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    • 25. 发明授权
    • Novel 3-(4'-aminobutylamino) propylaminobleomycin derivatives
    • 新型3-(4'-氨基丁基氨基)丙基氨基倍半霉素衍生物
    • US4808703A
    • 1989-02-28
    • US622884
    • 1984-06-21
    • Hamao UmezawaAkio FujiiYasuhiko MuraokaTokuji NakataniTakeyo FukuokaKatsutoshi Takahashi
    • Hamao UmezawaAkio FujiiYasuhiko MuraokaTokuji NakataniTakeyo FukuokaKatsutoshi Takahashi
    • C07H15/26A61K31/70A61K31/7028A61P31/04A61P35/00C07K9/00C07C103/52
    • C07K9/003
    • Disclosed is a 3-(4'-aminobutylamino) propylaminobleomycin having low pulmonary toxicity, which expressed by the following general formula[BX]--NH--(CH.sub.2).sub.3 --A--(CH.sub.2).sub.4 --Bwherein [BX] represents a residue remaining after removing a hydroxyl group from the carboxyl group of bleomycinic acid, A represents a group of the formula ##STR1## in which R.sub.1 represents (i) a hydrogen atom, (ii) an alkyl group having 1 to 10 carbon atoms, or (iii) a methyl which may be substituted by at least one of a phenyl group and a cycloalkyl group having 5 to 13 carbon atoms, said substituents being each optionally further substituted more than one position by one or more substituents selected from the class consisting of a halogen atom, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having 1 to 4 carbon atoms, and benzyloxy group; and R.sub.2 represents a lower alkyl group having 1 to 4 carbon atoms or a benzyl group, B represents a group of the formula ##STR2## in which R.sub.3 and R.sub.4 each represents (i) a hydrogen atom, (ii) an alkyl group having 5 to 10 carbon atoms, or (iii) a methyl which may be substituted by at least one of a phenyl group and a cycloalkyl group, said substituents being each optionally further substituted more than one position by one or more substituents selected from the class consisting of a halogen atom, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having 1 to 4 carbon atoms and a benzyloxy group, with the proviso that at least one of R.sub.3 and R.sub.4 is a group other than a hydrogen atom, and salt thereof.
    • 公开了具有低肺毒性的3-(4'-氨基丁基氨基)丙基氨基巴豆霉素,其由以下通式[BX] -NH-(CH 2)3 -A-(CH 2)4 -B表示,其中[BX]表示残基 在从博来霉素酸的羧基中除去羟基后残留,A代表式为“IMAGE”的基团,其中R1表示(i)氢原子,(ii)具有1-10个碳原子的烷基或( iii)可以被苯基和具有5至13个碳原子的环烷基中的至少一个取代的甲基,所述取代基各自任选地被一个或多个选自下列的取代基中的一个或多个取代基取代: 卤素原子,碳原子数1〜4的低级烷基,碳原子数1〜4的低级烷氧基和苄氧基; 并且R 2表示具有1至4个碳原子的低级烷基或苄基,B表示下式的基团:其中R 3和R 4各自表示(i)氢原子,(ii)具有5个 至少10个碳原子,或(iii)可以被苯基和环烷基中的至少一个取代的甲基,所述取代基各自任选地被一个或多个取代基取代,所述取代基选自: 卤素原子,碳原子数1〜4的低级烷基,碳原子数1〜4的低级烷氧基和苄氧基,条件是R3和R4中的至少一个为氢原子以外的基团, 及其盐。
    • 27. 发明授权
    • Aminopropylaminobleomycin derivatives and process for preparation thereof
    • 氨丙基氨基甜菜碱素衍生物及其制备方法
    • US4568490A
    • 1986-02-04
    • US743738
    • 1985-06-12
    • Hamao UmezawaAkio FujiiYasuhiko MuraokaTokuji NakataniTakeyo FukuokaKatsutoshi Takahashi
    • Hamao UmezawaAkio FujiiYasuhiko MuraokaTokuji NakataniTakeyo FukuokaKatsutoshi Takahashi
    • C07H15/26A61K31/70A61K31/7028A61P35/00C07K9/00
    • C07K9/003Y10S930/19Y10S930/27
    • An aminopropylaminobleomycin represented by the following formula or a salt thereof, which is minimized in side effects such as pulmonary toxicity:[BX]--NH--(CH.sub.2).sub.3 --A--)CH.sub.2).sub.3 --Bwherein[BX] represents the acyl group of bleomycinic acid whose formula differs from that of bleomycin acid by the removal of the hydroxyl group from the carboxyl group of said acid;A represents a group of the general formula ##STR1## wherein R.sub.1 is a lower alkyl or benzyl,R.sub.2 is a lower alkyl or benzyl,R is a lower alkylene, andn is 0 or 1; andB represents a group of the formula ##STR2## wherein (i) R.sub.3 is hydrogen and R.sub.4 is(a) benzyl substituted by one or more halogen atoms, provided that the benzyl is substituted by two halogen atoms when R.sub.1 is lower alkyl,(b) benzyl substituted by cyano, two or more alkoxy groups or two or more benzyloxy groups,(c) lower alkyl substituted by cycloalkyl or anthranyl,(d) phenylethyl substituted by one or more halogen atoms, or(e) diphenylethyl; or(ii) both R.sub.3 and R.sub.4 are benzyl which may be substituted by one or more(a) benzyloxy groups,(b) ring substituted benzyloxy groups in which the ring substituents may be one or more halogen atoms, lower alkoxy groups or benzyloxy groups, or(c) cycloalkylmethoxy groups;and a process for the preparation thereof.
    • 由下式表示的氨基丙基氨基伯合珠霉素或其盐,其在副作用如肺毒性中最小化:[BX] -NH-(CH2)3-A-)CH2)3-B其中[BX]表示酰基 通过从所述酸的羧基除去羟基,其公式不同于博来霉素酸的博来霉素酸; A表示通式为其中R 1为低级烷基或苄基的基团,R 2为低级烷基或苄基,R为低级亚烷基,n为0或1; 并且B代表下式的基团:其中(i)R3是氢,R4是(a)被一个或多个卤素原子取代的苄基,条件是当R 1是低级烷基时,苄基被两个卤原子取代,( (c)由氰基,两个或多个烷氧基或两个或更多个苄氧基取代的苄基,(c)被环烷基或蒽基取代的低级烷基,(d)被一个或多个卤素原子取代的苯基乙基,或(e)二苯基乙基; 或(ii)R 3和R 4均为可被一个或多个(a)苄氧基取代的苄基,(b)环取代的苄氧基,其中环取代基可以是一个或多个卤素原子,低级烷氧基或苄氧基 ,或(c)环烷基甲氧基; 及其制备方法。
    • 28. 发明授权
    • Aminopropylaminobleomycin derivatives and process for preparation thereof
    • 氨丙基氨基甜菜碱素衍生物及其制备方法
    • US4537880A
    • 1985-08-27
    • US635096
    • 1984-07-27
    • Hamao UmezawaAkio FujiiYasuhiko MuraokaTokuji NakataniTakeyo FukuokaKatsutoshi Takahashi
    • Hamao UmezawaAkio FujiiYasuhiko MuraokaTokuji NakataniTakeyo FukuokaKatsutoshi Takahashi
    • C07H15/26A61K31/70A61K31/7028A61P35/00C07K9/00A61K37/00C07C103/52
    • C07K9/003Y10S930/19Y10S930/27
    • An aminopropylaminobleomycin represented by the following formula or a salt thereof, which is minimized in side effects such as pulmonary toxicity:[BX]--NH--(CH.sub.2).sub.3 --A--(CH.sub.2).sub.3 --Bwherein[BX] represents the acyl group of bleomycinic acid whose formula differs from that of bleomycin acid by the removal of the hydroxyl group from the carboxyl group of said acid;A represents a group of the general formula ##STR1## wherein R.sub.1 is a lower alkyl or benzyl,R.sub.2 is a lower alkyl or benzyl,R is a lower alkylene, andn is 0 or 1; andB represents a group of the formula ##STR2## wherein (i) R.sub.3 is hydrogen and R.sub.4 is(a) benzyl substituted by one or more halogen atoms, provided that the benzyl is substituted by two halogen atoms when R.sub.1 is lower alkyl,(b) benzyl substituted by cyano, two or more alkoxy groups or two or more benzyloxy groups,(c) lower alkyl substituted by cycloalkyl or anthranyl,(d) phenylethyl substituted by one or more halogen atoms, or(e) diphenylethyl; or(ii) both R.sub.3 and R.sub.4 are benzyl which may be substituted by one or more(a) benzyloxy groups,(b) ring substituted benzyloxy groups in which the ring substituents may be one or more halogen atoms, lower alkoxy groups or benzyloxy groups, or(c) cycloalkylmethoxy groups;and a process for the preparation thereof.
    • 由下式表示的氨丙基氨基伯基霉素或其盐,其在副作用如肺毒性方面最小化:[BX] -NH-(CH2)3-A-(CH2)3-B其中[BX]表示酰基 通过从所述酸的羧基除去羟基,其公式不同于博来霉素酸的博来霉素酸; A表示通式为其中R 1为低级烷基或苄基的基团,R 2为低级烷基或苄基,R为低级亚烷基,n为0或1; 并且B代表下式的基团:其中(i)R3是氢,R4是(a)被一个或多个卤素原子取代的苄基,条件是当R 1是低级烷基时,苄基被两个卤原子取代,( (c)由氰基,两个或更多个烷氧基或两个或更多个苄氧基取代的苄基,(c)被环烷基或蒽基取代的低级烷基,(d)被一个或多个卤素原子取代的苯基乙基,或(e)二苯基乙基; 或(ii)R 3和R 4均为可被一个或多个(a)苄氧基取代的苄基,(b)环取代的苄氧基,其中环取代基可以是一个或多个卤素原子,低级烷氧基或苄氧基 ,或(c)环烷基甲氧基; 及其制备方法。
    • 30. 发明授权
    • Image encoding apparatus, method of controlling therefor, and program
    • 图像编码装置,其控制方法和程序
    • US08331452B2
    • 2012-12-11
    • US12207157
    • 2008-09-09
    • Akio Fujii
    • Akio Fujii
    • H04N11/02
    • H04N19/105H04N19/159H04N19/17H04N19/61
    • An image encoding apparatus for performing inter-frame encoding of moving image data is provided. The apparatus refers to a block within a frame other than a current frame to generate a first prediction image of a block to be encoded within the current frame, and performs prediction encoding using the first prediction image. The apparatus sets areas at set positions that differ from each other at least between mutually adjacent frames; and determines whether the block to be encoded within the current frame belongs to the area set with respect to the current frame. When the block to be encoded has been determined to belong to the area, the first prediction image is generated, with regard to the block to be encoded, upon referring to a frame that is decodable on its own and, in terms of time, is situated ahead of and closest to the frame to be encoded.
    • 提供一种用于执行运动图像数据的帧间编码的图像编码装置。 该装置是指当前帧以外的帧内的块,以生成当前帧内要编码的块的第一预测图像,并使用第一预测图像进行预测编码。 该装置至少在相互相邻的帧之间设定彼此不同的设定位置的区域; 并且确定当前帧内要编码的块是否属于相对于当前帧设置的区域。 当要编码的块被确定为属于该区域时,关于要编码的块,在引用自身可解码的帧,并且根据时间而言,生成第一预测图像 位于要编码的帧的前面并且最接近。