专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明专利

AT229940T 未知
公开(公告)号：AT229940T
公开(公告)日：2003-01-15
申请号：AT96934967
申请日：1996-10-24
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GARCIA GEORGES , SERRADEIL-LE GAL CLAUDINE , VALETTE GERARD
IPC分类号： C07D209/54 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/535 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/00 , A61P7/04 , A61P7/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/34 , A61P27/02 , A61P27/06 , A61P27/12 , A61P35/00 , A61P43/00 , C07D209/96 , C07D401/12 , C07D403/12 , C07D413/12
摘要： PCT No. PCT/FR96/01666 Sec. 371 Date Apr. 17, 1998 Sec. 102(e) Date Apr. 17, 1998 PCT Filed Oct. 24, 1996 PCT Pub. No. WO97/15556 PCT Pub. Date May 1, 1997The subject of the invention is indolin-2-one derivatives of formula: in which: W represents a -CH2- or -SO2- group; Cy forms, with the carbon to which it is bonded, a non-aromatic, saturated or unsaturated C3-C12 hydrocarbon ring which is optionally condensed or substituted by one or a number of (C1-C7)alkyl groups, it being possible for the said groups to substitute the same carbon atom one or a number of times, or by a C3-C6 spirocycloalkyl; T represents a (C1-C4)alkylene which is optionally interrupted by a (C3-C6)cycloalkylene, the said alkylenes optionally being substituted one or a number of times on the same carbon atom by a (C1-C3)alkyl; or alternatively T represents a direct bond; Z represents in particular an amino group; R1 and R2, as well as R3 and R4, are either hydrogen or substituents, such as, for example, a halogen, an alkyl, and the like.

22. 发明专利

AU4667101A Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands 未知
公开(公告)号：AU4667101A
公开(公告)日：2001-10-15
申请号：AU4667101
申请日：2001-04-02
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GARCIA GEORGES , SERRADEIL-LEGAL CLAUDINE , VALETTE GERARD
IPC分类号： A61K20060101 , A61K31/04 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/06 , A61P3/12 , A61P5/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/08 , A61P15/00 , A61P15/02 , A61P15/06 , A61P15/08 , A61P15/10 , A61P15/14 , A61P15/18 , A61P17/02 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/04 , C07D209/34 , C07D209/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12
摘要： The present invention relates to novel indolin-2-one derivatives of formula: to the preparation and to the pharmaceutical compositions comprising them. These compounds have an affinity for oxytocin receptors.

23. 发明专利

AU715841B2 3-spiro-indolin-2-one derivatives as vasopressin and/or oxytocin receptor ligands 未知
公开(公告)号：AU715841B2
公开(公告)日：2000-02-10
申请号：AU7308096
申请日：1996-10-24
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GARCIA GEORGES , SERRADEIL-LEGAL CLAUDINE , VALETTE GERARD
IPC分类号： C07D209/54 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/535 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/00 , A61P7/04 , A61P7/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/34 , A61P27/02 , A61P27/06 , A61P27/12 , A61P35/00 , A61P43/00 , C07D209/96 , C07D401/12 , C07D403/12 , C07D413/12
摘要： PCT No. PCT/FR96/01666 Sec. 371 Date Apr. 17, 1998 Sec. 102(e) Date Apr. 17, 1998 PCT Filed Oct. 24, 1996 PCT Pub. No. WO97/15556 PCT Pub. Date May 1, 1997The subject of the invention is indolin-2-one derivatives of formula: in which: W represents a -CH2- or -SO2- group; Cy forms, with the carbon to which it is bonded, a non-aromatic, saturated or unsaturated C3-C12 hydrocarbon ring which is optionally condensed or substituted by one or a number of (C1-C7)alkyl groups, it being possible for the said groups to substitute the same carbon atom one or a number of times, or by a C3-C6 spirocycloalkyl; T represents a (C1-C4)alkylene which is optionally interrupted by a (C3-C6)cycloalkylene, the said alkylenes optionally being substituted one or a number of times on the same carbon atom by a (C1-C3)alkyl; or alternatively T represents a direct bond; Z represents in particular an amino group; R1 and R2, as well as R3 and R4, are either hydrogen or substituents, such as, for example, a halogen, an alkyl, and the like.

24. 发明专利

DK0614911T3 未知
公开(公告)号：DK0614911T3
公开(公告)日：1999-11-08
申请号：DK94400331
申请日：1994-02-15
申请人： SANOFI SYNTHELABO , SANOFI SA
发明人： CHRISTOPHE BERNARD , FOULON LOIC , PELLET ALAIN , SERRADEIL-LE-GAL CLAUDINE , VALETTE GERARD
IPC分类号： A61K31/16 , A61K31/155 , A61K31/18 , A61K38/00 , A61P9/00 , A61P25/00 , C07C311/18 , C07D215/36 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/078 , A61K37/02 , A61K38/05
摘要： The subject of the invention is compounds of formula I in which Ar1 represents optionally substituted naphthyl, phenyl, quinolyl or isoquinolyl; Ar2 represents optionally substituted phenyl or thienyl; R1, R2 and R'2 represent, independently of each other, H, (C1-C4)alkyl or R1 represents nothing and N is linked to Ar2 and, optionally, R2 and R'2 form a double bond, or R1 or R2 is linked to Ar2 and represents (C1-C3)alkylene; R3 and R4, which are identical or different, represent H, (C1-C4)alkyl or form with the nitrogen atom to which they are attached a saturated (C5-C7)heterocycle; Z1 represents (C1-C12)alkylene; Q1 represents methyl, amino, (C1-C4)alkoxycarbonylamino, (C1-C4)alkylamino, di(C1-C4)alkylamino, pyrrolidinyl, piperidino, morpholino, piperazinyl, 4-(C1-C4)alkyl piperazinyl, amidino, (C1-C4)alkylamidino, guanidino, (C1-C4)alkylguanidino, pyridyl, imidazolyl, pyrimidinyl, indolyl, hydroxyl, (C1-C4)alkoxy, (C2-C8)alkoxycarbonyl, amino(C1-C4)alkyl-N-(C1-C4)alkylamino, carbamoyl or phenyl which is optionally substituted; Q2 represents H or (C1-C4)alkyl; Q3 represents H or (C1-C4)alkyl or Q1 and Q3 are linked to form a heterocycle and represent together (C2-C3)alkylene whereas Z1 represents nothing, in the form of pure enantiomers or of mixtures thereof in any proportions, as well as their salts with acids. These compounds have an affinity for the biological receptors of neuropeptide Y (NPY) which are present in the central and peripheral nervous systems.

25. 发明专利

SI0873309T1 3-SPIRO-INDOLIN-2-ONE DERIVATIVES AS VASOPRESSIN AND/OR OXYTOCIN RECEPTOR LIGANDS 未知
公开(公告)号：SI0873309T1
公开(公告)日：2003-04-30
申请号：SI9630571
申请日：1996-10-24
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GARCIA GEORGES , SERRADEIL-LE GAL CLAUDINE , VALETTE GERARD
IPC分类号： A61K31/40 , C07D209/96

26. 发明专利

TR200202288T2 未知
公开(公告)号：TR200202288T2
公开(公告)日：2003-01-21
申请号：TR200202288
申请日：2001-04-02
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GARCIA GEORGES , GAL CLAUDINE SERRADEIL-LE , VALETTE GERARD
IPC分类号： A61K20060101 , A61K31/04 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/06 , A61P3/12 , A61P5/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/08 , A61P15/00 , A61P15/02 , A61P15/06 , A61P15/08 , A61P15/10 , A61P15/14 , A61P15/18 , A61P17/02 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/04 , C07D209/34 , C07D209/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12
摘要： The present invention relates to novel indolin-2-one derivatives of formula: to the preparation and to the pharmaceutical compositions comprising them. These compounds have an affinity for oxytocin receptors.

27. 发明专利

NO313551B1 未知
公开(公告)号：NO313551B1
公开(公告)日：2002-10-21
申请号：NO992878
申请日：1999-06-11
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GAL CATHERINE SERRADEIL LE , VALETTE GERARD
IPC分类号： A61K31/404 , A61K31/407 , C07D491/107 , A61K31/454 , A61K31/5377 , A61P1/16 , A61P7/00 , A61P9/00 , A61P25/00 , A61P27/02 , A61P43/00 , C07D209/96 , C07D401/12 , C07D491/10 , A61K31/40
摘要： PCT No. PCT/FR97/02270 Sec. 371 Date Jun. 14, 1999 Sec. 102(e) Date Jun. 14, 1999 PCT Filed Dec. 11, 1997 PCT Pub. No. WO98/25901 PCT Pub. Date Jun. 18, 1998The invention relates to compounds with formula (I), a process for their preparation and pharmaceutical compositions containing them. These compounds have an excellent affinity for vasopressin and/or oxytocin

28. 发明专利

FR2807038A1 未知
公开(公告)号：FR2807038A1
公开(公告)日：2001-10-05
申请号：FR0004193
申请日：2000-04-03
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GARCIA GEORGES , SERRADEIL LE GAL CLAUDINE , VALETTE GERARD
IPC分类号： A61K20060101 , A61K31/04 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/06 , A61P3/12 , A61P5/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/08 , A61P15/00 , A61P15/02 , A61P15/06 , A61P15/08 , A61P15/10 , A61P15/14 , A61P15/18 , A61P17/02 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/04 , C07D209/34 , C07D209/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12
摘要： The invention concerns novel indolin-2-one derivatives or formula (I), their preparation and pharmaceutical compositions containing them. Said compounds have an affinity for ocytocin receptors.

29. 发明专利

ZA200207802B Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands. 未知
公开(公告)号：ZA200207802B
公开(公告)日：2003-09-29
申请号：ZA200207802
申请日：2002-09-27
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GARCIA GEORGES , GAL CLAUDINE SERRADEIL-LE , VALETTE GERARD
IPC分类号： A61K20060101 , A61K31/04 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/06 , A61P3/12 , A61P5/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/08 , A61P15/00 , A61P15/02 , A61P15/06 , A61P15/08 , A61P15/10 , A61P15/14 , A61P15/18 , A61P17/02 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/04 , C07D209/34 , C07D209/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D , A61K , A61P
摘要： The present invention relates to novel indolin-2-one derivatives of formula: to the preparation and to the pharmaceutical compositions comprising them. These compounds have an affinity for oxytocin receptors.

30. 发明专利

NZ521617A Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands 未知
公开(公告)号：NZ521617A
公开(公告)日：2003-05-30
申请号：NZ52161701
申请日：2001-04-02
申请人： SANOFI SYNTHELABO
发明人： FOULON LOIC , GARCIA GEORGES , SERRADEIL-LE GAL CLAUDINE , VALETTE GERARD
IPC分类号： A61K20060101 , A61K31/04 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/06 , A61P3/12 , A61P5/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/08 , A61P15/00 , A61P15/02 , A61P15/06 , A61P15/08 , A61P15/10 , A61P15/14 , A61P15/18 , A61P17/02 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/04 , C07D209/34 , C07D209/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12
摘要： A compound of formula (I) is described, pharmaceutical compositions containing the compounds and their uses as ocytocin receptor ligands, wherein; R0 represents a group chosen from formula (i) or (ii), wherein; Z1 represents a chlorine, bromine, iodine or fluorine atom or a (C1-C4)alkyl, (C1-C4)alkoxy or trifluoromethyl group, Z2 represents a hydrogen, chlorine, bromine, iodine or fluorine arom or a (C1-C4)alkyl, (C3-C5)cycloalkyl, (C1-C4)alkoxy, (C3-C5)cycloalkoxy or (C1-C4)polyfluoroalkyl group, R5 represents T1W in which T1 represents û(CH2)m, it being possible for m to be equal to 0 or 1, and W represents a hydrogen, hydroxycarbonyl, carboxyl, (C1-C4)alkoxycarbonyl, 1,3-dioxolan-2-yl, or 1,3-dioxan-2-yl, -NR6R7, -NR8COR9, -CONR13R14, OR18, Z6 represents a chlorine, (C1-C4)alkyl or (C1-C4)alkoxy, R1 represents a (C1-C4)alkyl, (C1-C4)alkoxycarbonyl, phenyloxycarbonyl group or a T1-R22 group in which T1 is as defined above, and R22 represents hydroxyl or (C1-C4)alkoxy, R2 and R4 represent, independently of one another hydrogen chlorine or fluorine or a (C1-C4)alkyl or (C1-C4)alkoxy, R3 represents a chlorine, fluorine, (C1-C4)alkyl, (C1-C4)alkoxy, hydroxyl, (C1-C4)carbamoyl, (C1-C4)alkylcarbonylamino, nitro, cyano, trifluoromethyl, amino, (C3-C6)cycloalkylamino, (C1-C4)alkylamino, di(C1-C4)alkylamino, tri(C1-C4alkylammonium A-, pyrrolidine-1-yl, piperid-1-yl, piperazin-1-yl, morpholin-4-yl or hexahydroazepin-1-yl, and X and Y represent, independently of one another, a hydrogen, chlorine, bromine, iodine, fluorine, or (C1-C4)alkoxy or trifluoromethoxy.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式