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21. 发明申请

WO1993023033A1 APOPTOSIS INDUCER 审中-公开
标题翻译：病毒感染
公开(公告)号：WO1993023033A1
公开(公告)日：1993-11-25
申请号：PCT/JP1993000614
申请日：1993-05-11
申请人： TSUMURA & CO. , KOJIRO, Masamichi , FUKUDA, Kazunori , MIZOGUCHI, Atsushi , OKADA, Hidechika
发明人： TSUMURA & CO.
IPC分类号： A61K31/35
CPC分类号： A61K31/35 , A61K31/70
摘要： An apoptosis inducer containing baicalin or baicalein as the active ingredient and utilizable as carcinostatic agent, antiviral agent, and so forth. It can be used advantageously as a new type of safe carcinostatic or anticancer drug, because it induces apoptosis programmed even in cancer cells and hence can kill cancer cells which are believed to be immortal. It is useful also in treating various diseases caused by viral infection, because it can induce apoptosis in various virally infected tissues or cells, which have been believed to be difficult to remove, to thereby permit easy removal of these tissues or cells.
摘要翻译：含有黄芩苷或黄芩素作为活性成分并可用作制癌剂，抗病毒剂等的凋亡诱导剂。它可以有利地用作新型的安全性制癌或抗癌药物，因为它诱导即使在癌细胞中编程的细胞凋亡，因此可以杀死被认为是不朽的癌细胞。因为可以诱导各种病毒感染的组织或细胞中的细胞凋亡，所以在治疗由病毒感染引起的各种疾病中也是有用的，这些组织或细胞被认为难以除去，从而容易地去除这些组织或细胞。

22. 发明申请

WO1993003039A1 CARCINOSTATIC COMPOUND AND PRODUCTION THEREOF 审中-公开
标题翻译：致癌化合物及其生产
公开(公告)号：WO1993003039A1
公开(公告)日：1993-02-18
申请号：PCT/JP1992001017
申请日：1992-08-07
申请人： TSUMURA & CO. , IKEKAWA, Tetsuro , IKEKAWA, Nobuo
发明人： TSUMURA & CO.
IPC分类号： C07D493/18
CPC分类号： C07D493/22
摘要： Stelleramacrin A or B represented by formula (I) or (II), a process for the production thereof, and an antitumor drug containing the same as the active ingredient. A solid antitumor drug containing gnidimacrin or pimelea factor P2 as the active ingredient.
摘要翻译：由式（I）或（II）表示的石蜡粉A或B，其制备方法和含有该活性成分的抗肿瘤药物。一种固体抗肿瘤药物，含有甘哌草胺或双黄单胞菌因子P2作为活性成分。

23. 发明申请

WO1992014479A1 COMPOSITION FOR RECTAL ADMINISTRATION OF DIFFICULTLY ABSORBABLE PEPTIDE 审中-公开
标题翻译：组合物对不同可吸收肽的直接管理
公开(公告)号：WO1992014479A1
公开(公告)日：1992-09-03
申请号：PCT/JP1992000168
申请日：1992-02-19
申请人： TSUMURA & CO. , AZECHI, Yasutaka , KIMURA, Takayoshi , YUN, Arifuku
发明人： TSUMURA & CO.
IPC分类号： A61K37/02
CPC分类号： A61K9/02 , A61K9/0031 , A61K38/23 , A61K38/28 , A61K38/55 , A61K47/12 , A61K31/20 , A61K31/245 , A61K31/24 , A61K31/195 , A61K2300/00
摘要： A composition for the rectal administration of difficultly absorbable peptides, comprising a difficultly absorbable peptide as the active ingredient, a C8 to C14 saturated fatty acid or an avirulent salt thereof, and a protease inhibitor. The composition allows peptides which have been believed to be difficult to absorb to be absorbed efficiently through the rectal mucosa, so that it can achieve an excellent pharmacological efficacy without resort to injection which is painful and is limited in its administration. Further it has an economic advantage because it can provide a pharmaceutical preparation of relatively expensive peptides witha reduced loss thereof.

24. 发明申请

WO1990007514A1 NEW BINUCLEAR PLATINUM COMPLEX AND ANTINEOPLASTIC AGENT CONTAINING SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：新的含有铂类复合物和含有相同活性成分的抗肿瘤药
公开(公告)号：WO1990007514A1
公开(公告)日：1990-07-12
申请号：PCT/JP1989001327
申请日：1989-12-28
申请人： TSUMURA & CO. , MIYAMOTO, Ken , FUJII, Yuichi
发明人： TSUMURA & CO.
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： This invention relates to binuclear platinum complexes including di-ν-sulfoacetatobis[diaminocyclohexanecobalt (II)] and its isomers and to an antineoplastic agent containing them as an active ingredient. These complexes have reduced side effects such as nephrotoxicity and a high antineoplastic activity.

25. 发明申请

WO1996026713A1 BATH OIL COMPOSITION 审中-公开
标题翻译：浴油组成
公开(公告)号：WO1996026713A1
公开(公告)日：1996-09-06
申请号：PCT/JP1996000437
申请日：1996-02-26
申请人： TSUMURA & CO. , NAKANISHI, Nobuyuki , TSUNAKAWA, Mitsuo , SAIMO, Yasuhiko , YANO, Shingo
发明人： TSUMURA & CO.
IPC分类号： A61K07/50
CPC分类号： A61K8/922 , A61K8/18 , A61K8/37 , A61K8/60 , A61Q19/10
摘要： A bath oil composition which comprises (A) an essential oil and/or a component originating in an essential oil having a specific gravity of less than 1.0 and (B) an oleaginous component compatible with the component (A). The component (B) has a specific gravity of 1.0 or more and the oleaginous component mixture consisting of the component (A) and the component (B) has such a specific gravity as to allow the uniform dispersion of the mixture in the bathwater as a whole. The component (A) is employed in such an amount as to give the concentration thereof in the bathwater of at least 2.0 ppm. Thus the essential oils can well adhere to the skin and exert enhanced effects thereof on the skin surface, which might enable the percutaneous absorption of the essential oils so as to establish their effects in vivo. The composition is excellent also from the viewpoints of the safety for the human body and the prevention of water pollution caused by drainage.
摘要翻译：一种沐浴油组合物，其包含（A）来自比重小于1.0的精油的精油和/或成分，和（B）与成分（A）相容的油性成分。组分（B）的比重为1.0以上，由（A）成分和（B）成分组成的含油成分混合物具有比重，使混合物在洗澡水中的均匀分散为整个。组分（A）的使用量使其在洗澡水中的浓度至少为2.0ppm。因此，精油可以很好地附着在皮肤上，并且对皮肤表面产生增强的作用，这可以使经皮吸收精油以确定它们在体内的作用。从人体的安全性和防止由排水引起的水污染的观点，组合物也是优异的。

26. 发明申请

WO1996004902A1 COMPOSITION OF EXTERNAL PREPARATION 审中-公开
标题翻译：外部制剂的组成
公开(公告)号：WO1996004902A1
公开(公告)日：1996-02-22
申请号：PCT/JP1995001576
申请日：1995-08-08
申请人： TSUMURA & CO. , SEKINE, Takashi , OHTSUBO, Eiji , OTA, Shinichi , ISHIKAWA, Kazuyuki
发明人： TSUMURA & CO.
IPC分类号： A61K31/195
CPC分类号： A61K31/196 , A61K9/0014 , A61K47/18
摘要： A composition of external preparation, such as solution, cream, ointment or poultice, containing a water-soluble salt of diclofenac, such as diclofenac sodium, water, and a fatty acid dialkylolamide and/or a polyoxyethylene adduct thereof. The water-soluble diclofenac salt is well absorbable in the composition, highly soluble in the preparation, and stable.
摘要翻译：含有双氯芬酸的水溶性盐如双氯芬酸钠，水和脂肪酸二烷基酰胺和/或其聚氧乙烯加合物的外用制剂如溶液，霜剂，软膏或泥敷剂的组合物。水溶性双氯芬酸盐在组合物中吸收良好，溶于制剂，稳定。

27. 发明申请

WO1995033474A1 MEDICINAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：WO1995033474A1
公开(公告)日：1995-12-14
申请号：PCT/JP1995001085
申请日：1995-06-02
申请人： TSUMURA & CO. , SEKINE, Takashi , ISHIKAWA, Kazuyuki , KIMURA, Takayoshi , NAKAI, Yoshinobu
发明人： TSUMURA & CO.
IPC分类号： A61K37/02
CPC分类号： A61K47/183 , A61K9/0019 , A61K38/23 , A61K47/10 , Y10S514/802
摘要： A medicinal composition comprising a peptide as the active ingredient and, as the base, epsilon -aminocaproic acid or tranexamic acid and a block copolymer of ethylene oxide and propylene oxide represented by the general formula (I): HO(C2H4O)a-(C3H6O)b-(C2H4O)cH, wherein a, b and c represent each an integer of 1 or above. This composition permits the peptide to be highly absorbed by mucous membranes, etc., and the pharmacological effect to be maintained for long.
摘要翻译：一种药物组合物，其包含作为活性成分的肽和作为碱的ε-氨基己酸或氨甲环酸，以及由通式（I）表示的环氧乙烷和环氧丙烷的嵌段共聚物：HO（C 2 H 4 O）a - （C 3 H 6 O ）b-（C 2 H 4 O）c H，其中a，b和c各自表示1以上的整数。该组合物允许肽被粘膜等高度吸收，药理作用长时间保持。

28. 发明申请

WO1995025517A1 REMEDY FOR INFECTIOUS DISEASES 审中-公开
标题翻译：补救感染性疾病
公开(公告)号：WO1995025517A1
公开(公告)日：1995-09-28
申请号：PCT/JP1995000491
申请日：1995-03-17
申请人： TSUMURA & CO. , SUZUKI, Fujio
发明人： TSUMURA & CO.
IPC分类号： A61K31/435
CPC分类号： A61K31/12 , A61K31/439 , A61K2300/00
摘要： An infectious disease remedy containing at least one member selected from the group consisting of aconite root alkaloids, aconite roots and extracts thereof, gingerols and analogs thereof, and ginger root stocks and products of treatment thereof. It has a remarkable effect of restoring the protective activity and is useful for treating and preventing various infectious diseases such as viral infection, fungal infection and opportunistic infection.
摘要翻译：含有至少一种选自乌头根生物碱，乌头根及其提取物，姜酚及其类似物，姜根原料及其处理产品的传染病治疗方法。它具有恢复保护活性的显着效果，可用于治疗和预防各种感染性疾病如病毒感染，真菌感染和机会性感染。

29. 发明申请

WO1995000466A1 DIBENZOCYCLOOCTANE COMPOUND AND RETROVIRUS INFECTION REMEDY CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：二苯并恶唑化合物和含有其作为活性成分的逆转录病毒感染
公开(公告)号：WO1995000466A1
公开(公告)日：1995-01-05
申请号：PCT/JP1994000990
申请日：1994-06-21
申请人： TSUMURA & CO. , TANAKA, Masahide , SAKATA, Toshiya , IKEYA, Yukinobu , KATO, Akihisa , MORI, Kazuya , WAKAMATSU, Takeshi , FUJIHASHI, Toshiaki , KAJI, Akira , KAJI, Hideko
发明人： TSUMURA & CO.
IPC分类号： C07C39/17
CPC分类号： C07C69/00 , C07C39/14 , C07C43/20 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C255/53 , C07C255/54 , C07C2603/00 , C07C2603/36
摘要： A dibenzocyclooctane compound, represented by general formula (I), useful as medicines such as an antiretroviral agent and intermediates for other medecines, wherein each R represents hydrogen, lower alkyl, or optionally substituted phenyl or alkylcarbonyl, or alternatively one of Rs is combined with the neighboring R to form lower alkylene; each R' represents lower alkyl; each Y represents hydrogen, halogen, alkyl, lower alkyloxy, acyl, formyl, hydroxy, cyano or di(lower alkyl)amino; and each R1 represents hydrogen, optionally substituted lower alkyl, optionally substituted aralkyl, lower alkoxy, aminocarbonyl, acyl, sulfonyl or phosphoryl, provided when R1 represents hydrogen or lower alkyl, then at least one Y does not represent hydrogen.
摘要翻译：由通式（I）表示的二苯并环辛烷化合物可用作药物如抗逆转录病毒药剂和其他药物的中间体，其中每个R代表氢，低级烷基或任选取代的苯基或烷基羰基，或者将其中一个与邻近的R形成低级亚烷基; 每个R'代表低级烷基; 每个Y代表氢，卤素，烷基，低级烷氧基，酰基，甲酰基，羟基，氰基或二（低级烷基）氨基; 并且当R 1表示氢或低级烷基时，每个R 1表示氢，任选取代的低级烷基，任选取代的芳烷基，低级烷氧基，氨基羰基，酰基，磺酰基或磷酰基，则至少一个Y不表示氢。

30. 发明申请

WO1994018237A1 NOVEL PEPTIDE HAVING RECEPTOR ACTIVITY AND DNA CODING FOR SAID PEPTIDE 审中-公开
标题翻译：具有受体活性的新肽和用于确定肽的DNA编码
公开(公告)号：WO1994018237A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000202
申请日：1994-02-10
申请人： TSUMURA & CO. , TAKUWA, Yoh
发明人： TSUMURA & CO.
IPC分类号： C07K13/00
CPC分类号： C07K14/723 , C07K14/705
摘要： A novel peptide represented by SEQ ID NO 2, which binds to primary information transfer substances and has a receptor activity of conjugating with a GTP-binding protein which promotes the dissociation of GDP bound thereto; and a DNA represented by SEQ ID NO 1, which codes for the above peptide.
摘要翻译：由SEQ ID NO 2表示的新型肽，其与初级信息转移物质结合，并且具有与促进与其结合的GDP的解离的GTP结合蛋白质的受体活性; 以及编码上述肽的由SEQ ID NO 1表示的DNA。

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