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21. 发明授权

US06709646B2 Bioactivated diagnostic imaging contrast agents 失效
标题翻译：生物活化诊断成像造影剂
公开(公告)号：US06709646B2
公开(公告)日：2004-03-23
申请号：US09952971
申请日：2001-09-14
申请人： Randall B. Lauffer , Thomas J. McMurry , Stephen O. Dunham , Daniel M. Scott , David J. Parmelee , Stéphane Dumas
发明人： Randall B. Lauffer , Thomas J. McMurry , Stephen O. Dunham , Daniel M. Scott , David J. Parmelee , Stéphane Dumas
IPC分类号： A61B5055
CPC分类号： A61K49/14 , A61K49/0002 , A61K49/0017 , A61K49/0019 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106
摘要： The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
摘要翻译：本发明涉及用于磁共振成像和光学成像的改进诊断剂。特别地，本发明涉及允许灵敏检测组织内的特异性活性的MRI和光学成像剂。这些试剂是在特异性生物活性存在下在体内生物活化的前体药物对比剂。本发明还涉及包含这些试剂的药物组合物以及使用包含该试剂的试剂和组合物的方法。

22. 发明授权

US06546372B2 Assistance method and apparatus 有权
公开(公告)号：US06546372B2
公开(公告)日：2003-04-08
申请号：US09782984
申请日：2001-02-13
申请人： Randall B. Lauffer
发明人： Randall B. Lauffer
IPC分类号： G06F1760
CPC分类号： H04M3/5191 , G06F19/00 , G06Q10/0631 , G06Q10/06311 , G06Q10/063112 , G06Q10/0639 , G06Q10/06398 , G06Q20/102 , G06Q30/02 , G06Q30/0206 , G06Q30/0241 , G06Q30/06 , G06Q30/0601 , G06Q30/0613 , G06Q50/24 , G06Q99/00 , H01L29/4908 , H01L29/66757 , H01L29/78675 , H04W4/021 , H04W4/029
摘要： This invention provides for a method of (or apparatus for) facilitating the delivery of advice to consumers using a server unit which can store and display the names and characteristics of experts and then rapidly assist in connecting the expert and consumer for real-time communication. The server can also have the ability to receive keywords from the consumer, match those keywords to one or more experts, and tell the consumer how to contact an expert.

23. 发明申请

US20120107249A1 Diagnostic Imaging Contrast Agents with Extended Blood Retention 失效
标题翻译：具有延长血液保留性的诊断成像对比剂
公开(公告)号：US20120107249A1
公开(公告)日：2012-05-03
申请号：US13220103
申请日：2011-08-29
申请人： Thomas J. McMurry , Hironao Sijiki , Daniel M. Scott , Randall B. Lauffer
发明人： Thomas J. McMurry , Hironao Sijiki , Daniel M. Scott , Randall B. Lauffer
IPC分类号： A61K49/10 , A61K49/00
CPC分类号： A61K49/085 , A61B6/507 , A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , C07F9/091
摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
摘要翻译：本发明涉及用于具有延长血液保留的诊断成像的造影剂。特别地，本发明涉及以图像增强部分（IEM）为特征的新化合物; 蛋白质血浆结合部分（PPBM）; 和血液半衰期延长部分（BHEM）。本发明还涉及包含这些化合物的药物组合物以及使用化合物和组合物用于诊断成像的血液半衰期延长和对比度增强的方法。

24. 发明授权

US07729938B2 Method and system to connect consumers to information 有权
标题翻译：将消费者连接到信息的方法和系统
公开(公告)号：US07729938B2
公开(公告)日：2010-06-01
申请号：US11772525
申请日：2007-07-02
申请人： Randall B. Lauffer
发明人： Randall B. Lauffer
IPC分类号： G06F17/30
CPC分类号： H04M3/5191 , G06F19/00 , G06Q10/0631 , G06Q10/06311 , G06Q10/063112 , G06Q10/0639 , G06Q10/06398 , G06Q20/102 , G06Q30/02 , G06Q30/0206 , G06Q30/0241 , G06Q30/06 , G06Q30/0601 , G06Q30/0613 , G06Q50/24 , G06Q99/00 , H01L29/4908 , H01L29/66757 , H01L29/78675 , H04W4/021 , H04W4/029
摘要： This invention provides for a method of (or apparatus for) facilitating the delivery of advice to consumers using a server unit which can store and display the names and characteristics of experts and then rapidly assist in connecting the expert and consumer for real-time communication. The server can also have the ability to receive keywords from the consumer, match those keywords to one or more experts, and tell the consumer how to contact an expert.
摘要翻译：本发明提供了一种使用可以存储和显示专家的名称和特性的服务器单元促进向消费者传递建议的（或装置）的方法，然后快速协助连接专家和消费者进行实时通信。服务器还可以从消费者接收关键字，将这些关键字与一个或多个专家相匹配，并告诉消费者如何联系专家。

25. 发明授权

US07175829B2 Contrast-enhanced diagnostic imaging method for monitoring interventional therapies 有权
标题翻译：用于监测介入治疗的对比增强诊断成像方法
公开(公告)号：US07175829B2
公开(公告)日：2007-02-13
申请号：US10961872
申请日：2004-10-08
申请人： Randall B. Lauffer , Stephen O. Dunham
发明人： Randall B. Lauffer , Stephen O. Dunham
IPC分类号： A61B5/055
CPC分类号： A61K49/10 , A61K49/0052 , A61K49/085 , A61K49/103 , A61K49/106
摘要： The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SDTBM). These contrast agents exhibit state-dependent binding to one or more components of a targeted tissue or tissue component and provide a detectable change in the signal characteristics of the agent once bound to the targeted tissue. As a result, these agents exhibit a binding affinity for, and thus image contrast of, the targeted tissue which changes as the tissue-state changes during therapy.
摘要翻译：本发明涉及用于监测介入治疗功效的对比度增强诊断成像方法。在该方法中有用的造影剂包括图像增强部分（IEM）和状态依赖性组织结合部分（SDTBM）。这些造影剂表现出与目标组织或组织成分的一种或多种组分的状态依赖性结合，并提供一旦结合到目标组织的药剂的信号特征的可检测变化。结果，这些试剂表现出随着组织状态在治疗期间改变而变化的靶组织的结合亲和力，并因此对其进行图像对比。

26. 发明授权

US07147837B2 Bioactivated diagnostic imaging constrast agents 失效
标题翻译：生物活化诊断成像对照药
公开(公告)号：US07147837B2
公开(公告)日：2006-12-12
申请号：US10758729
申请日：2004-01-16
申请人： Randall B. Lauffer , Thomas J. McMurry , Stephen O. Dunham , Daniel M. Scott , David J. Parmelee , Stéphane Dumas
发明人： Randall B. Lauffer , Thomas J. McMurry , Stephen O. Dunham , Daniel M. Scott , David J. Parmelee , Stéphane Dumas
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/14 , A61K49/0002 , A61K49/0017 , A61K49/0019 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106
摘要： The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
摘要翻译：本发明涉及用于磁共振成像和光学成像的改进诊断剂。特别地，本发明涉及允许灵敏检测组织内特定生物活性的MRI和光学成像剂。这些试剂是在特异性生物活性存在下在体内生物活化的前体药物对比剂。本发明还涉及包含这些试剂的药物组合物以及使用包含该试剂的试剂和组合物的方法。

27. 发明授权

US06549889B2 Assistance method and apparatus 有权
公开(公告)号：US06549889B2
公开(公告)日：2003-04-15
申请号：US09782925
申请日：2001-02-13
申请人： Randall B. Lauffer
发明人： Randall B. Lauffer
IPC分类号： G06F1760
CPC分类号： H04M3/5191 , G06F19/00 , G06Q10/0631 , G06Q10/06311 , G06Q10/063112 , G06Q10/0639 , G06Q10/06398 , G06Q20/102 , G06Q30/02 , G06Q30/0206 , G06Q30/0241 , G06Q30/06 , G06Q30/0601 , G06Q30/0613 , G06Q50/24 , G06Q99/00 , H01L29/4908 , H01L29/66757 , H01L29/78675 , H04W4/021 , H04W4/029
摘要： This invention provides for a method of (or apparatus for) facilitating the delivery of advice to consumers using a server unit which can store and display the names and characteristics of experts and then rapidly assist in connecting the expert and consumer for real-time communication. The server can also have the ability to receive keywords from the consumer, match those keywords to one or more experts, and tell the consumer how to contact an expert.

28. 发明授权

US5628982A Hydroxy-aryl metal chelates for diagnostic NMR imaging 失效
标题翻译：用于诊断NMR成像的羟基 - 芳基金属螯合物
公开(公告)号：US5628982A
公开(公告)日：1997-05-13
申请号：US466471
申请日：1995-06-06
申请人： Randall B. Lauffer , Scott K. Larsen
发明人： Randall B. Lauffer , Scott K. Larsen
IPC分类号： A61K49/06 , A61K49/00
CPC分类号： A61K49/06 , Y10T436/24
摘要： An NMR contrast agent composition contains a complex of a selected metal ion and a selected ligand. The ion is selected from the group consisting of gadolinium (III), iron (III), manganese (II), manganese (III), chromium (III), copper (II), dysprosium (III), terbium (III), holmium (III), erbium (III), europium (II), and europium (III); and the ligand is a linear two-nitrogen compound having one 2-hydroxy-aryl group at one of the nitrogen; or the ligand is a linear two-nitrogen compound having one or two 2-hydroxy-aryl groups at each of the nitrogens; or the ligand is a linear three-, four-, or five-nitrogen compound having one or two 2-hydroxy-aryl substituents at each of one or more of the nitrogens, or the ligand is a heterocyclic compound having a ring containing three or four nitrogens, and having a 2-hydroxy-aryl substitent at one or more of the nitrogens; or the ligand is a heterocyclic compound having a ring containing 4 nitrogens, and having a carboxyl group at two of the nitrogens and an aromatic substituent at the other two of the nitrogens. Also, a method for enhancing the contrast in NMR imaging in a patient includes steps of preparing an NMR contrast enhancing agent by mixing an NMR contrast compound of the invention with a pharmaceutically acceptable carrier, introducing the NMR contrast enhancing agent into the patient, and subjecting the patient to NMR imaging.
摘要翻译： NMR造影剂组合物含有所选择的金属离子和所选择的配体的络合物。离子选自钆（III），铁（III），锰（II），锰（III），铬（III），铜（II），镝（III），铽（III），钬（III），铒（III），铕（II）和铕（III）; 并且配体是在一个氮气下具有一个2-羟基 - 芳基的直链二氮化合物; 或者配体是在每个氮原子上具有一个或两个2-羟基 - 芳基的线性二氮化合物; 或者配体是在一个或多个氮的每一个上具有一个或两个2-羟基 - 芳基取代基的线性三，四或五氮化合物，或者配体是具有环的三价或四个氮，并且在一个或多个氮上具有2-羟基 - 芳基取代基; 或者配体是具有含有4个氮的环的杂环化合物，并且在两个氮原子处具有羧基，在另外两个氮原子具有芳香族取代基。此外，用于增强患者的NMR成像中的对比度的方法包括通过将本发明的NMR对比化合物与药学上可接受的载体混合来制备NMR对比度增强剂的步骤，将NMR对比度增强剂引入患者体内，患者以NMR成像。

29. 发明授权

US5582814A 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging 失效
标题翻译： 1-（对正丁基苄基）DTPA用于磁共振成像
公开(公告)号：US5582814A
公开(公告)日：1996-12-10
申请号：US227961
申请日：1994-04-15
申请人： Daniel M. Scott , Randall B. Lauffer
发明人： Daniel M. Scott , Randall B. Lauffer
IPC分类号： A61K49/00 , A61K49/04 , A61K49/06 , C07C229/76 , C07F1/08 , C07F5/00 , C07F11/00 , C07F13/00 , C07F15/02 , C07F15/00
CPC分类号： A61K49/06 , Y10T436/24
摘要： Paramagnetic metal complexes of 1-(p-n-butylbenzyl)diethylenetriamine pentaacetic acid and pharmaceutically acceptable salts thereof are effective as tissue-specific MRI contrast agents, and in particular as hepatobiliary MRI contrast agents.
摘要翻译： 1-（对正丁基苄基）二亚乙基三胺五乙酸及其药学上可接受的盐的顺磁金属络合物作为组织特异性MRI造影剂是有效的，特别是作为肝胆MRI造影剂。

30. 发明授权

US5527522A Hydroxy-aryl metal chelates for diagnostic NMR imaging 失效
标题翻译：用于诊断NMR成像的羟基 - 芳基金属螯合物
公开(公告)号：US5527522A
公开(公告)日：1996-06-18
申请号：US397892
申请日：1995-03-03
申请人： Randall B. Lauffer , Scott K. Larsen
发明人： Randall B. Lauffer , Scott K. Larsen
IPC分类号： A61K49/06 , A61K49/00 , A61B6/00
CPC分类号： A61K49/06 , Y10T436/24
摘要： An NMR contrast agent composition contains a complex of a selected metal ion and a selected ligand. The ion is selected from the group consisting of gadolinium (III), iron (III), manganese (II), manganese (III), chromium (III), copper (II), dysprosium (III), terbium (III), holmium (III), erbium (III), europium (II), and europium (III); and the ligand is a linear two-nitrogen compound having one 2-hydroxy-aryl group at one of the nitrogens: or the ligand is a linear two-nitrogen compound having one or two 2-hydroxy-aryl groups at each of the nitrogens; or the ligand is a linear three-, four-, or five-nitrogen compound having one or two 2-hydroxy-aryl substituents at each of one or more of the nitrogens, or the ligand is a heterocyclic compound having a ring containing three or four nitrogens, and having a 2-hydroxy-aryl substitent at one or more of the nitrogens; or the ligand is a heterocyclic compound having a ring containing 4 nitrogens, and having a carboxyl group at two of the nitrogens and an aromatic substituent at the other two of the nitrogens.
摘要翻译： NMR造影剂组合物含有所选择的金属离子和所选择的配体的络合物。离子选自钆（III），铁（III），锰（II），锰（III），铬（III），铜（II），镝（III），铽（III），钬（III），铒（III），铕（II）和铕（III）; 并且该配位体是在一个氮原子上具有一个2-羟基 - 芳基的直链二氮化合物：或配位体是在每个氮原子上具有一个或两个2-羟基 - 芳基的直链二氮化合物; 或者配体是在一个或多个氮的每一个上具有一个或两个2-羟基 - 芳基取代基的线性三，四或五氮化合物，或者配体是具有环的三价或四个氮，并且在一个或多个氮上具有2-羟基 - 芳基取代基; 或者配体是具有含有4个氮的环的杂环化合物，并且在两个氮原子处具有羧基，在另外两个氮原子具有芳香族取代基。

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