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21. 发明授权

US08506621B2 Flow-deflecting medical device 有权
标题翻译：流量偏转医疗器械
公开(公告)号：US08506621B2
公开(公告)日：2013-08-13
申请号：US13355959
申请日：2012-01-23
申请人： Charles W. Agnew , Ram H. Paul, Jr.
发明人： Charles W. Agnew , Ram H. Paul, Jr.
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016
摘要： The disclosure relates to a flow-deflecting medical device comprising a support structure and two flow-deflecting members attached to the support structure. The first flow-deflecting member is movable to a position in which it contacts and substantially seals against the second flow-deflecting member.
摘要翻译：本发明涉及一种流动偏转医疗装置，其包括支撑结构和附接到支撑结构的两个流动偏转构件。第一流动偏转构件可移动到其接触并基本上密封第二流动偏转构件的位置。

22. 发明授权

US08500772B2 Distal protection device 有权
标题翻译：远端保护装置
公开(公告)号：US08500772B2
公开(公告)日：2013-08-06
申请号：US11688430
申请日：2007-03-20
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0093
摘要： The present invention provides, in certain aspects, devices and methods for protecting the body from downstream embolization. In one embodiment, a distal protection device comprises a shaft and a jacket with the shaft being received within the jacket. The device also includes a filter, which is supported by a wire cone that has one end attached to the jacket and an opposite end attached to the shaft. The shaft is rotatable relative to the jacket to reduce the size of the cone for capturing embolic debris within the wire cone. The invention also provides such devices in combination with instruments (e.g., balloon stent catheters) for treating stenosis and other similar conditions.
摘要翻译：本发明在某些方面提供了用于保护身体免受下游栓塞的装置和方法。在一个实施例中，远侧保护装置包括轴和夹套，所述轴被容纳在护套内。该装置还包括一个过滤器，该过滤器由电线锥体支撑，其中一端连接到护套上，另一端连接到轴上。轴可相对于护套旋转以减小用于捕获线锥内的栓塞碎片的锥体的尺寸。本发明还提供了用于治疗狭窄和其他类似病症的器械（例如气囊支架导管）的这种装置。

23. 发明授权

US08216299B2 Method to retract a body vessel wall with remodelable material 有权
标题翻译：用可重塑材料收回体管壁的方法
公开(公告)号：US08216299B2
公开(公告)日：2012-07-10
申请号：US11095209
申请日：2005-03-31
申请人： Ram H. Paul, Jr. , Brian C. Case
发明人： Ram H. Paul, Jr. , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61L27/367 , A61F2/2475 , A61F2/82 , A61F2/958 , A61F2210/0004 , A61L27/227 , A61L27/3633 , A61L27/3641 , A61L27/3645
摘要： The present invention provides remodelable materials for retracting the interior walls of a body vessel via remodeling processes. Also provided are methods, kits and devices for the same.
摘要翻译：本发明提供了用于通过重塑过程回缩身体血管的内壁的可重塑材料。还提供了相同的方法，套件和设备。

24. 发明授权

US07776052B2 Medical grasping device 有权
标题翻译：医疗夹具
公开(公告)号：US07776052B2
公开(公告)日：2010-08-17
申请号：US10003011
申请日：2001-11-01
申请人： Roy K. Greenberg , Krasnodar Ivancev , Ram H. Paul, Jr.
发明人： Roy K. Greenberg , Krasnodar Ivancev , Ram H. Paul, Jr.
IPC分类号： A61F11/00
CPC分类号： A61B17/221 , A61B2017/00867 , A61B2017/22035 , A61B2017/22038 , A61B2017/2215 , A61B2090/08021 , A61F2/95
摘要： A medical grasping device (10) for vascular use, having an outer sheath (12), an elongate control member (50) extending within an outer sheath (12) to a distal tip section (54), and a proximal control assembly (22) including an actuation section (24) joined to the elongate control member (50). Adjacent to the distal tip section (54) is a grasping portion (70,70′) that is extendable from the outer sheath (12) to create loops (74,74′) for grasping a target object (T) for repositioning within the vascular system, or for removal from the patient, with loops being retractable into the outer sheath to hold the target object against the device (10) during movement of the device. Elongate control member (50) is preferably a cannula or tube having a lumen (58) extending completely therethrough for placement over a guide wire (28) already in the patient.
摘要翻译：一种用于血管使用的医疗夹持装置（10），具有外护套（12），在外护套（12）内延伸到远侧末端部分（54））的细长控制构件（50）和近端控制组件）包括连接到细长控制构件（50）的致动部分（24）。与远侧末端部分（54）相邻的是抓握部分（70,70'），其可从外部护套（12）延伸以产生用于抓握目标物体（T）的环（74,74'），用于重新定位血管系统或用于从患者移除的环，其中环可缩回到外护套中，以在装置移动期间将目标物体抵靠装置（10）保持。细长控制构件（50）优选地是具有完全延伸穿过其中的内腔（58）的插管或管，用于放置在已经在患者体内的引导线（28）上。

25. 发明授权

US07691140B2 Anastomosis device for vascular access 有权
标题翻译：用于血管通路的吻合装置
公开(公告)号：US07691140B2
公开(公告)日：2010-04-06
申请号：US10843816
申请日：2004-05-12
申请人： Brian L. Bates , Clay D. Fette , Ram H. Paul, Jr. , Paul D. Amarant
发明人： Brian L. Bates , Clay D. Fette , Ram H. Paul, Jr. , Paul D. Amarant
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/0644 , A61B2017/00252 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61F2/064 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2230/005
摘要： An anastomosis device (12) for advantageously bridging an artery and a vein. The anastomosis device includes a tubular graft (15) with first and second ends (47 and 48) and a longitudinal passageway extending longitudinally through the graft. The device further includes a first stent (10) disposed about the first end of the tubular graft and a second stent (10) disposed about the second end of the tubular graft. Each of the first and second stents has a plurality of hooks or barbs (11) pointed or releasable to the point toward the other end of the graft.
摘要翻译：一种用于有利地桥接动脉和静脉的吻合装置（12）。吻合装置包括具有第一和第二端（47和48）的管状移植物（15）和纵向延伸穿过移植物的纵向通道。该装置还包括围绕管状移植物的第一端设置的第一支架（10）和围绕管状移植物的第二端设置的第二支架（10）。第一和第二支架中的每一个具有多个钩或倒钩（11），所述钩或倒钩可指向或可释放到朝向移植物另一端的点。

26. 发明授权

US07604661B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

27. 发明授权

US06416499B2 Medical fluid flow control valve 失效
标题翻译：医用流体流量控制阀
公开(公告)号：US06416499B2
公开(公告)日：2002-07-09
申请号：US09126335
申请日：1998-07-30
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61M514
CPC分类号： A61M39/0606 , A61M39/0613 , A61M2039/062 , A61M2039/0633 , A61M2039/064 , A61M2039/0653 , A61M2039/066
摘要： A valve (10) useful as a fluid flow check valve or as a self-sealing, penetrable, hemostatic valve for sealing a catheter introducer (12) includes a seal (26) which is highly resistant to tearing and leakage, yet is capable of accepting repeated penetrations by devices of a wide variety of diameters. The seal (26) is disk-shaped and is composed of a thermoplastic styrenic elastomer, such as a styrene-ethylene/butylene-styrene block copolymer, of very low durometer (a hardness of no more than about 30 Shore A). The seal (26) is preferably contained in a valve body (40) and is disposed between a valve seat (48) in the valve body (40) and a cap (56) connected to the valve body (40) and becomes deflected upon assembly of the valve. The seal (26) includes at least one perforation (34) closed by such deflection. This deflection also provides the seal (26) with a proximal or upstream concave surface (30), and this deflection along with the clamping of the periphery of the seal by and between the cap and the valve seat, makes it highly resistant to inversion during repeated removals and manipulations of interventional devices passing through the valve (10). The valve (10) of the present invention is particularly advantageous in that it seals the introducer (12) with a high degree of effectiveness when no interventional device lies across its seal (26), and in that it offers a high resistance to tearing when penetrated by devices of large diameter.
摘要翻译：用作流体流动止回阀或用作密封导管引入器（12）的自密封，可穿透的止血阀的阀（10）包括密封件（26），其高度抵抗撕裂和渗漏，但是能够接受由各种直径的装置重复的穿透。密封件（26）是圆盘形的，并且由诸如苯乙烯 - 乙烯/丁烯 - 苯乙烯嵌段共聚物的热塑性苯乙烯弹性体组成，其硬度非常低（硬度不超过约30肖氏A）。密封件26优选地包含在阀体40中并且设置在阀体40内的阀座48和与阀体40连接的盖56之间，组装阀门。密封件（26）包括由这种偏转关闭的至少一个穿孔（34）。该偏转还使密封件（26）具有近端或上游凹形表面（30），并且这种偏转以及由帽盖和阀座之间以及在阀座之间夹紧密封件的周边使得其在通过阀（10）的介入装置的重复移除和操作。本发明的阀（10）特别有利的是，当没有介入装置位于其密封件（26）上时，它以高效率的方式密封导引器（12），并且因为它提供了高的撕裂能力穿透大直径的装置。

28. 发明授权

US08403977B2 Self-orienting delivery system 有权
标题翻译：自动送货系统
公开(公告)号：US08403977B2
公开(公告)日：2013-03-26
申请号：US11800292
申请日：2007-05-04
申请人： Brian C. Case , Ram H. Paul, Jr.
发明人： Brian C. Case , Ram H. Paul, Jr.
IPC分类号： A61F2/06 , A61F2/84 , A61M29/02
CPC分类号： A61M25/01 , A61F2/95 , A61F2002/30125 , A61F2002/30538 , A61F2230/0008 , A61F2250/0006 , A61M25/0074 , A61M25/0082
摘要： Delivery systems for delivering and deploying expandable intraluminal medical devices within a body vessel are provided. A portion of the delivery system that includes the expandable intraluminal medical device orients itself about an axis based on characteristics of the body vessel, such as the relative orientation of major and minor axes of the vessel. This allows the intraluminal medical device to be deployed in the vessel in a desired orientation relative to the vessel. Embodiments can be used with any suitable intraluminal medical device, including valve devices, stents, drug-coated stents, filters, and other suitable devices. Methods of delivering and deploying intraluminal medical devices are also described.
摘要翻译：提供了用于在身体容器内递送和部署可膨胀的管腔内医疗装置的输送系统。包括可扩展的管腔内医疗装置的输送系统的一部分基于身体血管的特征（例如血管的主轴和短轴的相对取向）绕轴线定向。这允许管腔内医疗装置相对于容器以期望的方向部署在容器中。实施例可以与任何合适的管腔内医疗装置一起使用，包括瓣膜装置，支架，药物涂层的支架，过滤器和其它合适的装置。还描述了递送和部署管腔内医疗装置的方法。

29. 发明授权

US08398663B2 Valvulotome device and method 有权
标题翻译：瓣膜切除装置及方法
公开(公告)号：US08398663B2
公开(公告)日：2013-03-19
申请号：US12781300
申请日：2010-05-17
申请人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices and methods are provided. Valvulotome devices include one or more valvulotome arms that have a u-shaped curved body with opposing arms and a base portion that extends between the arms. The valvulotome arm defines a notch open at one end on one of the arms and extending into the base portion of the u-shaped curved body. The notch defines an angled surface that provides a cutting edge. Methods of making valvulotome devices are also described.
摘要翻译：提供瓣膜切除装置和方法。瓣膜切开装置包括一个或多个瓣膜切开臂，其具有带相对臂的u形弯曲体和在臂之间延伸的基部。瓣膜切开臂限定了在一个臂上的一端处开口并且延伸到U形弯曲体的基部中的凹口。切口限定了提供切削刃的成角度的表面。还描述了制造瓣膜切开术装置的方法。

30. 发明申请

US20120232636A1 METHOD AND DEVICE FOR VASCULAR THERAPY 审中-公开
标题翻译：用于血管治疗的方法和装置
公开(公告)号：US20120232636A1
公开(公告)日：2012-09-13
申请号：US13476292
申请日：2012-05-21
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61F2/82 , A61F2/84
CPC分类号： A61M29/02 , A61M2025/0024 , A61M2025/0096 , A61M2025/0188
摘要： Medical devices, as well as methods of treatment and manufacturing such devices, are provided for applying vascular therapy locally within the body vessel. The medical devices include an expandable tubular frame and a sleeve. The medical devices can be used for local delivery of a therapeutic agent within a body vessel or a tamponade for a lacerated body vessel, while simultaneously allowing perfusion of fluid or blood flow distal of the implanted medical device. The tubular frame of the medical device can have a middle region with a plurality of members. The members can expand radially outward away from a longitudinal axis of the tubular frame, which can urge the sleeve to contact the wall of the body vessel. In the expanded configuration, a portion of the device allows fluid flow to continue while the sleeve is against the body vessel wall.
摘要翻译：提供医疗装置以及治疗和制造这种装置的方法，用于在体内血管局部施用血管治疗。医疗装置包括可扩张的管状框架和套筒。医疗装置可用于局部递送用于撕裂体血管的体内容器或填塞物中的治疗剂，同时允许灌注植入的医疗装置的远端的流体或血液流。医疗装置的管状框架可以具有带有多个构件的中间区域。构件可以从管状框架的纵向轴线径向向外膨胀，这可以促使套筒接触身体容器的壁。在扩展构型中，当套管抵靠身体血管壁时，该装置的一部分允许流体流动继续。

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