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21. 发明申请

WO2016040940A1 OCCIDIOFUNGIN FORMULATIONS AND USES THEREOF 审中-公开
标题翻译： OCCIDIOFUNGIN制剂及其用途
公开(公告)号：WO2016040940A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/049972
申请日：2015-09-14
申请人： SMITH, James , PRUETT, Stephen , AUSTIN, Frank , LU, Shien , AKSHAYA, Ravichandran , LAIHING, Steven
发明人： SMITH, James , PRUETT, Stephen , LU, Shien , AKSHAYA, Ravichandran , LAIHING, Steven
IPC分类号： A61K38/12
CPC分类号： A61K38/12 , A61K9/0019 , A61K9/08 , A61K9/127 , A61K31/724 , A61K45/06 , A61K47/40 , A61K2300/00
摘要： Disclosed are occidiofungin formulations and uses thereof for the treatment of proliferative disorders, such as cancer. Methods of producing the disclosed occidiofungin formulations are also provided. Further, methods of treating a subject with the formulations are provided. In some embodiments, the formulations include occidiofungin and one or more cyclodextrins. The formulations may optionally further comprise an additional chemotherapeutic agent for treating the proliferative disease, lipid vesicles, and/or aqueous solvents (including pharmaceutically acceptable buffers and/or exceipients).
摘要翻译：本发明涉及用于治疗增殖性疾病例如癌症的中毒素制剂及其用途。还提供了产生所公开的间苯二酚制剂的方法。此外，提供了用制剂治疗受试者的方法。在一些实施方案中，制剂包括间质生长素和一种或多种环糊精。制剂可以任选地进一步包含用于治疗增殖性疾病，脂质囊泡和/或水性溶剂（包括药学上可接受的缓冲液和/或优异剂）的另外的化学治疗剂。

22. 发明申请

WO2012009628A1 LAMP SYSTEMS AND METHODS FOR GENERATING ULTRAVIOLET LIGHT 审中-公开
标题翻译：用于产生紫外线灯的灯系统和方法
公开(公告)号：WO2012009628A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/044169
申请日：2011-07-15
申请人： NORDSON CORPORATION , BORSUK, James, M. , HARRELL, Greg , MCGHEE, Edward, C. , SMITH, James
发明人： BORSUK, James, M. , HARRELL, Greg , MCGHEE, Edward, C. , SMITH, James
IPC分类号： F21V29/00
CPC分类号： G21K5/00 , B05D3/061 , F26B3/28 , G21K5/08
摘要： Apparatus for generating ultraviolet light and methods of operating an ultraviolet light source. The apparatus may include a microwave chamber (16) enclosing an interior space, a light source (10) with a lamp head (28) coupled to the microwave chamber (16), an ultraviolet (UV) transmissive member (88) positioned above the lamp face (32) and below the interior space to define a plenum (116) therebetween, and an exhaust system (100) coupled in fluid communication with the plenum. The lamp head (28) has a lamp face (32) through which ultraviolet light (34) and cooling air (30) are emitted. The UV transmissive member (88) is configured to transmit the ultraviolet light (34) into the interior space and to divert the cooling air (30) from the interior space. The exhaust system (100) configured to exhaust the cooling air (30) from the plenum (116).
摘要翻译：用于产生紫外光的装置和操作紫外光源的方法。该装置可以包括：包围内部空间的微波室（16），具有与微波室（16）耦合的灯头（28）的光源（10）;位于所述微波室（32）并且在内部空间下方限定其间的气室（116），以及与气室流体连通的排气系统（100）。灯头（28）具有发射紫外线（34）和冷却空气（30）的灯面（32）。 UV透射构件（88）构造成将紫外光（34）传输到内部空间并且使冷却空气（30）从内部空间转移。排气系统（100）构造成从冷气室（116）排出冷却空气（30）。

23. 发明申请

WO2012049652A1 AN INVERSIBLE TUBULAR MEMBER AND A GRIPPING DEVICE INCLUDING SUCH A MEMBER 审中-公开
标题翻译：一个可逆的管状构件和一个包括这样一个会员的搬运装置
公开(公告)号：WO2012049652A1
公开(公告)日：2012-04-19
申请号：PCT/IB2011/054535
申请日：2011-10-13
申请人： ENDOGROWTH (PROPRIETARY) LIMITED , SMITH, James
发明人： SMITH, James
IPC分类号： A61B17/00 , A61B17/22 , A61B17/221
CPC分类号： A61B17/22031 , A61B17/221 , A61B2017/00287 , A61B2017/00867 , A61B2017/22035 , A61B2017/2215
摘要： This invention relates to a gripping device (10), e.g. a surgical retrieval device. The device includes an inversible tubular member (28), which is composed of interengaged stitches of resiliently flexible filamentary material and which is progressively transformable between an everted condition and an inverted condition. The device includes also actuation means (12,20) carrying the inversible tubular member and operable for effecting progressive inversion and eversion of the inversible tubular member. Through progressive inversion of the inversible tubular member, an object can be gripped thereby.
摘要翻译：本发明涉及一种夹持装置（10），例如，手术检索装置。该装置包括由弹性柔软的丝状材料的相互接合的线圈构成的可逆的管状构件（28），并且可在转动状态和倒置状态之间逐渐变换。该装置还包括承载可逆管状构件的致动装置（12,20），并可操作以实现可逆管状构件的逐渐反转和外翻。通过可逆管状构件的逐渐反转，可以夹持物体。

24. 发明申请

WO2010017575A1 COMPOSITIONS AND METHODS FOR INHIBITING EMULSION FORMATION IN HYDROCARBON BODIES 审中-公开
标题翻译：用于抑制碳氢化合物中乳化物形成的组合物和方法
公开(公告)号：WO2010017575A1
公开(公告)日：2010-02-18
申请号：PCT/AU2009/000985
申请日：2009-07-29
申请人： M-I AUSTRALIA PTY LTD , M-I SWACO NOREGE AS , KHANDEKAR, Chandrashekhar , WILSON, Rohan , SMITH, James
发明人： KHANDEKAR, Chandrashekhar , WILSON, Rohan , SMITH, James
IPC分类号： C09K8/52
CPC分类号： C09K8/524 , C10G33/04 , C10G2300/203 , C10G2300/205
摘要： A composition for inhibiting the formation of an emulsion between naphthenic acid and metal ions in a hydrocarbon body, the composition including at least one alkoxylated amine in an amount of up to 30 % w/w, at least one acid in an amount of from 2 to 10 % w/w and at least one alcohol in an amount of from 30 to 70 % w/w. A method for inhibiting the formation of an emulsion between naphthenic acid and metal ions in a hydrocarbon body using such a composition is also proposed.
摘要翻译：一种用于抑制在烃体中形成环烷酸和金属离子之间的乳液的组合物，该组合物包括至多一种烷氧基化胺，其量至多为30％w / w，至少一种酸的量为2 至10％w / w和至少一种量为30至70％w / w的醇。还提出了使用这种组合物抑制烃体中环烷酸和金属离子之间形成乳液的方法。

25. 发明申请

WO2003076591A3 COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE 审中-公开
公开(公告)号：WO2003076591A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/007177
申请日：2003-03-10
申请人： EMORY UNIVERSITY , UNITED STATES OF AMERICA, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES , ROBINSON, Harriet, L. , SMITH, James , HUA, Jian , MOSS, Bernard
发明人： ROBINSON, Harriet, L. , SMITH, James , HUA, Jian , MOSS, Bernard
IPC分类号： C12N15/09
摘要： We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes, or recombinant forms. Moreover, the vectors can encode a variety of antigens, which may be obtained from one clade or from two or more different clades, and the antigens selected and/or the manner in which the vectors are formulated ( e.g. , mixed) can be manipulated to generate a protective immune response against a variety of clades ( e.g. , the clades to which a patient is most likely to be exposed; with the proportions of the components of the vaccine tailored to the extent of the patient's risk to a particular clade or clades).

26. 发明申请

WO2011032227A1 METHODS FOR SELECTION OF A NAPHTHENATE SOLIDS INHIBITOR AND TEST KIT, AND METHOD FOR PRECIPITATING NAPHTHENATE SOLIDS 审中-公开
标题翻译：用于选择石墨固体抑制剂和测试试剂盒的方法和用于预处理固体的方法
公开(公告)号：WO2011032227A1
公开(公告)日：2011-03-24
申请号：PCT/AU2010/001219
申请日：2010-09-17
申请人： M-I AUSTRALIA PTY LTD , KHANDEKAR, Chandrashekhar , GOPAL, Suguna , SMITH, James
发明人： KHANDEKAR, Chandrashekhar , GOPAL, Suguna , SMITH, James
IPC分类号： C09K8/52 , C10G31/00 , C23F11/00
CPC分类号： G01N33/28 , C09K8/524
摘要： The present invention relates to a method for identifying an inhibitor to the formation of naphthenate solids in a liquid hydrocarbon including contacting a sample of the liquid hydrocarbon with an inhibitor and a buffered aqueous solution, observing the extent of formation of naphthenate solids, if any, the extent of formation of naphthenate solids being indicative of the effectiveness of the inhibitor, and repeating the steps, if necessary, until a suitable inhibitor is identified. The present invention also relates to a method for identifying an inhibitor to the formation of naphthenate scale in a liquid hydrocarbon system as well as test kits for use in the methods.
摘要翻译：本发明涉及一种用于鉴定在液体烃中形成环烷酸固体的抑制剂的方法，包括使液体烃样品与抑制剂和缓冲水溶液接触，观察环烷酸酯固体（如果有的话）的形成程度，环烷酸酯固体的形成程度指示抑制剂的有效性，如果需要，重复步骤，直到确定合适的抑制剂。本发明还涉及用于鉴定在液体烃系统中形成环烷酸盐垢的抑制剂的方法以及用于该方法的测试试剂盒。

27. 发明申请

WO2009108764A1 PROCESS FOR MAKING INTEGRATED LAYERED URETHANE PRODUCTS 审中-公开
标题翻译：制造集成层叠尿布产品的工艺
公开(公告)号：WO2009108764A1
公开(公告)日：2009-09-03
申请号：PCT/US2009/035261
申请日：2009-02-26
申请人： EVEREADY BATTERY COMPANY, INC. , SMITH, James
发明人： SMITH, James
IPC分类号： B29C44/24 , B29C39/20 , A61L15/26 , A61L15/42 , B29C33/68 , B26B21/44
CPC分类号： B29C39/203 , A61L15/26 , A61L15/425 , A61L15/46 , A61L2300/406 , A61L2300/602 , B26B21/44 , B26B21/443 , B29C33/68 , B29C44/24 , C08L75/04
摘要： Polyurethane shapes containing a core layer of a water soluble polymer such as polyethylene oxide (PEO) are produced by casting onto a surface (16) an aqueous mixture containing a pre-polymer of a hydrophilic polyurethane as a first layer (19) of uncured polyurethane, covering the uncured first layer with release paper (30) and compressing the layer, uncovering the uncured first layer and distributing PEO (42) on the uncured surface (40), applying a second layer of uncured polyurethane (62) on top of the PEO (42) while the polyurethane is still uncured, then covering the resulting mass with release paper (30) and compressing it to form an integrated, layered shaped article containing a core region enriched in PEO that when wetted releases PEO over an extended period. The second layer is applied by adhering about one-half of the first uncured foam layer (19) to the release paper (30) as the first uncured layer (19) is uncovered and then recombining the adhered material on top of the PEO (42) and further compressing the resulting mass to produce an integrated, layered shaped article. The second layer (62) can be applied, alternatively, by independently casting a second layer (62) of uncured polyurethane foam after distributing the PEO (42) and then compressing and curing. The PEO containing shapes are useful in making improved comfort strips for wet shaving razors. Shape products of the process where the core region- contains other specified working ingredients are useful in applications including bandages and wound dressings, cosmetic sponges, cleaning and polishing sponges, dry cleaning and anti-static sheets, and in household, industrial and environmental clean up and waste recovery.
摘要翻译：含有水溶性聚合物如聚环氧乙烷（PEO）核心层的聚氨酯形状通过将含有亲水性聚氨酯预聚物的含水混合物作为未固化聚氨酯（19）的第一层（19）浇注到表面（16）用隔离纸（30）覆盖未固化的第一层并压缩该层，露出未固化的第一层并在未固化的表面（40）上分配PEO（42），将第二层未固化的聚氨酯（62） PEO（42），而聚氨酯仍然未固化，然后用剥离纸（30）覆盖所得物料并压缩，形成包含富含PEO的核心区域的整体的层状成型制品，当润湿时，长时间释放PEO。当第一未固化层（19）未被覆盖时，通过将约一半的第一未固化泡沫层（19）粘附到剥离纸（30）上，然后将粘附的材料重新结合在PEO（42 ）并且进一步压缩所得到的物质以产生一体化的层状成形制品。第二层（62）可以替代地应用于分配PEO（42）之后独立地浇注未固化的聚氨酯泡沫的第二层（62），然后压缩和固化。含PEO的形状可用于制造用于湿剃剃刀的改进的舒适条。核心区域包含其他特定工作成分的过程的形状产品可用于包括绷带和伤口敷料，化妆品海绵，清洁和抛光海绵，干洗和防静电片以及家庭，工业和环境清洁和废物回收。

28. 发明申请

WO2012009353A1 ULTRAVIOLET LAMP SYSTEM AND METHOD FOR CONTROLLING EMITTED ULTRAVIOLET LIGHT 审中-公开
标题翻译：超紫外灯系统和控制发射超紫外线灯的方法
公开(公告)号：WO2012009353A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/043706
申请日：2011-07-12
申请人： NORDSON CORPORATION , BORSUK, James, M. , KHOURY, James , MCGHEE, Edward, C. , SMITH, James
发明人： BORSUK, James, M. , KHOURY, James , MCGHEE, Edward, C. , SMITH, James
IPC分类号： H05B41/24
CPC分类号： H05B41/38 , H05B41/2806 , Y02B20/22
摘要： Embodiments of the invention provide an apparatus, method, and program product to control a lamp system. The apparatus comprises a plasma lamp bulb (20) and a microwave generator (12) operable to generate a microwave energy field to excite the plasma lamp bulb (20) to emit ultraviolet light (24). The apparatus further comprises a sensor (70) to measure the intensity of the ultraviolet light (24) and a reflector (42) positioned between the plasma lamp bulb (20) and the sensor (70) The reflector (42) is operable to reflect at least a portion of the ultraviolet light (24) generated by the plasma lamp bulb (20). The method comprises receiving a target intensity for the ultraviolet light (24) and measuring an intensity of the ultraviolet light (24) using a sensor (70). The method further comprises comparing the target intensity to the measured intensity and, in response to the comparison, adjusting power to a microwave generator (12) to adjust the intensity of the ultraviolet light (24).
摘要翻译：本发明的实施例提供一种用于控制灯系统的装置，方法和程序产品。该装置包括等离子体灯泡（20）和微波发生器（12），其可操作以产生微波能场以激发等离子体灯泡（20）发射紫外光（24）。该装置还包括用于测量紫外光强度的传感器（70）和位于等离子体灯泡（20）和传感器（70）之间的反射器（42）。反射器（42）可操作以反射由等离子体灯泡（20）产生的紫外线（24）的至少一部分。该方法包括使用传感器（70）接收紫外光（24）的目标强度和测量紫外光（24）的强度。该方法还包括将目标强度与测量的强度进行比较，并且响应于比较，调整对微波发生器（12）的功率以调节紫外光的强度（24）。

29. 发明申请

WO2008112139A1 SHAVING AID DELIVERY SYSTEM FOR USE WITH WET SHAVE RAZORS 审中-公开
标题翻译： SHAVE AAC传送系统与WET SHAVE RAZORS一起使用
公开(公告)号：WO2008112139A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/003018
申请日：2008-03-07
申请人： EVEREADY BATTERY COMPANY, INC. , GUIMONT, Raymond , ROSEN, Meyer , SMITH, James
发明人： GUIMONT, Raymond , ROSEN, Meyer , SMITH, James
IPC分类号： B26B21/44 , A61K8/87 , A61Q9/02
CPC分类号： A61K8/87 , A61K8/0237 , A61K8/046 , A61Q9/02 , B26B21/222 , B26B21/44
摘要： A delivery system for a shaving aid material includes a hydrophilic foam pad or similar applicator device and shaving aid material disposed in the foam. The foam is attached to the razor cartridge such that during a shaving operation, the foam is squeezed against the user's skin and the shaving aid material is dispelled from the foam. The shaving aid material is a water soluble composition that may be impregnated into the foam, which may be a nanofoam. A razor cartridge with which the delivery system may be used has a frame that defines a skin-contacting surface, at least one razor blade located in the frame, and the shaving aid delivery system coupled to the skin-contacting surface. A shaving implement having a handle and a razor cartridge attached thereto has the shaving aid delivery system attached to the razor cartridge.
摘要翻译：用于剃刮助剂材料的递送系统包括亲水泡沫垫或类似的涂抹器装置和设置在泡沫中的剃刮助剂材料。泡沫被连接到剃刀刀片架上，使得在剃刮操作期间，泡沫被挤压到使用者的皮肤上，剃刮助剂材料从泡沫中排出。剃刮助剂材料是可以浸渍到泡沫中的水溶性组合物，其可以是纳米纤维。可以使用输送系统的剃刀筒具有限定皮肤接触表面的框架，位于框架中的至少一个剃刀刀片和耦合到皮肤接触表面的剃刮助剂输送系统。具有手柄和附接到其上的剃刀刀片的剃须刀具具有附接到剃刀刀片架的剃刮助剂输送系统。

30. 发明申请

WO2008112138A1 SHAVING PREPARATION DELIVERY SYSTEM FOR WET SHAVING SYSTEMS 审中-公开
标题翻译：冲洗系统的冲洗准备系统
公开(公告)号：WO2008112138A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/003017
申请日：2008-03-07
申请人： EVEREADY BATTERY COMPANY, INC. , GUIMONT, Raymond , MEHTA, Rooma , MCCORMACK, Robert , SMITH, James
发明人： GUIMONT, Raymond , MEHTA, Rooma , MCCORMACK, Robert , SMITH, James
IPC分类号： B26B21/44
CPC分类号： B26B21/44 , B26B21/222
摘要： A wet shave razor assembly includes a shaving aid delivery system surrounding a razor cartridge. The shaving aid delivery system includes a hydrophilic foam having a water soluble shaving preparation disposed therein. During a wet shave operation, the hydrophilic foam is compressed as the razor is stroked across a user's skin. The hydrophilic foam is an open-cell structure defined by a plurality of supporting elements that cooperate to form tortuous paths. The hydrophilic foam can also include closed cells, or it can be a combination of open cells and closed cells. The shaving preparation is disposed in the paths and/or closed cells. A combination razor cartridge/shaving aid delivery system assembly can be releasably attached to a handle. The razor cartridge may be movable relative to the hydrophilic foam and include a mechanism allowing such movement housed in the handle, or it can be fixed relative to the hydrophilic foam.
摘要翻译：湿剃剃刀组件包括围绕剃刀刀片架的剃刮助剂传送系统。剃刮助剂输送系统包括其中设置有水溶性剃须剂的亲水性泡沫。在湿剃刮操作期间，当剃须刀穿过使用者的皮肤时，亲水性泡沫被压缩。亲水性泡沫是由多个支撑元件限定的开孔结构，其协作以形成曲折路径。亲水性泡沫还可以包括闭孔，或者它可以是开孔和闭孔的组合。剃须准备物设置在路径和/或闭孔中。组合式剃刀刀片架/剃刮助剂传送系统组件可以可释放地附接到手柄。剃须刀片可以相对于亲水性泡沫是可移动的，并且包括允许容纳在手柄中的这种运动的机构，或者它可以相对于亲水性泡沫固定。

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