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21. 发明专利

CA2808457A1 INTELLIGENT DRUG AND/OR FLUID DELIVERY SYSTEM TO OPTIMIZE MEDICAL TREATMENT OR THERAPY USING PHARMACODYNAMIC AND/OR PHARMACOKINETIC DATA 未知
公开(公告)号：CA2808457A1
公开(公告)日：2012-02-23
申请号：CA2808457
申请日：2011-08-17
申请人： UNIV FLORIDA
发明人： MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT , GOLD MARK S
IPC分类号： A61M5/14 , A61M5/142 , A61M5/172 , A61M39/08 , A61M39/22 , G05B13/02 , G06F19/00 , G06Q50/00
摘要： A pharmacodynamic (PD), pharmacokinetic (PK), or both and PK guided infusion device, system and method optimizes the safety and efficacy of various forms of treatment or therapy (e.g., drug and/or fluid) in a variety of health-care and other settings.

22. 发明专利

DE602005019600D1 未知
公开(公告)号：DE602005019600D1
公开(公告)日：2010-04-08
申请号：DE602005019600
申请日：2005-09-20
申请人： UNIV FLORIDA
发明人： MELKER RICHARD J , MOREY TIMOTHY E , PROKAI LASZLO , DENNIS DONN M
IPC分类号： C12Q1/26 , C12Q1/00
摘要： The present invention provides systems and methods for determining enzymatic competency, which is important in determining whether a patient may suffer an adverse drug reaction, has a disease associated with defects in specific enzymatic function, and/or has an enzyme defect that is likely to cause pathophysiology. As contemplated herein, a parent molecular entity is administered to a patient in whom enzymatic competency is to be determined. A sample of the patient's bodily fluid is exposed to a sensor of the invention to distinguish, detect, and quantify a detectable entity in the bodily fluid. Sensor-acquired data regarding the detectable entity is used to determine enzymatic competency. Preferably, a sample of a patient's exhaled breath is collected and exposed to the sensor of the invention. Types of sensor systems of the invention include, but are not limited to, surface resonance arrays; microelectromechanical sensors (such as microcantilever-based technology); molecularly imprinted polymer sensors; amplifying fluorescent sensor technology; aptamer-based sensor technology; SAW sensors; infrared sensors; fuel cells; chemical reactors; and pH sensitive sensors.

24. 发明专利

CA2417800A1 NOVEL MICROEMULSION AND MICELLE SYSTEMS FOR SOLUBILIZING DRUGS 未知
公开(公告)号：CA2417800A1
公开(公告)日：2002-02-07
申请号：CA2417800
申请日：2001-07-31
申请人： UNIV FLORIDA
发明人： DENNIS DONN M , MOREY TIMOTHY E , MODELL JEROME H , GRAVENSTEIN NIKOLAUS , SHAH DINESH
IPC分类号： A61K9/107 , A61K47/12 , A61K47/34 , A61K31/05
摘要： A microemulsion delivery system for water insoluble or sparingly water solub le drugs that comprise a long polymer chain surfactant component and a short fatty acid sufractant component, with the amount of each being selected to provide stable microemulsion or micellar systems.

25. 发明专利

CA2808379C CENTRAL SITE PHOTOPLETHYSMOGRAPHY, MEDICATION ADMINISTRATION, AND SAFETY 未知
公开(公告)号：CA2808379C
公开(公告)日：2019-04-09
申请号：CA2808379
申请日：2011-08-08
申请人： UNIV FLORIDA , XHALE INC
发明人： MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT , GOLD MARK , ALLEN RICHARD
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/087 , A61B5/145
摘要： A monitoring and control system, apparatus and method for safe administration, reduction or cessation of administration of at least on medication, fluid or both, which includes at least one Central Source Site (CSS) Photoplethysmography (PPG) sensor coupled to means for control of delivery of the at least one medication, fluid or both.

26. 发明专利

CA2808457C INTELLIGENT DRUG AND/OR FLUID DELIVERY SYSTEM TO OPTIMIZE MEDICAL TREATMENT OR THERAPY USING PHARMACODYNAMIC AND/OR PHARMACOKINETIC DATA 未知
公开(公告)号：CA2808457C
公开(公告)日：2018-09-04
申请号：CA2808457
申请日：2011-08-17
申请人： UNIV FLORIDA
发明人： MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT , GOLD MARK S
IPC分类号： A61M5/14 , A61M5/142 , A61M5/172 , A61M39/08 , A61M39/22 , G05B13/02 , G06Q50/00
摘要： A pharmacodynamic (PD), pharmacokinetic (PK), or both and PK guided infusion device, system and method optimizes the safety and efficacy of various forms of treatment or therapy (e.g., drug and/or fluid) in a variety of health-care and other settings.

27. 发明专利

CA2912215A1 SMART® MEDICATION ADHERENCE FORMULATION, METHOD, DEVICE AND SYSTEM FOR TOPICAL, VAGINAL OR RECTAL ROUTES OF ADMINISTRATION 未知
公开(公告)号：CA2912215A1
公开(公告)日：2014-12-04
申请号：CA2912215
申请日：2014-05-21
申请人： UNIV FLORIDA
发明人： DENNIS DONN M
IPC分类号： A61K47/10 , A61B5/083 , A61J3/04 , A61J3/08 , A61K9/00 , G01N33/497
摘要： Novel compositions, methods, systems and devices are disclosed which contain markers for definitive medication adherence monitoring for Active Pharmaceutical Ingredients (APIs) delivered topically, vaginally or rectally. This invention is useful in a wide range of contexts, including, but not limited to, clinical trial settings, home use settings, or other settings, where it is necessary to definitively confirm that a given patient has taken or been administered a given medication at the correct time and in the correct dosage via a topical, vaginal or rectal route of delivery. Specific formulations of markers are disclosed for inclusion in compositions for Active Pharmaceutical Ingredient (API) delivery, including but not limited to delivery of microbicidally active compounds such that on topical, vaginal or rectal delivery, said AEM is detected in the breath or an Exhaled Drug Emplacement Marker, EDEM, which is a metabolite of the AEM, is detected in the breath.

28. 发明专利

CA2808379A1 CENTRAL SITE PHOTOPLETHYSMOGRAPHY, MEDICATION ADMINISTRATION, AND SAFETY 未知
公开(公告)号：CA2808379A1
公开(公告)日：2012-02-23
申请号：CA2808379
申请日：2011-08-08
申请人： UNIV FLORIDA , XHALE INC
发明人： MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT , GOLD MARK , ALLEN RICHARD
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/087 , A61B5/145
摘要： A monitoring and control system, apparatus and method for safe administration, reduction or cessation of administration of at least on medication, fluid or both, which includes at least one Central Source Site (CSS) Photoplethysmography (PPG) sensor coupled to means for control of delivery of the at least one medication, fluid or both.

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