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    • 23. 发明授权
    • Isolated polypeptides used for treatment of inflammatory diseases and inhibiting cancer metastasis
    • 用于治疗炎性疾病和抑制癌症转移的分离的多肽
    • US08530421B2
    • 2013-09-10
    • US13503262
    • 2010-08-24
    • Jang-Hee HahnKyoung-Jin LeeSun-Hee LeeHyun-Mi Ju
    • Jang-Hee HahnKyoung-Jin LeeSun-Hee LeeHyun-Mi Ju
    • A61K38/00A61K39/00C12P21/02C07K16/46C07K14/00C07K5/00C07K7/00
    • A61K38/16
    • The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX(or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a is pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer.
    • 本发明涉及一种衍生自CD99和CD99家族例如CD99L2和PBDX(或XG)的胞外区的高度保守区(HCR)I-III的多肽,其是一种跨膜蛋白,或融合 蛋白质。 多肽或其融合蛋白具有抑制白细胞外渗或抑制癌细胞生长和/或转移的活化功能。 本发明还提供了编码多肽的多核苷酸,包含其的载体和由载体转化的转化体。 此外,本发明提供了包含用于预防或治疗炎性疾病的多肽或其融合蛋白质的药物组合物。 此外,本发明提供了包含抑制癌细胞的生长和/或转移的多肽或其融合蛋白的药物组合物,即用于预防或治疗癌症的药物组合物。
    • 28. 发明申请
    • Immunostimulating Polysaccharides Isolated From Curcuma Xanthorrhiza and Manufacturing Method Thereof
    • 免疫刺激从姜黄素分离的多糖及其制备方法
    • US20100048885A1
    • 2010-02-25
    • US11922107
    • 2006-06-14
    • Jae-Kwan HwangAh-Jin KimJong-Hee SohnKyu-Lee HanSun-Hee LeeJeong-Han Choo
    • Jae-Kwan HwangAh-Jin KimJong-Hee SohnKyu-Lee HanSun-Hee LeeJeong-Han Choo
    • C07H1/00C07H3/00
    • C08B37/006C12P19/04
    • The present invention provides a method for manufacturing polysaccharides isolated from Curcuma xanthorrhiza, including steps of: (S1) preparing a powder of Curcuma xanthorrhiza Roxb.; (S2) extracting the powder with an organic solvent, and then filtering or centrifuging to obtain a residue; (S3) extracting the residue to prepare a solution containing polysaccharides; (S4) removing starch by adding starch-hydrolyzing enzyme to the polysaccharides-containing solution; (S5) precipitating the polysaccharides after the step (S4); and (S6) purifying the polysaccharides after the step (S5), polysaccharides obtained according to the manufacturing method, and a pharmaceutical composition in eluding the polysaccharides as effective component. The polysaccharides according to the present invention may be very effectively used in drugs and functional foods for stimulating macrophage activity, preventing and treating immunological diseases including cancer, and enhancing immunity after the treatment of the immunological diseases.
    • 本发明提供了从姜黄分离得到的多糖的制造方法,包括以下步骤:(S1)制备姜黄黄酮粉末; (S2)用有机溶剂萃取粉末,然后过滤或离心得到残留物; (S3)提取残渣以制备含有多糖的溶液; (S4)通过向含多糖溶液中加入淀粉水解酶除去淀粉; (S5)在步骤(S4)后沉淀多糖; 和(S6)步骤(S5)后的多糖的纯化,根据制造方法得到的多糖,以及除了多糖作为有效成分的药物组合物。 本发明的多糖可以非常有效地用于药物和功能性食品中,用于刺激巨噬细胞活性,预防和治疗免疫疾病,包括癌症,以及增强免疫疾病治疗后的免疫力。
    • 30. 发明申请
    • Modifying U-shaped window spacers to receive internal blinds or other hardware
    • 修改U型窗户间隔板以接收内部百叶窗或其他硬件
    • US20050153517A1
    • 2005-07-14
    • US10972702
    • 2004-10-25
    • John KimSun-Hee Lee
    • John KimSun-Hee Lee
    • E06B9/264E06B9/323H01L21/20
    • E06B9/323E06B9/264E06B2009/2646
    • Devices and methods are employed to convert an open, U-shaped flex-type window spacer to provide a surface for mounting an interior blind or other hardware. Such existing spacers have a generally U-shaped cross section and a groove with a width facing into a sealed cavity between panes of glass and opposing parallel lips on either side of the groove. The preferred embodiments include an elongate panel having an inner surface, an outer surface, and a width greater than the width of the groove, and barbs extending from the inner surface and configured to be retained by the lips so as to hold the panel in position with the outer surface facing into the sealed cavity. According to a basic configuration, the outer surface of the panel is generally flat, though the panel has an L-shaped cross section or may provide a clip to hold a blind control mechanism in position.
    • 使用装置和方法来转换开放的U形柔性型窗隔离件,以提供用于安装内帘或其它硬件的表面。 这种现有的间隔件具有大致U形的横截面,并且具有宽度的凹槽面向玻璃板之间的密封空腔和凹槽的任一侧上的相对的平行唇缘。 优选实施例包括具有内表面,外表面和大于凹槽宽度的宽度的细长面板,以及从内表面延伸并被构造成由唇缘保持以将面板保持在适当位置的倒钩 其外表面面向密封腔。 根据基本构造,面板的外表面通常是平坦的,尽管面板具有L形横截面,或者可以提供夹子以将盲控制机构保持在适当位置。