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    • 26. 发明授权
    • Process for the biotechnological preparation of optically active
alpha-arylalkanoic acids
    • 光学活性α-芳基链烷酸的生物技术制备方法
    • US4762793A
    • 1988-08-09
    • US840856
    • 1986-03-18
    • Pietro CestiPaolo Piccardi
    • Pietro CestiPaolo Piccardi
    • C12P7/40C12P17/10C12P17/14C12P41/00C12R1/72
    • C12P41/005C12P17/10C12P7/40Y10S435/921
    • There is described the preparation of S(+) alpha-aryl-alkanoic acids by means of the reaction of a racemic ester(R,S) of the formula: ##STR1## wherein: R is a group selected from the group consisting of --C.tbd.CH, a --CH.dbd.CH.sub.2, --CN; --COCH.sub.3, --COO alkyl C.sub.1 C.sub.4 and --CH.sub.2 --O alkyl C.sub.1 -C4 group, Ar is a group selected from the group consisting of an aryl group and an aryl substituted or condensed with other groups, in particular a group selected from the group consisting of groups of the formula: ##STR2## wherein: R' is selected from the group consisting of C.sub.1 -C.sub.8 linear or branch of chain alkyl, C.sub.1 -C.sub.4 alkenyl, alkoxy, phenyl, phenoxy, tenoyl and heterocyclic;R" is selected from the group consisting of hydrogen or halogen;R"' is a C.sub.1 -C.sub.4 alkyl,with an esterase, produced by microorganisms capable of selectively hydrolizing the S(+) form of said racemic ester and by successively separating the S(+) acid from the unreacted ester.
    • 描述了通过下式的外消旋酯(R,S)与下式的反应制备S(+)α-芳基 - 链烷酸:其中:R是选自下组的基团 由-C 3 CH 2,-CH = CH 2,-CN; -COCH 3,-COO烷基C1C4和-CH2-O烷基C1-C4基团,Ar是选自芳基和与其它基团取代或缩合的芳基的基团,特别是选自以下的基团: 具有下式的基团:其中:R'选自C 1 -C 8直链或支链烷基,C 1 -C 4烯基,烷氧基,苯基,苯氧基 ,tenoyl和杂环; R“选自氢或卤素; R“是具有酯酶的C1-C4烷基,其由能够选择性水解S(+)形式的所述外消旋酯并通过从未反应的酯连续分离S(+)酸的微生物产生。