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    • 27. 发明申请
    • A SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS
    • 用于产生长效抗原和防止病原体的合成免疫原
    • WO2012035558A3
    • 2012-05-31
    • PCT/IN2011000630
    • 2011-09-14
    • COUNCIL SCIENT IND RESUNIV MELBOURNEAGREWALA JAVED NAIMGOWTHAMAN UTHAMANJACKSON DAVIDZENG WEIGUANG
    • AGREWALA JAVED NAIMGOWTHAMAN UTHAMANJACKSON DAVIDZENG WEIGUANG
    • A61K39/04A61K39/39
    • C07K19/00A61K39/04A61K2039/55516A61K2039/6018
    • The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogen M. tuberculosis in this case. In the present invention, promiscuous peptides of M. tuberculosis are conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity. (The formula (I) should be inserted here) General formula (I) wherein, X1 = a promiscuous CD4 T helper epitope selected from SEQ ID No. 1 to 98 OR nil; X2 = a promiscuous CD8 T cytotoxic epitope selected from SEQ ID No. 99 to 103 OR nil; when X1 = nil; X2 = SEQ ID No. 99 to 103 and when X2 = nil; X1 = SEQ ID No. 1 to 98; Y = Lysine; and S = Serine.
    • 本发明涉及由通式1表示的合成免疫原,其可用于产生针对作为结核病,利什曼病,艾滋病,锥虫病,疟疾以及变态反应,癌症和癌症的致病因子的各种细胞内病原体的长效保护性免疫和 其制备。 发达的免疫原能够规避人类和家畜中的HLA限制。 本发明进一步涉及包含所述免疫原的疫苗,用于产生针对各种疾病的持久保护性免疫。 所述疫苗靶向细胞内病原体,在这种情况下更特别是病原体结核分枝杆菌。 在本发明中,结核分枝杆菌的混杂肽尤其与TLR配体缀合; Pam2Cys主要将其靶向树突状细胞,因此引发长效保护性免疫。 (式(I)应插入在此)通式(I)其中,X1 =选自SEQ ID No.1至98的混杂CD4T辅助表位或无; X2 =选自SEQ ID No.99至103的混杂CD8 T细胞毒性表位或无; 当X1 =零时; X2 = SEQ ID No.99至103,并且当X2 =零时; X1 = SEQ ID No.1至98; Y =赖氨酸; 和S =丝氨酸。
    • 28. 发明申请
    • DEVICE AND METHOD FOR MONITORING A COMMUNICATIONS SYSTEM
    • 用于监控通信系统的装置和方法
    • WO2010147866A2
    • 2010-12-23
    • PCT/US2010038450
    • 2010-06-14
    • MEZZALINGUA JOHN ASSJACKSON DAVIDMONTENA NOAH
    • JACKSON DAVIDMONTENA NOAH
    • H04N7/10
    • H04L12/4625H04N7/102
    • Disclosed herein is a condition responsive device for connection with a communication system. The device includes a receiver configured to receive a physical parameter status signal from a connector of the communication system, the physical parameter status signal containing data pertaining to a condition of the connector connection. The device further includes a processing circuit configured to analyze the data to determine whether a communications signal adjustment is appropriate, wherein the processing circuit is configured to initiate a communications signal adjustment in the communication system if the processing circuit determines that adjustment is appropriate, based on a predetermined set of parameters.
    • 这里公开了一种用于与通信系统连接的状况响应装置。 该设备包括被配置为从通信系统的连接器接收物理参数状态信号的接收机,该物理参数状态信号包含与连接器连接状况有关的数据。 该设备还包括处理电路,其被配置为分析数据以确定通信信号调整是否合适,其中处理电路被配置为如果处理电路确定该调整是合适的则基于通信系统中的通信信号调整,基于 一组预定的参数。
    • 29. 发明申请
    • UPSTREAM BANDWIDTH CONDITIONING DEVICE
    • 上行带宽调节装置
    • WO2010117496A3
    • 2010-12-09
    • PCT/US2010024281
    • 2010-02-16
    • MEZZALINGUA JOHN ASSJACKSON DAVID
    • JACKSON DAVID
    • H04N7/10H04N7/12
    • H04N21/44245H04N21/239H04N21/2408H04N21/6168H04N21/6332H04N21/6377
    • An upstream bandwidth conditioning device that can be inserted into a signal transmission line of a CATV system in or proximate to a premise of a user includes a main signal path divided into a forward path and a return path, the return path being divided into supplier side portion and a user side portion. The device further includes a supplier side termination device selectively connected to the supplier side portion by a supplier side termination switch, and a user side termination device selectively connected to the user side portion by a user side termination switch. A signal amplifier is selectively connected to the supplier side portion and the user side portion by at least one amplifier switch, and a switch controller is configured to actuate each of the supplier side termination switch, the user side termination switch, and the amplifier switch from a first position to a second position.
    • 可以插入到用户房屋中或附近的CATV系统的信号传输线中的上游带宽调节装置包括分成前向路径和返回路径的主信号路径,返回路径被划分成供应侧 部分和用户侧部分。 该设备还包括通过供应商侧终端交换机有选择地连接到供应商侧部分的供应商方终端设备,以及通过用户方终端交换机有选择地连接到用户方部分的用户方终端设备。 信号放大器通过至少一个放大器开关选择性地连接到供应者侧部分和用户侧部分,并且开关控制器被配置成致动供应者侧终端开关,用户侧终端开关和放大器开关中的每一个 第一位置到第二位置。