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21. 发明专利

ZA200803887B Heterocyclic modulators of ATP-Binding Cassette transporters 未知
公开(公告)号：ZA200803887B
公开(公告)日：2009-12-30
申请号：ZA200803887
申请日：2006-11-08
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , HAMILTON MATTHEW , MILLER MARK , GROOTENHUIS PETER D J , BEAR BRIAN , MCCARTHY JASON , ZHOU JINGLAN
IPC分类号： A61K20100101 , A61P20100101 , C07D20100101
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention..

22. 发明专利

CA2718310A1 PYRIDYL DERIVATIVES AS CFTR MODULATORS 未知
公开(公告)号：CA2718310A1
公开(公告)日：2009-10-08
申请号：CA2718310
申请日：2009-03-25
申请人： VERTEX PHARMA
发明人： HADIDA-RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER
IPC分类号： C07D213/75 , A61K31/44 , A61K31/4427 , A61P43/00 , C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, of formula (I), and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

23. 发明专利

CA3039943A1 HETEROARYL DERIVATIVES AS CFTR MODULATORS 未知
公开(公告)号：CA3039943A1
公开(公告)日：2009-09-03
申请号：CA3039943
申请日：2009-02-25
申请人： VERTEX PHARMA
发明人： HADIDA-RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN
IPC分类号： C07D405/12 , A61K31/495 , A61K31/497 , C07D241/20
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

24. 发明专利

AU2008322616A1 Isoquinoline modulators of ATP-Binding Cassette transporters 未知
公开(公告)号：AU2008322616A1
公开(公告)日：2009-05-22
申请号：AU2008322616
申请日：2008-11-14
申请人： VERTEX PHARMA
发明人： RUAH SARA HADIDA , BEAR BRIAN , GROOTENHUIS PETER D J , ZHOU JINGLAN , MILLER MARK
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14

25. 发明专利

CA2627358A1 HETEROCYCLIC MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 未知
公开(公告)号：CA2627358A1
公开(公告)日：2007-05-18
申请号：CA2627358
申请日：2006-11-08
申请人： VERTEX PHARMA
发明人： HAMILTON MATTHEW , HADIDA RUAH SARA , MILLER MARK , GROOTENHUIS PETER D J , ZHOU JINGLAN , MCCARTHY JASON , BEAR BRIAN
IPC分类号： C07D405/12 , A61K31/4418 , A61K31/5585 , A61P11/00 , C07D213/75 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention..

27. 发明专利

CA2718310C PYRIDYL DERIVATIVES AS CFTR MODULATORS 未知
公开(公告)号：CA2718310C
公开(公告)日：2018-08-07
申请号：CA2718310
申请日：2009-03-25
申请人： VERTEX PHARMA
发明人： HADIDA-RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER
IPC分类号： C07D213/75 , A61K31/44 , A61K31/4427 , A61P43/00 , C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, of formula (I), and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

28. 发明专利

NZ736561A Heteroaryl derivatives as cftr modulators 未知
公开(公告)号：NZ736561A
公开(公告)日：2018-02-23
申请号：NZ73656109
申请日：2009-02-25
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN
IPC分类号： C07D239/42 , A61K31/435 , A61K31/4965 , A61K31/505 , A61P3/00 , A61P25/00 , C07D213/75 , C07D241/20
摘要： Disclosed herein are 1-(benzo[d][1,3]dioxol-5-yl)-carboxamide compounds of formula (I), wherein the substituents are as defined in the specification, processes for its preparation, compositions comprising said compound and uses thereof. These compounds are useful as modulators of ATP-Binding Cassette (ABC) transporter or fragments thereof and is therefore useful in the treatment of condition, disease or disorders selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, protein C deficiency, Type 1 hereditary angioedema, familial hypercholesterolemia, Type 1 chylomicronemia, abetalipoproteinemia, I-cell disease/pseudo-Hurler, mucopolysaccharidoses, Sandhof/Tay-Sachs, Crigler-Najjar type II, polyendocrinopathy/hyperinsulemia, diabetes mellitus, laron dwarfism, myeloperoxidase deficiency, primary hypoparathyroidism, melanoma, glycanosis CDG type 1, hereditary emphysema, congenital hyperthyroidism, osteogenesis imperfecta, hereditary hypofibrinogenemia, ACT deficiency, diabetes insipidus (di), neurophyseal di, neprogenic DI, Charcot-Marie Tooth syndrome, Perlizaeus-Merzbacher disease, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, progressive supranuclear plasy, Pick’s disease, Huntington, spinocerebullar ataxia type I, spinal and bulbar muscular atrophy, dentatorubal pallidoluysian, myotonic dystrophy, hereditary Creutzfeldt-Jakob disease, Fabry disease, Straussler-Scheinker syndrome, COPD, dry-eye disease, and Sjögren’s disease.

29. 发明专利

PL2774925T3 Heterocykliczne modulatory transporterów z kasetą wiążącą ATP 未知
公开(公告)号：PL2774925T3
公开(公告)日：2017-07-31
申请号：PL14163968
申请日：2006-11-08
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARAH , HAMILTON MATTHEW , MILLER MARK , GROOTENHUIS PETER D J , BEAR BRIAN , MCCARTHY JASON , ZHOU JINGLAN
IPC分类号： C07D405/12 , A61K31/443 , A61P11/00

30. 发明专利

ES2619608T3 Moduladores heterocíclicos de transportadores de casete de unión a ATP 未知
公开(公告)号：ES2619608T3
公开(公告)日：2017-06-26
申请号：ES14163968
申请日：2006-11-08
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARAH , HAMILTON MATTHEW , MILLER MARK , GROOTENHUIS PETER D J , BEAR BRIAN , MCCARTHY JASON , ZHOU JINGLAN
IPC分类号： C07D405/12 , A61K31/443 , A61P11/00
摘要： Un compuesto de fórmula VI-A-i o fórmula VI-A-ii:**Fórmula** o una sal farmacéuticamente aceptable del mismo, en el que: T es -CH2-, -CF2- o -C(CH3)2-. R1' es H, alifático C1-6, halo, CF3, CHF2, -O(alifático C1-6), cicloalquilo C3-C5, o heterocicloalquilo C4-C6 que contiene un átomo de oxígeno; RD1 es ZDR9, en el que ZD está seleccionado de CONH, NHCO, SO2NH, SO2N(alquilo C1-6), NHSO2, CH2NHSO2, CH2N(CH3)SO2, CH2NHCO, COO, SO2, o CO; y R9 es H o alifático C1-6; y RD2 es H, hidroxilo, halo, alquilo C1-6, alcoxi C1-6, cicloalquilo C3-6, o NH2.

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