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21. 发明申请

US20070129896A1 Crystal structure and uses thereof 审中-公开
公开(公告)号：US20070129896A1
公开(公告)日：2007-06-07
申请号：US11650063
申请日：2007-01-04
申请人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
发明人： Andrew Wilks , Christopher Burns , Emmanuelle Fantino , Isabelle Lucet , Jamie Rossjohn , Michelle Styles
IPC分类号： G06F19/00
CPC分类号： C12N9/1205 , C07K2299/00 , Y02A90/26
摘要： The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.

22. 发明申请

US20060270687A1 Kinase inhibitors 有权
公开(公告)号：US20060270687A1
公开(公告)日：2006-11-30
申请号：US11397982
申请日：2006-04-04
申请人： Christopher Burns , Xianyong Bu , Andrew Wilks
发明人： Christopher Burns , Xianyong Bu , Andrew Wilks
IPC分类号： A61K31/497 , C07D403/04
CPC分类号： C07D401/14 , A61K31/497 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04
摘要： A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated disease states using the compound of formula I is also described.

23. 发明申请

US20060069084A1 Methods of inhibiting kinases 审中-公开
标题翻译：抑制激酶的方法
公开(公告)号：US20060069084A1
公开(公告)日：2006-03-30
申请号：US11223633
申请日：2005-09-09
申请人： Christopher Burns , Andrew Wilks
发明人： Christopher Burns , Andrew Wilks
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/498
CPC分类号： A61K31/551 , A61K31/435 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5377
摘要： The present invention provides methods of inhibiting JAK involving the use of a group of compounds based either upon a 2-amino-6-carba-disubstituted pyrazine scaffold or a 2-amino-6-carba-disubstituted pyridine scaffold. The invention also provides methods of treating JAK-associated disease states.
摘要翻译：本发明提供了基于2-氨基-6-羧基 - 二取代的吡嗪支架或2-氨基-6-碳 - 二取代的吡啶支架来抑制涉及使用一组化合物的JAK的方法。本发明还提供了治疗JAK相关疾病状态的方法。

24. 发明申请

US20050004140A1 Kinase inhibitors 有权
标题翻译：激酶抑制剂
公开(公告)号：US20050004140A1
公开(公告)日：2005-01-06
申请号：US10472156
申请日：2003-05-23
申请人： Christopher Burns , Xianyong Bu , Andrew Wilks
发明人： Christopher Burns , Xianyong Bu , Andrew Wilks
IPC分类号： C07D241/20 , A61K31/497 , A61K31/5377 , A61P3/10 , A61P5/14 , A61P11/06 , A61P17/00 , A61P19/02 , A61P21/00 , A61P27/16 , A61P29/00 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04 , C07
CPC分类号： C07D401/14 , A61K31/497 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04
摘要： A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated disease states using the compound of formula I is also described.
摘要翻译：描述了通式的化合物或其药学上可接受的盐，水合物，溶剂合物，结晶形式或非对映异构体。还描述了使用式I化合物治疗蛋白激酶相关疾病状态的方法。

25. 发明授权

US06393576B1 Apparatus and method for communication between integrated circuit connected to each other by a single line 失效
标题翻译：用于通过单线连接的集成电路之间的通信的装置和方法
公开(公告)号：US06393576B1
公开(公告)日：2002-05-21
申请号：US08938828
申请日：1997-09-29
申请人： Stillman F. Gates , Christopher Burns
发明人： Stillman F. Gates , Christopher Burns
IPC分类号： G06F1340
CPC分类号： G06F13/385 , G06F13/4295
摘要： A host adapter integrated circuit that contains data transfer modules has a serial port that uses a single serial port pin to communicate with a slave serial port input-output integrated circuit that interfaces to various resources that are included in a support circuit. The serial port forms a packet from each byte of information to be transferred from a module to the slave device by adding a start bit before the byte, followed by a parity bit at the end of the byte and followed by a stop bit. After transmitting the packet, the serial port waits for an acknowledge packet from the slave serial port input-output integrated circuit, for example for two clock cycles after transmission of the packet. For synchronous operation, a common oscillator drives the clock signal on the slave serial port input-output integrated circuit and host adapter integrated circuit. The serial port pin in the host adapter integrated circuit is connected to a shifter circuit in the serial port that serially clocks data from the serial port pin and passes the data parallelly to a bus in the host adapter integrated circuit and vice versa.
摘要翻译：包含数据传输模块的主机适配器集成电路具有使用单个串行端口引脚与从属串行端口输入 - 输出集成电路进行通信的串行端口，该串行端口输入输出集成电路与支持电路中包含的各种资源进行接口。串行端口通过在字节之前添加一个起始位，随后是字节结尾处的奇偶校验位，后跟一个停止位，形成从要从模块传送到从器件的信息的每个字节的数据包。在发送数据包之后，串行端口等待来自从串行端口输入 - 输出集成电路的确认数据包，例如传输数据包后的两个时钟周期。对于同步操作，公共振荡器驱动从串行端口输入输出集成电路和主机适配器集成电路的时钟信号。主机适配器集成电路中的串行端口引脚连接到串行端口的移位器电路，用于串行地串行串行端口引脚上的数据，并将数据并行传递到主机适配器集成电路中的总线，反之亦然。

26. 发明授权

US06381688B1 Serial port for a hose adapter integrated circuit using a single terminal 有权
标题翻译：使用单个终端的主机适配器集成电路的串行端口
公开(公告)号：US06381688B1
公开(公告)日：2002-04-30
申请号：US09579863
申请日：2000-05-25
申请人： Stillman F. Gates , Christopher Burns
发明人： Stillman F. Gates , Christopher Burns
IPC分类号： G06F1500
CPC分类号： G06F13/385 , G06F13/4295
摘要： A host adapter integrated circuit that contains data transfer modules has a serial port that uses a single serial port pin to communicate with a slave serial port input-output integrated circuit that interfaces to various resources that are included in a support circuit. The serial port forms a packet from each byte of information to be transferred from a module to the slave device by adding a start bit before the byte, followed by a parity bit at the end of the byte and followed by a stop bit. After transmitting the packet, the serial port waits for an acknowledge packet from the slave serial port input-output integrated circuit, for example for two clock cycles after transmission of the packet. For synchronous operation, a common oscillator drives the clock signal on the slave serial port input-output integrated circuit and host adapter integrated circuit. The serial port pin in the host adapter integrated circuit is connected to a shifter circuit in the serial port that serially clocks data from the serial port pin and passes the data parallelly to a bus in the host adapter integrated circuit and vice versa.
摘要翻译：包含数据传输模块的主机适配器集成电路具有使用单个串行端口引脚与从属串行端口输入 - 输出集成电路进行通信的串行端口，该串行端口输入输出集成电路与支持电路中包含的各种资源进行接口。串行端口通过在字节之前添加一个起始位，随后是字节结尾处的奇偶校验位，后跟一个停止位，形成从要从模块传送到从器件的信息的每个字节的数据包。在发送数据包之后，串行端口等待来自从串行端口输入 - 输出集成电路的确认数据包，例如传输数据包后的两个时钟周期。对于同步操作，公共振荡器驱动从串行端口输入输出集成电路和主机适配器集成电路的时钟信号。主机适配器集成电路中的串行端口引脚连接到串行端口的移位器电路，用于串行地串行串行端口引脚上的数据，并将数据并行传递到主机适配器集成电路中的总线，反之亦然。

27. 发明授权

US5861529A Farnesyl transferase inhibitors, their preparation and the pharmaceutical compositions which contain them 失效
标题翻译：法呢基转移酶抑制剂，它们的制备和含有它们的药物组合物
公开(公告)号：US5861529A
公开(公告)日：1999-01-19
申请号：US750819
申请日：1997-06-18
申请人： Bernard Baudoin , Christopher Burns , Alain Commercon , Jean-Dominique Guitton
发明人： Bernard Baudoin , Christopher Burns , Alain Commercon , Jean-Dominique Guitton
IPC分类号： C07C323/25 , C07C323/59 , C07C323/60 , A01N37/12
CPC分类号： C07C323/25 , C07C323/59 , C07C323/60 , C07C2102/08
摘要： This invention relates to transferase inhibitors of the formula (I), their preparation, and pharmaceutical compositions containing them. ##STR1## In formula (I), R.sub.1 is Y--S--A.sub.1 --(Y is a hydrogen atom, an amino acid residue, a fatty acid residue, an alkyl radical, an alkoxycarbonyl radical, or an R.sub.4 --S-- radical in which R.sub.4 is an alkyl radical containing 1 to 4 carbon atoms optionally substituted by a phenyl radical or a radical of the formula (II) ##STR2## in which A.sub.1 is an alkylene radical containing 1 to 4 carbon atoms optionally substituted at the position a in the grouping >C(X.sub.1)(Y.sub.1) with an amino, alkylamino, dialkylamino, alkanoylamino, or alkoxycarbonylamino radical); X.sub.1 and Y.sub.1 are each a hydrogen atom or form, together with the carbon atom to which they are connected, a >C.dbd.O grouping; R'.sub.1 is hydrogen or methyl; R.sub.2 is an alkyl, alkenyl or an alkynyl radical containing 1 to 6 carbon atoms optionally substituted by a hydroxyl, alkoxy, mercapto, alkylthio, alkylsulphinyl, or alkylsulphonyl, wherein when R.sub.2 is an alkyl radical substituted by a hydroxyl radical, R.sub.2 can form a lactone with the carboxyl radical at the .alpha. position; R'.sub.2 is hydrogen or methyl; and R is a hydrogen atom or an optionally substituted alkyl radical or an optionally substituted phenyl radical; and the radical ##STR3## is in position 5 or 6 of the naphthyl ring. These compounds have anti-cancer properties.
摘要翻译： PCT No.PCT / FR95 / 00739 Sec。 371日期：1997年6月18日 102（e）日期1997年6月18日PCT提交1995年6月7日PCT公布。第WO95 / 34535号公报日期1995年12月21日本发明涉及式（I）的转移酶抑制剂，其制备方法和含有它们的药物组合物。（I）式（I）中，R 1为YS-A1-（Y为氢原子，氨基酸残基，脂肪酸残基，烷基，烷氧基羰基或R4-S-基）其中R 4是任选被苯基或式（II）的基团取代的含有1至4个碳原子的烷基，其中A 1是含有1至4个碳原子的亚烷基，任选地被取代在在具有氨基，烷基氨基，二烷基氨基，烷酰基氨基或烷氧基羰基氨基的基团> C（X1）（Y1）中的位置a）; X1和Y1各自为氢原子或形式，与它们连接的碳原子一起为> C = O基团; R'1是氢或甲基; R2是任选被羟基，烷氧基，巯基，烷硫基，烷基亚磺酰基或烷基磺酰基取代的含有1至6个碳原子的烷基，烯基或炔基，其中当R2是被羟基取代的烷基时，R2可以形成内酯与羧基在α位置; R'2是氢或甲基; 并且R是氢原子或任选取代的烷基或任选取代的苯基; 并且基团在萘环的5或6位。这些化合物具有抗癌特性。

28. 发明申请

US20210345634A1 DISSOLVING COFFEE BEADS 有权
公开(公告)号：US20210345634A1
公开(公告)日：2021-11-11
申请号：US17315245
申请日：2021-05-07
申请人： Christopher Burns
发明人： Christopher Burns
IPC分类号： A23F5/24 , A23F5/40 , A23F5/26 , B65D65/46 , B65D25/22 , B65D25/54 , B65D85/00 , B65D25/52
摘要： A coffee capsule dispensing assembly that includes at least one substantially gelatin casing capsule or composite which contains a coffee concentrate or composite or coffee enhancing substance. The gelatin casing capsule with a hydrolyzed collagen gelatin portion is designed to dissolve in an aqueous solution. A housing assembly with a distal end and a proximal end is designed to contain the at least one gelatin casing capsule. A depressible button assembly is disposed substantially at the proximal end of the housing assembly and is designed to advance the at least one gelatin casing capsule toward the distal end of the housing assembly. A latch and release assembly at the distal end of the housing assembly is designed to singularly release the at least one gelatin casing capsule when the at least one gelatin casing capsule is advanced by the depressible button assembly.

29. 发明授权

US09292831B2 Monitoring data elements across multiple networks and processes 有权
标题翻译：监控跨多个网络和进程的数据元素
公开(公告)号：US09292831B2
公开(公告)日：2016-03-22
申请号：US14049581
申请日：2013-10-09
申请人： Christopher Burns , John Woolley
发明人： Christopher Burns , John Woolley
IPC分类号： G06F15/173 , G06Q10/10
CPC分类号： G06Q10/10
摘要： The invention described here is a computer-related method for analyzing and reporting the current status of a wide array of processes and conditions across multiple networks and systems. It employs independent software entities called “Blades” to control the retrieval, analysis and characterization of each situation, combined with a common presentation system that displays those characterizations in a simple graphical vocabulary for expressing degrees of positive and negative significance. By employing Tiles or similar independent graphical reports, shown together on the screen of a desktop computer, notebook, tablet, mobile device or wearable interactive display, the invention described here allows the user to see his or her world at a glance.
摘要翻译：这里描述的发明是一种用于分析和报告跨多个网络和系统的广泛流程和状况的当前状态的计算机相关方法。它采用名为“刀片”的独立软件实体来控制每种情况的检索，分析和表征，并结合一个共同的演示系统，在简单的图形词汇表中显示这些表征，以表达正面和负面意义的程度。通过使用台式计算机，笔记本，平板电脑，移动设备或可穿戴互动显示器的屏幕上一起显示的瓷砖或类似的独立图形报告，这里描述的发明允许用户一目了然地看到他或她的世界。

30. 发明申请

US20070285508A1 STEREO IMAGING SYSTEM AND METHOD FOR USE IN TELEROBOTIC SYSTEMS 审中-公开
标题翻译：立体成像系统和用于电磁系统的方法
公开(公告)号：US20070285508A1
公开(公告)日：2007-12-13
申请号：US11843871
申请日：2007-08-23
申请人： DAVID GERE , Christopher Burns , John Stern , Michael Tierney
发明人： DAVID GERE , Christopher Burns , John Stern , Michael Tierney
IPC分类号： H04N15/00
CPC分类号： G02B23/2415 , A61B1/00183 , A61B1/00193 , H04N13/10 , H04N13/239 , H04N13/246 , H04N13/296 , H04N13/327 , H04N2005/2255
摘要： This invention relates to a stereo imaging system for use in telerobotic systems. A method of imaging a target site in a stereo imaging system is provided. The method typically includes capturing a right and a left optical image of the target site and transforming the right and the left optical images preferably into digital information. The method further includes converting the digital information into opposed images of the target site displayed on a stereo display of the stereo imaging system, one of the opposed images being associated with the right optical image and the other of the opposed images being associated with the left optical image. The method further includes regulating the digital information to cause the positions of the target site displayed on the opposed images to change relative to each other. The invention further provides for a method of aligning the opposed images, to a method of adjusting the stereo working distance of an image capture device, such as an endoscope and to a stereo imaging system.
摘要翻译：本发明涉及一种用于远程遥控系统的立体成像系统。提供了一种在立体成像系统中成像目标部位的方法。该方法通常包括捕获目标站点的右光学图像和左光学图像，并将左右光学图像优选地变换为数字信息。该方法还包括将数字信息转换为立体成像系统的立体显示器上显示的目标站点的相对图像，相对图像中的一个与右光学图像相关联，另一个相对的图像与左侧光学图像。所述方法还包括调节所述数字信息以使所述相对图像上显示的所述目标站点的位置相对于彼此改变。本发明还提供了一种将相对图像对准的方法，一种调整诸如内窥镜和立体成像系统的图像捕获装置的立体声工作距离的方法。

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