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21. 发明授权

US4595771A Water-soluble antimony compounds and their preparation 失效
标题翻译：水溶性锑化合物及其制备方法
公开(公告)号：US4595771A
公开(公告)日：1986-06-17
申请号：US672556
申请日：1984-11-16
申请人： Marilyn W. Blaschke , Richard F. Miller , John Link
发明人： Marilyn W. Blaschke , Richard F. Miller , John Link
IPC分类号： C07F9/90 , C10G11/04
CPC分类号： C10G11/04 , C07F9/902
摘要： Novel organic water-soluble antimony compounds are prepared by reacting ammonia or an alkylamine with a hydroxycarboxylic acid to form an intermediate product and then reacting the intermediate product with an antimony oxide. These compounds are useful for use as catalyst metal poison passivators.
摘要翻译：通过使氨或烷基胺与羟基羧酸反应制备新的有机水溶性锑化合物以形成中间产物，然后使中间产物与氧化锑反应。这些化合物可用作催化剂金属毒物钝化剂。

22. 发明授权

US4488998A Preparation of higher antimony tricarboxylates in improved yields using an inert gas 失效
标题翻译：使用惰性气体以提高的产率制备较高锑三羧酸盐
公开(公告)号：US4488998A
公开(公告)日：1984-12-18
申请号：US412419
申请日：1982-08-27
申请人： Richard F. Miller , John Link
发明人： Richard F. Miller , John Link
IPC分类号： C07C51/41 , C11C1/00
CPC分类号： C07C51/412
摘要： Antimony tricarboxylates of higher carboxylic acids can be prepared in high yields by(a) reacting antimony oxide with an anhydride of a lower organic acid,(b) reacting the product from (a) with at least one higher carboxylic acid at a temperature sufficient to vaporize volatile material and removing the vaporized volatile material,(c) simultaneously passing a stream of an inert gas through the reaction mixture, and(d) recovering the antimony tricarboxylate of said higher carboxylic acid.

23. 发明授权

US08901362B2 Methods and compositions for styrene inhibition via in situ generation of quinone methides 有权
标题翻译：通过原位生成醌甲基化物进行苯乙烯抑制的方法和组合物
公开(公告)号：US08901362B2
公开(公告)日：2014-12-02
申请号：US13364554
申请日：2012-02-02
申请人： John Link
发明人： John Link
IPC分类号： C07C7/20
CPC分类号： C07C7/20 , C08F2/40 , C08F12/08 , C07C15/46
摘要： Methods and compositions are provided for inhibiting the polymerization of a vinyl aromatic monomer, such as styrene monomer, during elevated temperature processing or distillation thereof or during storage or shipment of polymer containing product. The compositions include a combination of a hydroxybenzyl alcohol (1) and a dehydration catalyst (2). The combination is added to a vinyl aromatic monomer. Typically, the hydroxybenzyl alcohol is dehydrated in the styrene solution by the use of a strong acid catalyst acting as the dehydration catalyst, and the resultant reaction product is a quinone methide styrene inhibitor.
摘要翻译：提供了用于在高温处理或蒸馏期间或在含聚合物的产品的储存或运输过程中抑制乙烯基芳族单体如苯乙烯单体聚合的方法和组合物。组合物包括羟基苄醇（1）和脱水催化剂（2）的组合。将该组合物加入到乙烯基芳族单体中。通常，通过使用充当脱水催化剂的强酸催化剂，苯乙烯溶液中羟基苄醇脱水，得到的反应产物是醌甲基苯乙烯抑制剂。

24. 发明申请

US20130072729A1 METHODS AND COMPOSITIONS FOR INHIBITING POLYSTYRENE FORMATION DURING STYRENE PRODUCTION 有权
标题翻译：在苯乙烯生产过程中抑制聚苯乙烯形成的方法和组合物
公开(公告)号：US20130072729A1
公开(公告)日：2013-03-21
申请号：US13235004
申请日：2011-09-16
申请人： John Link , Mike Hong
发明人： John Link , Mike Hong
IPC分类号： C07C7/20 , C09K3/00
CPC分类号： C07C7/20 , C07C7/05 , C07C17/42 , C08F12/08 , C08F2/40 , C07C15/46 , C07C15/44 , C07C25/28
摘要： Methods and compositions are provided for inhibiting the polymerization of a vinyl aromatic monomer, such as styrene monomer, during elevated temperature processing or distillation thereof. The compositions comprise an inhibitor combination of (A) a hydroxylamine and (B) a stable free radical plus a retarder that is either; (C) dinitrobutylphenol or (D) quinone methide. The ratio of (A) to (B) ranges from about 5% (A) to 95% (B) to about 95% (A) to about 5% (B). The compositions are added to the vinyl aromatic monomer in amounts sufficient to prevent polymerization during the distillation process. Typically the inhibitor combination is added to the vinyl aromatic monomer in an amount ranging from about 10 to 150 ppm of the monomer. Retarders are typically added in an amount ranging from 50 to 1500 ppm of the vinyl aromatic monomer.
摘要翻译：提供了用于在高温处理或蒸馏期间抑制乙烯基芳族单体如苯乙烯单体的聚合的方法和组合物。组合物包含（A）羟胺和（B）稳定的自由基加上缓凝剂的抑制剂组合; （C）二硝基丁基苯酚或（D）醌甲基化物。（A）至（B）的比例为约5％（A）至95％（B）至约95％（A）至约5％（B）。将组合物以足以防止在蒸馏过程中聚合的量加入到乙烯基芳族单体中。通常将抑制剂组合物加入到单体约10至150ppm范围内的乙烯基芳族单体中。通常，乙烯基芳族单体的加入量通常为50〜1500ppm。

25. 发明申请

US20070049594A1 Novel compounds and compositions as cathepsin inhibitors 审中-公开
标题翻译：新型化合物和组合物作为组织蛋白酶抑制剂
公开(公告)号：US20070049594A1
公开(公告)日：2007-03-01
申请号：US11295890
申请日：2005-12-07
申请人： Michael Graupe , John Patterson , David Aldous , Sukanthini Thurairatnam , Andreas Timm , John Link , Jiayao Li , Stephen Pickett , Frank Halley , Justine Lai
发明人： Michael Graupe , John Patterson , David Aldous , Sukanthini Thurairatnam , Andreas Timm , John Link , Jiayao Li , Stephen Pickett , Frank Halley , Justine Lai
IPC分类号： A61K31/501 , A61K31/50 , A61K31/4965 , A61K31/497 , C07D417/02 , C07D413/02
CPC分类号： C07D207/273 , A61K31/5375 , A61K31/5377 , C07C317/44 , C07C323/60 , C07D205/08 , C07D207/24 , C07D213/40 , C07D223/10 , C07D223/12 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/10 , C07D277/26 , C07D277/64 , C07D285/08 , C07D295/185 , C07D413/04 , C07D413/12 , Y02A50/411
摘要： The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译：本发明涉及新的选择性组织蛋白酶S抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。

26. 发明授权

US07178357B2 Portable air conditioning apparatus 失效
标题翻译：便携式空调机
公开(公告)号：US07178357B2
公开(公告)日：2007-02-20
申请号：US10392023
申请日：2003-03-19
申请人： John Link
发明人： John Link
IPC分类号： F25D11/00
CPC分类号： B60H1/00264 , B60H1/3235
摘要： A portable cooling or heating system suitable for use on a vehicle such as a car, plane or boat, that does not have its own air conditioning system. The system is intended to be combined with a portable cooler chest and includes an electric fan unit that can be powered from the power supply on a vehicle. The cooling is provided by ice and the like. The system can also be used to heat a confined space by placing a hot material in the chest.
摘要翻译：一种适用于汽车，飞机或船只等不具有自己的空调系统的便携式冷却或加热系统。该系统旨在与便携式冷却器箱结合，并且包括可以从车辆上的电源供电的电风扇单元。冷却由冰等提供。该系统也可用于通过将热材料放置在胸部来加热密闭空间。

27. 发明申请

US20070021353A1 Alpha ketoamide compounds as cysteine protease inhibitors 有权
标题翻译： α-酮酰胺化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：US20070021353A1
公开(公告)日：2007-01-25
申请号：US11384023
申请日：2006-03-17
申请人： Michael Graupe , John Link , Michael Roepel
发明人： Michael Graupe , John Link , Michael Roepel
IPC分类号： A61K38/04 , C07C237/02
CPC分类号： C07C317/48 , C07C2601/02 , C07D213/32
摘要： The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译：本发明涉及半胱氨酸蛋白酶，特别是组织蛋白酶B，K，L，F和S的抑制剂的化合物，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的药物组合物及其制备方法。

28. 发明申请

US20070000223A1 Adjustable combination propulsion and control handle for a work machine 有权
公开(公告)号：US20070000223A1
公开(公告)日：2007-01-04
申请号：US11171132
申请日：2005-06-30
申请人： John Link , Jay Schroeder
发明人： John Link , Jay Schroeder
IPC分类号： A01D41/127
CPC分类号： A01D41/127 , Y10T74/20201
摘要： A combination propulsion and control handle for a work machine, including an elongate control stalk having a mounting end, an opposite free end, and an internal cavity in connection with an opening in the free end, and a hand grip disposed in overlaying relation to the free end, the hand grip including at least one input device in a position so as to be operable by a finger of a hand grasping the hand grip for causing a change of state of the input device, the at least one input device including at least one elongate conductive element extending therefrom through the opening and the internal cavity of the control stalk, the hand grip being mounted so as to allow simultaneous limited rotation thereof about the control stalk and rotation of the elongate conductive element within the stalk, for allowing varying the positioning of an operator's hand, without twisting of the conductive elements.

29. 发明申请

US20050288336A1 Cysteine protease inhibitors 审中-公开
标题翻译：半胱氨酸蛋白酶抑制剂
公开(公告)号：US20050288336A1
公开(公告)日：2005-12-29
申请号：US10514804
申请日：2003-05-14
申请人： Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
发明人： Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
IPC分类号： A61K31/44 , A61K31/4436 , C07D213/56 , C07D263/56 , C07D271/10 , C07D413/12 , C07D417/12 , C07D498/04
CPC分类号： C07D263/56 , C07D271/10 , C07D413/12 , C07D417/12
摘要： The present invention is directed to compounds that are inhibitors of cysteine protease, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译：本发明涉及半胱氨酸蛋白酶，特别是组织蛋白酶B，K，L，F和S的抑制剂的化合物，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的药物组合物及其制备方法。

30. 发明授权

US06571568B1 Portable air conditioning apparatus 失效
标题翻译：便携式空调机
公开(公告)号：US06571568B1
公开(公告)日：2003-06-03
申请号：US10267395
申请日：2002-10-09
申请人： John Link
发明人： John Link
IPC分类号： B60H132
CPC分类号： B60H1/00264 , B60H1/3235
摘要： A portable cooling or heating system suitable for use on vehicle such as a car, plane or boat, that does not have its own air conditioning system. The system is intended to be combined with a portable cooler chest and includes an electric fan unit that can be powered from the power supply on a vehicle. The cooling is provided by ice and the like. The system can also be used to heat a confined space by placing a hot material in the chest.
摘要翻译：适用于不具有自己的空调系统的汽车，飞机或船上的便携式冷却或加热系统。该系统旨在与便携式冷却器箱结合，并且包括可以从车辆上的电源供电的电风扇单元。冷却由冰等提供。该系统也可用于通过将热材料放置在胸部来加热密闭空间。

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