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21. 发明授权

US4977320A Electrospray ionization mass spectrometer with new features 失效
标题翻译：具有新功能的电喷雾电离质谱仪
公开(公告)号：US4977320A
公开(公告)日：1990-12-11
申请号：US467978
申请日：1990-01-22
申请人： Swapan K. Chowdhury , Viswanatham Katta , Brian T. Chait
发明人： Swapan K. Chowdhury , Viswanatham Katta , Brian T. Chait
IPC分类号： H01J49/04 , H01J49/10
CPC分类号： H01J49/0404 , H01J49/044 , H01J49/0468 , H01J49/165
摘要： An electrospray ion source is designed for ready and simple plugging into commercial mass analyzers for mass spectrometric analysis of organic molecules. The electrospray is carried out is the ambient air and the ions and other charged species enter the mass analyuzer through a long metal capillary tube and three stages of differential pumping. The use of the long tube allows (a) convenient injection of the ions into the mass analyzer (b) optimization of the spray by direct visualization in the air (c) efficient and controlled heat transfer to the droplets and (d) efficient pumping of the region between the capillary exit and the skinner. Desolvation of the solvated ions is carried out using a combination of controlled heat transfer to the charged droplets during the transit through the tube and collisional activation in a region of reduced pressure. Desolvation with this system does not involve use of a strong countercurrent flow of heated gas. The system also may be used to obtain the collisional activated fragmentation spectra of molecule ions. The use of a metal capillary tube avoids complications from charging that arise from the use of dielectric capilliary tubes.
摘要翻译：电喷雾离子源设计用于准备和简单的插入商业质量分析仪，用于有机分子的质谱分析。进行电喷雾是环境空气，离子和其他带电物质通过长金属毛细管进入质量分析仪和三级差动泵送。使用长管允许（a）方便地将离子注入质量分析器中（b）通过在空气中直接可视化来优化喷雾（c）有效和可控制的热传递到液滴，以及（d）有效泵送毛细管出口与皮肤之间的区域。溶剂化离子的去溶剂使用在通过管的运输过程中受控的热传递到带电液滴和在减压区域中的碰撞活化的组合来进行。该系统的去溶剂不涉及使用强逆流的加热气体。该系统也可用于获得分子离子的碰撞激活的碎裂光谱。使用金属毛细管避免了使用电介质毛细管引起的充电并发症。

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