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21. 发明专利

CA2870666A1 COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY 未知
公开(公告)号：CA2870666A1
公开(公告)日：2013-10-24
申请号：CA2870666
申请日：2013-04-16
申请人： UNIV CASE WESTERN RESERVE , UNIV KENTUCKY , UNIV TEXAS
发明人： MARKOWITZ SANFORD , WILLSON JAMES K V , POSNER BRUCE A , READY JOSEPH , ZHANG YONGYOU , TAI HSIN-HSIUNG , MOSS MELISSA , ANTCZAK MONIKA , GERSON STANTON , BAE KIBEOM , YANG SUNG YEUN , DESAI AMAR
IPC分类号： A61K31/4365 , A61K31/4462 , A61P17/02 , A61P29/00 , C07D495/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.

22. 发明专利

CL2021001321A1 Composiciones y métodos para modular la actividad de deshidrogenasas de cadena corta 未知
公开(公告)号：CL2021001321A1
公开(公告)日：2022-04-01
申请号：CL2021001321
申请日：2021-05-20
申请人： UNIV CASE WESTERN RESERVE , UNIV TEXAS , RODEO THERAPEUTICS CORP
发明人： MARKOWITZ SANFORD , READY JOSEPH , GWALTNEY II STEPHEN L , ANTCZAK MONIKA
IPC分类号： A61K31/505 , A61K31/519 , C07D417/04 , C07D495/02 , C07D495/04
摘要： Los compuestos y métodos para modular la actividad de 15-PGDH, modular los niveles de prostaglandina tisular, tratar enfermedades, trastornos de enfermedades o afecciones donde se desea modular la actividad de 15-PGDH y/o los niveles de prostaglandinas incluyen inhibidores de 15-PGDH descritos en el presente documento.

23. 发明专利

SG11202105345TA COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY 未知
公开(公告)号：SG11202105345TA
公开(公告)日：2021-06-29
申请号：SG11202105345T
申请日：2019-11-21
申请人： UNIV CASE WESTERN RESERVE , UNIV TEXAS , RODEO THERAPEUTICS CORP
发明人： MARKOWITZ SANFORD , READY JOSEPH , GWALTNEY II , ANTCZAK MONIKA
IPC分类号： A61K31/519 , A61K31/505 , C07D417/04 , C07D495/02 , C07D495/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

24. 发明专利

AU2018272108A1 Compositions and methods of modulating short-chain dehydrogenase activity 未知
公开(公告)号：AU2018272108A1
公开(公告)日：2020-01-23
申请号：AU2018272108
申请日：2018-05-29
申请人： UNIV TEXAS , UNIV CASE WESTERN RESERVE
发明人： MARKOWITZ SANFORD , ANTCZAK MONIKA , READY JOSEPH , ZHANG YOUNGYOU
IPC分类号： C07D487/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

25. 发明专利

HK1250651A1 調控短鏈脫氫酶活性的組合物和方法未知
公开(公告)号：HK1250651A1
公开(公告)日：2019-01-11
申请号：HK18110182
申请日：2018-08-08
申请人： UNIV CASE WESTERN RESERVE , UNIV TEXAS
发明人： MARKOWITZ SANFORD D , READY JOSEPH , ZHANG YONGYOU , ANTCZAK MONIKA , WILLSON JAMES K V , POSNER BRUCE A , GREENLEE WILLIAM
IPC分类号： A61K20060101 , C07D20060101

26. 发明专利

HUE037262T2 Készítmények és 15-PGDH aktivitás modulálási módszerek 未知
公开(公告)号：HUE037262T2
公开(公告)日：2018-08-28
申请号：HUE13779034
申请日：2013-04-16
申请人： UNIV CASE WESTERN RESERVE , UNIV TEXAS , UNIV OF KENTUCKY
发明人： MARKOWITZ SANFORD , WILLSON JAMES , POSNER BRUCE , READY JOSEPH , ZHANG YONGYOU , TAI HSIN-HSIUNG , MOSS MELISSA , ANTCZAK MONIKA , GERSON STANTON , DESAI AMAR , BAE KIBEOM , YANG SUNG YEUN
IPC分类号： A61P17/02 , A61P29/00

27. 发明专利

AU2013249434B2 Compositions and methods of modulating 15-PGDH activity 未知
公开(公告)号：AU2013249434B2
公开(公告)日：2017-10-12
申请号：AU2013249434
申请日：2013-04-16
申请人： UNIV TEXAS , UNIV CASE WESTERN RESERVE , UNIV OF KENTUCKY
发明人： MARKOWITZ SANFORD , WILLSON JAMES K V , POSNER BRUCE A , READY JOSEPH , ZHANG YONGYOU , TAI HSIN-HSIUNG , MOSS MELISSA , ANTCZAK MONIKA , GERSON STANTON , BAE KIBEOM , YANG SUNG YEUN , DESAI AMAR
IPC分类号： C07D495/04 , A61K31/4365 , A61K31/4462 , A61P17/02 , A61P29/00
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.

28. 发明专利

CA2927730A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY 未知
公开(公告)号：CA2927730A1
公开(公告)日：2015-05-07
申请号：CA2927730
申请日：2014-10-15
申请人： UNIV CASE WESTERN RESERVE , UNIV TEXAS
发明人： MARKOWITZ SANFORD , WILLSON JAMES K V , POSNER BRUCE , READY JOSEPH , ANTCZAK MONIKA , ZHANG YONGYOU , DESAI AMAR , GERSON STANTON , GREENLEE WILLIAM
IPC分类号： A61K31/4743 , C07D495/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

29. 发明专利

AU2018272108B2 Compositions and methods of modulating short-chain dehydrogenase activity 未知
公开(公告)号：AU2018272108B2
公开(公告)日：2022-09-15
申请号：AU2018272108
申请日：2018-05-29
申请人： UNIV TEXAS , UNIV CASE WESTERN RESERVE
发明人： MARKOWITZ SANFORD , ANTCZAK MONIKA , READY JOSEPH , ZHANG YOUNGYOU
IPC分类号： C07D487/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

30. 发明专利

AR122137A1 COMPOSICIONES Y MÉTODOS PARA MODULAR LA ACTIVIDAD DE DESHIDROGENASAS DE CADENA CORTA 未知
公开(公告)号：AR122137A1
公开(公告)日：2022-08-17
申请号：ARP210101381
申请日：2021-05-20
申请人： UNIV CASE WESTERN RESERVE , UNIV TEXAS , RODEO THERAPEUTICS CORP
发明人： GWALTNEY STEPHEN L , READY JOSEPH , ANTCZAK MONIKA , MARKOWITZ SANFORD D , DESAI AMAR , GERSON STANTON
IPC分类号： C07D495/04 , A61K31/437 , A61K31/4985 , A61K31/513 , A61K31/517 , A61K31/519 , A61P1/04 , A61P1/16 , A61P5/44 , A61P9/00 , A61P13/12 , A61P29/00 , A61P35/00 , A61P35/02 , C07D519/00
摘要： Los compuestos y métodos para modular la actividad de 15-PGDH, modular los niveles de prostaglandina tisular, tratar enfermedades, trastornos de enfermedades o estados donde se desea modular la actividad de 15-PGDH y/o los niveles de prostaglandinas incluyen inhibidores de 15-PGDH descritos en el presente documento. Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable, tautómero o solvato del mismo, en la que: R¹ es alquilo, haloalquilo, cicloalquilo, alquileno-cicloalquilo, alquileno-alcoxilo, heterociclilo, o alquileno-heterociclilo; R² es -NH₂, CN, o -NHC(O)(alquilo C₁-C₆); R⁶ es un compuesto del grupo de fórmulas (2), cada uno de los cuales está opcionalmente sustituido con uno o más R³; R⁷ es alquilo, haloalquilo, cicloalquilo, arilo, heterociclilo, heteroarilo, -C(O)-alquilo, -C(O)O-alquilo, o -C(O)NR⁵-alquilo, cada uno de los cuales está opcionalmente sustituido con uno o más R⁴; R³ es -OH, -O-alqueileno-OH, -O-alqueileno-N(R⁵)₂, -N(R⁵)₂, -N(R⁵)(alquileno-OH), -N(R⁵)(alquileno-O-alquilo), alquilo, -alquileno-OH, haloalquilo, cicloalquilo, heterociclilo, -C(O)N(R⁵)₂, -C(O)N(R⁵)(alquileno-OH), -C(O)-alquilo, -C(O)O-alquilo, o -S(O)ₘ-alquilo, donde el cicloalquilo y el heterociclilo está cada uno opcionalmente sustituido con R¹⁰; R⁴ es oxo, halógeno, -CN, -N(R⁵)₂, -OH, -O-alquileno-OH, -S(O)ₘ-alquilo, -C(O)-alquilo, -C(O)-cicloalquilo, alquilo, -alquileno-O-alquilo, alcoxilo, haloalquilo, cicloalquilo, heterociclilo, o -alquileno-arilo opcionalmente sustituido con R⁸, donde cuando R⁴ es oxo y R⁷ es arilo o heteroarilo, oxo no viola la valencia del arilo o el heteroarilo; cada R⁵ es independientemente, H, alquilo, -alquileno-OH opcionalmente sustituido con -OH, -alquileno-NH₂, -alquileno-N(R⁹)₂, -alquileno-O-alquileno-OH, -alquileno-O alquileno-NH₂, -C(O)-alquilo, -C(O)O-alquilo, -alquileno-COOH, o -S(O)ₘ-alquilo; R⁸ es halógeno, alquilo C₁-C₆, o alcoxilo C₁-C₆; R⁹ es H o alquilo C₁-C₆; R¹⁰ es -OH, halógeno, alquilo C₁-C₆, o alcoxilo C₁-C₆; R¹¹ es H o alquilo C₁-C₆; X es N o CH; m es 0, 1, ó 2; y n es 0, 1 ó 2.

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