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21. 发明授权

US5627163A Treatment of traveller's diarrhea 失效
标题翻译：治疗旅行者腹泻
公开(公告)号：US5627163A
公开(公告)日：1997-05-06
申请号：US461294
申请日：1995-06-05
申请人： Louis D. Heerze , Glen D. Armstrong
发明人： Louis D. Heerze , Glen D. Armstrong
IPC分类号： C07H15/00 , A61K31/70 , A61K31/7028 , A61K47/48 , A61P31/04 , A61K31/715
CPC分类号： A61K47/48861 , Y10S514/867 , Y10S514/946 , Y10S514/965
摘要： This invention relates to treatment of traveller's diarrhea, including diarrhea caused by enterotoxigenic Escherichia coli (ETEC) which treatment uses an oligosaccharide-containing composition. The composition contains an oligosaccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm. The oligosaccharide-containing composition binds E. coli heat-labile toxin (LT) and/or one or more serotypes of enterotoxigenic E. coli organisms. More specifically, the invention relates to prevention of ETEC from colonizing the intestinal tract and inducing disease. This invention also concerns neutralization and removal of LT associated with traveller's diarrhea.
摘要翻译：本发明涉及治疗旅行者腹泻，包括由产生肠毒素的大肠杆菌（ETEC）引起的腹泻，该治疗使用含有寡糖的组合物。该组合物含有通过非肽基相容的连接臂共价连接到药学上可接受的固体惰性支持物上的寡糖序列。含寡糖的组合物结合大肠杆菌热不稳定毒素（LT）和/或一种或多种肠毒素性大肠杆菌生物体血清型。更具体地，本发明涉及ETEC的防止肠道定植和诱导疾病。本发明还涉及与旅行者腹泻相关的LT的中和和去除。

22. 发明授权

US06262037B1 Pharmaceutical compositions for the amelioration of enteropathogenic E. coli infection 失效
标题翻译：用于改善肠道致病性大肠杆菌感染的药物组合物
公开(公告)号：US06262037B1
公开(公告)日：2001-07-17
申请号：US09058776
申请日：1998-04-13
申请人： Glen D. Armstrong , Rosa P. Vanmaele
发明人： Glen D. Armstrong , Rosa P. Vanmaele
IPC分类号： A61K31715
CPC分类号： C07H3/04 , C07H3/06 , G01N33/56916
摘要： Therapeutic and diagnostic methods are provided for treatment and detection of enteropathogenic E. coli (EPEC) enteric infections. Also provided is an assay for the identification of compositions which are effective inhibitors of EPEC infection.
摘要翻译：提供治疗和诊断方法用于治疗和检测肠道致病性大肠杆菌（EPEC）肠道感染。还提供了用于鉴定作为EPEC感染的有效抑制剂的组合物的测定法。

23. 发明授权

US06224891B1 Compounds and methods for the treatment of bacterial dysentery using antibiotics and toxin binding oligosaccharide compositions 失效
标题翻译：使用抗生素和毒素结合寡糖组合物治疗细菌性痢疾的化合物和方法
公开(公告)号：US06224891B1
公开(公告)日：2001-05-01
申请号：US09255709
申请日：1999-02-23
申请人： David John Rafter , Robert Murray Ratcliffe , Bradley G. Thompson , Glen D. Armstrong
发明人： David John Rafter , Robert Murray Ratcliffe , Bradley G. Thompson , Glen D. Armstrong
IPC分类号： A01N2526
CPC分类号： A61K31/70 , A61K45/06 , A61K47/52 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： This invention relates to the treatment of diarrhea and related conditions caused by pathogenic E. coli infection. More specifically, this invention is drawn to the unexpected discovery that by administering a composition which binds and removes the shiga like toxins (SLT) produced by pathogenic E. coli whenever an antibiotic is administered, improved treatment is provided. Novel compositions containing both antibiotic and toxin binding composition and methods of treatment which use simultaneous administration toxin binding composition whenever antibiotic is administered are provided. These compositions and methods kill the enteric E. coli organisms which produce the conditions and neutralize the SLT produced by the organisms and/or released from the organisms when they are killed. Thus, these compositions and methods are better able to ameliorate the symptoms of the infection and inhibit progression of this infection into hemolytic uremic syndrome (HUS) than conventional treatment.
摘要翻译：本发明涉及由病原性大肠杆菌感染引起的腹泻及相关病症的治疗。更具体地，本发明涉及意想不到的发现：通过施用结合和除去由致病性大肠杆菌产生的志贺样毒素（SLT）的组合物，每当施用抗生素时，提供改进的治疗。提供了含抗生素和毒素结合组合物的新型组合物和每当施用抗生素时同时施用毒素结合组合物的治疗方法。这些组合物和方法杀死产生条件的肠道大肠杆菌生物体，并中和由生物体产生的SLT和/或当它们被杀死时从生物体中释放出来。因此，这些组合物和方法能够比常规治疗更好地改善感染的症状并抑制这种感染进入溶血性尿毒综合征（HUS）的进展。

24. 发明授权

US5891860A Treatment of traveller's diarrhea 失效
标题翻译：治疗旅行者腹泻
公开(公告)号：US5891860A
公开(公告)日：1999-04-06
申请号：US973443
申请日：1998-04-16
申请人： Louis D. Heerze , Glen D. Armstrong
发明人： Louis D. Heerze , Glen D. Armstrong
IPC分类号： A61K31/70 , A61K31/715
CPC分类号： A61K31/70 , Y10S514/867
摘要： This invention relates to treatment of traveller's diarrhea, including diarrhea caused by enterotoxigenic Escherichia coli (ETEC), using an oligosaccharide-containing composition. The composition contains an oligosaccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm. The oligosaccharide-containing composition binds E. coli heat-labile toxin (LT). More specifically, the invention concerns neutralization and removal of LT associated with traveller's diarrhea.
摘要翻译： PCT No.PCT / CA96 / 00144 Sec。 371日期：1998年4月16日 102（e）日期1998年4月16日PCT 1996年3月11日PCT公布。 WO96 / 39189 PCT公开号日期1996年12月12日本发明涉及使用含寡糖组合物治疗旅行者腹泻，包括肠毒素性大肠杆菌（ETEC）引起的腹泻。该组合物含有通过非肽基相容的连接臂共价连接到药学上可接受的固体惰性支持物上的寡糖序列。含有寡糖的组合物结合大肠杆菌热不稳定毒素（LT）。更具体地，本发明涉及与旅行者腹泻相关的LT的中和和去除。

25. 发明授权

US5747040A Anti-inflammatory, tolerogenic and immunoinhibiting properties of carbohydrate binding-peptides 失效
标题翻译：碳水化合物结合肽的抗炎，致耐受和免疫抑制性质
公开(公告)号：US5747040A
公开(公告)日：1998-05-05
申请号：US390790
申请日：1995-02-17
申请人： Louis D. Heerze , Glen D. Armstrong , Richard Smith
发明人： Louis D. Heerze , Glen D. Armstrong , Richard Smith
IPC分类号： A61K38/36 , A61K38/00 , A61K38/16 , A61K38/46 , A61K38/47 , A61K39/35 , A61P1/00 , A61P9/00 , A61P11/00 , A61P15/04 , A61P29/00 , A61P37/00 , C07K7/06 , C07K14/235 , C07K14/42 , A61K39/10
CPC分类号： A61K38/45 , C07K14/235 , Y10S514/885 , Y10S530/868
摘要： The present invention is directed to methods of suppressing inflammatory responses, inducing tolerance to an antigen, and suppressing cell adhesion, e.g., involved in metastasis, by the administration of lectin derived carbohydrate binding peptides or derivatives thereof, in particular, peptides capable of binding terminally linked .alpha.-sialic acid(2.fwdarw.6).beta.Gal- and/or .alpha.-sialic acid(2.fwdarw.3).beta.Gal- groups on structures or molecules comprising such groups. Pharmaceutical compositions containing such lectin derived carbohydrate binding peptides or derivatives thereof are also disclosed.
摘要翻译：本发明涉及通过施用凝集素衍生的碳水化合物结合肽或其衍生物，特别是能够结合末端的肽来抑制炎性反应，诱导对抗原的耐受性和抑制细胞粘附，例如参与转移的方法包含这些基团的结构或分子上连接的α-山梨醇酸（2-> 6）β-Gal-和/或α-山梨酸（2-> 3）βGal-基团。还公开了含有这种凝集素衍生的碳水化合物结合肽或其衍生物的药物组合物。

26. 发明授权

US5661131A Treatment of cholera 失效
标题翻译：治疗霍乱
公开(公告)号：US5661131A
公开(公告)日：1997-08-26
申请号：US442457
申请日：1995-06-05
申请人： Louis D. Heerze , Glen D. Armstrong
发明人： Louis D. Heerze , Glen D. Armstrong
IPC分类号： C07H15/00 , A61K31/70 , A61K31/7028 , A61K47/48 , A61P31/04
CPC分类号： A61K47/48861 , Y10S514/837
摘要： This invention relates to treatment of cholera and related conditions using oligosaccharide compositions which bind V. cholerae toxin and/or one or more serotypes of the organism V. cholerae. More specifically, the invention concerns neutralization and removal of V. cholerae toxin and/or organisms from the intestinal tract.
摘要翻译：本发明涉及使用结合霍乱弧菌的霍乱弧菌毒素和/或一种或多种血清型的寡糖组合物来治疗霍乱和相关病症。更具体地，本发明涉及从肠道中和和去除霍乱弧菌毒素和/或生物体。

27. 发明授权

US5484773A Treatment of antibiotic associated diarrhea 失效
标题翻译：治疗抗生素相关性腹泻
公开(公告)号：US5484773A
公开(公告)日：1996-01-16
申请号：US195009
申请日：1994-02-14
申请人： Louis D. Heerze , Glen D. Armstrong
发明人： Louis D. Heerze , Glen D. Armstrong
IPC分类号： A61K47/48 , C07K14/33 , A61K31/70
CPC分类号： A61K47/48861 , C07K14/33 , Y10S514/867
摘要： This invention relates to treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD) and pseudomembranous colitis (PMC), using oligosaccharide compositions which bind C. difficile toxin A. More specifically, the invention concerns neutralization of C. difficile toxin A associated with CDAD.
摘要翻译：本发明涉及使用结合艰难梭菌毒素A的寡糖组合物治疗抗生素相关性腹泻，包括难辨梭状芽孢杆菌相关性腹泻（CDAD）和假膜性结肠炎（PMC）。更具体地，本发明涉及艰难梭菌毒素A相关的中和与CDAD。

28. 发明授权

US06245883B1 Anti-flammatory carbohydrate binding-peptides 失效
标题翻译：抗炎性碳水化合物结合肽
公开(公告)号：US06245883B1
公开(公告)日：2001-06-12
申请号：US09149860
申请日：1998-09-09
申请人： Louis D. Heerze , Glen D. Armstrong , Richard Smith
发明人： Louis D. Heerze , Glen D. Armstrong , Richard Smith
IPC分类号： A61K3800
CPC分类号： A61K38/45 , C07K14/235 , Y10S514/885 , Y10S530/868
摘要： The present invention is directed to lectin derived carbohydrate binding peptides or derivatives thereof useful for suppressing inflammatory responses, inducing tolerance to an antigen, and suppressing cell adhesion, e.g., involved in metastasis. In particular, peptides capable of binding terminally linked &agr;-sialic acid(2-6)&bgr;Gal- and/or &agr;-sialic acid(2-3)&bgr;Gal-groups on structures or molecules comprising such groups are provided. Pharmaceutical compositions containing such lectin derived carbohydrate binding peptides are also disclosed.
摘要翻译：本发明涉及用于抑制炎症反应，诱导对抗原的耐受性和抑制细胞粘附的凝血素衍生的碳水化合物结合肽或其衍生物，例如参与转移。特别地，提供了能够在包含这些基团的结构或分子上结合末端连接的α-唾液酸（2-6）βGal-和/或α-唾液酸（2-3）βGal-基团的肽。还公开了含有凝集素衍生的碳水化合物结合肽的药物组合物。

29. 发明授权

US6121242A Treatment of bacterial dysentery 失效
标题翻译：治疗细菌性痢疾
公开(公告)号：US6121242A
公开(公告)日：2000-09-19
申请号：US296584
申请日：1999-04-23
申请人： David J. Rafter , Bradley G. Thompson , Peter N. McLaine , Peter C. Rowe , Elaine Orrbine , Terrance P. Klassen , Glen D. Armstrong , Paul R. Goodyer , Andrew M. MacKenzie , George A. Wells , Hermy Lior , Francois Auclair
发明人： David J. Rafter , Bradley G. Thompson , Peter N. McLaine , Peter C. Rowe , Elaine Orrbine , Terrance P. Klassen , Glen D. Armstrong , Paul R. Goodyer , Andrew M. MacKenzie , George A. Wells , Hermy Lior , Francois Auclair
IPC分类号： C08B37/00 , A61K31/70 , A61K47/48 , A61P31/04 , A61K31/695
CPC分类号： A61K31/7016 , A61K31/702 , A61K47/48861
摘要： Disclosed are methods for the neutralization of shiga-like toxins (SLT) associated with enteric E. coli infection which methods inhibit progression of this infection into hemolytic uremic syndrome (HUS).
摘要翻译：公开了用于中和与肠道大肠杆菌感染相关的志贺样毒素（SLT）的方法，其方法抑制该感染进入溶血性尿毒症综合征（HUS）。

30. 发明授权

US5955449A Diagnosis and treatment of bacterial dysentery 失效
标题翻译：诊断和治疗细菌性痢疾
公开(公告)号：US5955449A
公开(公告)日：1999-09-21
申请号：US868929
申请日：1997-06-04
申请人： Glen D. Armstrong , Robert M. Ratcliffe
发明人： Glen D. Armstrong , Robert M. Ratcliffe
IPC分类号： A61K38/00 , A61K47/48 , A61P31/04 , C07K14/245 , G01N33/569 , A61K31/70 , A61K31/715 , A61K31/695
CPC分类号： C07K14/245 , G01N33/56916 , A61K38/00 , G01N2469/00
摘要： Diagnostic and therapeutic compositions which comprise the .alpha.Gal(1-4).beta.Gal subunit are described. These compositions permit the rapid diagnosis and treatment of enteric infections caused by E. coli that produce shiga-like toxins (SLT).
摘要翻译：描述了包含αGal（1-4）βGal亚基的诊断和治疗组合物。这些组合物允许快速诊断和治疗由产生志贺样毒素（SLT）的大肠杆菌引起的肠道感染。

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