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21. 发明授权

US5599303A IV administration apparatus 失效
标题翻译： IV管理装置
公开(公告)号：US5599303A
公开(公告)日：1997-02-04
申请号：US344829
申请日：1994-11-21
申请人： Richard Melker , Eric J. Hulsman , Brad D. Wellington
发明人： Richard Melker , Eric J. Hulsman , Brad D. Wellington
IPC分类号： A61M5/168 , A61M5/14
CPC分类号： A61M5/16886
摘要： The subject invention is a novel apparatus for the administration of intravenous fluids. The invention is particularly well suited for accurately and efficiently administering intravenous fluids over a wide range of flow rates. Disclosed is an intravenous fluid administration apparatus having at lease one flow line capable of administering fluid at high flow rates and comprising an airless, dripless, fluid monitoring chamber. A preferred embodiment comprises a main flow line which diverges into at least two flow limbs, where one flow limb is a low-flow limb and another flow limb is a high-flow limb, each having separate flow indicators, and with the flow limbs typically converging into a common tube for fluid delivery to the patient. The subject invention also discloses a novel flow meter, which is particularly well suited for measuring and indicating flow rates over a wide range, without the introduction of air bubbles into the fluid flow being measured. The novel flow meter of the subject invention comprises an elastic displaceable member in a housing, whereby the relative position of the displaceable member, as effected by the amount of force exerted on the displaceable member by the fluid being measured, indicates the flow rate of the fluid.
摘要翻译：本发明是用于给予静脉注射液的新型装置。本发明特别适用于在宽范围的流速下准确和有效地施用静脉内流体。公开了一种具有至少一个能够以高流速施用流体并且包括无空气，无渗透的流体监测室的流动管线的静脉内流体给药装置。优选实施例包括主流线，其分叉成至少两个流动臂，其中一个流动臂是低流量肢体，另一个流动肢体是高流动肢体，每个流动肢体具有单独的流动指示器，并且通常具有流动肢体会聚到用于流体递送到患者的普通管中。本发明还公开了一种新颖的流量计，其特别适用于在宽范围内测量和指示流量，而不将气泡引入被测量的流体流中。本发明的新型流量计包括在壳体中的弹性可移动构件，由可动构件的相对位置，由所测量的流体施加在可移动构件上的力的影响，表示流量流体。

22. 发明申请

US20070258894A1 System and Method for Real-Time Diagnosis, Treatment, and Therapeutic Drug Monitoring 审中-公开
标题翻译：用于实时诊断，治疗和治疗药物监测的系统和方法
公开(公告)号：US20070258894A1
公开(公告)日：2007-11-08
申请号：US10588749
申请日：2005-02-28
申请人： Richard Melker , James Sackellares , Mark Gold , Donn Dennis
发明人： Richard Melker , James Sackellares , Mark Gold , Donn Dennis
IPC分类号： A61K9/51
CPC分类号： A61B5/14546 , A61B5/0836 , A61B5/145 , A61B5/411 , A61B5/4833 , G01N33/497
摘要： Systems and methods for diagnosing and/or treating diseases as well as monitoring disease treatment. For diagnosis, the present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. In certain embodiments, nanoparticle-based assemblies include a payload for simultaneous diagnosis and treatment of disease. In further embodiments, a therapeutic drug and therapeutic drug marker are administered to a patient to monitor disease treatment. Bodily fluid samples are analyzed using sensor technology to detect the presence of surrogate and/or therapeutic drug markers to provide an efficient and accurate means for diagnosing a disease and/or monitoring disease treatment.
摘要翻译：用于诊断和/或治疗疾病以及监测疾病治疗的系统和方法。为了诊断，本发明使用纳米颗粒基组件，其包含纳米颗粒; 替代标记以及用于检测特定化学实体的手段。在某些实施方案中，基于纳米颗粒的组件包括用于同时诊断和治疗疾病的有效载荷。在另外的实施方案中，将治疗药物和治疗药物标记物施用于患者以监测疾病治疗。使用传感器技术分析体液样品以检测替代物和/或治疗药物标记物的存在，以提供用于诊断疾病和/或监测疾病治疗的有效和准确的手段。

23. 发明授权

US07178519B2 Intubation tube placement assessment device 失效
标题翻译：插管管置放评估装置
公开(公告)号：US07178519B2
公开(公告)日：2007-02-20
申请号：US10301501
申请日：2002-11-21
申请人： Richard Melker , Dietrich Gravenstein , Andrea Gabrielli
发明人： Richard Melker , Dietrich Gravenstein , Andrea Gabrielli
IPC分类号： A61M16/00
CPC分类号： A61M16/0488 , A61M2016/0413 , A61M2230/432
摘要： A novel connection device, and method for its use, for connecting a volume displacement detection device and a gas composition detection device in line with an intubation tube is disclosed. The connection device allows a user to combine two systems commonly employed by medical personnel to assess the location of an intubation tube placed into a patient. The two systems have alternate means of assessing the location of an intubation tube in a patient and therefore, when combined into a single unit via the connection device, improve the accuracy of placing a tube in a desired location while reducing or eliminating complications associated with misplacement. A kit comprising components that may be assembled to provide a device for assessing the proper placement of an intubation tube in a patient is also disclosed. The kit may be used in any environment, but is particularly well suited for emergency, pre-hospital settings requiring intubation where quick assembly of the components is essential.
摘要翻译：公开了一种新颖的连接装置及其使用方法，用于连接体积位移检测装置和气体成分检测装置与插管一致。连接装置允许用户组合医疗人员通常使用的两个系统来评估放置在患者体内的插管的位置。两个系统具有评估插管在患者中的位置的替代方式，因此当通过连接装置组合成单个单元时，提高将管放置在所需位置的精度，同时减少或消除与错位相关的并发症。还公开了一种试剂盒，其包括可以组装以提供用于评估插管在患者体内的正确放置的装置的组件。该套件可以在任何环境中使用，但特别适用于紧急情况下，需要插管的紧急情况，需要快速组装组件是必需的。

24. 发明申请

US20060062734A1 Methods and systems for preventing diversion of prescription drugs 审中-公开
标题翻译：预防转运药物的方法和制度
公开(公告)号：US20060062734A1
公开(公告)日：2006-03-23
申请号：US10945732
申请日：2004-09-20
申请人： Richard Melker , Mark Gold
发明人： Richard Melker , Mark Gold
IPC分类号： A61K49/00
CPC分类号： G06Q50/22 , A61J1/1412 , A61J7/0418 , A61J2200/30 , G06F19/3418 , G06F19/3462
摘要： The subject invention provides systems and methods for monitoring prescription medications. In particular, systems and methods are provided for monitoring patient compliance with a given prescribed regimen as well as monitoring the origins of a prescription drug. The subject invention provides a central computer and a portable device, wherein the portable device includes at least one sensor for detecting a target marker. The target marker of the invention represents either the presence of a specific prescribed medication or identify the proper origins of a medication.
摘要翻译：本发明提供了用于监测处方药物的系统和方法。特别地，提供了系统和方法，用于监测患者对给定规定方案的依从性以及监测处方药物的来源。本发明提供了一种中央计算机和便携式设备，其中便携式设备包括用于检测目标标记的至少一个传感器。本发明的靶标表示特定处方药物的存在或鉴定药物的合适来源。

25. 发明授权

US5997891A Materials and methods utilizing a temporary visual indicator 失效
公开(公告)号：US5997891A
公开(公告)日：1999-12-07
申请号：US135768
申请日：1998-08-18
申请人： Ronnie S. Fuerst , Richard Melker , Christopher D. Batich
发明人： Ronnie S. Fuerst , Richard Melker , Christopher D. Batich
IPC分类号： A61K6/00 , A61K8/04 , A61K8/49 , A61K31/34 , A61Q17/04 , C09D7/00 , C11D3/40 , G01N31/22 , A61K7/00 , A61K7/42
CPC分类号： G01N31/221 , A61K6/0017 , A61K6/0058 , A61K8/046 , A61K8/4973 , A61Q17/04 , C09D7/00 , C11D3/40 , A61K2800/45 , Y10T428/13 , Y10T428/1352 , Y10T428/1397 , Y10T428/249995 , Y10T428/249997
摘要： This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.

26. 发明授权

US5837645A Materials and methods utilizing a temporary visual indicator 失效
公开(公告)号：US5837645A
公开(公告)日：1998-11-17
申请号：US674069
申请日：1996-07-01
申请人： Ronnie S. Fuerst , Richard Melker , Christopher D. Batich
发明人： Ronnie S. Fuerst , Richard Melker , Christopher D. Batich
IPC分类号： A61K6/00 , A61K8/04 , A61K8/49 , A61K31/34 , A61Q17/04 , C09D7/00 , C11D3/40 , G01N31/22 , B41M5/00 , A61K7/42 , B32B1/06
CPC分类号： G01N31/221 , A61K6/0017 , A61K6/0058 , A61K8/046 , A61K8/4973 , A61Q17/04 , C09D7/00 , C11D3/40 , A61K2800/45 , Y10T428/13 , Y10T428/1352 , Y10T428/1397 , Y10T428/249995 , Y10T428/249997
摘要： This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.

27. 发明申请

US20150048940A1 HAND HYGIENE COMPLICANCE CONFIRMATION SYSTEM 有权
标题翻译：手卫生合约确认系统
公开(公告)号：US20150048940A1
公开(公告)日：2015-02-19
申请号：US14234164
申请日：2012-08-17
申请人： Sam Keown , Mark Klusty , Eric Laster , Richard Melker , Henry Wohltjen , Ronald Youngblood
发明人： Sam Keown , Mark Klusty , Eric Laster , Richard Melker , Henry Wohltjen , Ronald Youngblood
IPC分类号： G08B21/24
CPC分类号： G08B21/245 , G06F19/00 , G09B19/0076 , G16H10/40 , G16H40/20
摘要： A Hand Hygiene Compliance Confirmation System (HHCCS) is disclosed for confirmation of compliance with Hand Hygiene Compliance Procedures (HHCPs) with minimized Response Time (RT) delay.
摘要翻译：公开了手卫生合规确认系统（HHCCS），以确保符合手卫生合规程序（HHCP），并以最小的响应时间（RT）延迟。

28. 发明申请

US20080059226A1 Methods and Systems for Preventing Diversion Of Prescription Drugs 审中-公开
标题翻译：防治处方药转移的方法与系统
公开(公告)号：US20080059226A1
公开(公告)日：2008-03-06
申请号：US11578322
申请日：2005-09-20
申请人： Richard Melker , Mark Gold
发明人： Richard Melker , Mark Gold
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , A61J1/1412 , A61J7/0418 , A61J2200/30 , G06F19/3418 , G06F19/3462
摘要： The subject invention provides systems and methods for monitoring prescription medications. In particular, systems and methods are provided for monitoring patient compliance with a given prescribed regimen as well as monitoring the origins of a prescription drug. The subject invention provides a central computer and a portable device, wherein the portable device includes at least one sensor for detecting a target marker. The target marker of the invention represents either the presence of a specific prescribed medication or identify the proper origins of a medication.
摘要翻译：本发明提供了用于监测处方药物的系统和方法。特别地，提供了系统和方法，用于监测患者对给定规定方案的依从性以及监测处方药物的来源。本发明提供了一种中央计算机和便携式设备，其中便携式设备包括用于检测目标标记的至少一个传感器。本发明的靶标表示特定处方药物的存在或鉴定药物的合适来源。

29. 发明申请

US20070027375A1 OPTIMIZED GAS SUPPLY USING PHOTOPLETHYSMOGRAPHY 有权
标题翻译：优化的气体供应使用光电子学
公开(公告)号：US20070027375A1
公开(公告)日：2007-02-01
申请号：US11535295
申请日：2006-09-26
申请人： Richard Melker , Brian Fuehrlein
发明人： Richard Melker , Brian Fuehrlein
IPC分类号： A61B5/00 , A61M16/00
CPC分类号： A61B5/0295 , A61B5/0205 , A61B5/02416 , A61B5/02427 , A61B5/0261 , A61B5/036 , A61B5/087 , A61B5/0873 , A61B5/14551 , A61B5/14552 , A61B5/4818 , A61B5/4836 , A61B5/6819 , A61B5/682 , A61B5/6826 , A61B5/6829 , A61B5/7278 , A61B5/7282 , A61B2560/0276 , A61B2562/247 , A61M16/0003 , A61M16/0051 , A61M16/0057 , A61M16/021 , A61M16/0666 , A61M16/0672 , A61M16/08 , A61M16/20 , A61M2202/0208 , A61M2202/03 , A61M2205/3561 , A61M2205/3569 , A61M2210/0618 , A61M2210/0625 , A61M2210/0662 , A61M2230/06 , A61M2230/205 , A61M2230/30 , A61M2230/42 , A61M2230/432 , A61M2230/005 , A61M2202/0007
摘要： The present invention relates to optimized gas supply utilizing photoplethysmography. Flow rate, pressure or amount of gas is adjusted as a function of blood oxygen saturation data, photoplethysmography signals, or both, obtained from the pulse oximeter probe.
摘要翻译：本发明涉及利用光电容积描记术优化的气体供应。流量，压力或气体量根据从脉搏血氧计探头得到的血氧饱和度数据，光谱体积描记信号或二者的函数进行调节。

30. 发明申请

US20060241506A1 Method and apparatus for diagnosing respiratory disorders and determining the degree of exacerbations 有权
标题翻译：用于诊断呼吸系统疾病和确定恶化程度的方法和装置
公开(公告)号：US20060241506A1
公开(公告)日：2006-10-26
申请号：US11122278
申请日：2005-04-25
申请人： Richard Melker , Neil Euliano
发明人： Richard Melker , Neil Euliano
IPC分类号： A61B5/08
CPC分类号： A61B5/4884 , A61B5/0205 , A61B5/02416 , A61B5/08 , A61B5/085 , A61B5/1073 , A61B5/14551 , A61B5/14552 , A61B5/411 , A61B5/4836 , A61B2560/0223 , A61M16/0069 , A61M16/1005 , A61M2205/3303 , A61M2205/3306 , A61M2205/502 , A61M2230/205
摘要： Disclosed herein are apparatuses and methods to monitor respiration and abnormal respiration events utilizing plethysmography. The apparatuses and methods provide an alternative to conventional respiration monitoring methods while enabling accurate yet minimally interruptive and invasive monitoring of respiration. The methods and apparatuses may be employed in the context of sleep studies to determine respiratory related sleep disorders.
摘要翻译：本文公开了利用体积描记法监测呼吸和异常呼吸事件的装置和方法。这些装置和方法提供了常规呼吸监测方法的替代方案，同时能够进行精确的，最小的中断和有创性的呼吸监测。可以在睡眠研究的上下文中使用方法和装置来确定呼吸相关的睡眠障碍。

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