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21. 发明授权

US06331302B1 Protein tyrosine kinase agonist antibodies 失效
标题翻译：蛋白酪氨酸激酶激动剂抗体
公开(公告)号：US06331302B1
公开(公告)日：2001-12-18
申请号：US08446648
申请日：1996-05-23
申请人： Brian D. Bennett , David Goeddel , James M. Lee , William Matthews , Siao Ping Tsai , William I. Wood
发明人： Brian D. Bennett , David Goeddel , James M. Lee , William Matthews , Siao Ping Tsai , William I. Wood
IPC分类号： A61K39395
CPC分类号： C12Q1/6876 , A61K38/00 , A61K2039/505 , C07K14/71 , C07K14/82 , C07K16/2863 , C07K19/00 , C07K2317/34 , C07K2317/75 , C07K2319/00 , C12N9/1205 , C12Q2600/158
摘要： Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.
摘要翻译：公开了激动剂抗体，其结合受体蛋白酪氨酸激酶pTK的细胞外结构域，从而引起细胞内酪氨酸激酶结构域的二聚化和活化。抗体可用于激活其各自的受体，从而能够研究酪氨酸激酶受体在细胞生长和/或分化中的作用。还公开了包含受体pTK的细胞外结构域和免疫球蛋白恒定域序列的嵌合蛋白。

22. 发明授权

US5851984A Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides 失效
标题翻译：使用Wnt多肽增强造血干细胞增殖或分化的方法
公开(公告)号：US5851984A
公开(公告)日：1998-12-22
申请号：US696566
申请日：1996-08-16
申请人： William Matthews , Timothy W. Austin
发明人： William Matthews , Timothy W. Austin
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/06 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/475 , C12N5/06 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00 , C12N2799/027
摘要： Uses for Wnt polypeptides in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for enhancing proliferation or differentiation of a hematopoietic stem/progenitor cell using a Wnt polypeptide, and optionally another cytokine, are described.
摘要翻译：公开了用于造血中Wnt多肽的用途。特别地，描述了使用Wnt多肽和任选的另外的细胞因子增强造血干细胞/祖细胞的增殖或分化的体外和体内方法。

23. 发明授权

US07524937B2 WSX receptor agonist antibodies 失效
标题翻译： WSX受体激动剂抗体
公开(公告)号：US07524937B2
公开(公告)日：2009-04-28
申请号：US11439325
申请日：2006-05-22
申请人： Paul J. Carter , Nancy Y. Chiang , Kyung Jin Kim , William Matthews , Maria L. Rodrigues
发明人： Paul J. Carter , Nancy Y. Chiang , Kyung Jin Kim , William Matthews , Maria L. Rodrigues
IPC分类号： C07K16/00
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/715 , C07K14/72 , C07K14/721 , C07K2317/24 , C07K2319/00 , C07K2319/02 , G01N33/6869 , G01N33/6893 , G01N2500/00 , G01N2800/042
摘要： Methods for identifying antibodies that decrease body weight, fat depot weight or food intake in an obese animal are provided, as well as antibodies. Preferred antibodies bind to a reactor having a WSX motif and the extracellular domain sequence within SEQ ID NO:2.
摘要翻译：提供了用于鉴定在肥胖动物体内降低体重，脂肪贮存量或食物摄取的抗体的方法以及抗体。优选的抗体结合到具有SEQ ID NO：2中的WSX基序和胞外结构域序列的反应器。

24. 发明申请

US20070158323A1 Grounding assembly for welding wire feeder 有权
标题翻译：焊丝给料机接地组件
公开(公告)号：US20070158323A1
公开(公告)日：2007-07-12
申请号：US11327048
申请日：2006-01-06
申请人： Edward Enyedy , William Matthews
发明人： Edward Enyedy , William Matthews
IPC分类号： B23K9/10
CPC分类号： B23K9/1336
摘要： A portable wire feeder for providing welding wire and welding current to a welding operation includes an input electrically connected to a power source. An output is electrically connected to the input to receive welding current delivered to the input from the power source and to provide the welding current and welding wire to the welding operation through a guide hose. A motorized wire feeding system includes a motor and a feed roll driven by the motor to direct the wire from a wire supply to the output for provision of the welding wire to the welding operation through the guide hose. Power for the motorized wire feeding system is drawn from the welding current passed from the input to the output. A grounding assembly nonattachably contacts a work piece of the welding operation to electrically ground the power drawn from the welding current directly to the work piece.
摘要翻译：用于向焊接操作提供焊丝和焊接电流的便携式送丝器包括电连接到电源的输入。输出电连接到输入端以接收从电源输送到输入端的焊接电流，并且通过引导软管将焊接电流和焊丝提供给焊接操作。电动送丝系统包括电动机和由电动机驱动的供给辊，以将电线从电线供给到输出端，以通过导管提供焊丝到焊接操作。电动送丝系统的电源是从输入到输出的焊接电流引出的。接地组件不可接触地接触焊接操作的工件，以将从焊接电流引出的功率直接电接地到工件。

25. 发明申请

US20060280737A1 WSX receptor agonist antibodies 失效
公开(公告)号：US20060280737A1
公开(公告)日：2006-12-14
申请号：US11439325
申请日：2006-05-22
申请人： Paul Carter , Nancy Chiang , Kyung Kim , William Matthews , Maria Rodrigues
发明人： Paul Carter , Nancy Chiang , Kyung Kim , William Matthews , Maria Rodrigues
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C07K16/28
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/715 , C07K14/72 , C07K14/721 , C07K2317/24 , C07K2319/00 , C07K2319/02 , G01N33/6869 , G01N33/6893 , G01N2500/00 , G01N2800/042
摘要： Methods for identifying antibodies that decrease body weight, fat depot weight or food intake in an obese animal are provided, as well as antibodies. Preferred antibodies bind to a reactor having a WSX motif and the extracellular domain sequence within SEQ ID NO:2.

26. 发明申请

US20060075512A1 Transgenic mice containing PAFR gene disruptions 审中-公开
公开(公告)号：US20060075512A1
公开(公告)日：2006-04-06
申请号：US11284710
申请日：2005-11-21
申请人： Thomas Brennan , William Matthews , Mark Moore
发明人： Thomas Brennan , William Matthews , Mark Moore
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a platelet-activating factor receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

27. 发明申请

US20060037953A1 Hybrid powered welder 有权
标题翻译：混合动力焊机
公开(公告)号：US20060037953A1
公开(公告)日：2006-02-23
申请号：US10919815
申请日：2004-08-17
申请人： William Matthews , Bryce Muter , Frank Stupczy
发明人： William Matthews , Bryce Muter , Frank Stupczy
IPC分类号： B23K9/10
CPC分类号： B23K9/1081 , B23K9/1006 , B23K9/1075
摘要： An electric arc welder that includes a energy storage device and non-battery power source for the formation of an electric arc. The welder also includes battery charging circuit that controls the charging of the energy storage device by the non-battery power source. The non-battery power source can include an engine driven electric generator, power grid or a fuel cell.
摘要翻译：一种电弧焊机，其包括用于形成电弧的能量存储装置和非电池电源。焊机还包括电池充电电路，其通过非电池电源来控制储能装置的充电。非电池电源可以包括发动机驱动的发电机，电网或燃料电池。

28. 发明授权

US06673343B2 SAL-S1 receptor protein tyrosine kinase agonist antibodies 失效
标题翻译： SAL-S1受体蛋白酪氨酸激酶激动剂抗体
公开(公告)号：US06673343B2
公开(公告)日：2004-01-06
申请号：US09982610
申请日：2001-10-17
申请人： Brian D. Bennett , David V. Goeddel , James M. Lee , William Matthews , Siao Ping Tsai , William I. Wood
发明人： Brian D. Bennett , David V. Goeddel , James M. Lee , William Matthews , Siao Ping Tsai , William I. Wood
IPC分类号： A61K39395
CPC分类号： C12Q1/6876 , A61K38/00 , A61K2039/505 , C07K14/71 , C07K14/82 , C07K16/2863 , C07K19/00 , C07K2317/34 , C07K2317/75 , C07K2319/00 , C12N9/1205 , C12Q2600/158
摘要： Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.
摘要翻译：公开了激动剂抗体，其结合受体蛋白酪氨酸激酶pTK的细胞外结构域，从而引起细胞内酪氨酸激酶结构域的二聚化和活化。抗体可用于激活其各自的受体，从而能够研究酪氨酸激酶受体在细胞生长和/或分化中的作用。还公开了包含受体pTK的细胞外结构域和免疫球蛋白恒定域序列的嵌合蛋白。

29. 发明授权

US5864020A HTK ligand 失效
标题翻译： HTK配体
公开(公告)号：US5864020A
公开(公告)日：1999-01-26
申请号：US436054
申请日：1995-05-05
申请人： Brian D. Bennett , William Matthews
发明人： Brian D. Bennett , William Matthews
IPC分类号： G01N33/577 , A61K38/00 , C07K14/47 , C07K14/71 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/91 , C07K16/00
CPC分类号： C07K14/71 , C07K14/47 , C07K19/00 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： A novel hepatoma transmembrane kinase receptor ligand (Htk ligand) which binds to, and activates, the Htk receptor is disclosed. As examples, mouse and human Htk ligands have been identified in a variety of tissues using a soluble Htk-Fc fusion protein. The ligands have been cloned and sequenced. The invention also relates to nucleic acids encoding the ligand, methods for production and use of the ligand, and antibodies directed thereto.
摘要翻译：公开了与Htk受体结合并激活Htk受体的新型肝癌跨膜激酶受体配体（Htk配体）。作为实例，使用可溶性Htk-Fc融合蛋白在多种组织中鉴定了小鼠和人类Htk配体。配体已被克隆并测序。本发明还涉及编码配体的核酸，配体的制备和使用方法以及针对其的抗体。

30. 发明授权

US5635388A Agonist antibodies against the flk2/flt3 receptor and uses thereof 失效
标题翻译：抗flk2 / flt3受体的激动剂抗体及其用途
公开(公告)号：US5635388A
公开(公告)日：1997-06-03
申请号：US222299
申请日：1994-04-04
申请人： Brian D. Bennett , Susan D. Broz , William Matthews , Francis C. Zeigler
发明人： Brian D. Bennett , Susan D. Broz , William Matthews , Francis C. Zeigler
IPC分类号： C12N15/09 , A61K38/00 , A61K38/16 , A61K38/21 , A61K38/28 , A61K39/395 , A61P7/00 , A61P7/06 , A61P37/00 , A61P43/00 , C07K16/28 , C12N5/20 , C12N15/13 , C12P21/08 , C07H15/12
CPC分类号： C07K16/2896 , A61K39/395 , A61K2039/505
摘要： Agonist antibodies are disclosed which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain thereof. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells for example. The antibodies are able to cause primitive hematopoietic cells to proliferate and/or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, for example.
摘要翻译：公开了激动剂抗体，其结合flk2 / flt3受体的细胞外结构域，从而激活其细胞内激酶结构域。标记的抗体可用作例如用于检测原始造血细胞中flk2 / flt3受体的存在的诊断。抗体能够引起原始造血细胞增殖和/或分化，从而增强已经进行化疗或放射治疗或骨髓移植的哺乳动物中成熟血细胞谱系的增殖。例如，抗体进一步用于治疗由于疾病或出血而导致的血细胞减少的哺乳动物。

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