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21. 发明授权

US5771893A Method and apparatus for nuclear magnetic resonance imaging of physiological function information 失效
公开(公告)号：US5771893A
公开(公告)日：1998-06-30
申请号：US524257
申请日：1995-09-06
申请人： Yoshimori Kassai , Shoichi Kanayama , Shigehide Kuhara , Arturo Calderon
发明人： Yoshimori Kassai , Shoichi Kanayama , Shigehide Kuhara , Arturo Calderon
IPC分类号： G01R33/48 , A61B5/055 , G01R33/56 , G01R33/563
CPC分类号： G01R33/4806 , G01R33/5616 , G01R33/563
摘要： A nuclear magnetic resonance imaging scheme suitable for an imaging of a physiological function information on a living body. The scheme uses a pulse sequence for realizing a first imaging scheme for obtaining the blood vessel image and a second imaging scheme for obtaining the physiological function image such as a brain function image by a single execution of the pulse sequence, where the first imaging scheme is executed before the second imaging scheme by controlling resolutions and imaging regions for the respective imaging schemes appropriately. The pulse sequence can also realize a third imaging scheme for obtaining the physical shape image, which is to be executed between the first imaging scheme and the second imaging scheme. The physiological function image can be obtained by selecting valid data from the image data acquired with/without stimulation or load by using the t-test, and determining active portions from the selected valid data by using the paired t-test. The physiological function image can then be displayed in superposition with the blood vessel image and/or the physical shape image.

22. 发明授权

US5722409A Nuclear magnetic resonance imaging with protection against artifacts 失效
标题翻译：核磁共振成像具有防伪影
公开(公告)号：US5722409A
公开(公告)日：1998-03-03
申请号：US588681
申请日：1996-01-19
申请人： Shigehide Kuhara , Kozo Sato , Shoichi Kanayama
发明人： Shigehide Kuhara , Kozo Sato , Shoichi Kanayama
IPC分类号： G01R33/421 , G01R33/561 , G01R33/565 , A61B5/055
CPC分类号： G01R33/56554 , G01R33/4215 , G01R33/56518 , G01R33/56527
摘要： A nuclear magnetic resonance imaging scheme capable of reducing the eddy currents induced within the living body outside of the imaging region, so as to protect the patient against the nerve stimulation due to the eddy currents, and obtaining the MR images at high image quality by protecting the image quality against the N/2 and chemical artifacts. The nerve stimulation is prevented by providing a shield member for shielding a nerve stimulation sensitive portion of the patient located outside of the imaging region from a change of the gradient magnetic fields. The artifacts are prevented by applying a reading gradient magnetic field which is repeatedly switching its polarity along a phase encoding gradient magnetic field applied at a rate of once in every two switchings of the reading gradient magnetic field, separating the acquired NMR signals resulting from odd and even turns of switchings of the reading gradient magnetic field as separate data sets, and re-constructing MR images from the separate data set for odd turns and even turns separately.
摘要翻译：一种核磁共振成像方案，其能够降低在成像区域外的生物体内感应的涡流，以保护患者免受由于涡流引起的神经刺激，并通过保护获得高图像质量的MR图像图像质量相对于N / 2和化学文物。通过设置用于屏蔽来自位于成像区域外的患者的神经刺激敏感部分的屏蔽构件，防止神经刺激与梯度磁场的变化。通过施加读取梯度磁场来防止伪影，该读取梯度磁场沿着读取梯度磁场的每两次切换中的一次的速率施加的相位编码梯度磁场重复地切换其极性，分离由奇数和将读取梯度磁场的切换的偶数圈作为单独的数据集，并且从单独的数据集重新构造用于奇数匝和偶数匝的MR图像。

23. 发明授权

US5497773A Nuclear magnetic resonance imaging with patient protection against nerve stimulation and image quality protection against artifacts 失效
标题翻译：核磁共振成像与患者保护免受神经刺激和图像质量保护的伪像
公开(公告)号：US5497773A
公开(公告)日：1996-03-12
申请号：US212145
申请日：1994-03-14
申请人： Shigehide Kuhara , Kozo Sato , Shoichi Kanayama
发明人： Shigehide Kuhara , Kozo Sato , Shoichi Kanayama
IPC分类号： G01R33/421 , G01R33/561 , G01R33/565 , A61B5/055
CPC分类号： G01R33/56554 , G01R33/4215 , G01R33/56518 , G01R33/56527
摘要： A nuclear magnetic resonance imaging scheme capable of reducing the eddy currents induced within the living body outside of the imaging region, so as to protect the patient against the nerve stimulation due to the eddy currents, and obtaining the MR images at high image quality by protecting the image quality against the N/2 and chemical artifacts. The nerve stimulation is prevented by providing a shield member for shielding a nerve stimulation sensitive portion of the patient located outside of the imaging region from a change of the gradient magnetic fields. The artifacts are prevented by applying a reading gradient magnetic field which is repeatedly switching its polarity along a phase encoding gradient magnetic field applied at a rate of once in every two switchings of the reading gradient magnetic field, separating the acquired NMR signals resulting from odd and even turns of switchings of the reading gradient magnetic field as separate data sets, and re-constructing MR images from the separate data set for odd turns and even turns separately.
摘要翻译：一种核磁共振成像方案，其能够降低在成像区域外的生物体内感应的涡流，以保护患者免受由于涡流引起的神经刺激，并通过保护获得高图像质量的MR图像图像质量相对于N / 2和化学文物。通过设置用于屏蔽来自位于成像区域外的患者的神经刺激敏感部分的屏蔽构件，防止神经刺激与梯度磁场的变化。通过施加读取梯度磁场来防止伪影，该读取梯度磁场沿着读取梯度磁场的每两次切换中的一次的速率施加的相位编码梯度磁场重复地切换其极性，分离由奇数和将读取梯度磁场的切换的偶数圈作为单独的数据集，并且从单独的数据集重新构造用于奇数匝和偶数匝的MR图像。

24. 发明授权

US4949042A Magnetic resonance imaging system 失效
标题翻译：磁共振成像系统
公开(公告)号：US4949042A
公开(公告)日：1990-08-14
申请号：US298947
申请日：1989-01-19
申请人： Sigehide Kuhara , Shoichi Kanayama
发明人： Sigehide Kuhara , Shoichi Kanayama
IPC分类号： G01R33/485 , G01R33/54 , G01R33/56 , G01R33/561
CPC分类号： G01R33/4828 , G01R33/485 , G01R33/56 , G01R33/5615 , G01R33/5616
摘要： A magnetic resonance imaging system is adapted to achieve the imaging of magnetic resonance signals detected from an object by applying a high frequency magnetic field and gradient field to the object in a homogeneous static field in accordance with a predetermined pattern and includes a data pick-up section and image processing section. The data pick-up section is of such a type that, with the use of a predetermined pulse sequence so time-adjusted that a phase difference between two predetermined substances somewhat differing in their magnetic resonance frequency due to a chemical shift is .pi./2 or -.pi./2 on a predetermined time, picks up all magnetic resonance data necessary for reconstruction of an image of a slice excited by the high frequency field into a magnetic resonance within a period of time in which that predetermined nuclear magnetization of the slice is relaxed due to the relaxation of a transverse magnetization. The image processing section obtains a magnetic resonance image of at least one of the two substances gained, in a manner separated into real and imaginary part of image information, by subjecting mangetic resonance data picked up by the data pick-up section to a two-dimension complex Fourier transformation. It is thus possible to obtain a magnetic resonance image of at least one of the two substances in a very small period of time.

25. 发明授权

US4871968A Magnetic resonance apparatus 失效
标题翻译：磁共振装置
公开(公告)号：US4871968A
公开(公告)日：1989-10-03
申请号：US235499
申请日：1988-08-24
申请人： Shoichi Kanayama
发明人： Shoichi Kanayama
IPC分类号： G01R33/34 , A61B5/055 , A61B10/00 , G01R33/20 , G01R33/341 , G01R33/385 , G01R33/44 , G01R33/48
CPC分类号： G01R33/385 , G01R33/341
摘要： A magnetic resonance apparatus comprises a main probe coil adapted for transmission and reception of a high frequency to and from a large region of an object under examination or for transmission of the high frequency to the object, a local probe coil formed of a surface coil adapted for transmission and reception of a high frequency to and from a local region corresponding to a local portion of the object or for reception of the high frequency, and a main gradient coil adapted for application of a gradient magnetic field to a large region of the object. The local probe coil is used for measurement of the local region. The magnetic resonance apparatus is further provided with a relatively small-sized local gradient coil for producing a local gradient magnetic field in the sensitive region of the local probe coil and its vicinities only.
摘要翻译：一种磁共振装置包括主探测线圈，其适用于高频频率传输和接收被检查物体的大区域，或用于将高频传输到物体;由表面线圈形成的局部探针线圈，其适于用于将高频发送到对应于对象的局部部分的局部区域或用于接收高频率的高频;以及主梯度线圈，适用于向物体的大区域施加梯度磁场。局部探针线圈用于局部区域的测量。磁共振装置还设置有相对较小尺寸的局部梯度线圈，用于在局部探针线圈的敏感区域及其附近产生局部梯度磁场。

26. 发明授权

US09423347B2 Automatic analyzing apparatus 有权
标题翻译：自动分析仪
公开(公告)号：US09423347B2
公开(公告)日：2016-08-23
申请号：US12365414
申请日：2009-02-04
申请人： Naoko Omuro , Shoichi Kanayama
发明人： Naoko Omuro , Shoichi Kanayama
IPC分类号： G01N21/00 , B01F3/00 , B01F13/08 , G01N21/59 , B01F11/00 , G01N35/02 , G01N35/00
CPC分类号： G01N21/5907 , B01F11/0082 , B01F11/0091 , B01F13/0818 , G01N35/025 , G01N2035/00534
摘要： An automatic analyzing apparatus includes a stir piece moving part that moves a stir piece for stirring a mixture into a reaction container, a reaction disk that rotationally moves and thereafter stops the reaction container in which the stir piece moved by the stir piece moving part and the mixture are housed, and first drivers that drive the stir piece in the reaction container to stir first and second mixtures. During the rotation movement of the reaction container into which first and second reagents have been dispensed at first and second reagent dispensing positions, the first drivers vertically move the stir piece in the reaction container and stir the first and second mixtures.
摘要翻译：一种自动分析装置，包括：搅拌片移动部，其将用于将混合物搅拌的搅拌片移动到反应容器中;旋转移动的反作用盘，然后停止由搅拌片移动部移动的搅拌片的反应容器，混合物，以及驱动反应容器中的搅拌块以搅拌第一和第二混合物的第一驱动器。在第一和第二试剂分配位置处分配有第一和第二试剂的反应容器的旋转运动期间，第一驱动器将搅拌块垂直移动到反应容器中并搅拌第一和第二混合物。

27. 发明授权

US09327255B2 Microchemical analysis device, a micro mixing device, and a microchemical analysis system comprising the same 有权
标题翻译：微量化学分析装置，微混合装置和包含该微量化学分析装置的微量化学分析系统
公开(公告)号：US09327255B2
公开(公告)日：2016-05-03
申请号：US11946339
申请日：2007-11-28
申请人： Naoko Ito , Shoichi Kanayama
发明人： Naoko Ito , Shoichi Kanayama
IPC分类号： B01F13/00 , B01F11/00 , B01F11/02 , B01L3/00 , B01F15/00
CPC分类号： B01F13/0064 , B01F11/0045 , B01F11/0258 , B01F15/00207 , B01F15/00214 , B01L3/5027 , B01L2200/04 , B01L2200/143 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867
摘要： By situating a mixing pot in a junction of a first solution and a second solution or after the junction in a channel to temporarily retain these solutions, and situating an analysis sensor downstream from the mixing pot to detect the result of reaction of the first solution and second solution, heterogeneous solutions are mixed so as to react within the channel, and chemical analysis of one of the solutions is performed. According to this system, before the solutions have fully flowed through the remainder of the channel following the junction, the solutions are mixed uniformly at once by the turbulent and vortex flow generated within the mixing pot.
摘要翻译：通过在第一溶液和第二溶液的接合处或在通道中的接头之后将混合釜定位以暂时保持这些溶液，并将分析传感器置于混合罐下游，以检测第一溶液和第二个解决方案是将异构解决方案混合，以便在通道内反应，并执行其中一个解决方案的化学分析。根据该系统，在溶液已经完全流过连接处的通道的其余部分之后，通过在混合罐内产生的湍流和涡流一次均匀地混合溶液。

28. 发明授权

US08999267B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08999267B2
公开(公告)日：2015-04-07
申请号：US13075524
申请日：2011-03-30
申请人： Shoichi Kanayama
发明人： Shoichi Kanayama
IPC分类号： B01L3/02 , G01N35/10 , G01N35/02 , G01N35/04 , G01N35/00
CPC分类号： G01N35/025 , B01L2200/141 , B01L2300/046 , G01N35/10 , G01N2035/00277 , G01N2035/00287 , G01N2035/0405
摘要： According to one embodiment, an automatic analyzer includes a reaction disc, cleaning mechanism, and cover. The reaction disc holds a cuvette which contains a sample and a reagent. The cleaning mechanism is configured to clean the cuvette using a nozzle. The cover is configured to be movable along an axis of the nozzle and to cover an opening of the cuvette.
摘要翻译：根据一个实施例，自动分析器包括反作用盘，清洁机构和盖。反应盘容纳含有样品和试剂的试管。清洁机构被配置为使用喷嘴清洁比色杯。盖被构造成可沿着喷嘴的轴线移动并且覆盖比色皿的开口。

29. 发明授权

US08600466B2 Living body information measuring apparatus 有权
标题翻译：生物体信息测量仪器
公开(公告)号：US08600466B2
公开(公告)日：2013-12-03
申请号：US12028410
申请日：2008-02-08
申请人： Shoichi Kanayama
发明人： Shoichi Kanayama
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A living body information measuring apparatus includes an optical system for irradiating light to a subject and detecting light from the subject, a signal processing portion for acquiring information with regard to a tissue condition of the subject based on a detecting signal of light, and a position determining portion for determining an acceptability of an irradiating position of light based on the detecting signal of light.
摘要翻译：生物体信息测量装置包括：用于向对象照射光并检测来自对象的光的光学系统，用于基于光的检测信号获取关于对象的组织状况的信息的信号处理部，以及位置确定部分，用于基于光的检测信号确定光的照射位置的可接受性。

30. 发明申请

US20120148450A1 AUTOMATIC ANALYZER 有权
标题翻译：自动分析仪
公开(公告)号：US20120148450A1
公开(公告)日：2012-06-14
申请号：US13401047
申请日：2012-02-21
申请人： Kanako IWAMURA , Shoichi Kanayama
发明人： Kanako IWAMURA , Shoichi Kanayama
IPC分类号： G01N21/59
CPC分类号： G01N21/253 , G01N35/025 , G01N35/04 , G01N2035/0455 , G01N2201/0415 , G01N2201/124 , G01N2201/1245 , G01N2201/127
摘要： According to one embodiment, an automatic analyzer comprises a light source, a spectroscope, a photo detection unit, a storage unit, a selection unit, and a calculation unit. The storage unit stores photo detector identifiers related to photo detectors and wavelength band identifiers in association with each other. The selection unit selects a specific photo detector from photo detectors. The specific photo detector corresponds to a specific photo detector identifier associated with a wavelength band identifier of a wavelength band according to a measurement item of a sample. The calculation unit calculates an absorbance related to the measurement item based on a signal from the selected specific photo detector.
摘要翻译：根据一个实施例，自动分析仪包括光源，分光镜，光检测单元，存储单元，选择单元和计算单元。存储单元相关联地存储与光检测器和波长带标识符相关的光检测器标识符。选择单元从光电检测器中选择特定的光电检测器。特定的光检测器对应于根据样品的测量项目与波长带的波长带标识符相关联的特定光检测器标识符。计算单元基于来自所选择的特定光检测器的信号计算与测量项目相关的吸光度。

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