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21. 发明授权

US06316472B1 Heterosubstituted pyridine derivatives as PDE 4 inhibitors 失效
公开(公告)号：US06316472B1
公开(公告)日：2001-11-13
申请号：US09551046
申请日：2000-04-17
申请人： Richard Frenette , Yves Ducharme , Sylvie Prescott
发明人： Richard Frenette , Yves Ducharme , Sylvie Prescott
IPC分类号： C07D40106
CPC分类号： C07D213/70 , A61K31/44 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3′,5′-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). The invention also encompasses pharmaceutical compositions and methods for treatment.

22. 发明授权

US5334719A Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis 失效
标题翻译：双环（氮杂芳族）吲哚作为白三烯双向合成的抑制剂
公开(公告)号：US5334719A
公开(公告)日：1994-08-02
申请号：US899399
申请日：1992-06-17
申请人： Richard Frenette
发明人： Richard Frenette
IPC分类号： C07D209/30 , C07D401/12 , C07D403/12 , C07D471/04 , C07D401/02 , A61K31/40 , C07D401/14 , C07D409/14
CPC分类号： C07D401/12 , C07D209/30 , C07D403/12 , C07D471/04
摘要： Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
摘要翻译：具有式I的化合物：I是抑制白三烯生物合成。这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。它们也可用于治疗腹泻，高血压，心绞痛，血小板聚集，脑痉挛，早产，自然流产，痛经和偏头痛。

23. 发明授权

US5204344A (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes 失效
标题翻译：（喹啉-2-基甲氧基）吲哚作为白三烯生物合成的抑制剂
公开(公告)号：US5204344A
公开(公告)日：1993-04-20
申请号：US650825
申请日：1991-02-05
申请人： Petpiboon Prasit , Rejean Fortin , John H. Hutchinson , Michel L. Belley , Serge Leger , John Gillard , Richard Frenette
发明人： Petpiboon Prasit , Rejean Fortin , John H. Hutchinson , Michel L. Belley , Serge Leger , John Gillard , Richard Frenette
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , Y10S514/826 , Y10S514/914
摘要： Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
摘要翻译：具有式I的化合物：（I）是白三烯生物合成的抑制剂。这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。它们也可用于治疗腹泻，高血压，心绞痛，血小板聚集，脑痉挛，早产，自然流产，痛经和偏头痛。

24. 发明授权

US4683325A Leukotriene antagonists 失效
标题翻译：白三烯拮抗剂
公开(公告)号：US4683325A
公开(公告)日：1987-07-28
申请号：US661560
申请日：1984-10-17
申请人： Richard Frenette , Joshua Rokach , Masatoshi Kakushima , Robert N. Young
发明人： Richard Frenette , Joshua Rokach , Masatoshi Kakushima , Robert N. Young
IPC分类号： C07C59/90 , C07D307/93 , C07C149/40
CPC分类号： C07D307/93 , C07C317/00 , C07C323/00 , C07C59/90
摘要： Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译：具有下式的化合物：I是C4，D4和E4的白细胞三烯的拮抗剂，其是过敏反应的缓慢反应物质。这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。

25. 发明授权

US08782978B1 Post footing device 有权
标题翻译：立脚装置
公开(公告)号：US08782978B1
公开(公告)日：2014-07-22
申请号：US14048503
申请日：2013-10-08
申请人： Gerry Frenette , Richard Frenette
发明人： Gerry Frenette , Richard Frenette
IPC分类号： E02D27/42 , E04H12/22
CPC分类号： E04H12/2269 , E02D27/42
摘要： A post footing device facilitates replacement of broken posts. The device includes a tube having an upper end, a lower end, and a perimeter wall extending between the upper end and the lower end. A sleeve has a top end, a bottom end, and a peripheral wall extending between the top end and the bottom end. The sleeve is insertable into the tube and configured for receiving and laterally supporting a post. Each of a plurality of alignment bars extends between the tube and the sleeve wherein the sleeve is held in position within the tube. The alignment bars are spaced around the sleeve such that the alignment bars align the sleeve in the tube. A support is positioned in the sleeve between the top end and the bottom end wherein the support is configured for supporting the post in the sleeve above the bottom end.
摘要翻译：支柱装置有助于更换破碎柱。该装置包括具有在上端和下端之间延伸的上端，下端和周边壁的管。套筒具有顶端，底端和在顶端和底端之间延伸的周壁。套管可插入到管中并且构造成用于容纳和横向支撑柱。多个对准杆中的每一个在管和套筒之间延伸，其中套筒保持在管内的适当位置。对准杆围绕套筒间隔开，使得对准杆将套管对准管中。支撑件位于套筒之间的顶端和底端之间，其中支撑件构造成用于支撑位于底端上方的套筒中的柱。

26. 发明申请

US20120208850A1 METHODS, COMPOUNDS, AND COMPOSITIONS FOR DELIVERING 1,3-PROPANEDISULFONIC ACID 有权
标题翻译：用于递送1,3-丙二酸的方法，化合物和组合物
公开(公告)号：US20120208850A1
公开(公告)日：2012-08-16
申请号：US13389606
申请日：2010-08-06
申请人： Xianqi Kong , Nigel Levens , Abderrahim Bouzide , Stephane Ciblat , Richard Frenette , Johanne Renaud
发明人： Xianqi Kong , Nigel Levens , Abderrahim Bouzide , Stephane Ciblat , Richard Frenette , Johanne Renaud
IPC分类号： A61K31/255 , C07C309/69 , A61K31/27 , A61K31/265 , C07D327/00 , A61K31/385 , C07D311/00 , A61K31/366 , C07D401/12 , A61K31/444 , A61P13/12 , A61P3/06 , A61P3/00 , A61P3/10 , A61P5/50 , A61P1/18 , C07C309/65
CPC分类号： C07C309/65 , A61K31/255 , A61K31/351 , A61K31/365 , A61K31/366 , C07C309/05 , C07C311/06 , C07C311/51 , C07C2601/04 , C07C2601/14 , C07D213/64 , C07D213/65 , C07D231/12 , C07D307/00 , C07D307/33 , C07D307/58 , C07D307/77 , C07D309/22 , C07D319/06 , C07D327/00 , C07D327/10 , C07F9/091 , C07F9/4006 , C07F9/4043
摘要： The invention relates to methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid (1,3PDS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 1,3PDS, either in vitro or in vivo. The invention also relates to sulfonate ester prodrugs of 1,3PDS as well as Gemini dimmers and oligomers of 1,3PDS for the prevention or treatment of associated diseases and conditions.
摘要翻译：本发明涉及在受试者，优选人受试者中递送1,3-丙二磺酸（1,3PDS）的方法，化合物和组合物。本发明包括在体外或体内产生或产生1,3PDS的化合物。本发明还涉及1,3PDS的磺酸酯前药以及用于预防或治疗相关疾病和病症的1,3PDS的双子座二聚体和寡聚体。

27. 发明申请

US20100312589A1 METHOD AND SYSTEM FOR IDENTIFYING AND EVALUATING THE RISK OF FAILURE OF A GEOLOGICAL CONFINEMENT SYSTEM 审中-公开
标题翻译：识别和评估地质会议制度失败风险的方法和系统
公开(公告)号：US20100312589A1
公开(公告)日：2010-12-09
申请号：US12279184
申请日：2007-02-22
申请人： Bruno Gerald , Laurent Auge , Richard Frenette , Emmanuel Houdu , Olivier Bernard , Jérôme Le Gouevec
发明人： Bruno Gerald , Laurent Auge , Richard Frenette , Emmanuel Houdu , Olivier Bernard , Jérôme Le Gouevec
IPC分类号： G06Q10/00
CPC分类号： G01V9/00 , E21B41/0064 , G06Q10/0635 , Y02C10/14 , Y02P90/84
摘要： A method for identifying the risk of failure of a geological confinement system (10), includes the following steps: acquiring data concerning the system; based on said data concerning the system, breaking down the system into a plurality of components (11-17); modelling at least one component by at least one volume (131-134), the modelling being performed by discretizing in volume the component; generating at least one failure scenario of the system, the generation including at least one iteration of the following steps: analyzing a state of at least one volume modelling at least one component of the system; detecting, based on the state of the volume, at least one potential failure mode of the volume. The inventive method and system enable the risks of failure of any system of geological confinement, natural and/or artificial, in particular oil tanks used for storing CO2, to be identified.
摘要翻译：一种确定地质限制系统（10）故障风险的方法，包括以下步骤：获取有关系统的数据; 基于关于所述系统的所述数据，将所述系统分解为多个组件（11-17）; 通过至少一个体积（131-134）对至少一个组件进行建模，所述建模通过以体积离散所述组件来执行; 生成所述系统的至少一个故障场景，所述生成包括以下步骤的至少一个迭代：分析至少一个体积建模所述系统的至少一个组件的状态; 根据卷的状态检测卷的至少一个潜在故障模式。本发明的方法和系统使得能够识别任何天然和/或人造地质限制系统（特别是用于储存二氧化碳的油罐）的故障的风险。

28. 发明授权

US06639077B2 Tri-aryl-substituted-ethane PDE4 inhibitors 失效
公开(公告)号：US06639077B2
公开(公告)日：2003-10-28
申请号：US10112535
申请日：2002-03-29
申请人： Bernard Cote , Evelyn Martins , Richard Frenette , Rick Friesen , Yves Ducharme
发明人： Bernard Cote , Evelyn Martins , Richard Frenette , Rick Friesen , Yves Ducharme
IPC分类号： C07D40110
CPC分类号： C07D417/06
摘要： Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.

29. 发明授权

US5389650A (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis 失效
标题翻译：（氮杂芳基甲氧基）吲哚作为白细胞三烯生物合成的抑制剂
公开(公告)号：US5389650A
公开(公告)日：1995-02-14
申请号：US951635
申请日：1992-09-25
申请人： Richard Frenette , John W. Gillard , John H. Hutchinson , Petpiboon Prasit , Michel Therien
发明人： Richard Frenette , John W. Gillard , John H. Hutchinson , Petpiboon Prasit , Michel Therien
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/495 , A61K31/505 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D401/12 , C07D403/06 , C07D403/12
CPC分类号： C07D401/12 , C07D403/06 , C07D403/12
摘要： Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
摘要翻译：具有式I的化合物：I是抑制白三烯生物合成。这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。它们也可用于治疗腹泻，高血压，心绞痛，血小板聚集，脑痉挛，早产，自然流产，痛经和偏头痛。

30. 发明授权

US4857659A Stereoselective synthesis of leukotriene antagonists 失效
标题翻译：白三烯拮抗剂的立体选择性合成
公开(公告)号：US4857659A
公开(公告)日：1989-08-15
申请号：US38814
申请日：1987-04-15
申请人： Richard Frenette , Jacques-Yves Gauthier , Robert N. Young , Robert Zamboni , Masatoshi Kakushima , Thomas R. Verhoeven
发明人： Richard Frenette , Jacques-Yves Gauthier , Robert N. Young , Robert Zamboni , Masatoshi Kakushima , Thomas R. Verhoeven
IPC分类号： C07C51/09 , C07C59/64 , C07C67/00 , C07C313/00 , C07C315/04 , C07C317/46 , C07C319/20 , C07C323/62 , C07D307/33
CPC分类号： C07D307/33 , C07C51/09
摘要： The present invention relates to a stereo-selective synthesis of leukotriene antagonists. More particularly, this invention relates to the stereo-selective synthesis of (.beta.S,.gamma.R) and (.beta.R,.gamma.S)-4-((3-(4-acetyl-3-hydroxy-2-propyl(phenoxy)propyl)-thio-.gamma.-hydroxy-.beta.-methylbenzenebutanoic acid, and related compounds. These compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular, disorders, inflammation and pain in mammals, especially humans. The compounds are also useful for inducing cytoprotection in mammals, especially humans.

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