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21. 发明授权

US06746403B2 Physiological-signal-analysis device for measuring a blood pressure and method 有权
标题翻译：用于测量血压和方法的生理信号分析装置
公开(公告)号：US06746403B2
公开(公告)日：2004-06-08
申请号：US09683911
申请日：2002-03-01
申请人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
发明人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
IPC分类号： A61B502
CPC分类号： A61B5/02225 , A61B5/021 , A61B5/02416 , A61B5/0402
摘要： A physiological-signal-analysis device for determining a blood pressure value of a patient and a method of operating the device. The device includes a cuff attachable to an extremity of the patient, a pneumatic system connected to the cuff that supplies a fluid to the cuff, a pressure transducer that measures the pressure signal having pressure oscillations, and a control unit connected to the pneumatic system and the pressure transducer. The control unit is operable to acquire a first oscillation having a first fiducial point, acquire a second oscillation having a second fiducial point, calculate a time interval representing a time from the first fiducial point to the second fiducial point, decide against selecting the second oscillation when the time interval is not a substantial integral multiple of a nominal oscillation period, and calculate a blood pressure value based on selected oscillations.
摘要翻译：一种用于确定患者的血压值的生理信号分析装置和操作该装置的方法。该装置包括可连接到患者的末端的袖带，连接到袖带的气动系统，其向袖带提供流体，测量具有压力振荡的压力信号的压力传感器，以及连接到气动系统的控制单元，压力传感器。控制单元可操作地获取具有第一基准点的第一振荡，获取具有第二基准点的第二振荡，计算表示从第一基准点到第二基准点的时间的时间间隔，决定不选择第二振荡当时间间隔不是标称振荡周期的实质整数倍时，并且基于所选择的振荡来计算血压值。

22. 发明授权

US08047998B2 Non-invasive blood pressure determination method 有权
标题翻译：无创血压测定方法
公开(公告)号：US08047998B2
公开(公告)日：2011-11-01
申请号：US11736276
申请日：2007-04-17
申请人： Sai Kolluri , Lawrence T. Hersh , Bruce A. Friedman
发明人： Sai Kolluri , Lawrence T. Hersh , Bruce A. Friedman
IPC分类号： A61B5/022
CPC分类号： A61B5/022 , A61B5/02125 , A61B5/0285 , A61B5/14551
摘要： A method for estimating systolic and diastolic pressure is disclosed herein. The method includes obtaining a predetermined type of blood pressure data from a patient, and providing previously acquired blood pressure data obtained from a plurality of different subjects. The method also includes implementing the previously acquired blood pressure data to select systolic and diastolic amplitude ratios that most closely correlate with the predetermined type of blood pressure data obtained from the patient. The selected systolic and diastolic amplitude ratios are adapted to compensate for the effects of arterial compliance. The method also includes implementing the selected systolic and diastolic amplitude ratios to generate a systolic and diastolic blood pressure estimates.
摘要翻译：本文公开了一种估计收缩压和舒张压的方法。该方法包括从患者获得预定类型的血压数据，并提供从多个不同主体获得的先前获得的血压数据。该方法还包括实施先前获得的血压数据，以选择与从患者获得的预定类型的血压数据最紧密相关的收缩和舒张振幅比。选择的收缩期和舒张期振幅比适应于补偿动脉顺应性的影响。该方法还包括实施选择的收缩和舒张振幅比以产生收缩压和舒张压。

23. 发明授权

US07678059B2 Non-invasive blood pressure monitor with improved performance 有权
标题翻译：非侵入性血压计，性能提升
公开(公告)号：US07678059B2
公开(公告)日：2010-03-16
申请号：US11248099
申请日：2005-10-12
申请人： Bruce A. Friedman , Sai Kolluri , Lawrence T. Hersh
发明人： Bruce A. Friedman , Sai Kolluri , Lawrence T. Hersh
IPC分类号： A61B5/02
CPC分类号： A61B5/02225 , A61B5/02125 , A61B5/02255 , A61B5/0402 , A61B5/0535 , A61B5/145
摘要： A blood pressure measurement system that utilizes both a non-invasive blood pressure (NIBP) monitor having a blood pressure cuff and a continuous non-invasive blood pressure (CNIBP) monitor. During operation of the NIBP monitor, the blood pressure cuff is inflated to an initial inflation pressure greater than the systolic blood pressure for the patient being monitored. The CNIBP monitor calculates an estimated blood pressure that is supplied to the NIBP monitor. The NIBP monitor utilizes the continuous, estimated blood pressure to select a target inflation pressure for the blood pressure cuff. During operation of the NIBP monitor, the size of the pressure steps from the initial inflation pressure to a final pressure can be varied based upon the continuous blood pressure estimate from the NIBP monitor.
摘要翻译：一种血压测量系统，其利用具有血压袖带的无创血压（NIBP）监测器和连续非侵入性血压（CNIBP）监测器。在NIBP监测器的操作期间，血压袖带膨胀至初始充气压力大于被监测患者的收缩压。 CNIBP监视器计算提供给NIBP监视器的估计血压。 NIBP监测器利用连续的估计血压来选择血压袖带的目标充气压力。在NIBP监视器的操作期间，从初始充气压力到最终压力的压力步长的大小可以基于来自NIBP监视器的连续血压估计而改变。

24. 发明申请

US20090177101A1 METHOD OF FETAL AND MATERNAL ECG IDENTIFICATION ACROSS MULTIPLE EPOCHS 失效
标题翻译：通过多个EPOCHS进行FETAL和MATERNAL ECG识别的方法
公开(公告)号：US20090177101A1
公开(公告)日：2009-07-09
申请号：US11970553
申请日：2008-01-08
申请人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman
发明人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman
IPC分类号： A61B5/0444
CPC分类号： A61B5/0444 , A61B5/04017 , A61B5/0472 , A61B5/04882 , A61B5/4362 , A61B5/7257 , G06F19/00 , G06K9/00536
摘要： A method of utilizing maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. The method places a series of ECG electrodes across the maternal patient's abdomen and receives ECG input waveforms across a plurality of separate channels. The method processes the channels using an ICA algorithm to generate a series of ICA output waveforms. The ICA output waveforms are analyzed for each individual epoch to determine which of the channels include a maternal signal or a fetal signal source. Based upon the determination of which channel includes the fetal and maternal signals, further processing is carried out on the ICA output waveform on the identified channel to obtain physiological properties for the patient and the fetus. During the next epoch, the same signal processing occurs, such that the system can identify the fetal and maternal signals even as the fetal and maternal jump channels from one epoch to another.
摘要翻译：一种利用母胎监测系统监测母亲患者和胎儿生理特性的方法。该方法将一系列ECG电极放置在母亲患者的腹部上，并在多个单独的通道中接收ECG输入波形。该方法使用ICA算法处理信道以产生一系列ICA输出波形。分析每个独立时期的ICA输出波形，以确定哪些通道包括母体信号或胎儿信号源。基于哪个信道包括胎儿和母体信号的确定，对所识别的信道上的ICA输出波形进行进一步处理，以获得患者和胎儿的生理特性。在下一个时代，发生相同的信号处理，使得系统可以识别胎儿和母亲信号，即使胎儿和母亲的跳跃信道从一个时期到另一个时代。

25. 发明申请

US20080262362A1 NON-INVASIVE BLOOD PRESSURE DETERMINATION METHOD 有权
标题翻译：非入血血压测定方法
公开(公告)号：US20080262362A1
公开(公告)日：2008-10-23
申请号：US11736276
申请日：2007-04-17
申请人： Sai Kolluri , Lawrence T. Hersh , Bruce A. Friedman
发明人： Sai Kolluri , Lawrence T. Hersh , Bruce A. Friedman
IPC分类号： A61B5/022
CPC分类号： A61B5/022 , A61B5/02125 , A61B5/0285 , A61B5/14551
摘要： A method for estimating systolic and diastolic pressure is disclosed herein. The method includes obtaining a predetermined type of blood pressure data from a patient, and providing previously acquired blood pressure data obtained from a plurality of different subjects. The method also includes implementing the previously acquired blood pressure data to select systolic and diastolic amplitude ratios that most closely correlate with the predetermined type of blood pressure data obtained from the patient. The selected systolic and diastolic amplitude ratios are adapted to compensate for the effects of arterial compliance. The method also includes implementing the selected systolic and diastolic amplitude ratios to generate a systolic and diastolic blood pressure estimates.
摘要翻译：本文公开了一种估计收缩压和舒张压的方法。该方法包括从患者获得预定类型的血压数据，并提供从多个不同主体获得的先前获得的血压数据。该方法还包括实施先前获得的血压数据，以选择与从患者获得的预定类型的血压数据最紧密相关的收缩和舒张振幅比。选择的收缩期和舒张期振幅比适应于补偿动脉顺应性的影响。该方法还包括实施选择的收缩和舒张振幅比以产生收缩压和舒张压。

26. 发明申请

US20090326392A1 METHOD AND SYSTEM FOR NON-INVASIVE BLOOD PRESSURE ESTIMATION 审中-公开
标题翻译：用于非入血血压估计的方法和系统
公开(公告)号：US20090326392A1
公开(公告)日：2009-12-31
申请号：US12146572
申请日：2008-06-26
申请人： Sai Kolluri , Bruce Arnold Friedman , Richard Medero , Lawrence T. Hersh
发明人： Sai Kolluri , Bruce Arnold Friedman , Richard Medero , Lawrence T. Hersh
IPC分类号： A61B5/02 , A61B19/00
CPC分类号： A61B5/022 , A61B5/02225
摘要： A method for non-invasively estimating blood pressure is disclosed herein. The method includes inflating a cuff and collecting first oscillation amplitude data at a first plurality of cuff pressure levels while inflating the cuff. The method includes identifying an artifact in the first oscillation amplitude data. The method includes identifying a specific cuff pressure level where the artifact occurs and deflating the cuff to the specific cuff pressure level. The method includes collecting second oscillation amplitude data at the specific cuff pressure level and estimating a blood pressure parameter based on both the first oscillation amplitude data and the second oscillation amplitude data. A non-invasive blood pressure system is also disclosed.
摘要翻译：本文公开了非侵入性估计血压的方法。该方法包括使袖带膨胀，并在袖带膨胀的同时以第一多个袖带压力水平收集第一振荡幅度数据。该方法包括识别第一振荡幅度数据中的伪影。该方法包括识别发生伪影的特定袖带压力水平并将袖带放气到特定袖带压力水平。该方法包括以特定袖带压力水平收集第二振荡幅度数据，并基于第一振荡幅度数据和第二振荡幅度数据两者估计血压参数。还公开了一种非侵入性血压系统。

27. 发明授权

US07311669B2 Oscillometric determination of blood pressure 有权
标题翻译：示波测定血压
公开(公告)号：US07311669B2
公开(公告)日：2007-12-25
申请号：US11082017
申请日：2005-03-16
申请人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
发明人： Sai Kolluri , Lawrence T. Hersh , Richard Medero
IPC分类号： A61B5/00
CPC分类号： A61B5/02225
摘要： A method and system for eliminating artifacts in an oscillation envelope are disclosed. The method and system comprise evaluating conformance of the oscillometric envelope blood pressure data with a predetermined expected pattern and excluding one or more data points of the oscillometric envelope blood pressure data based on non-conformance with the expected pattern. The expected pattern is based upon generally known physiological principles relating to oscillometric envelopes, a curve fit representing an oscillometric envelope from a previous determination, or other types of criteria.
摘要翻译：公开了一种用于消除振荡包络中的假象的方法和系统。所述方法和系统包括评估所述示波包络血压数据与预定预期模式的一致性，并且基于与所述期望模式的不一致性排除所述示波包络血压数据的一个或多个数据点。预期模式基于与示波包络相关的通常已知的生理原理，表示来自先前确定的示波包络的曲线拟合或其他类型的标准。

28. 发明授权

US07074192B2 Method and apparatus for measuring blood pressure using relaxed matching criteria 有权
标题翻译：使用放松的匹配标准测量血压的方法和装置
公开(公告)号：US07074192B2
公开(公告)日：2006-07-11
申请号：US10613333
申请日：2003-07-03
申请人： Bruce Arnold Friedman , Richard Medero , Lawrence T. Hersh , Sai Kolluri
发明人： Bruce Arnold Friedman , Richard Medero , Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/02405 , A61B5/021 , A61B5/02141 , A61B5/02225 , A61B5/0452
摘要： A technique for comparing pressure oscillations obtained during a blood pressure determination wherein two or more sets of matching criteria may be employed. The set of matching criteria to be employed is determined based on the heart rate variability or the presence of heart beat irregularities or arrhythmias as determined by an independent heart monitor, such as an ECG. The selected set of matching criteria may then be employed in determining the acceptability of the time interval between two oscillations and the equivalence of the two oscillations based upon one or more oscillation characteristics, such as peak amplitude. In this manner, non-consecutive oscillations may be matched and used in determining blood pressure.
摘要翻译：用于比较在血压测定期间获得的压力振荡的技术，其中可以采用两组或更多组匹配标准。基于通过独立心脏监测器（例如ECG）确定的心率变异性或心跳不规则性或心律失常的存在来确定要使用的匹配标准的集合。然后可以使用所选择的一组匹配标准来确定两个振荡之间的时间间隔的可接受性和基于一个或多个振荡特性（诸如峰值振幅）的两个振荡的等效性。以这种方式，非连续振荡可以匹配并用于确定血压。

29. 发明授权

US08740803B2 Use of the frequency spectrum of artifact in oscillometry 有权
标题翻译：在示波器中使用人造物的频谱
公开(公告)号：US08740803B2
公开(公告)日：2014-06-03
申请号：US12729883
申请日：2010-03-23
申请人： Lawrence T. Hersh , Sai Kolluri
发明人： Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/0225 , A61B5/024 , A61B5/7257
摘要： A system and method for processing oscillometric data from a plurality of pressure steps to determine the blood pressure of a patient. A heart rate monitor connected to the patient acquires the patient's heart rate. A time-to-frequency domain converter receives oscillometric data and converts the oscillometric data into the frequency domain. Based upon the calculated heart rate, the system and method filters the frequency domain oscillometric signal with pass bands centered at the fundamental frequency and at least one fundamental frequency. The energy of the frequency domain signal within the pass bands is compared to at least a portion of the energy of the frequency domain oscillometric signal outside of the pass bands. Based upon the comparison, the signal determines whether the signal at the current pressure step should be utilized in calculating the blood pressure of the patient.
摘要翻译：一种用于从多个压力步骤处理示波数据以确定患者的血压的系统和方法。连接到患者的心率监测器获取患者的心率。时域频域转换器接收示波数据并将示波数据转换为频域。基于计算出的心率，系统和方法以基频和至少一个基频为中心的通带对频域示波信号进行滤波。将通带内的频域信号的能量与通带外的频域示波信号的能量的至少一部分进行比较。基于比较，该信号确定在计算患者的血压时是否应利用当前压力步骤中的信号。

30. 发明申请

US20110237962A1 USE OF THE FREQUENCY SPECTRUM OF ARTIFACT IN OSCILLOMETRY 有权
标题翻译：在振荡中使用艺术家频率的频谱
公开(公告)号：US20110237962A1
公开(公告)日：2011-09-29
申请号：US12729883
申请日：2010-03-23
申请人： Lawrence T. Hersh , Sai Kolluri
发明人： Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B5/0225
CPC分类号： A61B5/0225 , A61B5/024 , A61B5/7257
摘要： A system and method for processing oscillometric data from a plurality of pressure steps to determine the blood pressure of a patient. A heart rate monitor connected to the patient acquires the patient's heart rate. A time-to-frequency domain converter receives oscillometric data and converts the oscillometric data into the frequency domain. Based upon the calculated heart rate, the system and method filters the frequency domain oscillometric signal with pass bands centered at the fundamental frequency and at least one fundamental frequency. The energy of the frequency domain signal within the pass bands is compared to at least a portion of the energy of the frequency domain oscillometric signal outside of the pass bands. Based upon the comparison, the signal determines whether the signal at the current pressure step should be utilized in calculating the blood pressure of the patient.
摘要翻译：一种用于从多个压力步骤处理示波数据以确定患者的血压的系统和方法。连接到患者的心率监测器获取患者的心率。时域频域转换器接收示波数据并将示波数据转换为频域。基于计算出的心率，系统和方法以基频和至少一个基频为中心的通带对频域示波信号进行滤波。将通带内的频域信号的能量与通带外的频域示波信号的能量的至少一部分进行比较。基于比较，该信号确定在计算患者的血压时是否应利用当前压力步骤中的信号。

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