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21. 发明申请

US20110065754A1 IMINOSUGARS AND METHODS OF TREATING FILOVIRAL DISEASES 审中-公开
标题翻译： IMINOSUGARS AND METHODS OF TREAL FILOVIRAL DISEASES
公开(公告)号：US20110065754A1
公开(公告)日：2011-03-17
申请号：US12873708
申请日：2010-09-01
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/14 , C12N5/02
CPC分类号： A61K31/445
摘要： Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Filoviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：本发明提供了使用亚氨基二糖（例如DNJ衍生物）治疗由属于病毒属的病毒引起的病毒或病症的方法。

22. 发明申请

US20100317696A1 IMINOSUGARS AND METHODS OF TREATING BUNYAVIRAL AND TOGAVIRAL DISEASES 有权
标题翻译：麻醉药和治疗疟疾和瘟疫的方法
公开(公告)号：US20100317696A1
公开(公告)日：2010-12-16
申请号：US12813882
申请日：2010-06-11
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/14
CPC分类号： A61K31/445 , Y02A50/382 , Y02A50/397 , Y02A50/409
摘要： Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：提供了治疗和/或预防使用亚氨基二糖（例如DNJ衍生物）引起的属于布尼亚病毒科或披膜病毒科的病毒引起的疾病或病症的新方法。

23. 发明申请

US20100222383A1 Iminosugars and methods of treating viral diseases 有权
标题翻译：伊莫诺斯和治疗病毒性疾病的方法
公开(公告)号：US20100222383A1
公开(公告)日：2010-09-02
申请号：US12656992
申请日：2010-02-22
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/20
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
摘要翻译：提供了使用亚氨基二糖治疗或预防由登革热病毒引起或与登革热病毒有关的病毒感染的方法。

24. 发明申请

US20070275998A1 DEOXYNOJIRIMYCIN AND D-ARABINITOL ANALOGS AND METHODS OF USING 有权
标题翻译：去氧吉西他滨和D-阿拉伯糖醇模拟物及其使用方法
公开(公告)号：US20070275998A1
公开(公告)日：2007-11-29
申请号：US11752015
申请日：2007-05-22
申请人： Terry D. Butters , Raymond A. Dwek , George W.J. Fleet
发明人： Terry D. Butters , Raymond A. Dwek , George W.J. Fleet
IPC分类号： A61K31/445 , A61K31/655 , C07D211/54
CPC分类号： C07D211/48 , C07D211/46
摘要： A compound of Formula I are provided: wherein R is: R1 is a substituted or unsubstituted alkyl group; W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; X1-5 are independently selected from H, NO2, N3, and NH2;Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.
摘要翻译：提供式I化合物：其中R是：R 1是取代或未取代的烷基; 取代或未取代的烷基，取代或未取代的烷基，取代或未取代的烷酰基，取代或未取代的芳酰基，或取代或未取代的卤代烷酰基; X 1-5独立地选自H，NO 2，N 3和NH 2; Y是不存在或是不是羰基的取代或未取代的C 1 - 烷基; Z选自键或NH，条件是当Z为键时，Y不存在，条件是当Z为NH时，Y为取代或未取代的C 1 - 烷基，除羰。还提供了D-阿拉伯糖醇化合物，制备这些化合物的方法和这些化合物的组合物，以及使用这些化合物的方法。

25. 发明授权

US06660749B2 Inhibition of glycolipid biosynthesis 有权
公开(公告)号：US06660749B2
公开(公告)日：2003-12-09
申请号：US10244628
申请日：2002-09-17
申请人： Terry D. Butters , Frances M. Platt , Raymond A. Dwek
发明人： Terry D. Butters , Frances M. Platt , Raymond A. Dwek
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445
摘要： Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.

26. 发明授权

US06465488B1 Inhibition of glycolipid biosynthesis 有权
标题翻译：抑制糖脂生物合成
公开(公告)号：US06465488B1
公开(公告)日：2002-10-15
申请号：US09553951
申请日：2000-04-21
申请人： Terry D. Butters , Frances M. Platt , Raymond A. Dwek
发明人： Terry D. Butters , Frances M. Platt , Raymond A. Dwek
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445
摘要： Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.
摘要翻译：本文公开了使用抑制葡糖基转移酶的化合物治疗脂质储存疾病的方法。本发明涉及利用抑制受影响细胞中葡糖基转移酶活性的化合物治疗脂质贮积病。特别涉及1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇及其衍生物的用途。

27. 发明授权

US06465487B1 Inhibition of membrane-associated viral replication 有权
标题翻译：抑制膜相关病毒复制
公开(公告)号：US06465487B1
公开(公告)日：2002-10-15
申请号：US09209033
申请日：1998-12-10
申请人： Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
发明人： Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.
摘要翻译：抑制宿主细胞膜出芽病毒的形态发生和由此引起的感染的方法使用抑制宿主细胞葡糖苷酶或葡糖基转移酶的化合物的方法。使用抑制葡糖基转移酶的化合物治疗脂质储存疾病的方法。

28. 发明授权

US06291657B1 Deoxygalactonojirimycin derivatives 失效
标题翻译：脱氧半乳甘露霉素衍生物
公开(公告)号：US06291657B1
公开(公告)日：2001-09-18
申请号：US08102654
申请日：1993-08-05
申请人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
发明人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
IPC分类号： C07H1500
CPC分类号： A61K31/131 , C07D211/46 , Y02A50/471
摘要： Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
摘要翻译：提供脱氧半乳糖吉非霉素的新型N-烷基衍生物，其中所述烷基含有3-6个碳原子。这些新型化合物可用于选择性抑制糖脂合成。

29. 发明授权

US5399567A Method of treating cholera 失效
标题翻译：治疗霍乱的方法
公开(公告)号：US5399567A
公开(公告)日：1995-03-21
申请号：US61645
申请日：1993-05-13
申请人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
发明人： Frances M. Platt , Gabrielle R. Neises , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： This invention discloses a method of treating cholera infection in a human by administering an effective amount of 1,5-dideoxy-1,5-imino-D-glucitol or a derivative thereof.
摘要翻译：本发明公开了一种通过施用有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇或其衍生物来治疗人的霍乱感染的方法。

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