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21. 发明申请

US20130053617A1 PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM 有权
标题翻译：颗粒光束辐射装置和颗粒束治疗系统
公开(公告)号：US20130053617A1
公开(公告)日：2013-02-28
申请号：US13696736
申请日：2011-06-22
申请人： Yuehu Pu , Hisashi Harada , Taizo Honda
发明人： Yuehu Pu , Hisashi Harada , Taizo Honda
IPC分类号： A61N5/10
CPC分类号： G21K1/046 , A61N5/1043 , A61N5/1045 , A61N5/1048 , A61N2005/1052 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , G21K1/10 , G21K5/00
摘要： A particle beam irradiation apparatus comprises a particle beam shielding member which shields a part of a particle beam which is scanned, a prompt signal detector which detects a prompt signal which is generated when the particle beam which is scanned collides with the particle beam shielding member and a signal comparison device which predicts and obtains a generation pattern of a prompt signal which is generated with a predetermined scanning pattern and stores as a signal time pattern for comparison, wherein the signal comparison device detects an abnormality of scanning of a particle beam or the particle beam shielding member by comparing a detected signal time pattern which is a time pattern of a signal which is detected by the prompt signal detector to a signal time pattern for comparison which is stored.
摘要翻译：粒子束照射装置包括：屏蔽被扫描的粒子束的一部分的粒子束屏蔽构件;检测当被扫描的粒子束与粒子束屏蔽构件相撞时产生的提示信号的迅速信号检测器;以及信号比较装置，其预测并获得以预定扫描图案生成的提示信号的生成模式，并存储为用于比较的信号时间图案，其中信号比较装置检测粒子束或粒子的扫描异常通过将作为由快速信号检测器检测的信号的时间图案的检测信号时间图案与存储的用于比较的信号时间模式进行比较来检测光束屏蔽部件。

22. 发明申请

US20110108737A1 PARTICLE BEAM IRRADIATION APPARATUS 有权
标题翻译：颗粒光束辐射装置
公开(公告)号：US20110108737A1
公开(公告)日：2011-05-12
申请号：US13003688
申请日：2009-06-03
申请人： Yuehu Pu , Katsuhisa Yoshida , Yuichi Yamamoto , Hidenobu Sakamoto , Taizo Honda , Hisashi Harada , Takaaki Iwata
发明人： Yuehu Pu , Katsuhisa Yoshida , Yuichi Yamamoto , Hidenobu Sakamoto , Taizo Honda , Hisashi Harada , Takaaki Iwata
IPC分类号： H01J37/147
CPC分类号： A61N5/10 , A61N5/1043 , A61N2005/1087
摘要： In order to obtain a particle beam irradiation apparatus that enlarges the dose distribution of beam spots while suppressing a decrease of the maximum available range of a charged particle beam, the particle beam irradiation apparatus includes a particle beam acceleration means; particle beam transport means; scanning apparatus that includes first scanning means and second scanning means, and two-dimensionally scans the beam; and irradiation control means that controls the scanning apparatus so as to irradiate the beam onto a target region including a plurality of small regions. The irradiation control means controls the first scanning means so as to scan the beam over a small region serving as an irradiation subject among the plurality of the small regions, and controls the second scanning means so as to change the small region serving as the irradiation subject to be a different small region among the plurality of the small regions.
摘要翻译：为了获得粒子束照射装置，其粒子束照射装置包括粒子束加速装置，粒子束照射装置在抑制带电粒子束的最大可用范围的减小的同时，扩大束斑的剂量分布，粒子束传送装置; 扫描装置，其包括第一扫描装置和第二扫描装置，并二维地扫描光束; 以及照射控制装置，其控制扫描装置以将束照射到包括多个小区域的目标区域上。照射控制装置控制第一扫描装置，以便在多个小区域中的用作照射对象的小区域上扫描光束，并且控制第二扫描装置以改变用作照射对象的小区域成为多个小区域中的不同小区域。

23. 发明申请

US20100288946A1 CHARGED PARTICLE BEAM IRRADIATION APPARATUS 有权
标题翻译：充电颗粒光束辐射装置
公开(公告)号：US20100288946A1
公开(公告)日：2010-11-18
申请号：US12812486
申请日：2008-05-12
申请人： Taizo Honda , Hisashi Harada , Yuehu Pu
发明人： Taizo Honda , Hisashi Harada , Yuehu Pu
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1095
摘要： In a charged particle beam irradiation apparatus to be adapted to a particle beam cancer treatment system or the like, a desired depth dose distribution is highly precisely created. In the charged particle beam irradiation apparatus that irradiates a particle beam, which is radiated from a particle beam generation unit, to a subject to be irradiated via a ridge filter exhibiting a cyclic thickness distribution for causing the particle beam to exhibit a desired energy distribution, the ridge filter has plural ridges thereof arranged to be perpendicular to entering directions of the particle beam.
摘要翻译：在适用于粒子束癌治疗系统等的带电粒子束照射装置中，高度精确地产生期望的深度剂量分布。在从粒子束发生单元照射粒子束的带电粒子束照射装置中，通过使粒子束呈现期望的能量分布的具有循环厚度分布的脊形过滤器照射到被照射对象，脊状过滤器具有多个脊，其布置成垂直于粒子束的进入方向。

24. 发明授权

US08304751B2 Charged particle beam irradiation apparatus 有权
标题翻译：带电粒子束照射装置
公开(公告)号：US08304751B2
公开(公告)日：2012-11-06
申请号：US12812486
申请日：2008-05-12
申请人： Taizo Honda , Hisashi Harada , Yuehu Pu
发明人： Taizo Honda , Hisashi Harada , Yuehu Pu
IPC分类号： G21K5/04
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1095
摘要： In a charged particle beam irradiation apparatus to be adapted to a particle beam cancer treatment system or the like, a desired depth dose distribution is highly precisely created. In the charged particle beam irradiation apparatus that irradiates a particle beam, which is radiated from a particle beam generation unit, to a subject to be irradiated via a ridge filter exhibiting a cyclic thickness distribution for causing the particle beam to exhibit a desired energy distribution, the ridge filter has plural ridges thereof arranged to be perpendicular to entering directions of the particle beam.
摘要翻译：在适用于粒子束癌治疗系统等的带电粒子束照射装置中，高度精确地产生期望的深度剂量分布。在从粒子束发生单元照射粒子束的带电粒子束照射装置中，通过使粒子束呈现期望的能量分布的具有循环厚度分布的脊形过滤器照射到被照射对象，脊状过滤器具有多个脊，其布置成垂直于粒子束的进入方向。

25. 发明申请

US20110260074A1 PARTICLE BEAM THERAPY SYSTEM 有权
标题翻译：颗粒束治疗系统
公开(公告)号：US20110260074A1
公开(公告)日：2011-10-27
申请号：US12864002
申请日：2010-01-28
申请人： Taizo Honda , Hisashi Harada , Yuehu Pu , Yuichi Yamamoto , Takaaki Iwata
发明人： Taizo Honda , Hisashi Harada , Yuehu Pu , Yuichi Yamamoto , Takaaki Iwata
IPC分类号： G21K1/08
CPC分类号： A61N5/1042 , A61N5/1043 , A61N5/1048 , A61N2005/1087
摘要： The objective of the present invention is to reduce the effect of the hysteresis of a scanning electromagnet so as to obtain a particle beam therapy system that realizes high-accuracy beam irradiation. There are included an irradiation management apparatus (32) that controls the scanning electromagnet (3), based on target irradiation position coordinates (Pi) of a charged particle beam (1b), and a position monitor (7) that measures measurement position coordinates (Ps) of the charged particle beam (1b). The irradiation management apparatus (32) has a command value creator (25) that outputs a control input (Io (Ir)) to the scanning electromagnet (3), based on the target irradiation position coordinates (Pi) and correction data (Ia) created on the basis of the measurement position coordinates (Ps), measured by the position monitor (7) in the preliminary irradiation in which the excitation pattern of the scanning electromagnet is the same as that of the main irradiation plan, and the target irradiation position coordinates (Pi).
摘要翻译：本发明的目的是减少扫描电磁体的滞后效果，以获得实现高精度光束照射的粒子束治疗系统。包括基于带电粒子束（1b）的目标照射位置坐标（Pi）来控制扫描电磁体（3）的照射管理装置（32）和测量位置坐标（ Ps）的带电粒子束（1b）。照射管理装置（32）具有基于目标照射位置坐标（Pi）和校正数据（Ia）向扫描电磁体（3）输出控制输入（Io（Ir））的指令值生成器（25）基于由扫描电磁体的激励图案与主照射平面的激励图案相同的预备照射中的位置监视器（7）测量的测量位置坐标（Ps）和目标照射位置坐标（Pi）。

26. 发明授权

US08586948B2 Particle beam irradiation apparatus and particle beam therapy system 有权
标题翻译：粒子束照射装置和粒子束治疗系统
公开(公告)号：US08586948B2
公开(公告)日：2013-11-19
申请号：US13696736
申请日：2011-06-22
申请人： Yuehu Pu , Hisashi Harada , Taizo Honda
发明人： Yuehu Pu , Hisashi Harada , Taizo Honda
IPC分类号： G21K5/04
CPC分类号： G21K1/046 , A61N5/1043 , A61N5/1045 , A61N5/1048 , A61N2005/1052 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , G21K1/10 , G21K5/00
摘要： A particle beam irradiation apparatus comprises a particle beam shielding member which shields a part of a particle beam which is scanned, a prompt signal detector which detects a prompt signal which is generated when the particle beam which is scanned collides with the particle beam shielding member and a signal comparison device which predicts and obtains a generation pattern of a prompt signal which is generated with a predetermined scanning pattern and stores as a signal time pattern for comparison, wherein the signal comparison device detects an abnormality of scanning of a particle beam or the particle beam shielding member by comparing a detected signal time pattern which is a time pattern of a signal which is detected by the prompt signal detector to a signal time pattern for comparison which is stored.
摘要翻译：粒子束照射装置包括：屏蔽被扫描的粒子束的一部分的粒子束屏蔽构件;检测当被扫描的粒子束与粒子束屏蔽构件相撞时产生的提示信号的迅速信号检测器;以及信号比较装置，其预测并获得以预定扫描图案生成的提示信号的生成模式，并存储为用于比较的信号时间图案，其中信号比较装置检测粒子束或粒子的扫描异常通过将作为由快速信号检测器检测的信号的时间图案的检测信号时间图案与存储的用于比较的信号时间模式进行比较来检测光束屏蔽部件。

27. 发明授权

US08405042B2 Particle beam therapy system 有权
标题翻译：粒子束治疗系统
公开(公告)号：US08405042B2
公开(公告)日：2013-03-26
申请号：US12864002
申请日：2010-01-28
申请人： Taizo Honda , Hisashi Harada , Yuehu Pu , Yuichi Yamamoto , Takaaki Iwata
发明人： Taizo Honda , Hisashi Harada , Yuehu Pu , Yuichi Yamamoto , Takaaki Iwata
IPC分类号： G21K1/08
CPC分类号： A61N5/1042 , A61N5/1043 , A61N5/1048 , A61N2005/1087
摘要： The objective of the present invention is to reduce the effect of the hysteresis of a scanning electromagnet so as to obtain a particle beam therapy system that realizes high-accuracy beam irradiation. There are included an irradiation management apparatus (32) that controls the scanning electromagnet (3), based on target irradiation position coordinates (Pi) of a charged particle beam (1b), and a position monitor (7) that measures measurement position coordinates (Ps) of the charged particle beam (1b). The irradiation management apparatus (32) has a command value creator (25) that outputs a control input (Io (Ir)) to the scanning electromagnet (3), based on the target irradiation position coordinates (Pi) and correction data (Ia) created on the basis of the measurement position coordinates (Ps), measured by the position monitor (7) in the preliminary irradiation in which the excitation pattern of the scanning electromagnet is the same as that of the main irradiation plan, and the target irradiation position coordinates (Pi).
摘要翻译：本发明的目的是减少扫描电磁体的滞后效果，以获得实现高精度光束照射的粒子束治疗系统。包括基于带电粒子束（1b）的目标照射位置坐标（Pi）来控制扫描电磁体（3）的照射管理装置（32）和测量位置坐标（ Ps）的带电粒子束（1b）。照射管理装置（32）具有基于目标照射位置坐标（Pi）和校正数据（Ia）向扫描电磁体（3）输出控制输入（Io（Ir））的指令值生成器（25）基于由扫描电磁体的激励图案与主照射平面的激励图案相同的预备照射中的位置监视器（7）测量的测量位置坐标（Ps）和目标照射位置坐标（Pi）。

28. 发明授权

US09265970B2 Particle beam irradiation system 有权
标题翻译：粒子束照射系统
公开(公告)号：US09265970B2
公开(公告)日：2016-02-23
申请号：US13393418
申请日：2011-03-02
申请人： Taizo Honda , Masahiro Ikeda
发明人： Taizo Honda , Masahiro Ikeda
IPC分类号： H01J3/26 , A61N5/10
CPC分类号： A61N5/1043 , A61N5/1067 , A61N5/1068 , A61N2005/1059 , A61N2005/1087 , A61N2005/1095
摘要： A particle beam irradiation system comprises deflection electromagnets which scan by deflecting the particle beam in two dimensions in the lateral direction which is perpendicular to an irradiation direction of the particle beam, and an energy width expanding device through which the particle beam passes so as to expand an energy width of the particle beam and form a SOBP in a depth direction of the irradiation target, that is, in an irradiation direction of the particle beam, wherein the energy width expanding device is configured to form the SOBP in the depth direction along whole irradiation area in the depth direction of the irradiation target, and the deflection electromagnets are controlled so as for an irradiation spot which is formed in the irradiation target by the particle beam to move stepwise along whole irradiation area in the lateral direction of the irradiation target.
摘要翻译：粒子束照射系统包括偏转电磁体，该偏转电磁体通过在与粒子束的照射方向垂直的横向方向上的二维偏转粒子束进行扫描;以及能量扩大装置，粒子束通过该能量扩张装置以扩展粒子束的能量宽度，并且在照射对象的深度方向，即在粒子束的照射方向上形成SOBP，其中，能量宽度扩展装置被构造成沿着整个深度方向形成SOBP 照射对象的深度方向的照射区域，并且对于通过粒子束形成在照射对象物上的照射点，控制偏转电磁体，沿着照射对象的横向的整个照射区域逐步移动。

29. 发明申请

US20120223247A1 PARTICLE BEAM IRRADIATION SYSTEM 有权
标题翻译：颗粒光束辐照系统
公开(公告)号：US20120223247A1
公开(公告)日：2012-09-06
申请号：US13393418
申请日：2011-03-02
申请人： Taizo Honda , Masahiro Ikeda
发明人： Taizo Honda , Masahiro Ikeda
IPC分类号： H01J3/26
CPC分类号： A61N5/1043 , A61N5/1067 , A61N5/1068 , A61N2005/1059 , A61N2005/1087 , A61N2005/1095
摘要： A particle beam irradiation system comprises deflection electromagnets which scan by deflecting the particle beam in two dimensions in the lateral direction which is perpendicular to an irradiation direction of the particle beam, and an energy width expanding device through which the particle beam passes so as to expand an energy width of the particle beam and form a SOBP in a depth direction of the irradiation target, that is, in an irradiation direction of the particle beam, wherein the energy width expanding device is configured to form the SOBP in the depth direction along whole irradiation area in the depth direction of the irradiation target, and the deflection electromagnets are controlled so as for an irradiation spot which is formed in the irradiation target by the particle beam to move stepwise along whole irradiation area in the lateral direction of the irradiation target.
摘要翻译：粒子束照射系统包括偏转电磁体，该偏转电磁体通过在垂直于粒子束的照射方向的横向方向上的二维偏转粒子束进行扫描;以及能量扩大装置，粒子束通过该能量扩展装置以扩展粒子束的能量宽度，并且在照射对象的深度方向，即在粒子束的照射方向上形成SOBP，其中，能量宽度扩展装置被构造成沿着整个深度方向形成SOBP 照射对象的深度方向的照射区域，并且对于通过粒子束形成在照射对象物上的照射点，控制偏转电磁体，沿着照射对象的横向的整个照射区域逐步移动。

30. 发明申请

US20150038766A1 PARTICLE BEAM SCANNING IRRADIATION SYSTEM 有权
标题翻译：粒子束扫描辐射系统
公开(公告)号：US20150038766A1
公开(公告)日：2015-02-05
申请号：US14386626
申请日：2012-03-21
申请人： Yuehu PU , Masahiro Ikeda , Taizo Honda
发明人： Yuehu PU , Masahiro Ikeda , Taizo Honda
IPC分类号： A61N5/10
CPC分类号： A61N5/1071 , A61N5/103 , A61N5/1031 , A61N5/1043 , A61N2005/1087
摘要： A particle beam scanning irradiation method includes the steps of calculating a planned irradiating particle count of a particle beam for each of irradiation spots, on the basis of a relative amount of particle beam irradiation and a prescription particle-beam dose determined from a particle-beam therapy plan; simulating an irradiation process of the particle beam at each irradiation spot, on the basis of the planned irradiating particle count and a beam current waveform of the particle beam, and calculating a particle count of the particle beam irradiating the diseased portion during a scan shift of the particle beam; correcting the planned irradiating particle count for each irradiation spot by using the irradiating particle count during the scan shift; converting the corrected planned-irradiation particle count into a count value used in a dose monitor; and irradiating the irradiation spot with the particle beam, on the basis of the converted count value.
摘要翻译：粒子束扫描照射方法包括以下步骤：基于粒子束照射的相对量和从粒子束确定的处方粒子束剂量来计算每个照射点的粒子束的计划照射粒子数治疗方案; 基于所计划的照射粒子数和粒子束的束电流波形，模拟在各照射点处的粒子束的照射过程，计算在扫描位移期间照射患病部位的粒子束的粒子数粒子束; 通过使用扫描偏移期间的照射粒子数来校正每个照射点的计划照射粒子数; 将校正的计划照射粒子数转换为剂量监视器中使用的计数值; 并且基于转换后的计数值，用粒子束照射照射点。

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