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21. 发明申请

US20100256180A1 FUSED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION 有权
标题翻译：熔化的杂环化合物作为核细胞受体功能的调节剂有用
公开(公告)号：US20100256180A1
公开(公告)日：2010-10-07
申请号：US12740221
申请日：2008-10-31
申请人： Weifang Shan , James Aaron Balog , Ashvinikumar V. Gavai , Yufen Zhao
发明人： Weifang Shan , James Aaron Balog , Ashvinikumar V. Gavai , Yufen Zhao
IPC分类号： A61K31/429 , A61K31/439 , C07D417/14 , A61P35/00
CPC分类号： C07D513/18 , C07D513/22
摘要： Disclosed are fused heterocyclic compounds of Formula (I): or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
摘要翻译：公开了式（I）的稠合杂环化合物或其药学上可接受的盐或立体异构体。还公开了使用这些化合物治疗至少一种雄激素受体相关病症（例如癌症）的方法和包含这些化合物的药物组合物。

22. 发明申请

US20100331324A1 FUSED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION 有权
标题翻译：熔化的杂环化合物作为核细胞受体功能的调节剂有用
公开(公告)号：US20100331324A1
公开(公告)日：2010-12-30
申请号：US12666423
申请日：2008-06-26
申请人： Derek J. Norris , Ashvinikumar V. Gavai , James Aaron Balog , Joel F. Austin , Weifang Shan , Yufen Zhao , Andrew James Nation , Wen-Ching Han
发明人： Derek J. Norris , Ashvinikumar V. Gavai , James Aaron Balog , Joel F. Austin , Weifang Shan , Yufen Zhao , Andrew James Nation , Wen-Ching Han
IPC分类号： A61K31/5377 , C07D491/18 , A61K31/4035 , C07D401/14 , A61K31/4709 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/4178 , C07D401/04 , A61K31/4439 , A61P35/00 , A61P17/10
CPC分类号： C07D491/22
摘要： Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
摘要翻译：公开了式（I）的稠合杂环化合物或其药学上可接受的盐或立体异构体。还公开了使用这些化合物治疗至少一种雄激素受体相关病症（例如癌症）的方法和包含这些化合物的药物组合物。

23. 发明授权

US07163917B2 Synthesis method of alanylglutamine 有权
标题翻译：丙氨基谷氨酰胺的合成方法
公开(公告)号：US07163917B2
公开(公告)日：2007-01-16
申请号：US10518940
申请日：2003-05-30
申请人： Yufen Zhao , Guo Tang , Ning Zhou , Liming Hu , Yong Chen
发明人： Yufen Zhao , Guo Tang , Ning Zhou , Liming Hu , Yong Chen
IPC分类号： A01N37/18
CPC分类号： C07K5/06026 , Y02P20/55
摘要： A synthesis method of alanyl-glutamine includes the steps of: The N-terminal protected alanine reacts with triphenylphosphine and hexachloroethane in organic solvent to form active ester, the active ester reacts with glutamine in a solution mixture containing organic solvent and aqueous solution of inorganic base, the resultant mixture is acidified with inorganic acid, and then the N-terminal protecting group is removed. In this method, the raw materials are cheap, the synthesis technique is simple, no disposals of separation and purification are needed, the product is easy to be separated and purified, the toxicities of all the reagents used in the course of production are minimal, it is advantageous to environment protection.
摘要翻译：丙氨酰 - 谷氨酰胺的合成方法包括以下步骤：N-末端保护的丙氨酸与三苯基膦和六氯乙烷在有机溶剂中反应形成活性酯，活性酯与含有机溶剂和无机碱水溶液的溶液中的谷氨酰胺反应，将所得混合物用无机酸酸化，然后除去N-末端保护基。在这种方法中，原料便宜，合成技术简单，不需要分离纯化处理，易于分离和纯化，生产过程中使用的所有试剂的毒性小，有利于环境保护。

24. 发明授权

US06953780B2 Endothelin antagonist 失效
标题翻译：内皮素拮抗剂
公开(公告)号：US06953780B2
公开(公告)日：2005-10-11
申请号：US10312012
申请日：2001-06-21
申请人： Keliang Liu , Wensheng Yu , Yuanjun Liang , Hai Wang , Yufen Zhao , Zhenkai Ding
发明人： Keliang Liu , Wensheng Yu , Yuanjun Liang , Hai Wang , Yufen Zhao , Zhenkai Ding
IPC分类号： A61K38/00 , A61P9/00 , C07K7/06 , A61K38/06 , C07K5/083 , C07K5/097
CPC分类号： C07K7/06 , A61K38/00
摘要： The instant invention relates to some tripeptide derivatives having activity against endothelin a process for preparing them, pharmaceutical composition containing the same and their use in prevention or treatment of some diseases associated with endothelin.
摘要翻译：本发明涉及具有抗内皮素活性的一些三肽衍生物，其制备方法，含有该三肽衍生物的方法，含有该三肽衍生物的药物组合物及其在预防或治疗与内皮素相关的一些疾病中的用途。

25. 发明申请

US20050233977A1 Process of producing ala-gln dipeptide 有权
标题翻译：生产ala-gln二肽的方法
公开(公告)号：US20050233977A1
公开(公告)日：2005-10-20
申请号：US10518940
申请日：2003-05-30
申请人： Yufen Zhao , Guo Tang , Ning Zhou , Liming Hu , Yong Chen
发明人： Yufen Zhao , Guo Tang , Ning Zhou , Liming Hu , Yong Chen
IPC分类号： C07K5/062 , A61K38/04 , C07K1/06 , C07K5/04 , C07K5/06
CPC分类号： C07K5/06026 , Y02P20/55
摘要： A synthesis method of alanyl-glutamine includes the steps of: The N-terminal protected alanine reacts with triphenylphosphine and hexachloroethane in organic solvent to form active ester, the active ester reacts with glutamine in a solution mixture containing organic solvent and aqueous solution of inorganic base, the resultant mixture is acidified with inorganic acid, and then the N-terminal protecting group is removed. In this method, the raw materials are cheap, the synthesis technique is simple, no disposals of separation and purification are needed, the product is easy to be separated and purified, the toxicities of all the reagents used in the course of production are minimal, it is advantageous to environment protection.
摘要翻译：丙氨酰 - 谷氨酰胺的合成方法包括以下步骤：N-末端保护的丙氨酸与三苯基膦和六氯乙烷在有机溶剂中反应形成活性酯，活性酯与含有机溶剂和无机碱水溶液的溶液中的谷氨酰胺反应，将所得混合物用无机酸酸化，然后除去N-末端保护基。在这种方法中，原料便宜，合成技术简单，不需要分离纯化处理，易于分离和纯化，生产过程中使用的所有试剂的毒性小，有利于环境保护。

26. 发明授权

US08466171B2 Fused heterocyclic compounds useful as modulators of nuclear hormone receptor function 有权
标题翻译：稠合杂环化合物可用作核激素受体功能的调节剂
公开(公告)号：US08466171B2
公开(公告)日：2013-06-18
申请号：US12740221
申请日：2008-10-31
申请人： Weifang Shan , James Aaron Balog , Ashvinikumar V. Gavai , Yufen Zhao
发明人： Weifang Shan , James Aaron Balog , Ashvinikumar V. Gavai , Yufen Zhao
IPC分类号： C07D221/22 , A61K31/439
CPC分类号： C07D513/18 , C07D513/22
摘要： Disclosed are fused heterocyclic compounds of Formula (I): or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
摘要翻译：公开了式（I）的稠合杂环化合物或其药学上可接受的盐或立体异构体。还公开了使用这些化合物治疗至少一种雄激素受体相关病症（例如癌症）的方法和包含这些化合物的药物组合物。

27. 发明授权

US08067582B2 Fused heterocyclic compounds useful as modulators of nuclear hormone receptor function 有权
标题翻译：稠合杂环化合物可用作核激素受体功能的调节剂
公开(公告)号：US08067582B2
公开(公告)日：2011-11-29
申请号：US12666423
申请日：2008-06-26
申请人： Derek J. Norris , Ashvinikumar V. Gavai , James Aaron Balog , Joel F. Austin , Weifang Shan , Yufen Zhao , Andrew James Nation , Wen-Ching Han
发明人： Derek J. Norris , Ashvinikumar V. Gavai , James Aaron Balog , Joel F. Austin , Weifang Shan , Yufen Zhao , Andrew James Nation , Wen-Ching Han
IPC分类号： C07D517/00 , C07D491/00 , A61K31/40
CPC分类号： C07D491/22
摘要： Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
摘要翻译：公开了式（I）的稠合杂环化合物或其药学上可接受的盐或立体异构体。还公开了使用这些化合物治疗至少一种雄激素受体相关病症（例如癌症）的方法和包含这些化合物的药物组合物。

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