areas in the region around the iris. Different colors or color patterns of the markings indicate which wavelengths the lens protects against. Other safety features may include fluorescent markers, added features and devices to facilitate placement and retention in the eye, pick-up or release.
    • 提供单独标记的隐形眼镜,用于保护人眼免受有害辐射。 隐形眼镜被涂覆或处理以吸收或反射到预选的波长或波长。 透镜在每个透镜上包含一个或多个识别区域以示出透镜被磨损并且指示应当使用透镜的适当应用和/或透镜保护的波长。 当佩戴到第三方和/或戴着镜片的人员时,识别区域应该可见,包括虹膜周围区域的彩色条纹或阴影区域等标记。 标记的不同颜色或颜色图案表示镜头防止哪些波长。 其他安全特征可以包括荧光标记,添加的特征和装置,以便于在眼睛中的放置和保留,拾取或释放。