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21. 发明申请

US20050148554A1 Anti-inflammatory and anti-thrombotic compounds and their compositions 审中-公开
标题翻译：抗炎和抗血栓形成的化合物及其组成
公开(公告)号：US20050148554A1
公开(公告)日：2005-07-07
申请号：US10986974
申请日：2004-11-12
申请人： Don Zhang , Guojian Xie , Zhengwei Huan , Hang Chen , Charles Davis
发明人： Don Zhang , Guojian Xie , Zhengwei Huan , Hang Chen , Charles Davis
IPC分类号： C07C203/04 , C07C203/10 , C07C381/00 , A61K31/60 , C07C23/02
CPC分类号： C07C203/10 , C07C203/04 , C07C381/00
摘要： The invention encompasses novel compounds of Formula I, which are anti-inflammatory and anti-thrombotic agents. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenases (COX-1 and COX-2) mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin, NSAIDs, or selective COX-2 inhibitors to treat chronic cyclooxygenases mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.
摘要翻译：本发明包括式I的新型化合物，其为抗炎和抗血栓形成剂。本发明还包括用于治疗环氧合酶（COX-1和COX-2）介导的疾病的某些药物组合物和方法，其包括使用式I化合物。上述化合物可以用作与低剂量阿司匹林，NSAIDs的组合疗法或选择性COX-2抑制剂来治疗慢性环氧合酶介导的疾病或病症，同时降低血栓性心血管事件的风险。

22. 发明授权

US5859343A Recombinant sweet protein mabinlin 失效
公开(公告)号：US5859343A
公开(公告)日：1999-01-12
申请号：US670186
申请日：1996-06-21
申请人： Samuel S. M. Sun , Liwen Xiong , Zhong Hu , Hang Chen
发明人： Samuel S. M. Sun , Liwen Xiong , Zhong Hu , Hang Chen
IPC分类号： A23L27/30 , C07K14/43 , C12N15/82 , A01H5/00 , C12N5/14
CPC分类号： C12N15/8242 , A23L27/31 , C07K14/43
摘要： Recombinant materials for the production of practical amounts of the sweet protein, mabinlin are provided. In addition, transgenic plants which have inherently sweetened edible parts result from modifying native plants containing edible parts to express the mabinlin gene. Single-chain forms of this protein which retain their sweetening property are also provided.

23. 发明申请

US20090274696A1 METHODS FOR TREATING INFLAMMATION 审中-公开
标题翻译：治疗炎症的方法
公开(公告)号：US20090274696A1
公开(公告)日：2009-11-05
申请号：US12432617
申请日：2009-04-29
申请人： Hang Chen , Michael R. Bowman , Bruce A. Jacobson , Lawrence Mason
发明人： Hang Chen , Michael R. Bowman , Bruce A. Jacobson , Lawrence Mason
IPC分类号： A61K39/395 , A61K31/7052 , A61P29/00 , C12Q1/02 , A61K38/16 , A61K39/00 , C07K16/00
CPC分类号： C07K14/575 , A61K31/00 , A61K38/1703 , C07K14/4702 , G01N33/5088 , G01N2333/52 , A61K2300/00
摘要： Provided are methods and compositions for reducing airway hyperresponsiveness and other inflammatory diseases, disorders and conditions in a mammal by decreasing FIZZ1 (Found in Inflammatory Zone 1) activity. Also provided are methods and compositions for identifying modulators of airway inflammation and/or inhibitors of FIZZ1. The present invention encompasses modulators of airway inflammation and/or inhibitors of FIZZ1 and uses thereof. In addition, the present invention provides methods and compositions for enhancing an immune response based on FIZZ1 protein.
摘要翻译：提供了通过减少FIZZ1（发现炎症区1）活性来减少哺乳动物气道高反应性和其它炎性疾病，病症和病症的方法和组合物。还提供了用于鉴定气道炎症调节剂和/或FIZZ1抑制剂的方法和组合物。本发明包括呼吸道炎症的调节剂和/或FIZZ1的抑制剂及其用途。此外，本发明提供了用于增强基于FIZZ1蛋白的免疫应答的方法和组合物。

24. 发明授权

US6051758A Recombinant sweet protein mabinlin 失效
标题翻译：重组甜蛋白mabinlin
公开(公告)号：US6051758A
公开(公告)日：2000-04-18
申请号：US81691
申请日：1998-05-20
申请人： Samuel S. M. Sun , Liwen Xiong , Zhong Hu , Hang Chen
发明人： Samuel S. M. Sun , Liwen Xiong , Zhong Hu , Hang Chen
IPC分类号： A23L27/30 , C07K14/43 , C12N15/82 , A01H5/00 , A23L1/236 , C12N5/14
CPC分类号： C12N15/8242 , A23L27/31 , C07K14/43
摘要： Recombinant materials for the production of practical amounts of the sweet protein, mabinlin are provided. In addition, transgenic plants which have inherently sweetened edible parts result from modifying native plants containing edible parts to express the mabinlin gene. Single-chain forms of this protein which retain their sweetening property are also provided.
摘要翻译：提供用于生产实用量的甜蛋白的重组材料，马丁林。此外，具有天然甜味的可食用部分的转基因植物可以通过改良含有可食用部分的天然植物来表达马宾林基因。还提供了保持其甜味性质的这种蛋白质的单链形式。

25. 发明授权

US5789157A Systematic evolution of ligands by exponential enrichment: tissue selex 失效
公开(公告)号：US5789157A
公开(公告)日：1998-08-04
申请号：US434425
申请日：1995-05-03
申请人： Kirk B. Jensen , Hang Chen , Kevin N. Morris , Andrew Stephens , Larry Gold
发明人： Kirk B. Jensen , Hang Chen , Kevin N. Morris , Andrew Stephens , Larry Gold
IPC分类号： A61K38/00 , C07B61/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K7/22 , C07K14/00 , C07K14/16 , C07K14/72 , C12N9/12 , C12N15/10 , C12N15/115 , C12Q1/37 , C12Q1/68 , C12Q1/70 , F02B75/02 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/569 , G01N33/68 , G01N33/76 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07H19/10 , B82Y5/00 , C07H19/06 , C07H21/00 , C12N15/1048 , C12N15/115 , C12N9/1276 , C12Q1/37 , C12Q1/6811 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/558 , G01N33/56988 , G01N33/57407 , G01N33/57426 , G01N33/68 , G01N33/76 , G01N33/80 , A61K38/00 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12Q1/6886 , C40B40/00 , F02B2075/027 , G01N2333/16 , G01N2333/163 , G01N2333/4724 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/7056 , G01N2333/8125 , G01N2333/96433 , G01N2333/96436 , G01N2333/96455 , G01N2333/96486 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976
摘要： This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.

26. 发明授权

US5712375A Systematic evolution of ligands by exponential enrichment: tissue selex 失效
公开(公告)号：US5712375A
公开(公告)日：1998-01-27
申请号：US434001
申请日：1995-05-03
申请人： Kirk B. Jensen , Hang Chen , Kevin N. Morris , Andrew Stephens , Larry Gold
发明人： Kirk B. Jensen , Hang Chen , Kevin N. Morris , Andrew Stephens , Larry Gold
IPC分类号： A61K38/00 , C07B61/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K7/22 , C07K14/00 , C07K14/16 , C07K14/72 , C12N9/12 , C12N15/10 , C12N15/115 , C12Q1/37 , C12Q1/68 , C12Q1/70 , F02B75/02 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/569 , G01N33/68 , G01N33/76 , C07K1/14 , C07H21/04 , C12P19/34
CPC分类号： C07H19/10 , B82Y5/00 , C07H19/06 , C07H21/00 , C07K1/22 , C12N15/1048 , C12N15/115 , C12N9/1276 , C12Q1/37 , C12Q1/6811 , G01N33/53 , G01N33/5308 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/57407 , G01N33/57426 , G01N33/68 , G01N33/76 , G01N33/80 , A61K38/00 , C12N2310/13 , C12N2310/16 , C12N2310/322 , C12N2310/53 , C12N2320/13 , C12Q1/6886 , C40B40/00 , F02B2075/027 , G01N2333/16 , G01N2333/163 , G01N2333/4724 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/7056 , G01N2333/8125 , G01N2333/96433 , G01N2333/96436 , G01N2333/96455 , G01N2333/96486 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976
摘要： This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.

27. 发明授权

US07439388B2 Process for converting primary amidoalcohols to amidocarboxylic acids in high yield using water as solvent 有权
标题翻译：使用水作为溶剂以高产率将伯酰胺醇转化为酰胺基羧酸的方法
公开(公告)号：US07439388B2
公开(公告)日：2008-10-21
申请号：US11753096
申请日：2007-05-24
申请人： Bijan Harichian , Hang Chen , Jose Guillermo Rosa
发明人： Bijan Harichian , Hang Chen , Jose Guillermo Rosa
IPC分类号： C07C51/29 , C07C51/16
CPC分类号： C07C231/12 , C07C233/47 , C07C233/49
摘要： The invention relates to an improved process for oxidizing a primary amidoalcohol to the corresponding amidocarboxylic acid in high yield.
摘要翻译：本发明涉及以高产率将伯酰胺醇氧化成相应的酰胺基羧酸的改进方法。

28. 发明授权

US06623738B1 Semaphorin receptors 有权
标题翻译：信号素受体
公开(公告)号：US06623738B1
公开(公告)日：2003-09-23
申请号：US09439711
申请日：1999-11-12
申请人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
发明人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
IPC分类号： A61K39395
CPC分类号： C07K14/7056 , A61K38/00
摘要： The invention provides methods and compositions relating to two classes of semaphorin receptors, SR1 and SR2. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SR encoding nucleic acids or purified from human cells. The invention provides isolated SR hybridization probes and primers, capable of specifically hybridizing with the disclosed SR genes. SR-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与两类信号素受体SR1和SR2相关的方法和组合物。可以从所公开的SR编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供了能够与所公开的SR基因特异性杂交的分离的SR杂交探针和引物。 SR特异性结合剂，例如特异性抗体，以及在诊断，治疗和生物制药工业中制备和使用本发明组合物的方法。

29. 发明申请

US20110002316A1 APPARATUS AND A METHOD FOR ENABLING A WLAN DEVICE TO ACCESS A WIMAX NETWORK 审中-公开
标题翻译：用于启用WLAN设备以访问WIMAX网络的装置和方法
公开(公告)号：US20110002316A1
公开(公告)日：2011-01-06
申请号：US12811651
申请日：2008-02-04
申请人： Hang Chen
发明人： Hang Chen
IPC分类号： H04W72/00 , H04L9/32
CPC分类号： H04W8/30 , H04L12/4633
摘要： The present invention provides an apparatus for enabling a wireless local area network device to access a WiMAX network, the apparatus comprises: WiMAX means, configured to encapsulate uplink data from data means into a transmission message in an 802.16e protocol format, to send the transmission message to a WiMAX base station, to re-encapsulate a received message from the WiMAX base station into downlink data that can be processed by the data means and to send the downlink data to the data means; the data means, configured to receive the downlink data from the WiMAX means and the uplink data from WLAN means and to perform processing to the uplink data and the downlink data; and the WLAN means, configured to encapsulate the downlink data received from the data means into a downlink data message in an 802.11a/b/g protocol format, to send the downlink data message to a terminal device, and to re-encapsulate the uplink data message received from the terminal device into the uplink data that can be processed by the data means. The present invention also provides a method for enabling a wireless local area network device to access a WiMAX network. Therefore the facile movement in a local area is achieved.
摘要翻译：本发明提供了一种使无线局域网设备能够访问WiMAX网络的装置，该装置包括：WiMAX装置，被配置为将数据装置的上行数据封装成802.16e协议格式的传输消息，以发送传输向WiMAX基站发送消息，将接收到的消息从WiMAX基站重新封装成可由数据装置处理的下行链路数据，并将下行链路数据发送到数据装置; 数据装置，被配置为从WiMAX装置接收下行链路数据和来自WLAN装置的上行链路数据，并对上行链路数据和下行链路数据执行处理; 并且所述WLAN装置被配置为将从所述数据装置接收的下行链路数据封装成802.11a / b / g协议格式的下行链路数据消息，以将所述下行链路数据消息发送到终端设备，并且重新封装所述上行链路数据消息从终端设备接收到可被数据装置处理的上行链路数据中。本发明还提供了一种使无线局域网设备能够访问WiMAX网络的方法。因此，实现了当地的轻松运动。

30. 发明申请

US20090156537A1 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING ASTHMA OR OTHER ALLERGIC OR INFLAMMATORY DISEASES 审中-公开
标题翻译：用于诊断和治疗哮喘或其他过敏或炎症疾病的组合物和方法
公开(公告)号：US20090156537A1
公开(公告)日：2009-06-18
申请号：US12257852
申请日：2008-10-24
申请人： Michael R. Bowman , Maximilliam T. Follettie , Hang Chen , Cara Williams , Aaron Winkler , Debra Ellis , Wei Liu
发明人： Michael R. Bowman , Maximilliam T. Follettie , Hang Chen , Cara Williams , Aaron Winkler , Debra Ellis , Wei Liu
IPC分类号： A61K31/7105 , A61P11/06 , A61P11/00 , A61K31/198
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1137 , C12N2310/14 , C12Y305/03001 , G01N33/6893 , G01N2500/10 , G01N2800/122
摘要： The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the present invention include inhibiting the activity or expression of a component of an arginine metabolic pathway in tissues affected by asthma or other allergic or inflammatory diseases. In many embodiments, the component being inhibited is a cationic amino acid transporter, an arginase, or a component downstream of the arginase. In many other embodiments, the activity or expression of the component is inhibited by an agent that binds to the component. In still many other embodiments, the activity or expression of the component is inhibited by an agent that binds a polynucleotide encoding the component.
摘要翻译：本发明提供了用于检测或治疗哮喘或其它过敏性或炎性疾病的组合物和方法。一方面，本发明的方法包括抑制受哮喘或其它过敏性或炎性疾病影响的组织中精氨酸代谢途径的成分的活性或表达。在许多实施方案中，被抑制的组分是阳离子氨基酸转运蛋白，精氨酸酶或精氨酸酶下游的组分。在许多其它实施方案中，组分的活性或表达被与组分结合的试剂抑制。在许多其它实施方案中，组分的活性或表达被结合编码组分的多核苷酸的试剂抑制。

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