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21. 发明申请

US20080056987A1 Quinoline derivatives, their preparation, their use, and medicaments comprising them 审中-公开
标题翻译：喹啉衍生物，其制备方法，用途以及包含它们的药物
公开(公告)号：US20080056987A1
公开(公告)日：2008-03-06
申请号：US11765683
申请日：2007-06-20
申请人： Olaf Prien , Knut Eis , Duy Nguyen , Christoph Huwe , Wolfgang Schwede , Judith Guenther , Dieter Zopf
发明人： Olaf Prien , Knut Eis , Duy Nguyen , Christoph Huwe , Wolfgang Schwede , Judith Guenther , Dieter Zopf
IPC分类号： A61K51/00 , A61K31/47 , A61P25/00 , A61P9/00 , C07D295/00 , C12Q1/00 , C12N9/99 , C07D215/00 , A61P43/00 , A61K31/5377
CPC分类号： C07D513/04 , C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A) in which R1, R2, W, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译：本发明涉及具有通式（A）的喹啉衍生物，其中R 1，R 2，W，X，Y和Z在说明书中表示，权利要求书，通式（A）的化合物用于各种病症的治疗，以及制备通式（A）的化合物。

22. 发明申请

US20070270679A1 Deflectable variable radius catheters 审中-公开
标题翻译：可变半径导管
公开(公告)号：US20070270679A1
公开(公告)日：2007-11-22
申请号：US11647311
申请日：2006-12-29
申请人： Duy Nguyen , Sheldon Nelson , Elizabeth Nee , Guy Vanney
发明人： Duy Nguyen , Sheldon Nelson , Elizabeth Nee , Guy Vanney
IPC分类号： A61M25/00
CPC分类号： A61M25/0152 , A61M25/0043 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61M2025/015 , A61M2025/0161 , A61M2025/105
摘要： The invention provides a deflectable catheter capable of forming many variable radius spiral forms from a single, flexible, distal end section. In one aspect, the catheter employs a variable radius control wire to extend or deform a pre-formed loop structure into a three dimensional spiral-like form or geometry. The ability of a single catheter to create the multitude of shapes and sizes possible allows users to access a greater number of anatomical areas without changing the catheter during a procedure or treatment. In another aspect, the invention encompasses methods of producing deflectable variable radius catheters, where two or more regions of the catheter having common control wires are fused or formed onto one another.
摘要翻译：本发明提供了一种能够从单个柔性远端部分形成许多可变半径螺旋形状的可偏转导管。在一个方面，导管使用可变半径控制线来将预成形的环结构延伸或变形为三维螺旋形的形状或几何形状。单个导管创建多种形状和尺寸的能力可能允许用户在手术或治疗期间不更换导管的情况下进入更多数量的解剖区域。在另一方面，本发明包括生产可偏转可变半径导管的方法，其中具有公共控制线的导管的两个或更多个区域彼此熔合或形成。

23. 发明申请

US20050143415A1 Substituted pentanols, a process for their production and their use as anti-inflammatory agents 失效
标题翻译：取代的戊醇，其生产方法及其作为抗炎剂的用途
公开(公告)号：US20050143415A1
公开(公告)日：2005-06-30
申请号：US10957742
申请日：2004-10-05
申请人： Stefan Jaroch , Stefan Baeurle , Markus Berger , Konrad Krolikiewicz , Duy Nguyen , Hartmut Rehwinkel , Norbert Schmees , Werner Skuballa , Heike Schaecke
发明人： Stefan Jaroch , Stefan Baeurle , Markus Berger , Konrad Krolikiewicz , Duy Nguyen , Hartmut Rehwinkel , Norbert Schmees , Werner Skuballa , Heike Schaecke
IPC分类号： A61K31/47 , C07D215/38 , C07D217/22
CPC分类号： C07D215/38 , C07D217/22
摘要： The invention relates to substituted pentanols, a process for their production and their use as anti-inflammatory agents.
摘要翻译：本发明涉及取代戊醇，其制备方法及其作为抗炎剂的用途。

24. 发明申请

US20050065244A1 Alkanolamine polymer salt additives for creping of fibrous webs 审中-公开
标题翻译：用于起皱纤维网的烷醇胺聚合物盐添加剂
公开(公告)号：US20050065244A1
公开(公告)日：2005-03-24
申请号：US10927204
申请日：2004-12-03
申请人： Duy Nguyen
发明人： Duy Nguyen
IPC分类号： C08F8/44 , D21H21/00 , D21H21/14 , C08L1/00
CPC分类号： D21H21/00 , C08F8/44 , D21H21/146
摘要： The present invention provides compositions a useful in the creping of paper products such as facial tissue and bathroom tissue. The compositions comprise an alkanolamine salt of a styrene-methacrylic acid co-polymer. According to a process according to the invention, a composition of the invention is contacted with the dryer cylinder in a creping process.
摘要翻译：本发明提供了用于起皱纸制品如面巾纸和卫生纸巾的组合物。组合物包含苯乙烯 - 甲基丙烯酸共聚物的链烷醇胺盐。根据本发明的方法，本发明的组合物在起皱过程中与干燥机筒接触。

25. 发明授权

US08790387B2 Expandable sheath for introducing an endovascular delivery device into a body 有权
标题翻译：用于将血管内输送装置引入体内的可扩展护套
公开(公告)号：US08790387B2
公开(公告)日：2014-07-29
申请号：US13312739
申请日：2011-12-06
申请人： Duy Nguyen , Kim Nguyen , Thanh V. Nguyen
发明人： Duy Nguyen , Kim Nguyen , Thanh V. Nguyen
IPC分类号： A61F2/06 , A61F2/24 , A61B19/00
CPC分类号： A61F2/2427 , A61B90/39 , A61F2/2418 , A61F2/2433 , A61F2/2436 , Y10T156/1026
摘要： Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.
摘要翻译：可扩张护套的实施例可以与导管组件一起使用以将诸如心脏瓣膜的假体装置引入患者体内。这样的实施例可以通过允许引导器护套的一部分临时膨胀以适应输送装置来最小化对容器的创伤，然后一旦假肢装置通过就恢复到原始直径。一些实施例可以包括具有内层和外层的护套，其中内层的折叠部分延伸穿过外层中的狭缝，并且外层的一部分与内层的折叠部分重叠。一些实施例包括位于外层外部的弹性外盖。本发明的可扩张护套的实施例可以避免需要多次插入用于扩张容器，从而提供优于现有技术的导引器护套的优点。

26. 发明申请

US20130065272A1 Synthesis of Site Specifically-Linked Ubiquitin 审中-公开
标题翻译：场地特异性连接的泛素的合成
公开(公告)号：US20130065272A1
公开(公告)日：2013-03-14
申请号：US13636618
申请日：2011-03-23
申请人： Jason Chin , Duy Nguyen , Satpal Virdee
发明人： Jason Chin , Duy Nguyen , Satpal Virdee
IPC分类号： C07K1/107 , C12P21/06 , C12N9/50 , C07K14/435
CPC分类号： C07K14/4702 , C07K1/064 , C07K1/065 , C07K1/068 , C07K1/1075 , C07K1/1077 , C07K14/435 , C12N9/50 , C12N9/93 , C12P21/02 , C12P21/06 , Y02P20/55
摘要： The invention relates to a method of modifying a specific lysine residue in a polypeptide comprising at least two lysine residues, said method comprising (a) providing a polypeptide comprising a target lysine residue protected by a first protecting group, and at least one further lysine residue; (b) treating the polypeptide to protect said further lysine residue(s), wherein the protecting group for said further lysine residues is different to the protecting group for the target lysine residue; (c) selectively deprotecting the target lysine residue; and (d) modifying the deprotected lysine residue of (c).
摘要翻译：本发明涉及一种修饰包含至少两个赖氨酸残基的多肽中的特定赖氨酸残基的方法，所述方法包括（a）提供包含被第一保护基团保护的靶赖氨酸残基的多肽和至少一种赖氨酸残基 ; （b）处理多肽以保护所述另外的赖氨酸残基，其中所述另外的赖氨酸残基的保护基与靶赖氨酸残基的保护基不同; （c）选择性脱保护目标赖氨酸残基; 和（d）修饰（c）的去保护的赖氨酸残基。

27. 发明授权

US07662821B2 Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 失效
标题翻译：四氢萘衍生物，其生产方法及其作为抗炎剂的用途
公开(公告)号：US07662821B2
公开(公告)日：2010-02-16
申请号：US10962169
申请日：2004-10-12
申请人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
发明人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
IPC分类号： A61K31/497 , A61K31/44 , A61K31/415 , A61K31/275 , C07D239/72 , C07D237/26 , C07D209/04 , C07C255/49 , C07C62/38 , C07C211/44
CPC分类号： C07D277/62 , C07D209/34 , C07D209/46 , C07D215/38 , C07D217/24 , C07D231/56 , C07D237/30 , C07D239/74
摘要： The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents.
摘要翻译：本发明涉及四氢萘衍生物，其制备方法及其作为抗炎剂的用途。

28. 发明授权

US07659297B2 Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 失效
标题翻译：四氢萘衍生物，其生产方法及其作为抗炎剂的用途
公开(公告)号：US07659297B2
公开(公告)日：2010-02-09
申请号：US10960754
申请日：2004-10-08
申请人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
发明人： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
IPC分类号： A01N43/56 , C07D231/02 , C07D231/54 , C07D487/00
CPC分类号： C07D209/34 , C07D209/46 , C07D215/38 , C07D217/24 , C07D231/56 , C07D237/30 , C07D239/74 , C07D277/62
摘要： The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as antiinflammatory agents.
摘要翻译：本发明涉及式（I）的多取代四氢萘衍生物的制备方法及其作为抗炎剂的用途。

29. 发明申请

US20060084652A1 Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 审中-公开
标题翻译：亚烷基 - 四氢萘衍生物，其制备方法及其作为抗炎剂的用途
公开(公告)号：US20060084652A1
公开(公告)日：2006-04-20
申请号：US11222250
申请日：2005-09-09
申请人： Stefan Baeurle , Markus Berger , Stefan Jaroch , Konrad Krolikiewicz , Duy Nguyen , Hartmut Rehwinkel , Heike Schaecke , Norbert Schmees , Werner Skuballa
发明人： Stefan Baeurle , Markus Berger , Stefan Jaroch , Konrad Krolikiewicz , Duy Nguyen , Hartmut Rehwinkel , Heike Schaecke , Norbert Schmees , Werner Skuballa
IPC分类号： A61K31/517 , A61K31/502 , A61K31/4704
CPC分类号： C07D247/00
摘要： The invention relates to alkylidene-tetrahydronaphthalene derivatives of general formula (I), process for their production, and their use as anti-inflammatory agents.
摘要翻译：本发明涉及通式（I）的亚烷基 - 四氢萘衍生物，其制备方法及其作为抗炎剂的用途。

30. 发明申请

US20050153866A1 Paper products softening process using amphoteric surfactants 审中-公开
标题翻译：造纸产品使用两性表面活性剂的软化工艺
公开(公告)号：US20050153866A1
公开(公告)日：2005-07-14
申请号：US11013079
申请日：2004-12-15
申请人： Duy Nguyen , Samir Ashrawi
发明人： Duy Nguyen , Samir Ashrawi
IPC分类号： B01F17/04 , D21H21/24 , C11D17/00
CPC分类号： C07C233/35 , D21H21/24
摘要： Provided herein are amphoteric surfactants derived from ethyleneamines, and processes for using such surfactants in the treatment of paper, fibers, textiles, hair, and human skin, to impart softness-to-the-touch properties to these and other substrates.
摘要翻译：本文提供了衍生自乙撑胺的两性表面活性剂，以及使用这种表面活性剂处理纸，纤维，纺织品，毛发和人皮肤的方法，以赋予这些和其它基材柔软的触感性质。

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