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21. 发明授权

US6096907A Process for preparing chromanol derivatives 失效
标题翻译：色原醇衍生物的制备方法
公开(公告)号：US6096907A
公开(公告)日：2000-08-01
申请号：US395774
申请日：1999-09-14
申请人： Kai-Uwe Baldenius , Bernhard Bockstiegel , Hagen Jaedicke , Detlef Ruff , Carsten Siedenbiedel , Rainer Sturmer
发明人： Kai-Uwe Baldenius , Bernhard Bockstiegel , Hagen Jaedicke , Detlef Ruff , Carsten Siedenbiedel , Rainer Sturmer
IPC分类号： C07D311/70 , C07D311/72 , C07D311/76
CPC分类号： C07D311/72 , Y02P20/55
摘要： A process for preparing chromanol derivatives of the formula I ##STR1## where n is from 1 to 10,R.sup.1, R.sup.2,R.sup.3, R.sup.4 independently of one another are hydrogen or C.sub.1 -C.sub.4 alkyl,R.sup.5 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.6 -C.sub.10 aryl, C.sub.7 -C.sub.18 aralkyl, C.sub.7 -C.sub.18 alkylaryl, C.sub.1 -C.sub.22 acyl, or a group protecting the hydroxyl,by reduction of the corresponding 4-oxochromanol derivatives of the formula II ##STR2## comprises reacting the 4-oxochromanol derivatives of the formula II with metallic zinc in the presence of an acid or an acid mixture.Compounds of the formula I having C.sub.1 -C.sub.22 acyl as radical R.sup.5 can also be prepared by the above-described reduction of the compounds of the formula II with hydrogen as radical R.sup.5 and simultaneous or subsequent esterification.
摘要翻译：一种制备式I的色原烷醇衍生物的方法，其中n为1至10，R 1，R 2，R 3，R 4彼此独立地为氢或C 1 -C 4烷基，R 5为氢，C 1 -C 4烷基，C 6 -C 10芳基，C 7 -C 18芳烷基，C 7 -C 18烷基芳基，C 1 -C 22酰基或保护羟基的基团，通过还原相应的式II的4-氧杂铬醇衍生物包括使式II的4-氧杂铬醇衍生物与金属锌在酸或酸的混合物存在下进行。具有作为自由基R5的C 1 -C 22酰基的式I化合物也可以通过上述将式II化合物以氢作为自由基R5还原并同时或随后进行酯化来制备。

22. 发明授权

US5468883A Preparation of vitamin E 失效
标题翻译：维生素E的制备
公开(公告)号：US5468883A
公开(公告)日：1995-11-21
申请号：US302743
申请日：1994-09-09
申请人： Paul Grafen , Hans Kiefer , Hagen Jaedicke
发明人： Paul Grafen , Hans Kiefer , Hagen Jaedicke
IPC分类号： B01J31/04 , C07B61/00 , C07D311/72
CPC分类号： C07D311/72
摘要： A process for preparing dl-.alpha.-tocopherol or dl-.alpha.-tocopheryl acetate by acid-catalyzed reaction of 2,3,5-trimethylhydroquinone (TMH) with phytol or isophytol in a solvent at elevated temperature, with or without subsequent esterification of the resulting tocopherol with acetic anhydride, entails the reaction being carried out in the presence of a mixture of ortho-boric acid and certain aliphatic di- or tricarboxylic acids, preferably in the presence of a mixture of ortho-boric acid and oxalic acid.
摘要翻译： PCT No.PCT / EP93 / 00498 Sec。 371日期1994年9月9日 102（e）1994年9月9日PCT 1993年3月5日PCT公布。第WO93 / 19057号公报日本1993年9月30日。一种通过2,3,5-三甲基氢醌（TMH）与植物醇或异植醇在溶剂中在升高的温度下酸催化反应制备dl-α-生育酚或dl-α-生育酚乙酸酯的方法，随着或不用所得到的生育酚与乙酸酐的酯化反应，需要在邻 - 硼酸和某些脂肪族二 - 或三羧酸的混合物存在下进行反应，优选在邻 - 硼酸酸和草酸。

23. 发明授权

US5128151A Stabilized menadione bisulfite formulations and their preparation 失效
标题翻译：稳定的MENADIONE BISULFITE制剂及其制备
公开(公告)号：US5128151A
公开(公告)日：1992-07-07
申请号：US141637
申请日：1988-01-07
申请人： Hans Kiefer , Wolfgang Buehler , Joachim U. Schneider , Hagen Jaedicke
发明人： Hans Kiefer , Wolfgang Buehler , Joachim U. Schneider , Hagen Jaedicke
IPC分类号： A23K1/16 , A61K9/14 , A61K31/12 , A61K31/122 , A61K47/00 , A61K47/02 , A61K47/12 , A61K47/20 , A61P3/02 , A61P7/04 , C07C67/00 , C07C301/00 , C07C309/25
CPC分类号： A61K47/12 , A61K31/12 , A61K47/02 , A61K9/14 , Y10S514/97
摘要： Powdered and/or granulated menadione sodium bisulfite formulations additionally contain a physiologically tolerated organic or inorganic acid.The novel formulations possess good water solubility and stability.
摘要翻译：粉状和/或颗粒的甲萘醌亚硫酸氢钠制剂另外含有生理上耐受的有机或无机酸。新型配方具有良好的水溶性和稳定性。

24. 发明授权

US4209450A Introduction of a carbonyl group into a cyclohexene ring 失效
标题翻译：将羰基引入环己烯环
公开(公告)号：US4209450A
公开(公告)日：1980-06-24
申请号：US868272
申请日：1978-01-10
申请人： Hagen Jaedicke , Joachim Paust
发明人： Hagen Jaedicke , Joachim Paust
IPC分类号： C07B61/00 , B01J23/00 , B01J23/16 , C07C20060101 , C07C45/00 , C07C45/30 , C07C49/00 , C07C49/647 , C07C67/00 , C07C401/00 , C07C403/00 , C07C403/02 , C07C403/08 , C07C403/12 , C07C403/14 , C07C403/16 , C07C403/24 , C09F5/08 , C11C3/00
CPC分类号： C07C403/02 , C07C403/10 , C07C403/12 , C07C403/14 , C07C403/16 , C07C403/20 , C07C403/24 , C07C2101/16
摘要： A process for introducing an allyl-positioned carbonyl group into a 2,6,6-trimethylcyclohexene ring which carries a polyenyl radical in the 1-position, by oxidizing the ring with a halogen(V)-oxyacid or a salt of such an acid, and the new oxo compounds obtainable by the said process, which may be used as dyes for foodstuffs or cosmetics. The oxidation is carried out in the presence of a catalyst and of an inert diluent or solvent, in an acid medium. Suitable catalysts are bromine and iodine and the oxides of elements of groups Va, VIa, VIIa and VIII of the periodic table.
摘要翻译：通过用卤素（V） - 氧酸或这种酸的盐氧化环，将烯丙基定位的羰基引入到携带1位上的聚烯基的2,6,6-三甲基环己烯环中的方法，以及可以通过所述方法获得的新的氧代化合物，其可以用作食品或化妆品的染料。在催化剂和惰性稀释剂或溶剂的存在下，在酸性介质中进行氧化。合适的催化剂是溴和碘，以及元素周期表Va，VIa，VIIa和VIII族元素的氧化物。

25. 发明授权

US06365758B1 Preparation of tocopheral carboxylates or tocotrienyl esters by acid-catalyzed reaction with carboxylic acids 失效
标题翻译：通过与羧酸的酸催化反应制备生育酚羧酸酯或生育三烯基酯
公开(公告)号：US06365758B1
公开(公告)日：2002-04-02
申请号：US09013813
申请日：1998-01-26
申请人： Joanna Linda von dem Bussche-Hünnefeld , Hagen Jaedicke , Guido Harms , Harald Laas
发明人： Joanna Linda von dem Bussche-Hünnefeld , Hagen Jaedicke , Guido Harms , Harald Laas
IPC分类号： C07D31104
CPC分类号： C07D311/72
摘要： A process for preparing tocopheryl esters or tocotrienyl esters by acid-catalyzed esterification of a tocopherol or a tocotrienol in a solvent while stirring at elevated temperature, which comprises a) carrying out the esterification with the appropriate carboxylic acid, b) carrying out the esterification with from 2.5 to 6 mol of the carboxylic acid in an aliphatic, cycloaliphatic or aromatic hydrocarbon boiling in the range from 80 to 200° C., or else with from 1.0 to 2.5 mol of the carboxylic acid in a mixture consisting of an aliphatic or cycloaliphatic hydrocarbon boiling in the range from 80 to 200° C. and a cyclic carbonate of the formula II or a &ggr;-lactone of the formula III where R1, R2 and R3 are each H or lower alkyl, and R4 is H, lower alkyl, phenyl or methoxymethyl, as solvent, c) using a nonoxidizing strong inorganic or organic acid, preferably sulfuric acid, boroxalic acid or benzene- or toluenesulfonic acids, in catalytic amounts as acid catalyst, and d) continuously removing the water formed in the reaction by azeotropic distillation during the reaction.
摘要翻译：一种在高温下搅拌下在溶剂中通过酸催化酯化生育酚或生育三烯酚制备生育酚酯或生育三烯基酯的方法，该方法包括a）用合适的羧酸进行酯化，b）进行酯化反应在80至200℃范围内沸腾的脂肪族，脂环族或芳族烃中的羧酸为2.5至6摩尔，或者由脂族或脂环族烃组成的混合物中的1.0至2.5摩尔羧酸沸程在80至200℃的范围内，和式II的环状碳酸酯或式III的γ-内酯，其中R 1，R 2和R 3各自为H或低级烷基，且R 4为H，低级烷基，苯基或甲氧基甲基，作为溶剂，c）使用非氧化的强无机或有机酸，优选硫酸，硼酸或苯或甲苯磺酸，催化量为酸催化剂，并且d）连续重新在反应期间通过共沸蒸馏移动反应中形成的水。

26. 发明授权

US06300524B1 Process for preparing higher unsaturated ketones 失效
标题翻译：制备高级不饱和酮的方法
公开(公告)号：US06300524B1
公开(公告)日：2001-10-09
申请号：US09440281
申请日：1999-11-15
申请人： Carsten Oost , Manfred Stroezel , Heinz Etzrodt , Dietmar Weller , Udo Rheude , Gerd Kaibel , Thomas Krug , Luise Spiske , Hagen Jaedicke
发明人： Carsten Oost , Manfred Stroezel , Heinz Etzrodt , Dietmar Weller , Udo Rheude , Gerd Kaibel , Thomas Krug , Luise Spiske , Hagen Jaedicke
IPC分类号： C07C4500
CPC分类号： C07C45/676 , Y02P20/582 , C07C49/255 , C07C49/203
摘要： The present invention relates to an improved process for preparing higher unsaturated ketones by reacting the corresponding &agr;,&bgr;-unsaturated alcohols with alkyl acetoacetates in a Carroll reaction , in a reactor system with fitted fractionation column, wherein A the &agr;,&bgr;-unsaturated alcohol is introduced into the reaction vessel together with the organic aluminum compound in the absence of effective amounts of a solvent, and the alkyl acetoacetate is metered into this mixture, B a reaction temperature which is as constant as possible at between 175° C. and 220° C., preferably between 180° C. and 200° C., is adjusted and C during the reaction the content of alkyl acetoacetate in the reaction mixture is adjusted to a value which is as constant as possible at between 1 and 3% by weight. It is advantageous in this process for the reaction temperature defined under B to be controlled by suitable variation of the heat input and/or by variation of the rate of addition of the alkyl acetoacetate, and for adequate mixing of the reaction mixture in the reaction vessel to be ensured This can be achieved with the aid of a stirrer, by pumping the reaction mixture through an external liquid circulation, by introducing the alkyl acetoacetate by means of a mixing nozzle or else by passing in a stream of inert gas. The process according to the invention is particularly suitable for the Carroll reaction of higher alcohols such as 3,7-dimethyl-1,6-octadien-3-ol (linalool), 3,7-dimethyl-1-octen-3-ol, 3,7,11-trimethyl-1,6,10-dodecatrien-3-ol (nerolidol), 3,7,11-trimethyl-1-dodecen-3-ol or 3,7,11-trimethyl-1,6-dodecadien-3-ol (dihydronerolidol).
摘要翻译：本发明涉及一种改进的制备高级不饱和酮的方法，该方法通过在具有合适分馏塔的反应器系统中，在卡罗尔反应中使相应的α，β-不饱和醇与烷基乙酰乙酸酯反应，其中引入α，β-不饱和醇在没有有效量的溶剂的情况下，将有机铝化合物与有机铝化合物一起加入到反应容器中，并将乙酰乙酸烷基酯计量加入到该混合物中，B在175℃和220℃之间的反应温度尽可能恒定在反应过程中，优选在180℃和200℃之间调节和C，将反应混合物中乙酰乙酸烷基酯的含量调节至1至3重量％之间尽可能恒定的值。在该方法中，通过适当变化的热输入和/或通过烷基的加成速率的变化来控制在B下限定的反应温度，乙酰乙酸酯，并使反应混合物在反应容器中充分混合以确保这可以借助于搅拌器，通过泵送反应混合物通过外部液体循环，通过引入烷基乙酰乙酸酯通过混合喷嘴或者通过流入惰性气体流。根据本发明的方法特别适用于高级醇如3,7-二甲基-1,6-辛二烯-3-醇（芳樟醇），3， 7,7-二甲基-1-辛烯-3-醇，3,7,11-三甲基-1,6,10-十二碳三烯-3-醇（橙花叔醇），3,7,11-三甲基-1-十二碳烯-3-醇或3,7,11-三甲基-1,6-十二碳二烯-3-醇（二氢吗啉醇）。

27. 发明授权

US5874635A Preparation of .gamma., .delta.-unsaturated ketones by the carroll reaction in cyclic carbonates or .gamma.-lactones 失效
标题翻译：通过循环碳酸酯或γ-内酯中的卡罗尔反应制备γ，δ-不饱和酮
公开(公告)号：US5874635A
公开(公告)日：1999-02-23
申请号：US965024
申请日：1997-11-05
申请人： Heinz Etzrodt , Manfred Stroezel , Dietmar Weller , Hagen Jaedicke
发明人： Heinz Etzrodt , Manfred Stroezel , Dietmar Weller , Hagen Jaedicke
IPC分类号： C07C45/69 , C07C45/67 , C07C45/71 , C07C45/76 , C07C49/203 , C07C45/51
CPC分类号： C07C45/676
摘要： A process for preparing .gamma.,.delta.-unsaturated ketones bya) reacting vinylcarbinols or propargyl alcohols with alkyl acetoacetates or diketene andb) thermally rearranging the resulting acetoacetates in the presence or absence of an aluminum catalyst to .gamma.,.delta.-unsaturated ketones (Carroll reaction),wherein step a) and/or step b) is carried out in a cyclic carbonate of the formula I or a .gamma.-lactone of the formula II ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are H, or lower alkyl and R.sup.4 is H, lower alkyl, phenyl or methoxymethyl, as solvent.
摘要翻译：通过以下方法制备γ，δ不饱和酮的方法：a）使乙烯基甲醇或炔丙醇与乙酰乙酸烷基酯或双烯酮酸烷基酯反应，和b）在存在或不存在铝催化剂的情况下，将得到的乙酰乙酸酯热重新排列到γ，δ-不饱和酮（Carroll反应），其中步骤a）和/或步骤b）在式I的环状碳酸酯或式II的γ-内酯中进行，其中R 4是H，低级烷基，苯基或甲氧基甲基，作为溶剂。

28. 发明授权

US5344995A Preparation of cyclic acetals of 3-formyl-2-butenyltriphenylphosphonium chloride 失效
标题翻译：制备3-甲酰基-2-丁烯基三苯基氯化鏻的环状缩醛
公开(公告)号：US5344995A
公开(公告)日：1994-09-06
申请号：US85903
申请日：1993-07-06
申请人： Wolfgang Krause , Joachim Paust , Walter Dobler , Hagen Jaedicke
发明人： Wolfgang Krause , Joachim Paust , Walter Dobler , Hagen Jaedicke
IPC分类号： C07F9/54 , C07D319/06 , C07F9/655 , C07C43/305 , C07C43/313
CPC分类号： C07F9/6552 , C07D319/06
摘要： An improved process for preparing cyclic acetals of 3-formyl-2-butenyltriphenylphosphonium chloride by acetalization of 3-formyl-2-butenyl acetate with an aliphatic 1,3-diol, conversion of the resulting 4-acetoxy acetal into the corresponding 4-hydroxy acetal, Vilsmeier chlorination to give the corresponding 4-chloro acetal and subsequent reaction with triphenylphosphine entails carrying out the first 3 steps in an aliphatic or cycloaliphatic hydrocarbon or mixture of hydrocarbons with 6-8 carbons and the reaction with triphenylphosphine in an alkanol with 1-3 carbons and/or in aliphatic or cycloaliphatic hydrocarbon with 6-8 carbons or a corresponding mixture of hydrocarbons. The process is particularly advantageous when conversion of the 4-acetoxy acetal into the 4-hydroxy acetal is carried out with an aqueous alkali metal hydroxide solution in the presence of phase-transfer catalysts, and the first three, or all four, reaction stages are carried out in the same C.sub.6 -C.sub.8 -hydrocarbon.
摘要翻译：通过用脂肪族1,3-二醇缩醛化3-甲酰基-2-丁烯基乙酸酯与3-甲酰基-2-丁烯基三苯基氯化鏻的环状缩醛的改进方法，将得到的4-乙酰氧基缩醛转化为相应的4-羟基缩醛，Vilsmeier氯化，得到相应的4-氯缩醛，随后与三苯基膦反应需要在脂族或脂环族烃或碳原子数为6〜8的混合物中进行前3个步骤，并与三苯基膦在链烷醇中与1- 3个碳原子和/或具有6-8个碳原子的脂族或脂环族烃或相应的烃混合物。当在相转移催化剂存在下，用碱金属氢氧化物水溶液进行4-乙酰氧基缩醛转化为4-羟基缩醛时，该方法是特别有利的，而前三个或所有四个反应阶段是在相同的C6-C8-烃中进行。

29. 发明授权

US4921711A Animal feed or drinking water containing propanediol formates 失效
标题翻译：含有丙二醇甲酸酯的动物饲料或饮用水
公开(公告)号：US4921711A
公开(公告)日：1990-05-01
申请号：US930527
申请日：1986-11-14
申请人： Hans Kiefer , Hansjoerg Bipp , Fritz Fink , Hagen Jaedicke , Dieter M. Poralla
发明人： Hans Kiefer , Hansjoerg Bipp , Fritz Fink , Hagen Jaedicke , Dieter M. Poralla
IPC分类号： A23K20/105 , A23K30/00 , A23L2/44 , A23L3/34 , A23L3/3517
CPC分类号： A23K30/00 , A23K20/105
摘要： An animal feed or drinking water contains a biocidally or biostatically active amount of not less than one formic acid ester of 1,2-propanediol.
摘要翻译：动物饲料或饮用水含有不少于一种1,2-丙二醇的甲酸酯的生物活性或生物活性的量。

30. 发明授权

US4268444A Preparation of polyene-aldehydes 失效
标题翻译：多烯醛的制备
公开(公告)号：US4268444A
公开(公告)日：1981-05-19
申请号：US94986
申请日：1979-11-16
申请人： Hagen Jaedicke
发明人： Hagen Jaedicke
IPC分类号： C07C47/21 , C07C67/00 , C07C401/00 , C07C403/00 , C07C403/14 , C07C403/16 , C07D319/06 , C07C45/45 , C07D319/04
CPC分类号： C07D319/06 , C07C403/14 , C07C2101/16
摘要： A process for the preparation of polyene-aldehydes, derived from 2,6-dimethyl-2,4,6,8-nonatetraen-1-al by substitution in the 9-position, by means of the Wittig ylide synthesis. The process is based on the observation, contrary to all expectation, that on reacting 2,6-dimethyl-octa-2,4,6-triene-1,8-dial with an equimolar amount of an ylide, it is exclusively the 8-al group of the dialdehyde which reacts. This specificity of the reaction is of particular importance for the preparation of the food dye .beta.-apo-8'-carotinal.
摘要翻译：通过Wittig内鎓盐合成制备衍生自2,6-二甲基-2,4,6,8-壬四烯-1-醇的在9-位取代的多烯醛的方法。该过程基于观察，与所有预期相反，在2,6-二甲基 - 八氢-2,4,6-三烯-1,8-表盘与等摩尔量的内鎓盐反应中，仅仅是8 一组二醛反应。反应的这种特异性对于制备食品染料β-8-8-胡萝卜素是特别重要的。

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