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21. 发明专利

DK129229B 未知
公开(公告)号：DK129229B
公开(公告)日：1974-09-16
申请号：DK531070
申请日：1970-10-19
申请人： SCHERING AG
发明人： PFEIFFER H , KOLB K , HARWART A , SCHULZE P
IPC分类号： C07C239/00 , A61K49/04 , C07C67/00 , C07C257/10 , C07C257/14 , C07C257/22 , C07D295/18 , C07C123/00 , A61K27/08
摘要： 1332833 3 - Amidino - 2,4,6 - triiodophenyl propionic acids SCHERING AG 9 Nov 1970 [8 Nov 1969] 53205/70 Heading C2C [Also in Division A5] Novel compounds of the Formula (I) in which R 1 , R 3 and R 4 are identical or different and each denotes H or C 1-4 alkyl, or R 3 R 4 N denotes a heterocyclic group which may contain a further hetero atom (preferably pyrrolidine, morpholine or piperidine), and R 2 denotes C 1-4 alkyl, and acid addition salts and salts with bases, may be obtained from compounds of Formula (II) in which -CO-X represents an ester or amide group, by converting the -CO-X into -COOH, optionally followed by salt formation. Compounds of Formula (II) may be obtained starting from corresponding #-(2,4,6-triiodo-3-aminophenyl)-propionic acids, its acid group is protected, e.g. by ester or amide formation, by acylating the amino group with an acid chloride or anhydride, reacting with PCl 5 to form an acid imide chloride and then reacting the latter without isolation with ammonia or an amine R 3 R 4 NH. The compounds of Formula I are useful as X-ray contrast agents .

22. 发明专利

ZA723271B NEW HYDROXY-AND ALKOXY-ACETAMIDO-TRIIODOBENZOIC ACIDS 未知
公开(公告)号：ZA723271B
公开(公告)日：1973-03-28
申请号：ZA723271
申请日：1972-05-15
申请人： SCHERING AG
发明人： ZOELLNER G , PFEIFFER H , BEICH W
IPC分类号： C07C235/16 , A61K49/04 , C07C233/47 , C07C
摘要： Hydroxy- and alkoxy-acetamidotriiodobenzoic acids of the formula COOH ¦ II ANGLE ANGLE RO-H2C-C-HN¦CH2-NH-Ac PARALLEL ¦ OI wherein R is a hydrogen atom or lower-alkyl of 1-4 carbon atoms and Ac is alkanoyl of up to 4 carbon atom

24. 发明专利

SE436871B 未知
公开(公告)号：SE436871B
公开(公告)日：1985-01-28
申请号：SE7707230
申请日：1977-06-22
申请人： SCHERING AG
发明人： PFEIFFER H , SPECK U
IPC分类号： A61K31/135 , A61K49/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/02 , C07C233/12 , C07C233/54 , C07C233/56 , C07C233/65 , C07C235/16 , C07C237/46 , C07C103/78

27. 发明专利

SE409992B 未知
公开(公告)号：SE409992B
公开(公告)日：1979-09-17
申请号：SE7501158
申请日：1975-02-03
申请人： SCHERING AG
发明人： PFEIFFER H , SPECK U , KOLB K H
IPC分类号： A61K49/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C235/16 , C07C103/46

29. 发明专利

SE7707230L 未知
公开(公告)号：SE7707230L
公开(公告)日：1977-12-24
申请号：SE7707230
申请日：1977-06-22
申请人： SCHERING AG
发明人： PFEIFFER H , SPECK U
IPC分类号： A61K31/135 , A61K49/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/02 , C07C233/12 , C07C233/54 , C07C233/56 , C07C233/65 , C07C235/16 , C07C237/46 , C07C103/78

30. 发明专利

NO133665C 未知
公开(公告)号：NO133665C
公开(公告)日：1976-06-09
申请号：NO168872
申请日：1972-05-12
申请人： SCHERING AG
发明人： PFEIFFER H , BEICH W , ZOELLNER G
IPC分类号： C07C235/16 , A61K49/04 , C07C233/47 , C07C103/46 , A61K27/08
摘要： Hydroxy- and alkoxy-acetamidotriiodobenzoic acids of the formula COOH ¦ II ANGLE ANGLE RO-H2C-C-HN¦CH2-NH-Ac PARALLEL ¦ OI wherein R is a hydrogen atom or lower-alkyl of 1-4 carbon atoms and Ac is alkanoyl of up to 4 carbon atom

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