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21. 发明授权

EP1716122B1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权转让
标题翻译： MODULATOREN VON ATP-BINDENDEN KASSETTENTRANSPORTERN
公开(公告)号：EP1716122B1
公开(公告)日：2017-04-19
申请号：EP05712188.1
申请日：2005-01-31
申请人： Vertex Pharmaceuticals Incorporated
发明人： HADIDA RUAH, Sarah, S. , GROOTENHUIS, Peter, D., J. , MILLER, Mark, T. , HAMILTON, Matthew
IPC分类号： C07D231/40 , C07D263/48 , C07D277/46 , C07D277/54 , C07D277/82 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D493/10
CPC分类号： C07D231/40 , C07D233/46 , C07D233/88 , C07D263/48 , C07D271/10 , C07D271/113 , C07D277/40 , C07D277/46 , C07D277/54 , C07D277/82 , C07D285/135 , C07D317/60 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D493/10

22. 发明公开

EP1716122A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权转让
标题翻译： ATP结合盒转运调节剂的
公开(公告)号：EP1716122A1
公开(公告)日：2006-11-02
申请号：EP05712188.1
申请日：2005-01-31
申请人： VERTEX PHARMACEUTICALS INCORPORATED
发明人： HADIDA RUAH, Sarah, S. , GROOTENHUIS, Peter, D., J. , MILLER, Mark, T. , HAMILTON, Matthew
IPC分类号： C07D231/40 , C07D263/48 , C07D277/46 , C07D277/54 , C07D277/82 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D493/10
CPC分类号： C07D231/40 , C07D233/46 , C07D233/88 , C07D263/48 , C07D271/10 , C07D271/113 , C07D277/40 , C07D277/46 , C07D277/54 , C07D277/82 , C07D285/135 , C07D317/60 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D493/10
摘要： The present invention relates to modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators (I) or a pharmaceutically acceptable salt thereof, wherein: Ht is a 5-membered heteroaromatic ring containing 1-4 heteroatoms selected from O, S, N or NH, wherein said ring is optionally fused to a 6-membered monocyclic or 10-membered bicyclic carbocyclic or heterocyclic, aromatic or non-aromatic ring, wherein Ht is optionally substituted with w occurrences of -WRw, wherein w is 0-5; ring A is 3-7 membered monocyclic ring having 0-3 heteroatoms selected from O, S, N, or NH, wherein ring A is optionally substituted with q occurrences of QRQ; ring B is optionally fused to 5-6 membered carbocyclic or heterocyclic, aromatic or non-aromatic ring .

23. 发明申请

WO2014164827A1 WORK TABLE HAVING ELEVATED SUPPORT MEMBERS 审中-公开
标题翻译：具有高度支持成员的工作表
公开(公告)号：WO2014164827A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/023568
申请日：2014-03-11
申请人： MILLER, Mark, T.
发明人： MILLER, Mark, T.
IPC分类号： F16M11/02
CPC分类号： F16M11/02 , B25H1/04
摘要： A work table having elevated support members is disclosed. The work table includes a plurality of generally parallel support arrangements. Each of the plurality of generally parallel support arrangements including a plurality of raised portions, wherein the plurality of raised portions are distributed substantially evenly along each of the plurality of generally parallel support arrangements. Each of the plurality of raised blocks defines an opening configured for receiving an attachment. The work table also includes an adaptor plate. The adapter plate may include a base member and a plurality of inserts, wherein the plurality of inserts are spaced apart for insertion into a plurality of raised block openings to removably attach the adaptor plate to the work table.
摘要翻译：公开了一种具有升高的支撑构件的工作台。工作台包括多个大致平行的支撑装置。所述多个大致平行的支撑装置中的每一个包括多个凸起部分，其中所述多个凸起部分基本上均匀地分布在所述多个大致平行的支撑装置中。多个凸起块中的每一个限定了用于接收附件的开口。工作台还包括适配器板。适配器板可以包括基部构件和多个插入件，其中多个插入件间隔开以插入多个凸起的块开口中，以将适配器板可移除地附接到工作台上。

24. 发明授权

EP2007756B1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权转让
标题翻译： ATP结合盒转运调节剂的
公开(公告)号：EP2007756B1
公开(公告)日：2015-08-26
申请号：EP07755298.2
申请日：2007-04-09
申请人： Vertex Pharmaceuticals Incorporated
发明人： RUAH, Sara, S., Hadida , GROOTENHUIS, Peter, D.J. , VAN GOOR, Fredrick , ZHOU, Jinglan , BEAR, Brian , MILLER, Mark, T. , MCCARTNEY, Jason , NUMA, Mehdi, Michel, Jamel , Yang, Xiaoqing
IPC分类号： C07D405/12 , C07D405/14 , A61K31/404 , A61P31/00
CPC分类号： C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10

25. 发明授权

EP2365972B1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权转让
标题翻译： ATP结合盒转运调节剂的
公开(公告)号：EP2365972B1
公开(公告)日：2014-12-17
申请号：EP08876364.4
申请日：2008-11-12
申请人： Vertex Pharmaceuticals Incorporated
发明人： RUAH, Sara, S., Hadida , GROOTENHUIS, Peter, D., J. , VAN GOOR, Fredrick , MILLER, Mark, T. , MCCARTNEY, Jason , ZHOU, Jinglan , BEAR, Brian , NUMA, Mehdi, Michel, Djamel
IPC分类号： C07D405/12 , A61K31/404 , A61P3/00 , A61P25/00
CPC分类号： C07D405/12 , C07D209/08 , C07D209/12 , C07D209/18 , C07D405/14 , C07D487/04

26. 发明公开

EP2365972A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权转让
公开(公告)号：EP2365972A1
公开(公告)日：2011-09-21
申请号：EP08876364.4
申请日：2008-11-12
申请人： Vertex Pharmaceuticals Incorporated
发明人： RUAH, Sara, Hadida, S. , GROOTENHUIS, Peter, D., J. , VAN GOOR, Fredrick , MILLER, Mark, T. , MCCARTNEY, Jason , ZHOU, Jinglan , BEAR, Brian , NUMA, Mehdi, Michel, Djamel
IPC分类号： C07D405/12 , A61K31/404 , A61P3/00 , A61P25/00
CPC分类号： C07D405/12 , C07D209/08 , C07D209/12 , C07D209/18 , C07D405/14 , C07D487/04
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

27. 发明公开

EP1646615A1 PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权
标题翻译：嘧啶衍生物FOR的使用视为调节剂的ATP结合盒转运
公开(公告)号：EP1646615A1
公开(公告)日：2006-04-19
申请号：EP04754303.8
申请日：2004-06-04
申请人： VERTEX PHARMACEUTICALS INCORPORATED
发明人： MAKINGS, Lewis, R. , SINGH, Ashvani, K. , MILLER, Mark, T. , HADIDA RUAH, Sarah, S. , GROOTENHUIS, Peter , HAMILTON, Matthew , HAZELWOOD, Anna, R. , HUANG, Liming
IPC分类号： C07D239/90 , C07D403/04 , C07D471/10 , C07D403/06 , C07D401/06 , C07D487/04 , C07D417/12 , C07D409/12 , C07D401/12 , C07D405/12 , C07D413/12 , C07D403/12 , C07D409/14 , C07D513/04 , C07D417/14
CPC分类号： C07D239/36 , C07D239/42 , C07D239/90 , C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/10 , C07D513/04
摘要： The present invention relates to compounds of Formula (I) as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

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