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21. 发明申请

US20100210630A1 Diamine Derivatives as Inhibitors of Leukotriene A4 Hydrolase 有权
标题翻译：二胺衍生物作为白三烯A4水解酶的抑制剂
公开(公告)号：US20100210630A1
公开(公告)日：2010-08-19
申请号：US12771659
申请日：2010-04-30
申请人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
发明人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
IPC分类号： A61K31/551 , C07D487/08 , A61K31/504 , C07D243/08 , C07D263/32 , A61K31/421 , C07D211/58 , A61K31/4468 , C07D207/09 , A61K31/40 , C07D413/00 , A61K31/5377 , A61P29/00
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译：本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。

22. 发明申请

US20080020965A1 NOVEL TISSUE FACTOR TARGETED THROMBOMODULIN FUSION PROTEINS AS ANTICOAGULANTS 失效
标题翻译：新型组织因子靶向的血栓调节蛋白融合蛋白作为抗凝剂
公开(公告)号：US20080020965A1
公开(公告)日：2008-01-24
申请号：US11766160
申请日：2007-06-21
申请人： David Light , Kirk McLean
发明人： David Light , Kirk McLean
IPC分类号： A61K38/16 , A61K31/7088 , A61K48/00 , A61P7/02 , A61K35/14
CPC分类号： C07K16/36 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/485 , C07K14/7455 , C07K16/40 , C07K19/00 , C07K2317/21 , C07K2317/32 , C07K2317/622 , C07K2319/00
摘要： This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM) EGF456 domain alone or in combination with at least one other TM domain selected from the group consisting of the N-terminal hydrophobic region domain, the EGF123 domain, the interdomain loop between EGF3 and EGF4, and the O-glycosylated Ser/Thr-rich domain, or analogs, fragments, derivatives or variants thereof. The fusion protein binds at the site of injury and prevents the initiation of thrombosis. The fusion protein can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.
摘要翻译：本发明涉及新颖的融合蛋白，其由结合组织因子（TF）的靶向蛋白组成，其与单独的血栓调节蛋白EGF456结构域或与至少一种其它TM结构域可操作地连接，所述TM结构域选自的N末端疏水区域，EGF123结构域，EGF3和EGF4之间的域间环和O-糖基化的Ser / Thr富集结构域，或其类似物，片段，衍生物或变体。融合蛋白在损伤位点处结合并防止血栓形成的发生。融合蛋白可用于治疗各种血栓形成病症，包括但不限于深静脉血栓形成，弥散性血管内凝血和急性冠状动脉综合征。

23. 发明申请

US20080019985A1 NOVEL TISSUE FACTOR TARGETED THROMBOMODULIN FUSION PROTEINS AS ANTICOAGULANTS 失效
公开(公告)号：US20080019985A1
公开(公告)日：2008-01-24
申请号：US11766155
申请日：2007-06-21
申请人： David Light , Kirk McLean
发明人： David Light , Kirk McLean
IPC分类号： A61K39/00 , A61K48/00 , A61P7/02 , C07H21/04 , C07K16/46 , C07K19/00
CPC分类号： C07K16/36 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/485 , C07K14/7455 , C07K16/40 , C07K19/00 , C07K2317/21 , C07K2317/32 , C07K2317/622 , C07K2319/00
摘要： This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM) EGF456 domain alone or in combination with at least one other TM domain selected from the group consisting of the N-terminal hydrophobic region domain, the EGF123 domain, the interdomain loop between EGF3 and EGF4, and the O-glycosylated Ser/Thr-rich domain, or analogs, fragments, derivatives or variants thereof. The fusion protein binds at the site of injury and prevents the initiation of thrombosis. The fusion protein can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.

24. 发明授权

US06657286B2 Microelectronic assembly formation with lead displacement 有权
公开(公告)号：US06657286B2
公开(公告)日：2003-12-02
申请号：US09957120
申请日：2001-09-20
申请人： David Light
发明人： David Light
IPC分类号： H01L23495
CPC分类号： H01L24/81 , H01L21/6835 , H01L23/49811 , H01L24/97 , H01L29/0657 , H01L2224/81801 , H01L2224/97 , H01L2924/01005 , H01L2924/01006 , H01L2924/01023 , H01L2924/01027 , H01L2924/01033 , H01L2924/01039 , H01L2924/01078 , H01L2924/01082 , H01L2924/01322 , H01L2924/014 , H01L2224/81
摘要： Leads are connected between first and second elements so that a first end of each lead is connected to the first element and a second end of each lead is connected to the second element. and the elements are moved away from one another so as to bend the leads towards a vertically-extensive disposition. The direction of each lead, prior to the movement step, is represented by a lead direction vector from the first end of the lead to the second end of the same lead. At least some of these lead direction vectors are non-parallel with at least some other lead direction vectors, but the various lead direction vectors have components in a common direction. During the vertical movement step, the first element is moved in a horizontal direction of motion in this common direction, thereby moving the first end of each lead horizontally toward the second end of that lead, so as to provide or maintain slack in the leads.

25. 发明授权

US08574835B2 Scaffolded nucleic acid polymer particles and methods of making and using 有权
标题翻译：支架核酸聚合物颗粒及其制备和使用方法
公开(公告)号：US08574835B2
公开(公告)日：2013-11-05
申请号：US12785685
申请日：2010-05-24
申请人： Wolfgang Hinz , John Leamon , David Light , Jonathan Rothberg
发明人： Wolfgang Hinz , John Leamon , David Light , Jonathan Rothberg
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , C12M3/00
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00596 , B01J2219/00722 , C12N15/1093 , C12Q1/6874 , C40B40/08 , C40B50/06 , Y10T428/2982
摘要： The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.
摘要翻译：本发明提供了在核酸分析中具有应用的颗粒组合物。本发明的核酸聚合物颗粒允许多核苷酸在其整个体积中被连接，以便比仅通过表面附着可实现的更高的负载能力。在一个方面，本发明的核酸聚合物颗粒包含具有低变异系数的具有均匀尺寸分布的聚丙烯酰胺颗粒，这导致分析测定中粒子与粒子变化的减少。这种颗粒组合物用于各种扩增反应以制备来自核酸片段文库的扩增子文库。

26. 发明申请

US20110318820A1 Immobilized Buffer Particles and Uses Thereof 审中-公开
标题翻译：固定缓冲颗粒及其用途
公开(公告)号：US20110318820A1
公开(公告)日：2011-12-29
申请号：US13172048
申请日：2011-06-29
申请人： Wolfgang Hinz , David Light , Todd Rearick , James Ball
发明人： Wolfgang Hinz , David Light , Todd Rearick , James Ball
IPC分类号： C12M1/34
CPC分类号： C12Q1/6874 , G01N27/4145
摘要： The disclosure relates to novel particle compositions and methods of making said compositions having applications in nucleic acid analysis, as well as apparatuses and systems for the same.
摘要翻译：本公开涉及新型颗粒组合物和制备所述组合物在核酸分析中的应用的方法，以及用于其的装置和系统。

27. 发明申请

US20110195459A1 Methods of Making Libraries of Nucleic Acids Using Porous Particles 审中-公开
标题翻译：使用多孔颗粒制备核酸图谱的方法
公开(公告)号：US20110195459A1
公开(公告)日：2011-08-11
申请号：US13029664
申请日：2011-02-17
申请人： Wolfgang HINZ , John Leamon , David Light , Jonathan Rothberg
发明人： Wolfgang HINZ , John Leamon , David Light , Jonathan Rothberg
IPC分类号： C12P19/34
CPC分类号： C12N15/1093 , B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00596 , B01J2219/00722 , C12Q1/6874 , C40B40/08 , C40B50/06 , Y10T428/2982
摘要： The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.
摘要翻译：本发明提供了在核酸分析中具有应用的颗粒组合物。本发明的核酸聚合物颗粒允许多核苷酸在其整个体积中被连接，以便比仅通过表面附着可实现的更高的负载能力。在一个方面，本发明的核酸聚合物颗粒包含具有低变异系数的具有均匀尺寸分布的聚丙烯酰胺颗粒，这导致分析测定中粒子与粒子变化的减少。这种颗粒组合物用于各种扩增反应以制备来自核酸片段文库的扩增子文库。

28. 发明申请

US20110104058A1 DIMERIC MOLECULAR COMPLEXES 失效
标题翻译：二元分子复合物
公开(公告)号：US20110104058A1
公开(公告)日：2011-05-05
申请号：US12302283
申请日：2007-05-24
申请人： Tara Heitner , David Light , Kirk McLean , Renate Parry , Noboru Satozawa , Douglas Schneider , Marian Seto
发明人： Tara Heitner , David Light , Kirk McLean , Renate Parry , Noboru Satozawa , Douglas Schneider , Marian Seto
IPC分类号： A61K39/395 , C07K19/00 , C12N9/96 , C07H21/04 , C12N5/10 , A61K49/16 , A61P35/00
CPC分类号： C07K16/00 , C07K16/3069 , C07K2317/52 , C07K2317/53 , C07K2317/55 , C07K2317/622 , C07K2319/30
摘要： Dimeric molecular complexes comprising an IgE CH4 dimerization domain useful for diagnostics and therapeutics.
摘要翻译：包含可用于诊断和治疗的IgE CH4二聚化结构域的二聚体分子复合物。

29. 发明授权

US07579000B2 Tissue factor targeted antibodies as anticoagulants 失效
标题翻译：组织因子靶向抗体作为抗凝剂
公开(公告)号：US07579000B2
公开(公告)日：2009-08-25
申请号：US10512215
申请日：2004-04-30
申请人： David Light , Kirk McLean
发明人： David Light , Kirk McLean
IPC分类号： A61K39/395
CPC分类号： G01N33/86 , A61K2039/505 , C07K16/36 , C07K16/40 , C07K2317/622 , G01N2800/224
摘要： This invention relates to novel antibodies that bind with greater affinity to the factor VIIa/tissue factor (FVIIa/TF) complex than to tissue factor (TF) alone, do not compete for binding to TF with FVII and FX, an inhibit FX activation. The antibodies bind at the site of injury and prevent the initiation of thrombosis. The antibodies can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.
摘要翻译：本发明涉及与单独的组织因子（TF）相比，与因子VIIa /组织因子（FVIIa / TF）复合物具有更高亲和力结合的新型抗体，不竞争与FVII和FX的结合，抑制FX激活。抗体在损伤部位结合并防止血栓形成的发生。抗体可用于治疗各种血栓形成病症，包括但不限于深静脉血栓形成，弥散性血管内凝血和急性冠状动脉综合征。

30. 发明申请

US20080093108A1 Layered metal structure for interconnect element 有权
标题翻译：用于互连元件的分层金属结构
公开(公告)号：US20080093108A1
公开(公告)日：2008-04-24
申请号：US11801336
申请日：2007-05-09
申请人： David Light
发明人： David Light
IPC分类号： H01B5/00 , H01R43/00
CPC分类号： H05K3/062 , H05K3/202 , H05K2201/0361 , H05K2203/0384 , Y10T29/49224
摘要： A layered metal structure is provided in accordance with an aspect of the invention. The structure can be used, for example, to fabricate a conductive interconnect element for conductively interconnecting one or more microelectronic elements. The layered structure includes first and second metal layers each of which may include one or more of copper or aluminum, for example. An intervening layer, may include for example, chromium between the first and second metal layers, chromium being resistant to an etchant usable to pattern the first and second metal layers selectively to the intervening layer. An etchant such as cupric chloride, ferric chloride (FeCl3), a peroxysulfuric composition, or a persulfate composition may be used to pattern the first and second metal layers in such case.
摘要翻译：根据本发明的一个方面提供了层状金属结构。该结构可以用于例如制造导电互连一个或多个微电子元件的导电互连元件。层状结构包括例如可以包括铜或铝中的一种或多种的第一和第二金属层。中间层可以包括例如在第一和第二金属层之间的铬，铬耐腐蚀剂可以选择性地将第一和第二金属层图案化成中间层。在这种情况下，可以使用诸如氯化铜，氯化铁（FeCl 3 N 3），过氧化硫组合物或过硫酸盐组合物的蚀刻剂来图案化第一和第二金属层。

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