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21. 发明授权

US07056892B2 Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof 有权
标题翻译：吡喃葡萄糖氧吡唑衍生物，含有该衍生物的药物组合物及其生产中的中间体
公开(公告)号：US07056892B2
公开(公告)日：2006-06-06
申请号：US11189832
申请日：2005-07-27
申请人： Hideki Fujikura , Toshihiro Nishimura , Kenji Katsuno , Masahiro Hiratochi , Akira Iyobe , Minoru Fujioka , Masayuki Isaji
发明人： Hideki Fujikura , Toshihiro Nishimura , Kenji Katsuno , Masahiro Hiratochi , Akira Iyobe , Minoru Fujioka , Masayuki Isaji
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/415 , C07H17/00
CPC分类号： C07D231/20 , C07H17/02 , Y10S514/866 , Y10S514/909
摘要： The present invention relates to glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 represents a hydrogen atom or a lower alkyl group; one of Q1 and T1 represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; and R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom, or pharmaceutically acceptable salts thereof, which have an inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of diabetes, diabetic complications or obesity, and to pharmaceutical compositions comprising the same and intermediates thereof.
摘要翻译：本发明涉及由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中R 1表示氢原子或低级烷基; Q 1和T 1之一表示由通式表示的基团：而另一个表示低级烷基或卤代（低级烷基）基团; 和R 2表示氢原子，低级烷基，低级烷氧基，低级烷硫基，卤代（低级烷基）基或卤素原子或其药学上可接受的盐，它们具有在人SGLT2中的抑制活性，并且可用作预防或治疗糖尿病，糖尿病并发症或肥胖症的药剂，以及包含其的药物组合物及其中间体。

22. 发明授权

US06531546B2 Rubber composition 有权
公开(公告)号：US06531546B2
公开(公告)日：2003-03-11
申请号：US09947525
申请日：2001-09-07
申请人： Katsumi Oka , Toshihiro Nishimura , Fumio Tsutsumi , Yutaka Abe
发明人： Katsumi Oka , Toshihiro Nishimura , Fumio Tsutsumi , Yutaka Abe
IPC分类号： C08L2300
CPC分类号： C08L23/16 , C08L2205/02 , C08L2205/06 , C08L2666/04
摘要： A rubber composition comprising (a) a low molecular weight copolymer rubber which is an ethylene/&agr;-olefin/non-conjugated diene copolymer rubber having a limiting viscosity [&eegr;] of 0.4-1.6 dl/g measured in decalin at 135° C., and an ethylene content of 40-60 wt % and (b) a high molecular weight copolymer rubber which is an ethylene/&agr;-olefin/non-conjugated diene copolymer rubber having a Mooney viscosity (ML1+4,100° C.) of 60-150, an ethylene content of 60-80 wt %, and an iodine number of 5-35, wherein the difference between the iodine number of the low molecular weight copolymer rubber (a) and the iodine number of the high molecular weight copolymer rubber (b) is 5 or less and the ratio by weight of the low molecular weight copolymer rubber (a) and the high molecular weight copolymer rubber (b) is 50/50 to 80/20, the rubber composition having a Mooney viscosity (ML1+4,100° C.) of 20-50. The rubber composition exhibits superior roll processability and extrusion processability, excellent surface appearance and adhesiveness, can be processed easily, and produces vulcanized rubber exhibiting excellent mechanical characteristics and good low and high temperature properties.

23. 发明授权

US4865649A Coating solution for forming a silica-based coating film 失效
标题翻译：用于形成二氧化硅基涂膜的涂布溶液
公开(公告)号：US4865649A
公开(公告)日：1989-09-12
申请号：US277497
申请日：1988-11-30
申请人： Eiichi Kashiwagi , Muneo Nakayama , Akira Hashimoto , Toshihiro Nishimura
发明人： Eiichi Kashiwagi , Muneo Nakayama , Akira Hashimoto , Toshihiro Nishimura
IPC分类号： C08L83/00 , C08L83/02 , C09D4/00 , C09D183/00 , C09D183/04
CPC分类号： C09D4/00 , C09D183/04
摘要： The coating solution of the invention is useful for forming a silica-based coating layer on a substrate such as semiconductor silicon wafers in the manufacturing process of semiconductor devices such as VLSIs. The coating solution is particularly advantageous to smooth a substrate surface having a difference in levels by completely filling the recessed areas. The coating solution is an organic solution of a cohydrolyzate of an alkoxy silane mixture composed of at least two kinds of di-, tri- and tetraalkoxy silane compounds such as a combination of methyl trimethoxy silane and tetramethoxy silane in a specified molar ratio and can be prepared by adding water to an organic solution of these alkoxy silane compounds without using any acid catalyst to effect the cohydrolysis of the silane compounds.
摘要翻译：本发明的涂布溶液在诸如VLSI等半导体装置的制造过程中可用于在诸如半导体硅晶片的基板上形成二氧化硅基涂层。涂覆溶液特别有利的是通过完全填充凹陷区域来平滑具有差异水平的基底表面。涂布溶液是由至少两种二 - ，三 - 和四 - 烷氧基硅烷化合物（例如甲基三甲氧基硅烷和四甲氧基硅烷的组合）以特定摩尔比组成的烷氧基硅烷混合物的共水解产物的有机溶液，并且可以是通过向这些烷氧基硅烷化合物的有机溶液中加入水而不使用任何酸催化剂来进行硅烷化合物的共水解制备。

24. 发明授权

US4474642A Method for pattern-wise etching of a metallic coating film 失效
标题翻译：金属涂膜的图案蚀刻方法
公开(公告)号：US4474642A
公开(公告)日：1984-10-02
申请号：US514793
申请日：1983-07-18
申请人： Hisashi Nakane , Muneo Nakayama , Akira Hashimoto , Toshihiro Nishimura
发明人： Hisashi Nakane , Muneo Nakayama , Akira Hashimoto , Toshihiro Nishimura
IPC分类号： C23F1/00 , C23F4/00 , H01L21/302 , H01L21/3065 , H01L21/312 , H01L21/3213 , C23F1/02 , B44C1/22 , C03C15/00 , C03C25/06
CPC分类号： H01L21/32139 , H01L21/312
摘要： The invention provides an improved process for providing wirings and electrodes of aluminum film on the surface of a substrate. Instead of the conventional method of directly forming an organic resist layer on the metal film, a remarkable improvement in the fineness and accuracy of patterning is obtained by providing a subsidiary masking layer, mainly composed of silicon dioxide, between the metal film and the organic resist layer; and pattern-wise etching by first etching the subsidiary masking layer through a patterned mask of the organic resist layer with a fluorine-containing etching gas to form a patterned subsidiary masking layer, and then etching the metal film with a chlorine-containing etching gas through the mask of the patterned subsidiary masking layer, followed by final removal of the remaining subsidiary masking layer.
摘要翻译：本发明提供了一种用于在衬底的表面上提供铝膜的布线和电极的改进方法。代替在金属膜上直接形成有机抗蚀剂层的常规方法，通过在金属膜和有机抗蚀剂之间设置主要由二氧化硅构成的辅助掩模层，可以显着提高图案的细度和精度层; 并通过用含氟蚀刻气体通过有机抗蚀剂层的图案化掩模蚀刻辅助掩模层以形成图案化的掩蔽层，然后用含氯蚀刻气体通过蚀刻气体蚀刻金属膜，并进行图案蚀刻图案化的辅助掩模层的掩模，然后最后去除剩余的辅助掩模层。

25. 发明授权

US07465713B2 Glucopyranosyloxypyrazole derivatives and use thereof in medicines 有权
标题翻译：吡喃葡萄糖氧吡唑衍生物及其在药物中的应用
公开(公告)号：US07465713B2
公开(公告)日：2008-12-16
申请号：US11247216
申请日：2005-10-12
申请人： Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Takeshi Nakabayashi , Masayuki Isaji
发明人： Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Takeshi Nakabayashi , Masayuki Isaji
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K45/06 , A61K31/7056 , C07H17/02 , A61K2300/00
摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.
摘要翻译：本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中R表示氢原子，低级烷基或形成前药的基团; Q和T之一表示由通式表示的基团：（其中P表示氢原子或形成前药的基团），而另一个表示低级烷基或卤代（低级烷基）基团; R2表示氢原子，低级烷基，低级烷氧基，低级烷硫基，卤代（低级烷基）或卤素原子; 并且条件是当R表示氢原子或低级烷基时，P不表示氢原子，或其药学上可接受的盐，其在人SGLT2中具有抑制活性并具有改善的口服吸收，因此可用作用于预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症或肥胖症的药剂及其药学上可接受的盐及其药学用途。

26. 发明授权

US07172718B2 Method of manufacturing a rubber sheet for a power transmission belt and a power transmission belt incorporating the rubber sheet 失效
标题翻译：动力传动带用橡胶片的制造方法以及安装有橡胶片的动力传递带
公开(公告)号：US07172718B2
公开(公告)日：2007-02-06
申请号：US10747636
申请日：2003-12-29
申请人： Takayuki Tagawa , Tomohiro Miwa , Toshihiro Nishimura
发明人： Takayuki Tagawa , Tomohiro Miwa , Toshihiro Nishimura
IPC分类号： B29C47/06 , B29D29/08
CPC分类号： B29C47/0004 , B29C47/0023 , B29C47/065 , B29C47/261 , B29D29/00 , B29K2021/00 , B29K2105/06 , B29K2301/10 , B29L2031/7094
摘要： A method of manufacturing a power transmission belt having a body with a length and a cushion rubber layer in which at least one carrying member is embedded so as to extend lengthwise of the body. The method includes the steps of: extrusion molding (a) a first rubber composition including rubber with short fibers therein and (b) a second rubber composition that is different than the first rubber composition to produce a first sheet in which the second rubber composition defines at least a part of the cushion rubber layer; applying the at least one load carrying member to the second rubber composition to produce a preform assembly; and processing the preform assembly to produce a power transmission belt.
摘要翻译：一种制造具有长度的本体和缓冲橡胶层的动力传递带的方法，其中至少一个承载构件被嵌入以沿身体的纵向延伸。该方法包括以下步骤：挤压成型（a）包含短纤维的橡胶的第一橡胶组合物和（b）不同于第一橡胶组合物的第二橡胶组合物，以制备其中第二橡胶组合物定义的第一片缓冲橡胶层的至少一部分; 将所述至少一个承载构件施加到所述第二橡胶组合物以产生预成型件组件; 并处理预制组件以产生动力传动带。

27. 发明授权

US07087579B2 Glucopyranosyloxypyrazole derivatives and medicinal use thereof 有权
公开(公告)号：US07087579B2
公开(公告)日：2006-08-08
申请号：US10468454
申请日：2002-02-26
申请人： Toshihiro Nishimura , Nobuhiko Fushimi , Hideki Fujikura , Kenji Katsuno , Yoshimitsu Komatsu , Masayuki Isaji
发明人： Toshihiro Nishimura , Nobuhiko Fushimi , Hideki Fujikura , Kenji Katsuno , Yoshimitsu Komatsu , Masayuki Isaji
IPC分类号： A01N43/04 , A61K31/70 , C07H17/00
CPC分类号： C07H15/203 , C07H17/02
摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; R1 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R2 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.

28. 发明申请

US20060142209A1 Glucopyranosyloxypyrazole derivatives and medicinal use thereof 有权
标题翻译：吡喃葡萄糖氧吡唑衍生物及其医药用途
公开(公告)号：US20060142209A1
公开(公告)日：2006-06-29
申请号：US11358400
申请日：2006-02-22
申请人： Toshihiro Nishimura , Nobuhiko Fushimi , Hideki Fujikura , Kenji Katsuno , Yoshimitsu Komatsu , Masayuki Isaji
发明人： Toshihiro Nishimura , Nobuhiko Fushimi , Hideki Fujikura , Kenji Katsuno , Yoshimitsu Komatsu , Masayuki Isaji
IPC分类号： A61K31/7052
CPC分类号： C07H15/203 , C07H17/02
摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; R1 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R2 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.
摘要翻译：本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中Q和T之一表示由通式表示的基团，而另一个代表低级烷基或卤代（低级烷基）基团; R 1表示氢原子，任选取代的低级烷基，低级烯基，环状低级烷基等; R 2表示氢原子，任选取代的低级烷基，低级烷氧基，低级烯基，环状低级烷基，环状低级烷氧基等，其具有优异的因此可用作预防或治疗与糖尿病，糖尿病并发症或肥胖症，糖尿病并发症或肥胖症，糖尿病并发症或肥胖症，其药学上可接受的盐或其前药，与其生产中间体及其药物用途有关的疾病的药物。

29. 发明授权

US07045665B2 Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives 有权
标题翻译：吡喃葡萄糖氧基苄基苯衍生物，含有该衍生物的药物组合物和用于制备衍生物的中间体
公开(公告)号：US07045665B2
公开(公告)日：2006-05-16
申请号：US10959505
申请日：2004-10-07
申请人： Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Kazuya Tatani , Kenji Katsuno , Masahiro Hiratochi , Yoshiki Tokutake , Masayuki Isaji
发明人： Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Kazuya Tatani , Kenji Katsuno , Masahiro Hiratochi , Yoshiki Tokutake , Masayuki Isaji
IPC分类号： C07C39/12 , C07C27/10 , C07C33/18
CPC分类号： C07H15/203
摘要： The present invention relates to benzylphenol derivatives represented by the general formula: wherein R11 represents a hydrogen atom or a protected hydroxy(lower alkyl) group; and R12 represents a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a protected hydroxy(lower alkyl) group, a protected hydroxy(lower alkoxy) group, a protected hydroxy(lower alkylthio) group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted (lower alkoxy) group or a lower alkoxy-substituted (lower alkylthio) group; with the proviso that R12 is not a methyl group, an ethyl group, an isopropyl group, a tert-butyl group or a methoxy group when R11 is a hydrogen atom, or a salt thereof, which are used as intermediates for making glucopyranosyloxybenzylbenzene compounds having inhibitory activity in human SGLT2 and are useful in treating diseases associated with hyperglycemia, such as diabetes.
摘要翻译：本发明涉及由以下通式表示的苄基酚衍生物：其中R 11表示氢原子或被保护的羟基（低级烷基）基团; R 12表示低级烷基，低级烷氧基，低级烷硫基，被保护的羟基（低级烷基），被保护的羟基（低级烷氧基），被保护的羟基（低级烷硫基）基团，低级烷氧基取代的（低级烷基）基团，低级烷氧基取代的（低级烷氧基基团）或低级烷氧基取代的（低级烷硫基）基团; 条件是当R 11是氢原子时，R 12不是甲基，乙基，异丙基，叔丁基或甲氧基或其盐，其用作制备在人SGLT2中具有抑制活性的吡喃葡萄糖氧基苄基苯化合物的中间体，并且可用于治疗与高血糖相关的疾病如糖尿病。

30. 发明申请

US20060035840A1 Nitrogen-containing heterocyclic derivatives, medicinal compositions containing the same and medicinal use thereof 失效
标题翻译：含氮杂环衍生物，含有该杂环衍生物的医药组合物及其医药用途
公开(公告)号：US20060035840A1
公开(公告)日：2006-02-16
申请号：US10540519
申请日：2003-12-19
申请人： Hideki Fujikura , Toshihiro Nishimura , Kenji Katsuno , Masayuki Isaji
发明人： Hideki Fujikura , Toshihiro Nishimura , Kenji Katsuno , Masayuki Isaji
IPC分类号： A61K31/7052 , C07H17/02
CPC分类号： C07H17/02 , A61K31/706
摘要： The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 represents Nor CR1; X2 represents Nor CR2; X3 represents N or CR3; X4 represents N or CR4; and with the proviso that one or two of X1 to X4 represent N; R represents optionally substituted C3-8 cycloalkyl, optionally substituted C6-10 aryl, etc.; R1 to R4 represent H, a halogen atom, etc.) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an excellent inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications, obesity or the like, pharmaceutical compositions comprising the same, and medicinal uses thereof.
摘要翻译：本发明提供由以下通式表示的含氮杂环衍生物：其中X 1表示Nor CR 1; X <2>表示Nor CR 2; X 3表示N或CR 3; X 4表示N或CR 4; 并且条件是X 1至X 4中的一个或两个表示N; R表示任选取代的C 3-8环烷基，任选取代的C 6-10芳基等; R 1至R 4代表H，卤素原子等）或其药学上可接受的盐或其前药，其在人SGLT2中具有优异的抑制活性，并且为可用作预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症，肥胖症等的药剂，其药物组合物及其药物用途。

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