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    • 21. 发明申请
    • Processes for preparing bis(urea-urethane) compounds
    • 制备双(脲 - 氨基甲酸酯)化合物的方法
    • US20060122415A1
    • 2006-06-08
    • US11097758
    • 2005-04-01
    • Rina CarliniAdela GoredemaEniko TomaChristine Bedford
    • Rina CarliniAdela GoredemaEniko TomaChristine Bedford
    • C07C275/38
    • C07C273/1854C07C2601/14C07C275/26
    • Processes for preparing bis(urea-urethane) compounds wherein R1 is alkyl, aryl, arylalkyl, or alkylaryl, R2 is alkylene, arylene, arylalkylene, or alkylarylene, R3 is alkylene, arylene, arylalkylene, or alkylarylene, and R4 is hydrogen or alkyl, comprising: (1) first bring to a reaction temperature of about 20-125° C. a reaction mixture comprising monoalcohol reactant R1—OH and diisocyanate reactant OCN—R2—NCO, the monoalcohol being present in an amount of about 0.8-1.2 moles monoalcohol per mole diisocyanate, the monoalcohol and diisocyanate reactants being admixed in a solvent, the reactants and solvent being present in relative amounts of at least about 1 milliliter solvent per millimole diisocyanate, the reaction temperature continuing until reaction between the monoalcohol and the diisocyanate is complete; and (2) subsequent to step (1), adding to the reaction mixture diamine without isolating the reaction product of step (1), thereby forming compound of the formula in desirably high yield and purity.
    • 制备其中R 1为烷基,芳基,芳基烷基或烷基芳基的双(脲 - 氨基甲酸酯)化合物的方法是亚烷基,亚芳基,芳基亚烷基或烷基亚芳基,R 3是亚烷基,亚芳基,芳基亚烷基或烷基亚芳基,R 4是氢或烷基,包括:(1)首先使反应温度为约20-125℃ C.一种包含一元醇反应物R 1 -OH和二异氰酸酯反应物OCN-R 2 -NCO的反应混合物,一元醇的存在量为约0.8-1.2摩尔一元醇 每摩尔二异氰酸酯,一元醇和二异氰酸酯反应物在溶剂中混合,反应物和溶剂以至少约1毫升溶剂/毫摩尔二异氰酸酯的相对量存在,反应温度持续到一元醇和二异氰酸酯反应完成; 和(2)在步骤(1)之后,在不分离步骤(1)的反应产物的情况下向反应混合物二胺中加入,从而以期望的高产率和纯度形成式的化合物。