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22. 发明专利

PE09972001A1 COMPUESTO DE ANILLO FUNDIDO 未知
公开(公告)号：PE09972001A1
公开(公告)日：2001-10-22
申请号：PE0014032000
申请日：2000-12-27
申请人： JAPAN TOBACCO INC
发明人： HASHIMOTO HIROMASA , YOSHIDA ATSUHITO , MIZUTANI KENJI
IPC分类号： C07D209/12 , C07D235/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： SE REFIERE A UN AGENTE TERAPEUTICO PARA LA HEPATITIS C QUE COMPRENDE UN COMPUESTO DE ANILLO FUNDIDO DE FORMULA I DONDE G1 ES C(-R1), N; G2 ES C(-R2), N; G3 ES C(-R3), N; G4 ES C(-R4), N; G5, G6, G9, G8 SON C, N; G7 ES C(-R7), O, S, N OPCIONALMENTE SUSTITUIDO CON R8; R1, R2, R3, R4 SON N, ALCANOIL C1-C6, CARBOXIL, CIANO, NITRO, ALQUILO C1-C6, COORa1, CONRa2Ra3, C(=NRa4)NH2, NHRa5, ORa6, SO2Ra7, POO(Ra31)2, ENTRE OTROS; Ra1 ES ALQUILO C1-C6; Ra2, Ra3 SON H, ALCOXI C1-C6, ALQUILO C1-C6; Ra4 ES H, OH; Ra5 ES H, ALCANOIL C1-C6, ALQUILSULFONIL C1-C6; Ra6 ES H, ALQUILO C1-C6; Ra7 ES OH, AMINO, ALQUILO C1-C6, ALQUILAMINO C1-C6; Ra31 ES H, ALQUILO C1-C6; ANILLO Cy ES CICLOALQUILO C3-C8, CICLOALQUENILO C3-C8; ANILLO A ES ARILO C6-C14, CICLOALQUILO C3-C8, CICLOALQUENILO C3-C8, HETEROCICLO; R5 Y R6 SON H, HALOGENO, ALQUILO C1-C6, ORa8; X ES H, HALOGENO, CIANO, NITRO, AMINO, ALQUILSULFONILO C1-C6, ENTRE OTROS. UN COMPUESTO PREFERIDO ES ETIL 2-[4-(3-BROMOFENOXI)FENIL]-1-CICLOHEXILBENCIMIDAZOL-5-CARBOXILATO. EL COMPUESTO INHIBE A LA POLIMERASA DE LA HEPATITIS C

23. 发明专利

NO20014134L 未知
公开(公告)号：NO20014134L
公开(公告)日：2001-10-22
申请号：NO20014134
申请日：2001-08-24
申请人： JAPAN TOBACCO INC
发明人： HASHIMOTO HIROMASA , MIZUTANI KENJI , YOSHIDA ATSUHITO
IPC分类号： A61K31/4184 , A61K31/42 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4523 , A61K31/496 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/55 , A61K31/7076 , A61P1/16 , A61P31/20 , C07D235/18 , C07D235/30 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04 , C07D521/00 , C07D209/12

24. 发明公开

EP1653969A4 PYRROLO 1,2-B PYRIDAZINE DERIVATIVES 审中-公开
标题翻译：吡咯烷1,2-B吡啶衍生物
公开(公告)号：EP1653969A4
公开(公告)日：2006-12-20
申请号：EP04780428
申请日：2004-08-06
申请人： JAPAN TOBACCO INC
发明人： FOX BRIAN M , IIO KIYOSEI , INABA TAKASHI , KAYSER FRANK , LI KEXUE , SAGAWA SHOICHI , TANAKA MASAHIRO , YOSHIDA ATSUHITO
IPC分类号： C07D487/04 , A01N43/58 , A01N43/60 , A61K20060101 , A61K31/495 , A61K31/497 , A61K31/50 , A61K31/503 , A61K31/535 , A61P3/00 , C07D237/26 , C07D237/28 , C07D413/00 , C07D487/00
CPC分类号： C07D487/04

25. 发明公开

EP1162196A4 FUSED-RING COMPOUNDS AND USE THEREOF AS DRUGS 审中-公开
标题翻译：与稠环及其作为药物CONNECTIONS
公开(公告)号：EP1162196A4
公开(公告)日：2003-04-16
申请号：EP00987728
申请日：2000-12-22
申请人： JAPAN TOBACCO INC
发明人： HASHIMOTO HIROMASA , MIZUTANI KENJI , YOSHIDA ATSUHITO
IPC分类号： A61K31/4184 , A61K31/42 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4523 , A61K31/496 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/55 , A61K31/7076 , A61P1/16 , A61P31/20 , C07D235/18 , C07D235/30 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04 , C07D521/00 , C07D209/12 , A61K31/4188 , A61P31/12
CPC分类号： C07D231/12 , A61K9/2018 , A61K31/404 , A61K31/4184 , A61K31/42 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4523 , A61K31/4745 , A61K31/496 , A61K31/498 , A61K31/503 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/53 , A61K31/55 , A61K31/7076 , C07D233/56 , C07D235/18 , C07D235/30 , C07D249/08 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Fused-ring compounds represented by general formula [I] or the like, or pharmaceutically acceptable salts thereof; and hepatitis C remedies containing the compounds or salts: [I] (wherein each symbol is as defined in the description). The above compounds and salts exhibit an anti-HCV (hepatitis C virus) activity by virtue of their inhibitory activity against HCV polymerase, thus being useful as therapeutic or preventive agents for hepatitis C.

26. 发明公开

EP1400241A4 FUSED CYCLIC COMPOUNDS AND MEDICINAL USE THEREOF 审中-公开
标题翻译： ZYKLISCHE FUSIONSVERBINDUNGEN UND IHRE MEDIZINISCHE ANWENDUNG
公开(公告)号：EP1400241A4
公开(公告)日：2004-10-06
申请号：EP02743728
申请日：2002-06-26
申请人： JAPAN TOBACCO INC
发明人： HASHIMOTO HIROMASA , MIZUTANI KENJI , YOSHIDA ATSUHITO
IPC分类号： A61K31/4184 , A61K31/42 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4523 , A61K31/496 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/55 , A61K31/7076 , A61K38/21 , A61K45/06 , A61P1/16 , A61P31/12 , A61P43/00 , C07D209/12 , C07D235/18 , C07D235/30 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D419/12 , C07D471/04 , C07D495/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K31/00 , A61K31/506
CPC分类号： C07D401/04 , A61K9/2059 , A61K31/4184 , A61K31/42 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4523 , A61K31/496 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/55 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D209/12 , C07D235/18 , C07D235/30 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D419/12 , C07D471/04 , C07D495/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Fused cyclic compounds represented by the following general formula [I] or pharmaceutically acceptable salts thereof and remedies for hepatitis C containing these compounds: [I] wherein each symbol is as defined in the description. Because of having an effect against hepatitis C virus (HVC) based on an HCV polymerase inhibitory effect, these compounds are useful as remedies or preventives for hepatitis C.
摘要翻译：由下述通式[I]表示的稠合环状化合物或其药学上可接受的盐以及含有这些化合物的丙型肝炎治疗剂：[I]其中每个符号如说明书中所定义。由于基于HCV聚合酶抑制作用具有抗丙型肝炎病毒（HVC）的作用，所以这些化合物可用作丙型肝炎的治疗或预防剂。

27. 发明专利

HU0301490A2 CONDENSED CYCLYC COMPOUNDS AND THEIR PHARMACEUTICAL USE 未知
公开(公告)号：HU0301490A2
公开(公告)日：2008-01-28
申请号：HU0301490
申请日：2002-06-26
申请人： JAPAN TOBACCO INC
发明人： HASHIMOTO HIROMASA , MIZUTANI KENJI , YOSHIDA ATSUHITO
IPC分类号： A61K31/4184 , A61K31/42 , A61K31/4439 , A61K31/55 , C07D235/18 , C07D401/12 , C07D409/12
摘要： Antihepatitis C agents comprise a fused cyclic compound (I). Antihepatitis C agents comprise a fused cyclic compound of formula (I) or its salt. [Image] G 1-G 4CR 1 or N; G 5, G 6, G 8, G 9C or N; G 7CR 7, O, S, N or NR 8; R 1H, COAlk, COOH, CN, NO 2, Alk 1, COOR a 1, CONR a 2R a 3, C(=NR a 4)NH 2, NHR a 5, OR a 6, SO 2R a 7, P(=O)(OR a 3 1) 2 or Het; Alk : 1-6C alkyl; Alk 1Alk (optionally substituted by 1-3 Q); Q : halo, OH, COOH, NH 2, OAlk, OAlkOAlk, COOAlk or NHAlk); R a 1Alk 1, AlkAr or glucuronic acid; Ar : 6-14C aryl; Ar 1Ar optionally substituted by 1-5 Q 1; Q 1halo, CN, NO 2, Alk, COAlk, (CH 2) rCOOR b 1, (CH 2) rCONR b 1R b 2, (CH 2) rNR b 1R b 2, (CH 2) rNR b 1COR b 2, (CH 2) rNHSO 2R b 1, (CH 2) rOR b 1, (CH 2) rS(O) zR b 1 or SO 2NR b 1R b 2; z : 0-2; R b 1, R b 2H or Alk; r : 0-6; R a 2, R a 3H, OAlk or Alk 1; R a 4H or OH; R a 5H, COAlk or SO 2Alk; R a 6H or Alk 1; R a 7OH, NH 2, Alk or NHAlk; R a 3 1H, Alk 1 or AlkAr 1; Het : heterocyclyl containing 1-4 O, N or S; R 7, R 8H or Alk 1; Cy : Cyc or a group of formula (i)-(iv); Cyc : 3-8C cycloalkyl or 3-8C cycloalkenyl both optionally substituted by 1-5 OH, halo, Alk or OAlk; u, v : 1-3; A : Ar, 3-8C cycloalkyl, 3-8C cycloalkenyl or Het all substituted by R 5, R 6 and X; R 5, R 6H, halo, Alk 1 or OR a 8; R a 8H, Alk or AlkAr; X : H, halo, CN, NO 2, NH 2, NHCOAlk, SO 2Alk, Alk 1, 2-6C alkenyl (optionally substituted by 1-3 Q), COOR b 1, CONH(CH 2) rR a 1 0, OR a 6 or YB; R a 1 0Alk 1, COOAlk or NHCOAlk; B : Ar, 3-8C cycloalkyl or Het all optionally substituted by 1-3 Z; Z : D or Ar, 3-8C cycloalkyl, AlkAr, Het or AlkHet all optionally substituted by 1-5 halo, CN, NO 2, Alk 1, (CH 2) rCOR a 1 8, (CH 2) rCOOR a 1 9, (CH 2) rCONR a 2 7R a 2 8, (CH 2) rC(=NR a 3 3)NH 2, (CH 2) rOR a 2 0, (CH 2) rO(CH 2) pCOR a 2 1, (CH 2) rNR a 2 2R a 2 3, (CH 2) rNR a 2 9R a 2 4, (CH 2) rNR a 2 9SO 2R a 1 8, (CH 2) rS(O) qR a 1 8, (CH 2) rSO 2NHR a 1 8 or Het; R a 1 8Alk 1, Ar 1 or Het 1; Het 1Het optionally substituted by 1-5 Q 1; R a 1 8H, Alk 1, Ar 1 or Het 1; R a 2 7, R a 2 8H, Alk 1, Ar 1, AlkAr 1, Het 1, AlkHet 1, Cyc 1, AlkCyc 1, OH or OAlk; Cyc 13-8C cycloalkyl optionally substituted by 1-5 Q 1; R a 3 3H, Alk, OH or OAlk; R a 2 0H, Alk 1, Alk 2, Ar 1, AlkAr 1, Het 1, AlkHet 1 or Cyc 1; Alk 22-6C alkenyl or 2-6C alkynyl both optionally substituted by 1-3 Q; R a 2 1NH 2, NHAlk or Het 1; p : 0-6; R a 2 2, R a 2 3H, Alk 1, Ar 1, AlkAr 1, Het 1 or AlkHet 1; R 2 9H, Alk or COAlk; R 2 4NH 2, NHAlk, Alk 1, Ar 1, Het 1 or AlkHet 1; Y : bond, 1-6C alkylene, 2-6C alkenylene, (CH 2) rO(CH 2) r, CO, CO(CH 2) r, CONH(CH 2) rNH, NHCO 2, NHCONH, O(CH 2) rCO, O(CH 2) rO, SO 2, (CH 2) rNR a 1 2, (CH 2) rNR a 1 2CO, CONR b 5(CH 2) r, CONHCHAr 1, O(CH 2) rCR a 1 5R a 1 6, (CH 2) rNR a 1 2CHR a 1 5, NHSO 2, NHAlkSO 2, S(O) q(CH 2) rCR a 1 5R a 1 6(CH 2) r or (CH 2) rCR a 1 5R a 1 6(CH 2) r; R a 1 2Alk 1, AlkAr 1, Ar 1, COR b 5 or COOR b 5; R b 5H, Alk 1 or AlkAr 1; R a 1 5, R a 1 6H, COOH, Alk, OAlk, OAlkAr or NR b 7; or R a 1 5(CH 2) rB; and R b 7H, Alk, COAlk COOAlkAr. [Image] An independent claim is also included for some new compounds (I). ACTIVITY : Virucide; Hepatotropic; Antiinflammatory MECHANISM OF ACTION : HCV-Polymerase-Inhibitor. In assays 2-{4-{2-(4-chlorophenyl)-5-methoxybenzyloxy]phenyl}-1-(4-tetrahydrothiopyranyl)benzimidazole-5-carboxylic acid (Ib) inhibited hepatitis C polymerase with an IC 5 0 of less than 0.01 MicroM.

28. 发明专利

ZA200503823B Fused bicyclic nitrogen-containing heterocycles. 未知
公开(公告)号：ZA200503823B
公开(公告)日：2006-02-22
申请号：ZA200503823
申请日：2005-05-12
申请人： JAPAN TOBACCO INC
发明人： FOX BRIAN M , FURUKAWA NOBORU , HAO XIAOLIN , LIO KIYOSEI , INABA TAKASHI , JACKSON SIMON M , KAYSER FRANK , LABELLE MARC , LI KEXUE , MATSUI TAKUYA , MCMINN DUSTIN L , OGAWA NOBUYA , RUBENSTEIN STEVEN M , SAGAWA SHOICHI , SUGIMOTO KAZUYUKI , SUZUKI MASAHIRO , TANAKA MASAHIRO , YE GUOSEN , YOSHIDA ATSUHITO , ZHANG JIAN
IPC分类号： A61K31/519 , A61K31/538 , A61K31/542 , C07D491/02 , C07D491/04 , C07D498/02 , C07D498/04 , C07D498/10 , C07D498/16 , A61K
摘要： Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.

30. 发明专利

ZA200301393B Fused cyclic compounds and medicinal use thereof. 未知
公开(公告)号：ZA200301393B
公开(公告)日：2004-07-15
申请号：ZA200301393
申请日：2002-06-26
申请人： JAPAN TOBACCO INC
发明人： HASHIMOTO HIROMASA , MIZUTANI KENJI , YOSHIDA ATSUHITO
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101 , A61K , A61P , C07D

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