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21. 发明申请

US20120316586A1 MECHANICAL PUMP FOR REMOVAL OF FRAGMENTED MATTER AND METHODS OF MANUFACTURE AND USE 有权
标题翻译：用于移除机器人的机械泵及其制造和使用方法
公开(公告)号：US20120316586A1
公开(公告)日：2012-12-13
申请号：US13589431
申请日：2012-08-20
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61B17/22
CPC分类号： A61M25/0023 , A61B17/320725 , A61B2017/00685 , A61B2017/320775 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor fainted over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转和用于防止材料在导管体开口处积累的清除元件。叶轮优选地包括内管或轴，其具有在其外表面上晕倒的螺旋形转子。清除元件可以包括靠近导管主体的远端的结构的自由端，用于破坏凝块，其中结构的自由端延伸到导管主体的远端开口以在叶轮旋转时分解材料。或者，清除元件可以包括设置在导管主体的远端开口处的切割构件。

22. 发明申请

US20120283513A1 ORAL AIRWAY DEVICES AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：口腔航空设备及其制造和使用的方法
公开(公告)号：US20120283513A1
公开(公告)日：2012-11-08
申请号：US13419430
申请日：2012-03-13
申请人： Stephen A. Leeflang , Christian S. Eversull
发明人： Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61B1/273 , A61B1/00
CPC分类号： A61B1/00071 , A61B1/00154 , A61B1/015 , A61B1/24
摘要： Airway devices are provided for introducing an endoscope into a patient's gastrointestinal system that include a tubular proximal portion sized for placement in an oral cavity and including a passage for receiving an endoscope therethrough, and a curved distal portion. The distal portion may have a “C” shaped wall defining a channel extending from the passage to a distal tip of the distal portion. The proximal portion may include a flange for placement adjacent the patient's teeth when the airway device is inserted into the oral cavity, and the airway device may include sampling and fluid delivery lumens including ports on the face of the flange. The sampling lumen may include an inlet port within the passage, and the fluid delivery lumen may include an outlet port communicating with the channel such that the outlet port is offset distally relative to the inlet port.
摘要翻译：提供气道装置用于将内窥镜引入到患者的胃肠系统中，该系统包括尺寸适于放置在口腔中的管状近端部分，并且包括用于接收内窥镜的通道和弯曲远端部分。远侧部分可以具有限定从该通道延伸到远侧部分的远侧末端的通道的C形壁。当气道装置插入口腔时，近侧部分可包括用于放置在患者牙齿附近的凸缘，并且气道装置可包括取样和流体输送腔，其包括在凸缘表面上的端口。采样腔可以包括通道内的入口端口，并且流体输送腔可以包括与通道连通的出口端口，使得出口端口相对于入口端口向远侧偏移。

23. 发明申请

US20120035594A1 MECHANICAL PUMP FOR REMOVAL OF FRAGMENTED MATTER AND METHODS OF MANUFACTURE AND USE 有权
标题翻译：用于移除机器人的机械泵及其制造和使用方法
公开(公告)号：US20120035594A1
公开(公告)日：2012-02-09
申请号：US13278210
申请日：2011-10-21
申请人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
发明人： Denise M. Demarais , Stephen A. Leeflang , Michael A. Evans , Gwendolyn A. Watanabe , John C. Tanner, III , Christian S. Eversull
IPC分类号： A61M1/00
CPC分类号： A61M25/0023 , A61B17/320725 , A61B2017/00685 , A61B2017/320775 , A61M29/02
摘要： Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor formed over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
摘要翻译：材料输送导管及其使用方法依赖于导管主体内的叶轮的旋转和用于防止材料在导管主体开口处积累的清除元件。叶轮优选地包括在其外表面上形成有螺旋转子的内管或轴。清除元件可以包括靠近导管主体的远端的结构的自由端，用于破坏凝块，其中结构的自由端延伸到导管主体的远端开口以在叶轮旋转时分解材料。或者，清除元件可以包括设置在导管主体的远端开口处的切割构件。

24. 发明授权

US07785434B2 Catheters with lubricious linings and methods for making and using them 有权
标题翻译：具有润滑衬垫的导管和制造和使用它们的方法
公开(公告)号：US07785434B2
公开(公告)日：2010-08-31
申请号：US12489357
申请日：2009-06-22
申请人： Stephen A. Leeflang , Christian S. Eversull , Nicholas J. Mourlas
发明人： Stephen A. Leeflang , Christian S. Eversull , Nicholas J. Mourlas
IPC分类号： B32B7/08
CPC分类号： A61M25/0009 , A61L29/085 , A61L29/14 , A61M25/0045 , A61M25/005 , A61M2025/0046 , A61M2025/0047 , A61M2025/0048 , A61M2025/006 , A61N1/056 , B29C47/0014 , B29C47/0028 , B29C47/0033 , B29C53/40 , B29C53/46 , B29C61/006 , B29C66/112 , B29C66/1122 , B29C66/1142 , B29C66/133 , B29C66/135 , B29C66/432 , B29C66/4322 , B29C66/438 , B29C66/49 , B29C66/52272 , B29C66/71 , B29C66/723 , B29C67/0018 , B29C69/001 , B29C2793/009 , B29D23/001 , B29L2031/602 , B29L2031/753 , B29L2031/7542 , B32B1/08 , B32B5/028 , B32B27/08 , B32B27/12 , B32B27/285 , B32B27/34 , B32B27/40 , B32B2250/24 , B32B2255/10 , B32B2255/26 , B32B2262/0269 , B32B2262/101 , B32B2262/103 , B32B2307/728 , B32B2307/736 , B32B2307/746 , B32B2535/00 , Y10T156/1008 , Y10T156/101 , Y10T156/1038 , Y10T156/1054 , Y10T156/1062 , Y10T156/1066 , Y10T156/1313 , Y10T156/1322 , C08L75/04 , B29K2075/00
摘要： Apparatus and methods are provided for substantially continuously forming thin-walled sleeves that may be incorporated into tubular devices sized for introduction into a patient. In one embodiment, a pair of sheets including coated surfaces oriented towards one another are directed through a cutting apparatus to cut the sheets into multiple pairs of strips. The pairs of strips are bonded together to create a plurality of sleeves having lumens defined by the coated surfaces. In another embodiment, a sheet having a coated surface is fed through a cutting tool to separate the sheet into a plurality of strips, and the strips are formed into sleeves, e.g., by feeding the strips through a die or mandrel using a substantially continuous process. Optionally, the sleeves may be subsequently cut into individual tubular devices and/or further processed, e.g., by providing one or more layers around the sleeves to create catheters, sheaths, or other apparatus.
摘要翻译：提供了用于基本上连续地形成薄壁套筒的装置和方法，所述薄壁套筒可并入到尺寸适于引入患者体内的管状装置中。在一个实施例中，包括朝向彼此定向的涂覆表面的一对片材被引导通过切割装置以将片材切割成多对条带。这些条带被粘合在一起以产生多个具有被涂覆表面限定的腔的套筒。在另一个实施例中，具有涂覆表面的片材通过切割工具进给以将片材分离成多个条带，并且条形成为套筒，例如通过使用基本连续的方法将条带穿过模具或心轴。任选地，可以随后将套管切割成单独的管状装置和/或进一步加工，例如通过围绕套管提供一个或多个层以产生导管，护套或其它装置。

25. 发明授权

US07744564B2 Apparatus and methods for delivering stem cells and other agents into cardiac tissue 有权
标题翻译：将干细胞和其他药物递送到心脏组织中的装置和方法
公开(公告)号：US07744564B2
公开(公告)日：2010-06-29
申请号：US12463111
申请日：2009-05-08
申请人： Christian S. Eversull , Stephen A. Leeflang , Christine P. Ventura , Nicholas J. Mourlas
发明人： Christian S. Eversull , Stephen A. Leeflang , Christine P. Ventura , Nicholas J. Mourlas
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： A system for delivering an agent to tissue surrounding a target vessel includes an elongate delivery device and a source coupled to a proximal tubular portion of the device. A first lumen extends through the tubular portion and an expandable sheath of the device, wherein the expandable sheath has a proximal end that surrounds and overlies a distal end of the tubular portion. The device further includes a stiffening member, attached to the sheath, and a balloon attached to the stiffening member, at a location spaced apart from the sheath. A second lumen extends, within the tubular portion and the stiffening member, to the balloon. A volume of fluid may be delivered, from the source, through the first lumen and into a section of the target vessel that is downstream from the expandable sheath and upstream of the balloon, in order to expand the sheath, fill the section and apply a pressure sufficient to cause extravasation of the section.
摘要翻译：用于将试剂递送到围绕目标血管的组织的系统包括细长输送装置和耦合到装置的近端管状部分的源。第一腔延伸穿过管状部分和装置的可膨胀护套，其中可扩张护套具有围绕并覆盖管状部分的远端的近端。该装置还包括附接到护套的加强构件和附接到加强构件的气囊，在与护套间隔开的位置处。第二内腔在管状部分和加强构件内延伸到气囊。一定体积的流体可以从源通过第一内腔并进入目标血管的可扩张护套下游和气囊上游的部分，以便扩张护套，填充该部分并施加一个压力足以导致部分外渗。

26. 发明申请

US20100160952A1 Expandable Guide Sheath and Apparatus and Methods for Making Them 有权
标题翻译：可扩展指南护套及其制造方法
公开(公告)号：US20100160952A1
公开(公告)日：2010-06-24
申请号：US12715517
申请日：2010-03-02
申请人： Stephen A. Leeflang , Christine P. Ventura , Christian S. Eversull , Nicholas J. Mourlas , Christopher Loew
发明人： Stephen A. Leeflang , Christine P. Ventura , Christian S. Eversull , Nicholas J. Mourlas , Christopher Loew
IPC分类号： A61M29/00
CPC分类号： A61M25/0662 , A61B17/3439 , A61M25/003 , A61M2025/0024 , A61M2025/0035 , A61N1/056
摘要： An apparatus for providing access to a body lumen includes a tubular proximal portion and an expandable distal portion, which extends distally from a distal end of the proximal portion. The expandable distal portion includes an expandable sheath and a stiffening member. The proximal portion has a first lumen extending from a proximal end to a distal end thereof, and the expandable sheath defines a second lumen that is in fluid communication with the first lumen and extends distally from the proximal portion to a distal terminal opening of the second lumen. The stiffening member is attached directly to the expandable sheath so as to extend alongside the second lumen, and the distal terminal opening of the second lumen is defined by a portion of a perimeter of a distal terminal end of the expandable sheath that becomes spaced apart from the stiffening member when the sheath is expanded.
摘要翻译：用于提供对体腔的通路的装置包括管状近端部分和可伸展远侧部分，其从近端部分的远端向远侧延伸。可扩展的远侧部分包括可扩张护套和加强构件。近端部分具有从近端延伸到其远端的第一腔，并且可扩张护套限定与第一腔流体连通的第二腔，并且从第二内腔的近端部向远端延伸到第二腔的远侧端部开口流明。加强构件直接附接到可膨胀护套，以便沿着第二内腔延伸，并且第二内腔的远端终端开口由可扩张护套的远端终端的周边的一部分限定，当护套膨胀时的加强构件。

27. 发明授权

US07637902B2 Slittable and peelable sheaths and methods for making and using them 有权
标题翻译：可剥离和可剥离的护套及其制造和使用方法
公开(公告)号：US07637902B2
公开(公告)日：2009-12-29
申请号：US11563142
申请日：2006-11-24
申请人： Christian S. Eversull , Stephen A. Leeflang , Nicholas J. Mourlas
发明人： Christian S. Eversull , Stephen A. Leeflang , Nicholas J. Mourlas
IPC分类号： A61M25/00
CPC分类号： A61M25/0668 , A61M25/0045 , A61M25/005
摘要： Splittable tubular devices and methods for making them are provided. In one embodiment, a tubular device includes a proximal end, a distal end sized for introduction into a body lumen, and a lumen extending between the proximal and distal ends. The tubular device includes an outer tubular layer defining a circumference; and a reinforcing layer bonded to the outer tubular layer, the reinforcing layer including a circumferential interruption. To make a tubular device, an elongate tubular reinforcing structure may be folded into itself to define first and second longitudinal edges, and rolled until the longitudinal edges are disposed adjacent one another. The reinforcing structure may be attached to a tubular structure such that the longitudinal edges define a circumferential interruption extending along a length of the tubular structure.
摘要翻译：提供可分离的管状装置及其制造方法。在一个实施例中，管状装置包括近端，尺寸适于引入体腔的远端和在近端和远端之间延伸的内腔。管状装置包括限定圆周的外管层; 以及加强层，其与所述外管层接合，所述加强层包括周向中断。为了制造管状装置，细长管状加强结构可以折叠成自身以限定第一和第二纵向边缘，并且滚动直到纵向边缘彼此相邻地设置。加强结构可以附接到管状结构，使得纵向边缘限定沿着管状结构的长度延伸的圆周中断。

28. 发明授权

US07556710B2 Catheters with lubricious linings and methods for making and using them 有权
标题翻译：具有润滑衬垫的导管和制造和使用它们的方法
公开(公告)号：US07556710B2
公开(公告)日：2009-07-07
申请号：US11340944
申请日：2006-01-26
申请人： Stephen A. Leeflang , Christian S. Eversull , Nicholas J. Mourlas , Christine P. Ventura
发明人： Stephen A. Leeflang , Christian S. Eversull , Nicholas J. Mourlas , Christine P. Ventura
IPC分类号： B29C63/10 , B29C53/78 , B29C53/00 , B29C47/00 , B29C65/00 , B32B27/00 , B32B37/00 , A61M5/32 , A61M25/00
CPC分类号： B29C61/006 , A61L29/085 , A61L29/14 , A61M25/0009 , A61M25/0045 , A61M2025/0046 , B29C47/0023 , B29C47/0026 , B29C47/0028 , B29C47/0033 , B29C47/0038 , B29C47/021 , B29C47/065 , B29C53/40 , B29C66/1122 , B29C66/1142 , B29C66/131 , B29C66/432 , B29C66/4322 , B29C66/49 , B29C66/52272 , B29C67/0018 , B29C69/001 , B29C2793/009 , B29D23/001 , B29L2031/602 , B29L2031/753 , B29L2031/7542 , B32B1/08 , B32B5/028 , B32B27/08 , B32B27/12 , B32B27/285 , B32B27/32 , B32B27/34 , B32B27/40 , B32B2255/10 , B32B2255/24 , B32B2255/26 , B32B2535/00 , Y10T156/1038 , C08L75/04
摘要： Coated devices for introduction into bodies and methods for making and using them are provided, such as delivery sheaths, guidewire lumen cores, and elongate leads. In one embodiment, a tubular device includes a proximal end, a distal end sized for introduction into a body lumen, and a lumen extending between the proximal and distal ends. The tubular device includes a relatively thin inner polyurethane liner including a coating on an inner surface thereof, e.g., providing a lubricious and/or hydrophilic lumen, and an outer layer surrounding the liner. In another embodiment, a lead is provided that includes a proximal end, a distal end, and at least one electrode on the distal end. A polyurethane cover surrounds at least a portion of an outer surface of the lead that include a coating, e.g., including a lubricious and/or hydrophilic material. Optionally, the cover may be removable from around the lead body.
摘要翻译：提供用于引入主体的涂覆装置和用于制造和使用它们的方法，例如输送护套，导丝管芯芯和细长引线。在一个实施例中，管状装置包括近端，尺寸适于引入体腔的远端和在近端和远端之间延伸的内腔。管状装置包括相对薄的内部聚氨酯衬里，其包括在其内表面上的涂层，例如提供润滑和/或亲水的内腔以及围绕衬垫的外层。在另一个实施例中，提供了一种引线，其包括近端，远端和远端上的至少一个电极。聚氨酯覆盖物包围引线的外表面的至少一部分，其包括涂层，例如包括润滑和/或亲水材料。可选地，盖可以从引线主体周围移除。

29. 发明公开

US20230310819A1 FLOW DISTRIBUTION PAD AND METHODS FOR USING THEM 审中-公开
公开(公告)号：US20230310819A1
公开(公告)日：2023-10-05
申请号：US18112425
申请日：2023-02-21
申请人： Stephen A. Leeflang , Christian S. Eversull
发明人： Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61M35/00 , A61M31/00 , A61M1/00
CPC分类号： A61M35/00 , A61M31/00 , A61M1/85 , A61M2202/048 , A61M2205/0222
摘要： Apparatus and methods are provided for delivering fluids into a patient's body that includes a tubular member including a proximal end, a distal end sized for introduction into a patient's body, and a fluid delivery lumen extending between the proximal and distal ends; and a flexible pad on the distal end including a tissue contacting surface, a passage communicating with the fluid delivery lumen, and plurality of capillary channels in the tissue contact surface communicating with the passage, the capillary channels configured to deliver fluid from the fluid delivery lumen and passage to tissue contacted by the tissue contact surface.

30. 发明授权

US11357897B2 Apparatus and methods for accessing the lymphatic system 有权
公开(公告)号：US11357897B2
公开(公告)日：2022-06-14
申请号：US16105722
申请日：2018-08-20
申请人： Matthew J. Callaghan , Stephen A. Leeflang , Christian S. Eversull
发明人： Matthew J. Callaghan , Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61M1/34 , A61B5/00 , A61M1/36 , A61M1/14 , A61M1/16 , A61B5/145 , A61B5/01 , A61B8/08
摘要： Systems and methods are provided for performing a medical procedure within a patient's body that involves a thoracic duct including an ostium communicating with the patient's venous system. A distal end of a catheter is introduced through the patient's venous system into a body lumen adjacent the ostium of the thoracic duct. An expandable member on the distal end of the tubular member may be expanded adjacent the ostium, e.g., within the body lumen or the thoracic duct itself, and used to isolate the thoracic duct from the body lumen, whereupon a medical procedure may be performed via the thoracic duct. For example, lymphatic fluid may be removed from the thoracic duct through a lumen of the tubular member and/or one or more agents may be introduced into the thoracic duct through the tubular member.

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