专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20050239836A1 Substituted hydroxyethylamine aspartyl protease inhibitors 审中-公开
公开(公告)号：US20050239836A1
公开(公告)日：2005-10-27
申请号：US11075312
申请日：2005-03-09
申请人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
发明人： Varghese John , Michel Maillard , John Tucker , Jose Aquino , Barbara Jagodzinska , Louis Brogley , Jay Tung , Simeon Bowers , Darren Dressen , Gary Probst , Neerav Shah
IPC分类号： A61K31/382 , A61K31/453 , C07D207/32 , C07D207/325 , C07D233/54 , C07D257/04 , C07D335/06 , C07D403/12 , C07D405/12 , C07D419/12 , C07D49/02
CPC分类号： C07D419/12 , C07C215/28 , C07C215/50 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/58 , C07C225/06 , C07C225/20 , C07C229/16 , C07C229/42 , C07C229/60 , C07C233/43 , C07C237/20 , C07C237/30 , C07C271/12 , C07C311/24 , C07C317/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/04 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D207/323 , C07D207/325 , C07D213/38 , C07D215/42 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D249/04 , C07D249/06 , C07D249/14 , C07D257/04 , C07D263/34 , C07D271/113 , C07D275/02 , C07D277/42 , C07D285/08 , C07D285/10 , C07D285/135 , C07D307/52 , C07D309/14 , C07D311/74 , C07D333/36 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

22. 发明授权

US08103001B2 Method for verifying rights contained in a security module 有权
标题翻译：用于验证安全模块中包含的权限的方法
公开(公告)号：US08103001B2
公开(公告)日：2012-01-24
申请号：US11543831
申请日：2006-10-06
申请人： Dominique Le Floch , Michel Maillard
发明人： Dominique Le Floch , Michel Maillard
IPC分类号： H04N7/167 , H04L9/00 , H04L9/08
CPC分类号： H04L63/104 , G06F21/10 , H04L63/0428 , H04L2463/101 , H04N21/26606 , H04N21/4181 , H04N21/44236
摘要： A method of verification of rights is disclosed, contained in a security module associated to an apparatus processing broadcasted digital data. The apparatus is connected to a management center transmitting encrypted rights messages for accessing the digital data. The method includes reception and reading by the security module of all or part of a rights message including at least one right and means for verifying the right, decryption and verification of the rights message and updating of a rights memory, and storage of all or part of the rights message in a messages memory. During a further verification step, the method includes identification of at least one right present in the rights memory, search of the corresponding stored rights message and verification of the rights message, comparison of the right contained in the rights message with the corresponding right stored in the rights memory, and determination of a default state when the result of the comparison indicates a difference.
摘要翻译：公开了一种包含在与处理广播数字数据的设备相关联的安全模块中的权限验证方法。该装置连接到管理中心，发送用于访问数字数据的加密权限消息。该方法包括由安全模块接收和读取包括至少一个权利的全部或部分权利消息和用于验证权利消息的权利，解密和验证以及更新权利存储器的装置，以及存储全部或部分的消息存储器中的权限消息。在进一步的验证步骤中，该方法包括识别权利存储器中存在的至少一个权利，搜索对应的存储的权利消息和验证权利消息，权利消息中包含的权利与存储在权限消息中的对应权限的比较权限存储器和当比较结果指示差异时的默认状态的确定。

23. 发明授权

US07645780B2 Acetyl 2-hydroxy-1, 3-diaminoalkanes 失效
标题翻译：乙酰基2-羟基-1,3-二氨基烷烃
公开(公告)号：US07645780B2
公开(公告)日：2010-01-12
申请号：US11447789
申请日：2006-06-06
申请人： Varghese John , Michel Maillard , James P. Beck , Eric T. Baldwin , Robert Hughes , Shon R. Pulley , Ruth T. TenBrink
发明人： Varghese John , Michel Maillard , James P. Beck , Eric T. Baldwin , Robert Hughes , Shon R. Pulley , Ruth T. TenBrink
IPC分类号： C07D213/56 , A61K31/44
CPC分类号： C07C233/36 , C07C235/10 , C07C235/74 , C07C271/24 , C07C311/05 , C07C327/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D209/14 , C07D213/38 , C07D213/64 , C07D215/233 , C07D215/38 , C07D215/42 , C07D215/46 , C07D217/22 , C07D233/61 , C07D233/64 , C07D237/08 , C07D237/14 , C07D239/26 , C07D239/38 , C07D241/12 , C07D249/08 , C07D261/08 , C07D265/02 , C07D277/28 , C07D295/135 , C07D307/52 , C07D309/14 , C07D311/68 , C07D311/74 , C07D333/20 , C07D333/22 , C07D335/06 , C07D405/04 , C07D407/06 , C07D409/12 , C07D495/04
摘要： Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
摘要翻译：公开了下式的化合物：其中变量Z，X，R 15，R 2，R 3和R c在本文中定义。本文公开的化合物是β-分泌酶的抑制剂，因此可用于治疗阿尔茨海默病和以哺乳动物中Aβ肽沉积为特征的其它疾病。

24. 发明申请

US20090042961A1 OXIME DERIVATIVE SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS 审中-公开
标题翻译： OXIME衍生的取代羟基乙酰胺ASPARTYL蛋白酶抑制剂
公开(公告)号：US20090042961A1
公开(公告)日：2009-02-12
申请号：US12117094
申请日：2008-05-08
申请人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
IPC分类号： A61K31/165 , A61P43/00 , C07D257/04 , C07C233/36 , C07C243/20 , C07D405/10 , A61K31/4155 , A61K31/41 , C07D231/12 , A61K31/415 , C07D231/54 , A61K31/416
CPC分类号： C07D285/08 , C07C233/36 , C07C237/20 , C07C251/44 , C07C251/54 , C07C251/84 , C07C255/42 , C07C255/58 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D257/04 , C07D261/20 , C07D271/10 , C07D335/06 , C07D405/10
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译：本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。

25. 发明申请

US20070149584A9 Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors 失效
标题翻译：肟衍生物取代的羟乙基胺天冬氨酰蛋白酶抑制剂
公开(公告)号：US20070149584A9
公开(公告)日：2007-06-28
申请号：US11177324
申请日：2005-07-11
申请人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
IPC分类号： A61K31/42 , A61K31/416 , A61K31/165
CPC分类号： C07D285/08 , C07C233/36 , C07C237/20 , C07C251/44 , C07C251/54 , C07C251/84 , C07C255/42 , C07C255/58 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D257/04 , C07D261/20 , C07D271/10 , C07D335/06 , C07D405/10
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译：本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。

26. 发明申请

US20060135581A1 Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors 失效
标题翻译：肟衍生物取代的羟乙基胺天冬氨酰蛋白酶抑制剂
公开(公告)号：US20060135581A1
公开(公告)日：2006-06-22
申请号：US11177324
申请日：2005-11-17
申请人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
发明人： Varghese John , Michel Maillard , Barbara Jagodzinska , Jose Aquino , Gary Probst , Jay Tung
IPC分类号： A61K31/42 , A61K31/416 , A61K31/165
CPC分类号： C07D285/08 , C07C233/36 , C07C237/20 , C07C251/44 , C07C251/54 , C07C251/84 , C07C255/42 , C07C255/58 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D257/04 , C07D261/20 , C07D271/10 , C07D335/06 , C07D405/10
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译：本发明涉及治疗与淀粉样变性相关的疾病，病症和病症的新化合物和方法。淀粉样变性是指与A-β蛋白异常沉积相关的疾病，病症和病症的集合。

27. 发明授权

US06846813B2 Compounds to treat alzheimer's disease 失效
标题翻译：治疗阿尔茨海默病的化合物
公开(公告)号：US06846813B2
公开(公告)日：2005-01-25
申请号：US09895843
申请日：2001-06-29
申请人： James P. Beck , Andrea Gailunas , Roy Hom , Barbara Jagodzinska , Varghese John , Michel Maillard
发明人： James P. Beck , Andrea Gailunas , Roy Hom , Barbara Jagodzinska , Varghese John , Michel Maillard
IPC分类号： A61P25/28 , C07C215/28 , C07C233/78 , C07C235/84 , C07C239/20 , C07C243/22 , C07C243/28 , C07C271/16 , C07C271/18 , C07C275/24 , C07C311/03 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/37 , C07C317/44 , C07C323/60 , C07D211/60 , C07D215/12 , C07D223/10 , C07D277/04 , C07D295/13 , C07D303/36 , C07D307/52 , C07D307/54 , C07D333/24 , A61K31/33 , A61K31/495 , C07D241/00 , C07D241/04
CPC分类号： C07D295/13 , C07C215/28 , C07C233/78 , C07C235/84 , C07C239/20 , C07C243/22 , C07C243/28 , C07C271/16 , C07C271/18 , C07C275/24 , C07C311/03 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/37 , C07C317/44 , C07C323/60 , C07D211/60 , C07D215/12 , C07D223/10 , C07D277/04 , C07D303/36 , C07D307/52 , C07D307/54 , C07D333/24
摘要： The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译：本发明是式（I）的二取代胺和式（II）的二取代的胺，其可用于治疗阿尔茨海默病和其它类似疾病。

28. 发明授权

US5620676A Biologically active ATP analogs 失效
标题翻译：生物活性ATP类似物
公开(公告)号：US5620676A
公开(公告)日：1997-04-15
申请号：US414438
申请日：1995-03-31
申请人： Kenneth A. Jacobson , Bilha Fischer , Michel Maillard
发明人： Kenneth A. Jacobson , Bilha Fischer , Michel Maillard
IPC分类号： A61K51/04 , C07H19/20 , A61K51/00 , A61M36/14
CPC分类号： A61K51/0491 , C07H19/20 , A61K2121/00
摘要： The present invention provides certain novel adenosine triphosphate (ATP) analogs, pharmaceutical compositions, and methods of using such analogs in the treatment of septic shock and other disease conditions. Examples of the ATP analogs include the mono-, di- and triphosphates of adenosines with various selected substituents at the 2, 6, 8, and 9-positions, such as alkyl, alkylphenyl, phenylalkyl, S-alkyl, S-alkenyl, S-alkylcyano, S-phenyl, S-alkylphenyl, S-alkylamino, S-alkylthioalkyl, S-alkylthiocyanato, S-alkylaminophenyl, S-alkylnitrophenyl, hydroxy, bromo, fluoro, chloro, and aminoalkylamino. The present invention also provides pharmaceutical compositions of and methods of using certain xanthine and uracil derivatives for the above disease conditions. Examples of the xanthine derivatives include xanthines having alkyl or alkyltriphosphate substituents at the 1, 3, and 7-positions. Examples of the uracil derivatives include 5-fluoro- and 5-bromo uracil triphosphates. Also provided are assays for assessing the binding of the ATP analogs.
摘要翻译：本发明提供某些新颖的三磷酸腺苷（ATP）类似物，药物组合物，以及在治疗败血性休克和其它疾病状况中使用这些类似物的方法。 ATP类似物的实例包括在2,6,8和9位具有各种选择的取代基的腺苷的单，二和三磷酸，例如烷基，烷基苯基，苯基烷基，S-烷基，S-链烯基，S - 烷基氰基，S-苯基，S-烷基苯基，S-烷基氨基，S-烷硫基烷基，S-烷硫基氰基，S-烷基氨基苯基，S-烷基硝基苯基，羟基，溴，氟，氯和氨基烷基氨基。本发明还提供了用于上述疾病状况的药物组合物和使用某些黄嘌呤和尿嘧啶衍生物的方法。黄嘌呤衍生物的实例包括在1,3和7位具有烷基或烷基三磷酸取代基的黄嘌呤。尿嘧啶衍生物的实例包括5-氟 - 和5-溴尿嘧啶三磷酸。还提供了用于评估ATP类似物的结合的测定。

29. 发明授权

US5280762A Device for the articulation of the sail in horizontal and in vertical direction, associated with a hoist block, a drop block and a rod system 失效
标题翻译：用于在水平和垂直方向上关联帆的装置，其与起重块，落块和杆系相关联
公开(公告)号：US5280762A
公开(公告)日：1994-01-25
申请号：US691047
申请日：1991-08-10
申请人： Michel Maillard
发明人： Michel Maillard
IPC分类号： B63H9/06 , B63H9/08
CPC分类号： B63H9/0642 , B63H9/08 , B63H2009/086
摘要： A hoist block is fixed on an inside edge of the sail and to articulated slide in order to enable a rotation in the axis of a sail boat mast groove. A drop block is on the outside edge of the sail. An associated tube or slat extends between the hoist and drop blocks in order to stiffen the sail profile. The block 2 or 9 is rigidly fixed on an articulated slider to hoist or lower the sail mechanism.
摘要翻译： PCT No.PCT / FR90 / 00778 371日期1991年8月10日 102（e）日期1991年8月10日PCT提交1990年10月26日PCT公布。出版物WO91 / 06469 日期1991年5月16日。起重机组固定在帆的内侧边缘和铰接滑动件上，以便能够在帆船帆杆槽的轴线上旋转。一个落地块在帆的外边缘。相关联的管子或板条在升降机和落料块之间延伸，以便加强帆形轮廓。块2或9刚性地固定在铰接的滑动件上以提升或降低帆机构。

30. 发明申请

US20080298585A1 Smartcard Dynamic Management 有权
标题翻译：智能卡动态管理
公开(公告)号：US20080298585A1
公开(公告)日：2008-12-04
申请号：US10591142
申请日：2005-02-18
申请人： Michel Maillard , Le Floch Dominique
发明人： Michel Maillard , Le Floch Dominique
IPC分类号： H04N7/167
CPC分类号： H04N7/163 , H04N7/1675 , H04N21/4181 , H04N21/4367
摘要： A method for securing a portable security module for use with a decoding element, the portable security module and the decoding element allowing to descramble scrambled audiovisual information. The method comprises analyzing at the portable security module a sequence of command messages, the command messages of the sequence being received at the portable security module at distinct times.
摘要翻译：一种用于保护与解码元件一起使用的便携式安全模块的方法，便携式安全模块和解码元件允许解扰加扰的视听信息。该方法包括在便携式安全模块处分析一系列命令消息，该序列的命令消息在不同时刻在便携式安全模块处接收。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式