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21. 发明授权

US4209445A Process for the preparation of piperonylidenecrotonic acid amides 失效
标题翻译：制备胡椒基丁烯酸酰胺的方法
公开(公告)号：US4209445A
公开(公告)日：1980-06-24
申请号：US969113
申请日：1978-12-13
申请人： Hermann Oediger , Andreas Schulze
发明人： Hermann Oediger , Andreas Schulze
IPC分类号： C07D317/60 , C07D317/44
CPC分类号： C07D317/60
摘要： Process for the preparation of piperonylidenecrotonic acids amides of the formula ##STR1## in which R.sub.1 and R.sub.2 have the meaning given in the disclosure wherein piperonal is reacted with crotonic acid amides of the formula ##STR2## in the presence of hydroxides of the formulaA.sup.+ OH.sup.-in whichA.sup.+ represents a quaternary ammonium or phosphonium group or an alkali metal complex with neutral organic complex ligands,and polar aprotic or polar, sterically hindered protic organic solvents which are inert under the reaction conditions.
摘要翻译：制备式“IMAGE”的哌嗪基次丁酸酰胺的方法，其中R 1和R 2具有本公开内容中给出的含义，其中在式A + H的氢氧化物存在下，将胡椒醛与式“IMAGE”的巴豆酸酰胺反应， OH-，其中A +表示季铵或鏻基或具有中性有机络合物配体的碱金属络合物，以及在反应条件下为惰性的极性非质子或极性的空间位阻质子有机溶剂。

22. 发明授权

US3993666A Coumaranedione-3-monoximes 失效
标题翻译：香豆酮-3单肟
公开(公告)号：US3993666A
公开(公告)日：1976-11-23
申请号：US495550
申请日：1974-08-08
申请人： Hermann Oediger , Rudolf Braden
发明人： Hermann Oediger , Rudolf Braden
IPC分类号： C07D307/83 , C07D493/00
CPC分类号： C07D307/83
摘要： Coumaranedione-3-monoximes which may be substituted in the benzene ring by halo or alkyl. The compounds are obtained by treating the corresponding 2-hydroxyphenylacetic acid lactone with nitrous acid or with an ester, salt or chloride of nitrous acid in an acid medium. The coumaranedione-3-monoxime thus obtained is an intermediate which undergoes hydrogenation in the presence of a suitable acid anhydride to afford the corresponding 3-amidocoumaranone, which compound, upon hydrolysis in the presence of dilute acid, affords the corresponding .alpha.-amino-2-hydroxyphenylacetic acid. That product is also an intermediate which has utility in the synthesis of antibiotics, including cephalosporin and penicillin derivatives.
摘要翻译：可以在苯环中被卤素或烷基取代的甘油二酮-3-单肟。该化合物通过在酸性介质中用亚硝酸或亚硝酸的酯，盐或氯化物处理相应的2-羟基苯基乙酸内酯而获得。由此获得的香豆素二酮-3-肟是在合适的酸酐存在下进行氢化得到相应的3-氨基香豆素的中间体，该化合物在稀酸存在下水解时，得到相应的α-氨基-2 - 羟基苯乙酸。该产品也是在抗生素合成中具有用途的中间体，包括头孢菌素和青霉素衍生物。

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