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21. 发明授权

US5472621A Method for treating transition zone material 失效
标题翻译：处理过渡带材料的方法
公开(公告)号：US5472621A
公开(公告)日：1995-12-05
申请号：US9867
申请日：1993-01-27
申请人： Vlado I. Matkovich , Thomas J. Bormann , Thomas C. Gsell , Frank R. Pascale , Keith S. Morris
发明人： Vlado I. Matkovich , Thomas J. Bormann , Thomas C. Gsell , Frank R. Pascale , Keith S. Morris
IPC分类号： A61M1/02 , A61M1/36 , B01D37/00 , B01D21/26
CPC分类号： A61M1/3652 , A61M1/0222 , A61M1/0231 , A61M1/0236 , A61M2202/0427 , A61M2202/0429
摘要： Methods and devices for treating transition zone material are disclosed. Transition zone material is processed to form a supernatant layer which includes platelets and a sediment layer which includes red blood cells, and the supernatant layer is separated from the sediment layer by passing the supernatant layer through a porous medium. Once the supernatant layer has been separated from the sediment layer, gas may be separated from the supernatant layer.
摘要翻译：公开了用于处理过渡区材料的方法和装置。处理过渡带材料以形成包括血小板和包含红细胞的沉淀层的上清液层，并且通过使上清液层通过多孔介质将沉淀层与沉积物层分离。一旦从沉淀层中分离出上清液层，就可以从上清液层中分离出气体。

22. 发明授权

US5364526A System for processing separate containers of biological fluid 失效
标题翻译：用于处理生物流体分离容器的系统
公开(公告)号：US5364526A
公开(公告)日：1994-11-15
申请号：US107033
申请日：1993-08-17
申请人： Vlado I. Matkovich , Thomas J. Bormann , Thomas C. Gsell , Frank R. Pascale
发明人： Vlado I. Matkovich , Thomas J. Bormann , Thomas C. Gsell , Frank R. Pascale
IPC分类号： A61K35/14 , A61M1/02 , A61M1/36 , B01D37/00 , B67D99/00 , B01D36/00 , B01D61/00
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/3646 , A61M1/3652 , A61M2202/0439 , A61M2205/7527 , A61M2205/7536
摘要： Processes and systems for combining multiple units of a biological fluid in independent containers into a single container are disclosed.
摘要翻译：公开了将独立容器中的生物流体的多个单元组合成单一容器的方法和系统。

23. 发明授权

US5334315A Priming system 失效
标题翻译：启动系统
公开(公告)号：US5334315A
公开(公告)日：1994-08-02
申请号：US824788
申请日：1992-01-17
申请人： Vlado I. Matkovich , Thomas J. Bormann , Gerard R. DelGiacco
发明人： Vlado I. Matkovich , Thomas J. Bormann , Gerard R. DelGiacco
IPC分类号： A61M1/14 , A61M1/36 , A61M27/00 , B01D19/00 , B01D61/14 , B01D65/00 , B01D61/20
CPC分类号： B01D19/0068 , A61M1/3643 , A61M1/3646 , A61M1/3647 , B01D65/00 , A61M2202/0464 , A61M27/006
摘要： Processes and systems and methods for priming a fluid processing apparatus and for treating a fluid are disclosed.
摘要翻译：公开了用于启动流体处理设备和处理流体的方法和系统和方法。

24. 发明授权

US5302299A Biological semi-fluid processing assembly 失效
标题翻译：生物半流体加工总成
公开(公告)号：US5302299A
公开(公告)日：1994-04-12
申请号：US854588
申请日：1992-03-20
申请人： Frank R. Pascale , Thomas J. Bormann , Vlado I. Matkovich
发明人： Frank R. Pascale , Thomas J. Bormann , Vlado I. Matkovich
IPC分类号： A61M1/02 , A61M1/36 , A61M5/38 , B01D5/00 , B01D19/00 , B01D37/00
CPC分类号： A61M1/3643 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/3646 , A61M1/3652 , A61M5/38 , B01D19/0031 , B01D5/0054 , A61M2202/0429 , A61M2202/0439 , A61M2205/7527 , A61M2205/7536
摘要： The invention involves a method and apparatus for treating and administering biological fluids, particularly hyperconcentrated biological fluids.
摘要翻译：本发明涉及用于治疗和给予生物流体，特别是高浓度生物流体的方法和装置。

25. 发明申请

US20130143195A1 LEUKOCYTE PURIFICATION 审中-公开
标题翻译：白俄罗斯清洁剂
公开(公告)号：US20130143195A1
公开(公告)日：2013-06-06
申请号：US13311046
申请日：2011-12-05
申请人： Mikhail Fomovsky , Thomas J. Bormann
发明人： Mikhail Fomovsky , Thomas J. Bormann
IPC分类号： C12N5/078
CPC分类号： C12N5/0087
摘要： A method for purifying leukocytes is disclosed. The method can further include recovering the purified leukocytes, or lysing the purified leukocytes.
摘要翻译：公开了一种纯化白细胞的方法。该方法可进一步包括回收纯化的白细胞或裂解纯化的白细胞。

26. 发明授权

US06655655B1 Connector assemblies, fluid systems, and methods for making a connection 有权
标题翻译：连接器组件，流体系统和连接方法
公开(公告)号：US06655655B1
公开(公告)日：2003-12-02
申请号：US09423374
申请日：2000-06-26
申请人： Vlado Ivan Matkovich , Thomas J. Bormann , Gerard R. Delgiacco , Mladen Franovic
发明人： Vlado Ivan Matkovich , Thomas J. Bormann , Gerard R. Delgiacco , Mladen Franovic
IPC分类号： F16L3728
CPC分类号： A61M39/1011 , A61M39/02 , A61M39/14 , A61M39/18 , F16L37/0985 , F16L47/14 , F16L2201/44 , Y10S285/915 , Y10S604/905 , Y10T29/49872 , Y10T137/87933
摘要： A connector assembly and a fluid system or device comprise a connector assembly which includes first and second fittings, each fitting having an aperture, and a stem disposed in the aperture of the first fitting. In various embodiments of the invention, the connector assembly may further comprise a socket cooperatively arranged with one of the first and second fittings, at least one resilient sealing member, a sealing layer joined to the socket or covering the resilient sealing member, and/or a deformable locking device. A method for making a connection includes mating a first fitting having an aperture and a second fitting having an aperture without fluid within the first and second fittings, establishing a fluid flowpath through the first and second fittings by advancing a stem having a head through the aperture of the first fitting into the aperture of the second fitting, and establishing fluid flow through the first and second fittings by opening a fluid blocking mechanism.
摘要翻译：连接器组件和流体系统或装置包括连接器组件，该连接器组件包括第一和第二配件，每个配件具有孔，以及设置在第一配件的孔中的杆。在本发明的各种实施例中，连接器组件还可以包括与第一和第二配件中的一个协作地布置的插座，至少一个弹性密封构件，连接到插座或覆盖弹性密封构件的密封层，和/或可变形的锁定装置。一种用于制造连接的方法包括：将具有孔的第一配件和具有孔的第二配件与第一和第二配件内的流体相配合，通过使具有头部的杆前进穿过该孔而建立通过第一和第二配件的流体流路的第一配件插入第二配件的孔中，并且通过打开流体阻塞机构来建立通过第一和第二配件的流体流动。

27. 发明授权

US06322709B1 Automated method for processing biological fluid 失效
标题翻译：自动化处理生物体液的方法
公开(公告)号：US06322709B1
公开(公告)日：2001-11-27
申请号：US09558270
申请日：2000-04-25
申请人： Eric J. Krasnoff , Thomas J. Bormann , Thomas C. Gsell , Frank R. Pascale , Vlado I. Matkovich
发明人： Eric J. Krasnoff , Thomas J. Bormann , Thomas C. Gsell , Frank R. Pascale , Vlado I. Matkovich
IPC分类号： B01D3700
CPC分类号： B01D61/22 , A61M1/02 , A61M1/0227 , A61M1/025 , A61M1/029 , A61M5/1486 , A61M2202/0413 , A61M2202/0429 , A61M2202/0439 , B01D61/20 , B01D65/08 , B01D2321/04 , B01D2321/2066 , A61M2202/0092 , A61M2202/005
摘要： A method for automatically processing a biological fluid is disclosed. The method includes the steps of obtaining a container having a biological fluid therein, providing a first signal and communicating with an automated control arrangement to establish flow of at least a portion of the biological fluid along a fluid flow path through a leukocyte depletion medium, providing a second signal and communicating with the automatic control arrangement to terminate flow along the fluid flow path wherein providing the second signal includes sensing the back pressure in the fluid flow path or the flow rate through the leukocyte depletion medium.
摘要翻译：公开了一种用于自动处理生物流体的方法。该方法包括以下步骤：在其中获得具有生物流体的容器，提供第一信号并与自动控制装置连通，以建立至少一部分生物流体沿着通过白细胞消耗介质的流体流动路径的流动，从而提供第二信号并与自动控制装置通信以终止沿着流体流动路径的流动，其中提供第二信号包括感测流体流动路径中的背压或通过白细胞消耗介质的流速。

28. 发明授权

US06106727A Automated system and method for processing biological fluid 失效
标题翻译：自动化系统和处理生物体液的方法
公开(公告)号：US06106727A
公开(公告)日：2000-08-22
申请号：US949817
申请日：1997-10-14
申请人： Eric J. Krasnoff , Thomas J. Bormann , Thomas C. Gsell , Frank R. Pascale , Vlado I. Matkovich
发明人： Eric J. Krasnoff , Thomas J. Bormann , Thomas C. Gsell , Frank R. Pascale , Vlado I. Matkovich
IPC分类号： A61M1/02 , A61M5/148 , B01D21/30 , B01D61/20 , B01D61/22 , B01D65/08 , B01D36/00 , B01D37/00
CPC分类号： B01D61/22 , A61M1/02 , A61M1/0227 , A61M1/025 , A61M1/029 , B01D61/20 , B01D65/08 , A61M2202/0413 , A61M2202/0429 , A61M2202/0439 , A61M5/1486 , B01D2321/04 , B01D2321/2066
摘要： An automated system for processing biological fluid includes a pressure differential generator, a biological fluid processing assembly, and an automated control arrangement coupled to at least one of the pressure differential generator and the biological fluid processing assembly. The automated system may include a porous medium, such as a red cell barrier medium, a leukocyte depletion medium, or a combination red cell barrier/leukocyte depletion medium. The automated system may also include a sensor producing a signal reflecting a parameter of fluid flow.
摘要翻译：用于处理生物流体的自动化系统包括压差发生器，生物流体处理组件和耦合到压力差发生器和生物流体处理组件中的至少一个的自动控制装置。自动化系统可以包括多孔介质，例如红细胞屏障介质，白细胞消耗介质，或组合的红细胞屏障/白细胞消耗介质。自动化系统还可以包括产生反映流体流动参数的信号的传感器。

29. 发明授权

US5545339A Method for processing biological fluid and treating separated component 失效
标题翻译：处理生物流体和处理分离成分的方法
公开(公告)号：US5545339A
公开(公告)日：1996-08-13
申请号：US202111
申请日：1994-02-25
申请人： Thomas J. Bormann , Frank R. Pascale , Thomas C. Gsell
发明人： Thomas J. Bormann , Frank R. Pascale , Thomas C. Gsell
IPC分类号： A61M1/02 , A61M1/34 , A61M1/36 , B01D37/00 , A61M1/00 , B01D21/26 , B01D36/00
CPC分类号： A61M1/3472 , A61M1/0218 , A61M1/0231 , A61M1/3652 , A61M1/3627 , A61M2202/0439
摘要： Methods and systems for processing a biological fluid and treating a separated component of the biological fluid are disclosed.
摘要翻译：公开了用于处理生物流体和处理生物流体的分离组分的方法和系统。

30. 发明授权

US5540841A Cardioplegia filter and method for processing cardioplegia fluid 失效
标题翻译：心脏停搏过滤器及心脏停搏液治疗方法
公开(公告)号：US5540841A
公开(公告)日：1996-07-30
申请号：US95595
申请日：1993-07-26
申请人： Thomas C. Gsell , Thomas J. Bormann , Vlado I. Matkovich , Frank R. Pascale
发明人： Thomas C. Gsell , Thomas J. Bormann , Vlado I. Matkovich , Frank R. Pascale
IPC分类号： A61M1/14 , A61M1/36 , B01D37/00 , A61M37/00 , B01D36/00
CPC分类号： A61M1/3633 , A61M1/3664 , A61M1/14 , A61M1/3687 , A61M2202/0439 , A61M2205/366
摘要： Methods, systems, and devices for processing a biological fluid including leukocytes during cardioplegia are disclosed. A method for processing a biological fluid including leukocytes comprises passing a cardioplegia fluid through a bacterial removing filter; mixing the cardioplegia fluid with the biological fluid including leukocytes to form a cardioplegia mixture; and, passing the cardioplegia mixture through a cardioplegia mixture filter assembly to produce a leukocyte-depleted cardioplegia mixture, said assembly comprising a porous medium to remove leukocytes from the cardioplegia mixture.
摘要翻译：公开了用于在心麻痹期间处理包括白细胞的生物流体的方法，系统和装置。一种用于处理包括白细胞的生物流体的方法包括使一个心麻痹液通过细菌去除过滤器; 将心麻痹液与包括白细胞的生物流体混合以形成心麻痹混合物; 并且通过心麻痹混合物通过心麻痹混合物过滤器组件以产生白细胞贫乏的心麻痹混合物，所述组合件包括从心麻痹混合物中除去白细胞的多孔介质。

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