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21. 发明授权

US07691810B2 Method of producing recombinant antithrombin III composition 有权
标题翻译：重组抗凝血酶III组合物的制备方法
公开(公告)号：US07691810B2
公开(公告)日：2010-04-06
申请号：US10959322
申请日：2004-10-07
申请人： Tsuyoshi Yamada , Mitsuo Satoh , Yutaka Kanda , Kazuya Yamano
发明人： Tsuyoshi Yamada , Mitsuo Satoh , Yutaka Kanda , Kazuya Yamano
IPC分类号： A61K38/36 , C07K14/81 , C07K14/475
CPC分类号： C12N15/8257 , C07K14/8128 , C12P21/005
摘要： The present invention provides a process for producing an antithrombin III composition comprising an antithrombin III molecule having complex type N-glycoside-linked sugar chains, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains.
摘要翻译：本发明提供一种制备抗凝血酶III组合物的方法，其包含具有复合型N-糖苷连接的糖链的抗凝血酶III分子，其中复合型N-糖苷连接的糖链具有其中岩藻糖不与N结合的结构乙酰葡萄糖胺在糖链的还原端。

22. 发明授权

US07655228B2 Method of modulating the activity of functional immune molecules to GM2 有权
标题翻译：调节功能性免疫分子对GM2的活性的方法
公开(公告)号：US07655228B2
公开(公告)日：2010-02-02
申请号：US11686911
申请日：2007-03-15
申请人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
发明人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
摘要翻译：本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子活动。

23. 发明申请

US20090048253A1 BENZENOID ANSAMYCIN DERIVATIVE 失效
公开(公告)号：US20090048253A1
公开(公告)日：2009-02-19
申请号：US11917239
申请日：2006-06-29
申请人： Shinpei Yamaguchi , Takayuki Nakashima , Yutaka Kanda
发明人： Shinpei Yamaguchi , Takayuki Nakashima , Yutaka Kanda
IPC分类号： A61K31/5377 , C07D225/04 , A61K31/33 , A61P35/00 , A61K31/40
CPC分类号： C07D225/06 , C07F7/1804
摘要： The present invention provides a benzenoid ansamycin derivative represented by Formula (I) (wherein R1 and R2 each represent a hydrogen atom or are combined together to form a bond, R8 represents a bond or an oxygen atom, R11 represents hydroxy, substituted or unsubstituted lower alkoxy or substituted or unsubstituted lower alkanoyloxy, R15 represents a hydrogen atom or methoxy, R22 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl or substituted or unsubstituted aroyl, R4 and R5 each represent a hydrogen atom or are combined together to form a bond, R18 represents a hydrogen atom, or the like, R21 represents hydroxy or the like, and R17 and R19 may be the same or different and each represents a hydrogen atom, or the like) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供由式（I）表示的苯并安莎霉素衍生物（其中R1和R2各自表示氢原子或组合在一起形成键，R8表示键或氧原子，R11表示羟基，取代或未取代的低级烷氧基或取代或未取代的低级烷酰氧基，R 15表示氢原子或甲氧基，R 22表示氢原子，取代或未取代的低级烷基，取代或未取代的低级烷酰基或取代或未取代的芳酰基，R4和R5各自表示氢原子或被结合一起形成键，R 18表示氢原子等，R 21表示羟基等，R 17和R 19可以相同或不同，各自表示氢原子等）或其药学上可接受的盐。

24. 发明申请

US20090042883A1 ANTITUMOR AGENT 审中-公开
标题翻译：抗菌剂
公开(公告)号：US20090042883A1
公开(公告)日：2009-02-12
申请号：US11816736
申请日：2006-02-21
申请人： Yutaka Kanda , Shiro Soga , Takayuki Nakashima , Shinji Nara , Hiroshi Nakagawa , Yukimasa Shiotsu
发明人： Yutaka Kanda , Shiro Soga , Takayuki Nakashima , Shinji Nara , Hiroshi Nakagawa , Yukimasa Shiotsu
IPC分类号： A61K31/05 , C07C39/04 , C07D211/70 , C07D241/04 , A61K31/4406 , A61K31/496 , A61K31/5377 , A61P35/00 , A61K31/5375 , A61K31/495 , C07D403/04 , C07D265/30 , C07D413/04
CPC分类号： A61K31/12 , A61K31/165 , A61K31/216 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4406 , A61K31/445 , A61K31/4535 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , C07C235/78 , C07D207/09 , C07D207/24 , C07D207/27 , C07D211/22 , C07D211/42 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/50 , C07D217/06 , C07D239/42 , C07D241/18 , C07D295/088 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/46 , C07D307/52 , C07D317/60 , C07D333/22
摘要： The present invention provides a therapeutic agent for a tumor selected from a hematopoietic tumor and a solid tumor which comprises, as an active ingredient, a benzoyl compound represented by General Formula (I): (wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R3 and R5 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl or the like), a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供一种选自造血肿瘤和实体肿瘤的肿瘤治疗剂，其包含通式（I）表示的苯甲酰基化合物作为活性成分：（其中n表示1〜5的整数; R1 表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR 7 R 8等; R 2表示取代或未取代的芳基或取代或未取代的芳族杂环基; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R4表示氢原子，羟基或卤素; R6表示氢原子，卤素，取代或未取代的低级烷基等），其前药或其药学上可接受的盐。

25. 发明授权

US07393683B2 Mammalian host cell modified by RNAi to inhibit α 1,6-fucosyltransferase 有权
标题翻译：通过RNAi修饰的哺乳动物宿主细胞抑制α1,6-岩藻糖基转移酶
公开(公告)号：US07393683B2
公开(公告)日：2008-07-01
申请号：US11287324
申请日：2005-11-28
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： C12N5/00 , C12N5/02 , C12N9/88 , G01N33/53 , C12P21/04 , A01K67/00 , A01K67/033
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译：本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。

26. 发明申请

US20060281789A1 Protein kinase inhibitors 审中-公开
标题翻译：蛋白激酶抑制剂
公开(公告)号：US20060281789A1
公开(公告)日：2006-12-14
申请号：US10548592
申请日：2004-07-30
申请人： Yukimasa Shiotsu , Hiroshi Umehara , Fumihiko Kanai , Shinji Nara , Yoshihisa Ohta , Yutaka Kanda , Shiro Akinaga , Tomoki Naoe , Hitoshi Kiyoi , Tomoyuki Nakazato , Satoshi Tashiro
发明人： Yukimasa Shiotsu , Hiroshi Umehara , Fumihiko Kanai , Shinji Nara , Yoshihisa Ohta , Yutaka Kanda , Shiro Akinaga , Tomoki Naoe , Hitoshi Kiyoi , Tomoyuki Nakazato , Satoshi Tashiro
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D231/56
摘要： The present invention provides a protein kinase inhibitor (excluding c-Jun N-terminal kinase inhibitor) which comprises, as an active ingredient, an indazole derivative represented by Formula (I) (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供一种蛋白激酶抑制剂（不包括c-Jun N-末端激酶抑制剂），其包含作为活性成分的由式（I）表示的吲唑衍生物（其中R 1表示取代或未取代的芳基或取代或未取代的杂环基）或其药学上可接受的盐。

27. 发明申请

US20060024800A1 Method of modulating the activity of functional immune molecules 有权
标题翻译：调节功能性免疫分子活性的方法
公开(公告)号：US20060024800A1
公开(公告)日：2006-02-02
申请号：US11126298
申请日：2005-05-11
申请人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
发明人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
IPC分类号： C12P21/06 , C12P19/18 , A01H1/00 , C12N5/06 , C07K16/44 , A01K67/027
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
摘要翻译：本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子活动。

28. 发明授权

US06946292B2 Cells producing antibody compositions with increased antibody dependent cytotoxic activity 有权
标题翻译：产生具有增加的抗体依赖性细胞毒活性的抗体组合物的细胞
公开(公告)号：US06946292B2
公开(公告)日：2005-09-20
申请号：US09971773
申请日：2001-10-09
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： C07K16/18 , C07K16/28 , C07K16/32 , C12N9/04 , C12N9/10 , C12N9/90 , C12N5/06 , C12N5/16 , C12N9/00 , C12N9/88 , C12P21/04
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译：本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。

29. 发明授权

US5733924A DC 107 derivatives and treatment methods 失效
标题翻译： DC 107衍生物和处理方法
公开(公告)号：US5733924A
公开(公告)日：1998-03-31
申请号：US776938
申请日：1997-04-17
申请人： Yutaka Kanda , Yutaka Saitoh , Hiromitsu Saito , Tadashi Ashizawa , Kazuyo Sugiyama , Katsushige Gomi , Shingo Kakita , Yuichi Takahashi , Chikara Murakata
发明人： Yutaka Kanda , Yutaka Saitoh , Hiromitsu Saito , Tadashi Ashizawa , Kazuyo Sugiyama , Katsushige Gomi , Shingo Kakita , Yuichi Takahashi , Chikara Murakata
IPC分类号： C07D513/08 , A61K37/00
CPC分类号： C07D513/08
摘要： DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, �wherein R.sup.1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4 or the like; R.sup.2 represents hydrogen or COR.sup.5 ; R.sup.3 represents lower alkyl, lower alkenyl, aralkyl which may be substituted with substituted or unsubstituted aryl, lower alkoxyalkyl, aralkyloxyalkyl, substituted or unsubstituted aryloxyalkyl, lower alkoxycarbonylalkyl, lower alkanoyloxyalkyl, alicyclic alkanoyloxyalkyl or the like, or bonds to Y to represent a single bond; Y bonds to R.sup.3 to represent a single bond, or bonds to Z to represent a single bond; Z represents hydrogen or bonds to Y to represent a single bond; W represents oxygen or NR.sup.6, with the proviso that the compound wherein R.sup.1, R.sup.2 and Z each represents hydrogen, R.sup.3 bonds to Y to represent a single bond, and W represents oxygen (DC107) is excluded.!
摘要翻译： PCT No.PCT / JP96 / 01646 Sec。 371日期1997年04月17日 102（e）1997年4月17日PCT PCT 1996年6月14日PCT公布。出版物WO97 / 00260 PCT 日本1997年3月1日由式（I）代表的DC107衍生物：其中R1为氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR4或类似; R2表示氢或COR5; R3代表低级烷基，低级烯基，可被取代或未取代的芳基取代的芳烷基，低级烷氧基烷基，芳烷氧基烷基，取代或未取代的芳氧基烷基，低级烷氧基羰基烷基，低级烷酰氧基烷基，脂环族烷酰氧基烷基等，或与Y键合以表示单键 ; Y键合到R3表示单键，或键合到Z表示单键; Z表示氢或与Y键合以表示单键; W表示氧或NR 6，条件是其中R1，R2和Z各自表示氢，R3与Y键合以表示单键，W表示氧（DC107）的化合物。

30. 发明授权

US5187186A Pyrroloindole derivatives 失效
标题翻译：吡咯并吲哚衍生物
公开(公告)号：US5187186A
公开(公告)日：1993-02-16
申请号：US755760
申请日：1991-09-06
申请人： Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
发明人： Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
IPC分类号： C07D487/04 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10
摘要： DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.
摘要翻译：其中X表示氢或CO 2 R 1（其中R 1表示氢，具有1至4个碳原子的直链或支链烷基，烯丙基或苄基）表示的DC-88A衍生物。和具有优异的抗肿瘤活性，可用作抗肿瘤剂。

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