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21. 发明申请

US20100114195A1 IMPLANTABLE MEDICAL DEVICE INCLUDING EXTRAVASCULAR CARDIAC STIMULATION AND NEUROSTIMULATION CAPABILITIES 审中-公开
标题翻译：包括超声心动图刺激和神经细胞功能的可植入医疗装置
公开(公告)号：US20100114195A1
公开(公告)日：2010-05-06
申请号：US12362662
申请日：2009-01-30
申请人： John E. Burnes , Chris Zillmer , Paul G. Krause , Gerald P. Arne , Timothy Davis , David J. Peichel , James D. Reinke , William T. Donofrio , Xiaohong Zhou
发明人： John E. Burnes , Chris Zillmer , Paul G. Krause , Gerald P. Arne , Timothy Davis , David J. Peichel , James D. Reinke , William T. Donofrio , Xiaohong Zhou
IPC分类号： A61N1/39 , A61N1/36 , A61N1/362
CPC分类号： A61N1/0504 , A61B5/046 , A61N1/0587 , A61N1/36114 , A61N1/3622 , A61N1/365 , A61N1/3962
摘要： An implantable medical device may deliver pacing, cardioversion, and/or defibrillation stimulation to a heart of a patient via extravascular electrodes and delivers electrical stimulation to a nonmyocardial tissue site to modulate the autonomic nervous system of the patient. The implantable medical device may include a cardiac therapy module that generates and delivers at least one of pacing, cardioversion, or defibrillation therapy to a patient via an extravascular electrode, and a neurostimulation therapy module that generates and delivers a neurostimulation signal to the patient via a neurostimulation electrode. The cardiac therapy module and neurostimulation therapy module may be disposed in a common housing of the medical device. In some examples, at least one common lead may electrically couple the neurostimulation electrode and the extravascular electrode to the neurostimulation and cardiac therapy modules, respectively.
摘要翻译：可植入医疗装置可以通过血管外电极向患者的心脏递送起搏，心脏复律和/或除颤刺激，并将电刺激递送至非心肌组织部位以调节患者的自主神经系统。可植入医疗装置可以包括心脏治疗模块，该心脏治疗模块通过血管外电极产生并向患者提供起搏，心脏复律或除颤疗法中的至少一种，以及神经刺激治疗模块，其通过以下方式产生并递送神经刺激信号给患者神经刺激电极。心脏治疗模块和神经刺激治疗模块可以设置在医疗装置的公共壳体中。在一些示例中，至少一个共同的引线可以将神经刺激电极和血管外电极分别电耦合到神经刺激和心脏治疗模块。

22. 发明申请

US20100114216A1 INTERFERENCE MITIGATION FOR IMPLANTABLE DEVICE RECHARGING 有权
公开(公告)号：US20100114216A1
公开(公告)日：2010-05-06
申请号：US12610053
申请日：2009-10-30
申请人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , James D. Reinke , David J. Peichel , Timothy Davis , John E. Burnes
发明人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , James D. Reinke , David J. Peichel , Timothy Davis , John E. Burnes
IPC分类号： A61N1/08 , A61N1/378 , A61N1/39 , A61N1/37
CPC分类号： A61N1/3787 , A61N1/3704 , A61N1/3718 , A61N1/37264 , A61N1/37288
摘要： A therapy or monitoring system may implement one or more techniques to mitigate interference between operation of a charging device that charges a first implantable medical device (IMD) implanted in a patient and a second IMD implanted in the patient. In some examples, the techniques may include modifying an operating parameter of the charging device in response to receiving an indication that a second IMD is implanted in the patient. The techniques also may include modifying an operating parameter of the second IMD in response to detecting the presence or operation of the charging device.

23. 发明授权

US08406893B2 Interference mitigation for implantable device recharging 有权
标题翻译：可植入装置充电的干扰减轻
公开(公告)号：US08406893B2
公开(公告)日：2013-03-26
申请号：US12610053
申请日：2009-10-30
申请人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , James D. Reinke , David J. Peichel , Timothy Davis , John E. Burnes
发明人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , James D. Reinke , David J. Peichel , Timothy Davis , John E. Burnes
IPC分类号： A61N1/08
CPC分类号： A61N1/3787 , A61N1/3704 , A61N1/3718 , A61N1/37264 , A61N1/37288
摘要： A therapy or monitoring system may implement one or more techniques to mitigate interference between operation of a charging device that charges a first implantable medical device (IMD) implanted in a patient and a second IMD implanted in the patient. In some examples, the techniques may include modifying an operating parameter of the charging device in response to receiving an indication that a second IMD is implanted in the patient. The techniques also may include modifying an operating parameter of the second IMD in response to detecting the presence or operation of the charging device.
摘要翻译：治疗或监测系统可以实施一种或多种技术，以减轻对植入患者中的第一可植入医疗装置（IMD）充电的充电装置的操作与植入患者体内的第二IMD之间的干扰。在一些示例中，技术可以包括响应于接收到将第二IMD植入患者中的指示来修改充电装置的操作参数。这些技术还可以包括响应于检测到充电装置的存在或操作来修改第二IMD的操作参数。

24. 发明申请

US20100114209A1 COMMUNICATION BETWEEN IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械之间的通讯
公开(公告)号：US20100114209A1
公开(公告)日：2010-05-06
申请号：US12363215
申请日：2009-01-30
申请人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
发明人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
IPC分类号： A61N1/08
CPC分类号： A61N1/37288 , A61N1/36082 , A61N1/362 , A61N1/3706 , A61N1/37217 , A61N1/3727
摘要： A first implantable medical device (IMD) implanted within a patient may communicate with a second IMD implanted within the patient by encoding information in an electrical stimulation signal. The delivery of the electrical stimulation signal may provide therapeutic benefits to the patient. The second IMD may sense the electrical stimulation signal, which may be presented as an artifact in a sensed cardiac signal, and process the sensed signal to retrieve the encoded information. The second IMD may modify its operation based on the received therapy information. Crosstalk between the first and second IMDs may be reduced using various techniques described herein. For example, the first IMD may generate the electrical stimulation signal to include a spread spectrum energy distribution or a predetermined signal signature. The second IMD may effectively remove a least some of the signal artifact in a sensed cardiac signal based on the predetermined signal signature.
摘要翻译：植入在患者体内的第一可植入医疗装置（IMD）可以通过对电刺激信号中的信息进行编码来与植入患者内的第二IMD进行通信。电刺激信号的传递可以为患者提供治疗益处。第二IMD可以感测电刺激信号，其可以被呈现为感测到的心脏信号中的伪像，并且处理感测到的信号以检索经编码的信息。第二IMD可以基于接收到的治疗信息修改其操作。可以使用本文所述的各种技术来减少第一和第二IMD之间的串扰。例如，第一IMD可以产生电刺激信号以包括扩频能量分布或预定信号特征。基于预定的信号签名，第二IMD可以有效地去除感测到的心脏信号中的至少一些信号伪像。

25. 发明授权

US08301263B2 Therapy module crosstalk mitigation 有权
标题翻译：治疗模块串扰减轻
公开(公告)号：US08301263B2
公开(公告)日：2012-10-30
申请号：US12363180
申请日：2009-01-30
申请人： William T. Donofrio , Paul G. Krause , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
发明人： William T. Donofrio , Paul G. Krause , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/36114
摘要： A first implantable medical device (IMD) implanted within a patient may communicate with a second IMD implanted within the patient by encoding information in an electrical stimulation signal. The delivery of the electrical stimulation signal may provide therapeutic benefits to the patient. The second IMD may sense the electrical stimulation signal, which may be presented as an artifact in a sensed cardiac signal, and process the sensed signal to retrieve the encoded information. The second IMD may modify its operation based on the received therapy information. Crosstalk between the first and second IMDs may be reduced using various techniques described herein. For example, the first IMD may generate the electrical stimulation signal to include a spread spectrum energy distribution or a predetermined signal signature. The second IMD may effectively remove a least some of the signal artifact in a sensed cardiac signal based on the predetermined signal signature.
摘要翻译：植入在患者体内的第一可植入医疗装置（IMD）可以通过对电刺激信号中的信息进行编码来与植入患者内的第二IMD进行通信。电刺激信号的传递可以为患者提供治疗益处。第二IMD可以感测电刺激信号，其可以被呈现为感测到的心脏信号中的伪像，并且处理感测到的信号以检索经编码的信息。第二IMD可以基于接收到的治疗信息修改其操作。可以使用本文所述的各种技术来减少第一和第二IMD之间的串扰。例如，第一IMD可以产生电刺激信号以包括扩频能量分布或预定信号特征。基于预定的信号签名，第二IMD可以有效地去除感测到的心脏信号中的至少一些信号伪像。

26. 发明申请

US20100114189A1 THERAPY MODULE CROSSTALK MITIGATION 有权
标题翻译：治疗模块CROSSTALK减缓
公开(公告)号：US20100114189A1
公开(公告)日：2010-05-06
申请号：US12363180
申请日：2009-01-30
申请人： William T. Donofrio , Paul G. Krause , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
发明人： William T. Donofrio , Paul G. Krause , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
IPC分类号： A61N1/36
CPC分类号： A61N1/37288 , A61N1/36114
摘要： A first implantable medical device (IMD) implanted within a patient may communicate with a second IMD implanted within the patient by encoding information in an electrical stimulation signal. The delivery of the electrical stimulation signal may provide therapeutic benefits to the patient. The second IMD may sense the electrical stimulation signal, which may be presented as an artifact in a sensed cardiac signal, and process the sensed signal to retrieve the encoded information. The second IMD may modify its operation based on the received therapy information. Crosstalk between the first and second IMDs may be reduced using various techniques described herein. For example, the first IMD may generate the electrical stimulation signal to include a spread spectrum energy distribution or a predetermined signal signature. The second IMD may effectively remove a least some of the signal artifact in a sensed cardiac signal based on the predetermined signal signature.
摘要翻译：植入在患者体内的第一可植入医疗装置（IMD）可以通过对电刺激信号中的信息进行编码来与植入患者内的第二IMD进行通信。电刺激信号的传递可以为患者提供治疗益处。第二IMD可以感测电刺激信号，其可以被呈现为感测到的心脏信号中的伪像，并且处理感测到的信号以检索经编码的信息。第二IMD可以基于接收到的治疗信息修改其操作。可以使用本文所述的各种技术来减少第一和第二IMD之间的串扰。例如，第一IMD可以产生电刺激信号以包括扩频能量分布或预定信号特征。基于预定的信号签名，第二IMD可以有效地去除感测到的心脏信号中的至少一些信号伪像。

27. 发明授权

US09192769B2 Shunt-current reduction techniques for an implantable therapy system 有权
标题翻译：用于植入式治疗系统的分流电流还原技术
公开(公告)号：US09192769B2
公开(公告)日：2015-11-24
申请号：US12551331
申请日：2009-08-31
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
IPC分类号： A61N1/08 , A61N1/37 , A61N1/36 , A61N1/372
CPC分类号： A61N1/3718 , A61N1/08 , A61N1/086 , A61N1/36114 , A61N1/37288
摘要： Techniques for minimizing interference between the first and second medical devices or between the different therapy modules of a common medical device are described herein. In some examples, a medical device may include shunt-current mitigation circuitry and/or at least one clamping structure that helps minimize or even eliminate shunt-current that feeds into a first therapy module of the medical device via one or more electrodes electrically connected to the first therapy module. The shunt-current may be generated by the delivery of electrical stimulation by a second therapy module. The second therapy module may be enclosed in a common housing with the first therapy module or may be separate, e.g., a part of a separate medical device.
摘要翻译：本文描述了用于最小化第一和第二医疗装置之间或在普通医疗装置的不同治疗模块之间的干扰的技术。在一些示例中，医疗装置可以包括分流电流缓解电路和/或至少一个夹持结构，其有助于最小化或甚至消除通过电连接到医疗装置的一个或多个电极馈入医疗装置的第一治疗模块的分流电流第一疗法模块。分流电流可以通过第二治疗模块的电刺激递送来产生。第二治疗模块可以用第一治疗模块封闭在共同的壳体中，或者可以是分离的，例如单独的医疗装置的一部分。

28. 发明申请

US20100114211A1 SHUNT-CURRENT REDUCTION TECHNIQUES FOR AN IMPLANTABLE THERAPY SYSTEM 有权
标题翻译：用于可植入治疗系统的分流电流减少技术
公开(公告)号：US20100114211A1
公开(公告)日：2010-05-06
申请号：US12551331
申请日：2009-08-31
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Gerald P. Arne , Xiaohong Zhou
IPC分类号： A61N1/08 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3718 , A61N1/08 , A61N1/086 , A61N1/36114 , A61N1/37288
摘要： Techniques for minimizing interference between the first and second medical devices or between the different therapy modules of a common medical device are described herein. In some examples, a medical device may include shunt-current mitigation circuitry and/or at least one clamping structure that helps minimize or even eliminate shunt-current that feeds into a first therapy module of the medical device via one or more electrodes electrically connected to the first therapy module. The shunt-current may be generated by the delivery of electrical stimulation by a second therapy module. The second therapy module may be enclosed in a common housing with the first therapy module or may be separate, e.g., a part of a separate medical device.
摘要翻译：本文描述了用于最小化第一和第二医疗装置之间或在普通医疗装置的不同治疗模块之间的干扰的技术。在一些示例中，医疗装置可以包括分流电流缓解电路和/或至少一个夹持结构，其有助于最小化或甚至消除通过电连接到医疗装置的一个或多个电极馈入医疗装置的第一治疗模块的分流电流第一疗法模块。分流电流可以通过第二治疗模块的电刺激递送来产生。第二治疗模块可以用第一治疗模块封闭在共同的壳体中，或者可以是分离的，例如单独的医疗装置的一部分。

29. 发明授权

US08265771B2 Interference mitigation for implantable device recharging 有权
标题翻译：可植入装置充电的干扰减轻
公开(公告)号：US08265771B2
公开(公告)日：2012-09-11
申请号：US12610025
申请日：2009-10-30
申请人： William T. Donofrio , Paul Gordon Krause , Gerald P. Arne , James D. Reinke , David Jerome Peichel , Timothy Davis , John E. Burnes
发明人： William T. Donofrio , Paul Gordon Krause , Gerald P. Arne , James D. Reinke , David Jerome Peichel , Timothy Davis , John E. Burnes
IPC分类号： A61N1/08
CPC分类号： A61N1/37 , A61N1/3718 , A61N1/3787 , H02M1/44
摘要： A therapy or monitoring system may implement one or more techniques to mitigate interference between operation of a charging device that charges a first implantable medical device (IMD) implanted in a patient and a second IMD implanted in the patient. In some examples, the techniques may include modifying an operating parameter of the charging device in response to receiving an indication that a second IMD is implanted in the patient. The techniques also may include modifying an operating parameter of the second IMD in response to detecting the presence or operation of the charging device.
摘要翻译：治疗或监测系统可以实施一种或多种技术，以减轻对植入患者中的第一可植入医疗装置（IMD）充电的充电装置的操作与植入患者体内的第二IMD之间的干扰。在一些示例中，技术可以包括响应于接收到将第二IMD植入患者中的指示来修改充电装置的操作参数。这些技术还可以包括响应于检测到充电装置的存在或操作来修改第二IMD的操作参数。

30. 发明申请

US20100114241A1 INTERFERENCE MITIGATION FOR IMPLANTABLE DEVICE RECHARGING 有权
标题翻译：用于可移植设备充电的干扰减轻
公开(公告)号：US20100114241A1
公开(公告)日：2010-05-06
申请号：US12610025
申请日：2009-10-30
申请人： William T. Donofrio , Paul Gordon Krause , Gerald P. Arne , James D. Reinke , David Jerome Peichel , Timothy Davis , John E. Burnes
发明人： William T. Donofrio , Paul Gordon Krause , Gerald P. Arne , James D. Reinke , David Jerome Peichel , Timothy Davis , John E. Burnes
IPC分类号： A61N1/08
CPC分类号： A61N1/37 , A61N1/3718 , A61N1/3787 , H02M1/44
摘要： A therapy or monitoring system may implement one or more techniques to mitigate interference between operation of a charging device that charges a first implantable medical device (IMD) implanted in a patient and a second IMD implanted in the patient. In some examples, the techniques may include modifying an operating parameter of the charging device in response to receiving an indication that a second IMD is implanted in the patient. The techniques also may include modifying an operating parameter of the second IMD in response to detecting the presence or operation of the charging device.
摘要翻译：治疗或监测系统可以实施一种或多种技术，以减轻对植入患者中的第一可植入医疗装置（IMD）充电的充电装置的操作与植入患者体内的第二IMD之间的干扰。在一些示例中，技术可以包括响应于接收到将第二IMD植入患者中的指示来修改充电装置的操作参数。这些技术还可以包括响应于检测到充电装置的存在或操作来修改第二IMD的操作参数。

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