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    • 22. 发明申请
    • AGENTS FOR SUPPRESSING HEPATIC FIBROSIS
    • 用于抑制HEPATIC FIBROSIS的药剂
    • US20090060892A1
    • 2009-03-05
    • US11912061
    • 2006-09-27
    • Hiroyuki Yoneyama
    • Hiroyuki Yoneyama
    • A61K38/43A61K38/10A61P43/00
    • A61K38/51C12Y402/02019C12Y402/02021G01N33/5088
    • The present invention relates to hepatic fibrosis-suppressing agents that are suitable for treating or preventing fibrotic liver diseases such as cirrhosis, which comprise as an active ingredient a substance that inhibits the production or accumulation of chondroitin sulfate proteoglycans including chondroitinase ABC and ADAMTS-4; and methods of screening for the agents.The present inventors discovered for the first time that hepatic fibrosis could be efficiently suppressed by suppressing the production or accumulation of chondroitin sulfate proteoglycans. Specifically, fibrosis of liver tissues can be suppressed by administering chondroitinase ABC, a chondroitin sulfate proteoglycan-degrading enzyme, or by using siRNA to suppress the expression of C4ST-1, C6ST-1, or C6ST-2, a sulfotransferase for chondroitin sulfate proteoglycans. Compounds such as nucleic acids that are used as siRNA can be used as effective agents for suppressing hepatic fibrosis. Furthermore, hepatic fibrosis-suppressing agents can be found by screening for compounds that suppress the production or accumulation of chondroitin sulfate proteoglycans.
    • 本发明涉及适用于治疗或预防纤维化肝病如肝硬化的肝纤维化抑制剂,其包括抑制硫酸软骨素蛋白聚糖(包括软骨素酶ABC和ADAMTS-4)的产生或积累的物质作为活性成分; 以及筛选试剂的方法。 本发明人首次发现通过抑制硫酸软骨素蛋白聚糖的产生或积累可以有效地抑制肝纤维化。 具体而言,可以通过施用软骨素酶ABC,硫酸软骨素蛋白聚糖降解酶或通过使用siRNA来抑制硫酸软骨素蛋白聚糖的C4ST-1,C6ST-1或C6ST-2的表达来抑制肝组织的纤维化 。 用作siRNA的核酸等化合物可以用作抑制肝纤维化的有效药剂。 此外,通过筛选抑制硫酸软骨素蛋白聚糖的产生或积累的化合物,可以发现肝纤维化抑制剂。
    • 29. 发明授权
    • Silver halide color photographic photosensitive material and process for forming color image
    • 卤化银彩色照相感光材料和形成彩色图像的工艺
    • US06818388B2
    • 2004-11-16
    • US10654064
    • 2003-09-04
    • Toshiyuki MakutaShin SoejimaHiroyuki Yoneyama
    • Toshiyuki MakutaShin SoejimaHiroyuki Yoneyama
    • G03C173
    • G03C7/407G03C1/825G03C7/3041G03C7/346G03C7/3825G03C7/3835G03C7/3885G03C2200/52
    • A silver halide color photographic photosensitive material comprising, on a reflective support, at least one yellow-coloring photosensitive silver halide emulsion layer, at least one magenta-coloring photosensitive silver halide emulsion layer, at least one cyan-coloring photosensitive silver halide emulsion layer and at least one non-photosensitive, non-coloring hydrophilic colloid layer. Reflective density A(&lgr;) at a wavelength &lgr; at an unexposed portion of the material after a color development treatment is 0.08 or less for 450 nm, 0.10 or less for 550 nm, and 0.08 or less for 650 nm. Alternatively, chromaticity at the unexposed portion of the material after the color development treatment satisfies the condition: 91≦L*≦96, 0≦a*≦2.0, −9.0≦b*≦−3.0. Also provided is a process for forming an image using the silver halide color photographic photosensitive material.
    • 一种卤化银彩色照相感光材料,其在反射载体上包含至少一种黄色着色感光卤化银乳剂层,至少一种品红色着色感光卤化银乳剂层,至少一种青色着色感光卤化银乳剂层和 至少一种非光敏非着色亲水胶体层。 显色处理后的材料未曝光部分的波长λ处的反射密度A(λ)在450nm为0.08以下,550nm为0.10以下,650nm为0.08以下。 或者,显色处理后的材料的未曝光部分的色度满足条件:91 <= L * <= 96,0 <= a * <= 2.0,-9.0 <= b * <= - 3.0。 还提供了使用卤化银彩色照相感光材料形成图像的方法。