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21. 发明申请

WO2008012837A1 PROCESS FOR PRODUCING 10-OXO-L10, 11-DIHYDR0-5H-DIBENZ [B, F] AZEPINE-5-CARBOXAMIDE STARTING FROM 5-CYANOIMINOSTILBENE 审中-公开
标题翻译：从5-氰基咪唑开始制备10-OXO-L10,11-二氢-5H-二苯并[B，F]氮杂卓-5-羧酰胺的方法
公开(公告)号：WO2008012837A1
公开(公告)日：2008-01-31
申请号：PCT/IN2007/000307
申请日：2007-07-24
申请人： JUBILANT ORGANOSYS LIMITED , SINGH, Harnam , GUPTA, Nitin , KUMAR, Parmod , DUBEY, Sushil, Kumar
发明人： SINGH, Harnam , GUPTA, Nitin , KUMAR, Parmod , DUBEY, Sushil, Kumar
IPC分类号： C07D223/26 , C07D223/28
CPC分类号： C07D223/26 , C07D223/28
摘要： Disclosed herein is a process for producing 10-oxo-10,11-dihydro-5H-dibenz[ bf ] azepine-5-carboxamide of formula I via novel intermediates 11-alkoxy-10-halo-10,11-dihydro-5H-dibenzo [ b,f ] azepine-5-carbonitrile [XIX] or 10-alkoxy-5H-dibenz [ b,f ] azepine -5-carbonitrile [XX]. Further the present invention also provides a process for preparation of said intermediates.
摘要翻译：本文公开了通过新中间体11生产式I的10-氧代-10,11-二氢-5H-二苯并[b] az -5-甲酰胺的方法 - 烷氧基-10-卤代-10,11-二氢-5H-二苯并[b，f]吖庚因-5-腈[XIX]或10-烷氧基-5H-二苯并[b， f]吖庚因-5-腈[XX]。此外，本发明还提供了制备所述中间体的方法。

22. 发明授权

EP1900126B1 SERIAL CLUSTERING 有权
标题翻译：串行集群
公开(公告)号：EP1900126B1
公开(公告)日：2015-10-21
申请号：EP06844157.5
申请日：2006-07-26
申请人： Riverbed Technology, Inc.
发明人： WU, David Tze-Si , GUPTA, Nitin , LY, Kand
IPC分类号： H04J1/16 , H04L29/08 , H04L29/06
CPC分类号： H04L47/12 , H04L47/10 , H04L47/125 , H04L69/16 , H04L69/162 , H04L69/165 , H04L69/32

23. 发明申请

WO2013069027A1 PROCESSES FOR THE PREPARATION OF CABAZITAXEL INVOLVING C(7) -OH AND C(13) -OH SILYLATION OR JUST C(7) -OH SILYLATION 审中-公开
标题翻译：涉及C（7）-OH和C（13）-OH硅烷的CABAZITAXEL的制备方法或者只是C（7）-OH硅烷化
公开(公告)号：WO2013069027A1
公开(公告)日：2013-05-16
申请号：PCT/IN2012/000630
申请日：2012-09-21
申请人： FRESENIUS KABI ONCOLOGY LTD. , LAHIRI, Saswata , GUPTA, Nitin , AZIM, Abul , PANDA, Nilendu , MISHRA, Bhuwan Bhaskar , SANGHANI, Sunil
发明人： LAHIRI, Saswata , GUPTA, Nitin , AZIM, Abul , PANDA, Nilendu , MISHRA, Bhuwan Bhaskar , SANGHANI, Sunil
IPC分类号： C07D305/14 , A61K31/335
CPC分类号： C07F7/1856 , C07D305/14
摘要： Disclosed are processes towards Cabazitaxel (I) starting from 10-Deacetylbaccatin (III) that involve steps of either 7-OH monosilylation (passing through formula V) or 7,13-disilylation (passing through formulae XI, XII). Isopropanol Solvates of Cabazitaxel and processes to make this are also described.
摘要翻译：公开了从10-脱乙酰基浆果赤霉素（III）开始的涉及卡巴他昔（I）的方法，其涉及7-OH单甲硅烷基化（通过式V）或7,13-二甲硅烷基化（通过式XI，XII）的步骤。异丙醇卡巴他赛的溶剂化物及其制备方法也被描述。

24. 发明申请

WO2011119648A1 DIRECT SCATTER LOADING OF EXECUTABLE SOFTWARE IMAGE FROM A PRIMARY PROCESSOR TO ONE OR MORE SECONDARY PROCESSOR IN A MULTI-PROCESSOR SYSTEM 审中-公开
标题翻译：直接散射器将可执行软件映像从主处理器加载到多处理器系统中的一个或多个二次处理器
公开(公告)号：WO2011119648A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029484
申请日：2011-03-22
申请人： QUALCOMM Incorporated , GUPTA, Nitin , KIM, Daniel H. , MALAMANT, Igor , HAEHNICHEN, Steve
发明人： GUPTA, Nitin , KIM, Daniel H. , MALAMANT, Igor , HAEHNICHEN, Steve
IPC分类号： G06F15/177
CPC分类号： G06F15/177 , G06F9/4405 , G06F9/445
摘要： In a multi-processor system, an executable software image including an image header and a segmented data image is scatter loaded from a first processor to a second processor. The image header contains the target locations for the data image segments to be scatter loaded into memory of the second processor. Once the image header has been processed, the data segments may be directly loaded into the memory of the second processor without further CPU involvement from the second processor.
摘要翻译：在多处理器系统中，包括图像头部和分段数据图像的可执行软件图像从第一处理器分散加载到第二处理器。图像标题包含要分散加载到第二处理器的存储器中的数据图像片段的目标位置。一旦处理了图像头，数据段可以被直接加载到第二处理器的存储器中，而不需要来自第二处理器的进一步的CPU参与。

25. 发明申请

WO2009013764A2 PROCESS FOR PRODUCING 6(R)-[2-(8'(S)-2 ",2 "-DIMETHYLBUTYRYLOXY-2'(S),6'(R)-DIMETHYL-1,2,6,7', 8',8A'(R)- HEXAHYDRONAPHTHYL-L'(S))ETHYL]-4(R)-HYDROXY-3,4,5,6- TETRAHYDRO-2H-PYRAN-2-ONE 审中-公开
标题翻译：生产6（R） - [2-（8'（S）-2'，2“ - 二甲基丁酰氧基-2'（S），6'（R） - 二甲基-1,2,6,7'，8 '，8A'（R） - 六氢萘-2-基]（S））乙基] -4（R） - 羟基-3,4,5,6-四氢-2H-吡喃-2-酮
公开(公告)号：WO2009013764A2
公开(公告)日：2009-01-29
申请号：PCT/IN2008/000467
申请日：2008-07-24
申请人： JUBILANT ORGANOSYS LIMITED , SINGH, Harnam , DUBEY, Shailendra Kumar , GUPTA, Nitin , DUBEY, Sushil Kumar
发明人： SINGH, Harnam , DUBEY, Shailendra Kumar , GUPTA, Nitin , DUBEY, Sushil Kumar
CPC分类号： C07D309/30
摘要： Disclosed herein is an improved process for producing HMG-CoA reductase inhibitor, 6(R)-[2-(8 '(S)-2 ",2 ''-dimethylbutyryloxy-2'(S),6 '(R)-dimethyl- 1', 2', 6', 7', 8',8a'(R)-hexahydronaphthyl-r(S))ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H- pyran-2-one, the process comprising hydrolyzing (lS,3R,7S,8S,8aR)-8-{2-[(2R,4R)- 4-hydroxy-6-oxotetrahydro-2H-ρyran-2-yl]ethyl}-3,7-dimethyl-l,2,3,7,8,8a- hexahydronaphthalen-1-yl (2S)-2-methylbutanoate in presence of a base and antioxidant, lactonizing and selectively protecting the hydroxyl group of the resultant compound, followed by acylation with an acylating agent to obtain 6(R)-[2-(8'(S)- 2",2''-dimethylbutyryloxy-2 '(S),6 '(R)-dimethyl- 1',2',6',7',8',8a'(R)- hexahydronaphthyl-r(S))ethyl]-4(R)-substituted)-3,4,5,6-tetrahydro-2H-pyran-2-one and further deprotection to obtain 6(R)-[2-(8'(S)-2",2"-dimethylbutyryloxy- 2'(S),6'(R)-dimethyl-1',2',6',7',8',8a'(R)-hexahydronaphthyl-1'(S))ethyl]-4(R)- hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one.
摘要翻译：本文公开了用于制备HMG-CoA还原酶抑制剂6（R） - [2-（8'（S）-2“，2” - 二甲基丁酰氧基-2'（ S），6'（R） - 二甲基-1'，2'，6'，7'，8'，8a'（R） - 六氢萘基-r（S））乙基] -4（R） - 羟基-3 （1S，3R，7S，8S，8aR）-8- {2 - [（2R，4R）-4-羟基-6,7-二氢-5H-吡咯并[2,3-b] - 氧代四氢-2H-吡喃-2-基]乙基} -3,7-二甲基-1,2,3,7,8,8a-六氢萘-1-基（2S）-2-甲基丁酸酯和得到6（R） - [2-（8'（S）-2'，2“ - 二甲基丁酰氧基-2'（2'，3”，4'-二叔丁基二甲基甲硅烷基）氨基甲酸酯），并将其与酰化剂酰化，（R） - 二甲基-1'，2'，6'，7'，8'，8a'（R） - 六氢萘基-r（S））乙基] -4（R） - 取代的） - （S）-2“，2” - 二甲基丁酰氧基-2'（S）-2 - [（2R）（R） - 二甲基-1'，2'，6'，7'，8'，8a'（R） - 六氢萘基-1'（S））乙基] -4（R） - 羟基-3' 4,5 ，6-四氢-2H-吡喃-2-酮

26. 发明申请

WO2007136507A1 EFFICIENT PIECE-WISE UPDATES OF BINARY ENCODED XML DATA 审中-公开
标题翻译：二进制编码XML数据的有效性更新
公开(公告)号：WO2007136507A1
公开(公告)日：2007-11-29
申请号：PCT/US2007/010163
申请日：2007-04-24
申请人： ORACLE INTERNATIONAL CORPORATION , CHANDRASEKAR, Sivansankaran , GUPTA, Nitin , MURTHY, Ravi , AGARWAL, Nipun , SEDLAR, Eric
发明人： CHANDRASEKAR, Sivansankaran , GUPTA, Nitin , MURTHY, Ravi , AGARWAL, Nipun , SEDLAR, Eric
IPC分类号： G06F17/30
CPC分类号： G06F17/24 , G06F17/22 , G06F17/2247 , G06F17/2264 , G06F17/30911 , G06F17/30917
摘要： An XML document can be represented in a compact binary form that maintains all of the features of XML data in a useable form. In response to a request for a modification (e.g., insert, delete or update a node) to an XML document that is stored in the compact binary form, a certain representation of the requested modification is computed for application directly to the binary form of the document. Thus, the requested modification is applied directly to the persistently stored binary form without constructing an object tree or materializing the XML document into a corresponding textual form. Taking into account the nature of the binary form in which the document is encoded, the bytes that actually require change are identified, including identifying where in the binary representation the corresponding actual changes need to be made.
摘要翻译： XML文档可以以紧凑的二进制形式表示，以可用的形式维护XML数据的所有功能。响应于以紧凑二进制形式存储的XML文档的修改（例如，插入，删除或更新节点）的请求，计算所请求的修改的特定表示，直接应用于二进制形式的文件。因此，所请求的修改直接应用于永久存储的二进制形式，而不构造对象树或将XML文档实现为相应的文本形式。考虑到文档编码的二进制形式的性质，确定实际需要更改的字节，包括识别二进制表示中需要进行相应实际更改的位置。

27. 发明申请

WO2012004009A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒性剂的结合物及其制备方法
公开(公告)号：WO2012004009A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/003462
申请日：2011-07-11
申请人： FRESENIUS KABI DEUTSCHLAND GMBH , KNOLLER, Helmut , HECKMANN, Dominik , HACKET, Frank , ZANDER, Norbert , LAHIRI, Saswata , GUPTA, Nitin , KUMAR, Vivek , MUDGAL, Mukesh, Madan
发明人： KNOLLER, Helmut , HECKMANN, Dominik , HACKET, Frank , ZANDER, Norbert , LAHIRI, Saswata , GUPTA, Nitin , KUMAR, Vivek , MUDGAL, Mukesh, Madan
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： C08B31/00 , A61K47/61
摘要： The present invention relates to hydroxyalkyl starch conjugates and a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one primary hydroxyl group, wherein the hydroxyalkyl starch is linked via said primary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS'(-L-M) n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS' is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold and a molar substitution (MS) in the range of from 0.6 to 1.5.
摘要翻译：本发明涉及羟烷基淀粉共轭物及其制备方法，包含羟烷基淀粉衍生物和细胞毒性剂的羟烷基淀粉缀合物，所述细胞毒性剂包含至少一个伯羟基，其中所述羟烷基淀粉通过所述初级羟基对细胞毒性剂。根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，以及 n大于或等于1，并且其中羟烷基淀粉衍生物的平均分子量（MW）高于肾阈值，摩尔取代度（MS）在0.6至1.5的范围内。

28. 发明申请

WO2011089627A1 INTEGRATED REMOTE POLLUTION MONITORING AND INDEXING SYSTEM AND METHOD THEREOF 审中-公开
标题翻译：综合远程污染监测和指标体系及其方法
公开(公告)号：WO2011089627A1
公开(公告)日：2011-07-28
申请号：PCT/IN2011/000047
申请日：2011-01-21
申请人： DAS, Pranamesh , GUPTA, Nitin
发明人： DAS, Pranamesh , GUPTA, Nitin
IPC分类号： H04Q9/02 , G01D21/02 , G08B25/00 , H04L29/08
CPC分类号： H04Q9/02 , G01D21/02 , G01W1/00 , G01W2001/006 , G08C2201/42 , H04Q9/00 , H04Q2209/10 , H04Q2209/30 , H04Q2209/40 , Y02A90/14
摘要： The invention relates to a system for integrated remote monitoring and measuring of real time pollution levels together with real time weather details and a method of aggregating, analyzing and indexing the disparate data into a single measurable and accessible real time data for the user. The invention further relates to a method and means of displaying the pollution index of different types of pollution levels of air, water, sewage, noise, radiation, light and soil and weather details in real time through various displaying methods.
摘要翻译：本发明涉及用于综合远程监测和测量实时污染水平以及实时天气细节的系统，以及将不同数据聚合，分析和索引到用户的单个可测量和可访问的实时数据的方法。本发明还涉及通过各种显示方法实时显示空气，水，污水，噪声，辐射，光和土壤和天气细节的不同类型污染水平的污染指数的方法和手段。

29. 发明申请

WO2010092588A3 METHOD AND SYSTEM FOR MEASURING AND ANALYZING THE PRODUCTION DATA DIRECTLY FROM MACHINE 审中-公开
公开(公告)号：WO2010092588A3
公开(公告)日：2010-08-19
申请号：PCT/IN2009/000296
申请日：2009-05-22
申请人： GUPTA, Nitin , KOTWAL, Rupesh, Vasant
发明人： GUPTA, Nitin , KOTWAL, Rupesh, Vasant
IPC分类号： G05B19/418 , G07C3/00 , G07C3/14 , G06Q10/00
摘要： The present invention relates to a method for measuring and analyzing the production data directly from machines. The said method comprises the steps of : a. measuring the parameters relating to machine and parameters of the process to be carried on by machine; b. storing values of parameters measured for the analysis purpose; c. providing standard values of said parameters being provided by the user; d. comparing said standard values and the measured values of the parameters for checking performance of machine and consistency in product quality; e. deciding whether the machine performance and product quality are consistently maintained to required standards; and f. displaying the standard values and measured values of said parameters, and decision taken in respect of machine performance and product quality. Also the system for implementing the aforesaid method is disclosed.

30. 发明申请

WO2007030721A2 PROCESSES FOR THE PREPARATION OF (3R,4S)-4-((4-BENZYLOXY)PHENYL)-1-(4-FLUOROPHENYL)-3-((S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-2-AZETIDINONE, AN INTERMEDIATE FOR THE SYNTHESIS OF EZETIMIBE 审中-公开
标题翻译：制备（3R，4S）-4 - （（4-苄氧基）苯基）-1-（4-氟苯基）-3 - （（S）-3-（4-氟苯基）-3-羟基丙基） 2-AZETIDINONE，一种用于合成EZETIMIBE的中间体
公开(公告)号：WO2007030721A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/035060
申请日：2006-09-08
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , TEVA PHARMACEUTICALS USA, INC. , KANSAL, Vinod, Kumar , AHMAD, Suhail , TYAGI, Bhupendra , GUPTA, Nitin , PERLMAN, Nurit
发明人： KANSAL, Vinod, Kumar , AHMAD, Suhail , TYAGI, Bhupendra , GUPTA, Nitin , PERLMAN, Nurit
IPC分类号： C07D205/08 , A61K31/397 , A61P3/04
CPC分类号： C07D205/08 , Y02P20/55
摘要： The invention encompasses (3R,4S)-4-((4-benzyloxy)phenyl)-l-(4-fluorophenyl)-3- (3-(4-fluorophenyl)-3-oxopropyl)-2-azetidinone (Compound 2a) having an enantiomeric purity of at least about 97.5%. The invention also encompasses Compound 2a having a chemical purity of at least about 97%. The invention further encompasses processes for preparing Compound 2a from Compound 1 having the following formula (I). Compound 1. The invention also encompasses processes for preparing a compound having the formula(II). from a compound having the following formula (III), wherein R is selected from the group consisting of: H or a hydroxyl protecting group. The invention also encompasses processes for preparing Compound 2a, preferably to form Compound 2a-Form 01. Also included are processes for preparing ezetimibe from Compound 2a-Form 01 or Compound 2a prepared according to the invention, compositions containing such ezetimibe, and methods for reducing cholesterol using such compositions.
摘要翻译：本发明包括（3R，4S）-4 - （（4-苄氧基）苯基）-1-（4-氟苯基）-3-（3-（4-氟苯基）-3-氧代丙基）-2-氮杂环丁酮（化合物2a ）具有至少约97.5％的对映体纯度。本发明还包括具有至少约97％的化学纯度的化合物2a。本发明还包括由具有下式（I）的化合物1制备化合物2a的方法。化合物1.本发明还包括制备具有式（II）的化合物的方法。由具有下式（III）的化合物，其中R选自：H或羟基保护基。本发明还包括制备化合物2a，优选形成化合物2a-形式01的方法。还包括用于制备根据本发明制备的化合物2a-形式01或化合物2a的依泽替米贝的方法，含有这种依泽替米贝的组合物，以及还原方法使用这种组合物的胆固醇。

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