专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US5559111A .delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides 失效
标题翻译： δ-氨基-γ-羟基-ω-芳基 - 链烷酸酰胺
公开(公告)号：US5559111A
公开(公告)日：1996-09-24
申请号：US416242
申请日：1995-04-04
申请人： Richard G oschke , J urgen K. Maibaum , Walter Schilling , Stefan Stutz , Pascal Rigollier , Yasuchika Yamaguchi , Nissim C. Cohen , Peter Herold
发明人： Richard G oschke , J urgen K. Maibaum , Walter Schilling , Stefan Stutz , Pascal Rigollier , Yasuchika Yamaguchi , Nissim C. Cohen , Peter Herold
IPC分类号： C07D295/14 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/27 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4245 , A61K31/44 , A61K31/445 , A61K31/4468 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/20 , A61P27/02 , A61P43/00 , C07C213/00 , C07C229/36 , C07C235/34 , C07C235/36 , C07C237/20 , C07C237/22 , C07C237/24 , C07C255/13 , C07C255/16 , C07C255/60 , C07C271/16 , C07C271/18 , C07C271/22 , C07C311/30 , C07C311/32 , C07C317/18 , C07C317/28 , C07C317/44 , C07C323/10 , C07C323/12 , C07D207/27 , C07D207/40 , C07D211/32 , C07D211/88 , C07D213/30 , C07D213/40 , C07D213/65 , C07D213/89 , C07D233/64 , C07D233/76 , C07D239/10 , C07D241/08 , C07D257/04 , C07D263/20 , C07D263/26 , C07D263/38 , C07D265/30 , C07D271/06 , C07D277/14 , C07D277/18 , C07D277/28 , C07D295/13 , C07D295/18 , C07D295/22 , C07D307/32 , C07D307/33 , C07D317/64 , C07D319/18 , C07D319/20 , C07D413/06 , C07D521/00 , C07F7/18 , C07D237/20 , C07D294/14
CPC分类号： C07D307/33 , C07C229/36 , C07C237/20 , C07C255/13 , C07C271/16 , C07C271/18 , C07C271/22 , C07D241/08
摘要： .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
摘要翻译：式I（Ⅰ）的α-氨基-γ-羟基-ω-芳基 - 链烷酸酰胺及其盐具有肾素抑制性质，可用作抗高血压药用活性成分。

22. 发明授权

US08680079B2 Tetrahydro-imidazo [1,5-A] pyridyin derivatives as aldosterone synthase inhibitors 失效
标题翻译：四氢 - 咪唑并[1,5-A]吡啶并衍生物作为醛固酮合酶抑制剂
公开(公告)号：US08680079B2
公开(公告)日：2014-03-25
申请号：US11597623
申请日：2005-05-27
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christoph Schumacher , Michael Quirmbach
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , C07D345/00 , C07D517/00
CPC分类号： C07D221/04 , C07D217/02 , C07D239/74 , C07D471/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) in which R, R1, R2, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物，其中R，R 1，R 2，X，Y，Z和n具有本说明书中定义的含义，其制备方法和这些化合物的用途作为药物，特别是作为醛固酮合酶抑制剂。

23. 发明授权

US08076327B2 Condensed imidazole derivatives as aldosterone synthase inhibitors 失效
标题翻译：缩合咪唑衍生物作为醛固酮合酶抑制剂
公开(公告)号：US08076327B2
公开(公告)日：2011-12-13
申请号：US12857032
申请日：2010-08-16
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stefan Stutz , Bibia Bennacer
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stefan Stutz , Bibia Bennacer
IPC分类号： C07D513/04 , A61K31/542
CPC分类号： C07D513/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferable pharmaceutically acceptable salts, thereof, in which R, R1, R2, R3, Q, m and n have the meanings explained in detail in the description, a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物及其盐，优选的药学上可接受的盐，其中R，R 1，R 2，R 3，Q，m和n具有在说明书中详细说明的含义，其制备方法和这些化合物作为药物的用途，特别是作为醛固酮合酶抑制剂。

24. 发明授权

US08003640B2 Organic compounds 失效
标题翻译：有机化合物
公开(公告)号：US08003640B2
公开(公告)日：2011-08-23
申请号：US12745100
申请日：2008-12-04
申请人： Peter Herold , Stjepan Jelakovic , Robert Mah , Vincenzo Tschinke
发明人： Peter Herold , Stjepan Jelakovic , Robert Mah , Vincenzo Tschinke
IPC分类号： C07D413/12 , A61K31/538
CPC分类号： C07D413/12
摘要： The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which in which R1 has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译：本发明涉及通式（I）的化合物及其盐，优选其药学上可接受的盐; 其中R1具有说明书中解释的含义，其制备方法和这些化合物用作药物，特别是作为肾素抑制剂。

25. 发明申请

US20110028512A1 BIS-HETEROCYCLIC IMIDAZOLYL COMPOUNDS 失效
标题翻译：双相异构体咪唑啉化合物
公开(公告)号：US20110028512A1
公开(公告)日：2011-02-03
申请号：US12900779
申请日：2010-10-08
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Michael Quirmbach , Christiane Marti , Aleksandar Stojanovic , Stefan Stutz
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Michael Quirmbach , Christiane Marti , Aleksandar Stojanovic , Stefan Stutz
IPC分类号： A61K31/437 , C07D487/04 , C07D471/04 , A61K31/4188 , A61P9/12 , A61P3/06 , A61P3/00 , A61P9/04
CPC分类号： C07D471/04
摘要： Heterocyclic compounds of the general formula (I) are provided in which R, R1, R2, R3, R4 and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldostereone synthase inhibitors,
摘要翻译：提供通式（I）的杂环化合物，其中R，R 1，R 2，R 3，R 4和n具有在说明书中更详细阐述的定义，其制备方法和这些化合物作为药物的用途，特别是作为醛固酮合成酶抑制剂，

26. 发明授权

US07851634B2 5-amino 4-hydroxy-7-(1H-indolmethyl)-8-methylnonamide derivatives as renin inhibitors for the treatment of hypertension 失效
标题翻译： 5-氨基-4-羟基-7-（1H-吲哚甲基）-8-甲基壬酰胺衍生物作为治疗高血压的肾素抑制剂
公开(公告)号：US07851634B2
公开(公告)日：2010-12-14
申请号：US10593460
申请日：2005-03-17
申请人： Peter Herold , Stefan Stutz , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Nathalie Jotterand , Michael Quirmbach , Dirk Behnke , Christiane Marti
发明人： Peter Herold , Stefan Stutz , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Nathalie Jotterand , Michael Quirmbach , Dirk Behnke , Christiane Marti
IPC分类号： C07D405/02 , A61K31/44
CPC分类号： C07C237/06 , C07C237/22 , C07D209/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The application relates to novel alkanamides of the general formula (I) where X is —CH2— or >CH—OH; (A) R1 is e.g. an optionally substituted heterocyclyl radical or an optionally substituted polycyclic, unsaturated hydrocarbon radical where X is hydroxymethylene; R2 is C1-C6-alkyl or C3-C6-cydoalkyl; R3 are each independently H, C1-C6-alkyl, C1-6-alkoxycarbonyl or C1-C6-alkanoyl; R4 is C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl or unsubstituted or substituted arylC1-C6-alkyl; R5 is C1-C6-alkyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkanoyloxy C1-C6-alkyl, C1-C6-aminoalkyl, C1-C6-alkylamino-C1-C6-alkyl, C1-C6-dialkylamino-C1-C6-alkyl, C1-C6-alkanoylamido-C1-C6-alkyl, HO(O)C—C1-C6-alkyl, C1-C6-alkyl-O—(O)C—C1-C6-alkyl, H2N—C(O)—C1-C6-alkyl, C1-C6-alkyl-HN—C(O)—C1-C6-alkyl, (C1,-C6-alkyl)2N—C(O)—C1-C6-alkyl, C2-C8-alkenyl, C2-C8-alkynyl, cyano-C1-C6-alkyl, halo-C1-C6-alkyl, optionally substituted aryl-Co-C6-alkyl, optionally substituted C3-C8-cycloalkyl-Co-C6-alkyl or optionally substituted heterocydyl-Co-C6-alkyl; to a process for their preparation and to the use of these compounds as medicines, especially as renin inhibitors for the treatment of hypertension.
摘要翻译：本申请涉及通式（I）的新型烷酰胺，其中X为-CH 2 - 或> CH-OH; （A）R1是例如任选取代的杂环基或任选取代的多环不饱和烃基，其中X是羟基亚甲基; R2是C1-C6-烷基或C3-C6-环烷基; R 3各自独立地为H，C 1 -C 6 - 烷基，C 1-6 - 烷氧基羰基或C 1 -C 6 - 烷酰基; R4是C1-C6-烷基，C3-C6-环烷基，C2-C6-烯基或未取代或取代的芳基C1-C6-烷基; R5是C1-C6-烷基，C1-C6-羟基烷基，C1-C6-烷氧基-C1-C6-烷基，C1-C6-烷酰氧基C1-C6-烷基，C1-C6-氨基烷基，C1-C6烷基氨基-C1 C 1 -C 6 - 烷基，C 1 -C 6 - 二烷基氨基-C 1 -C 6 - 烷基，C 1 -C 6 - 烷酰基氨基-C 1 -C 6烷基，HO（O）C 1 -C 6 - 烷基，C 1 -C 6烷基-O-（ O）-C 1 -C 6烷基，H 2 N-C（O）-C 1 -C 6 - 烷基，C 1 -C 6烷基-NH-C（O）-C 1 -C 6 - 烷基，（C 1 -C 6 - 烷基） C 1 -C 6 - 烷基，C 2 -C 8 - 烯基，C 2 -C 8炔基，氰基-C 1 -C 6烷基，卤代-C 1 -C 6烷基，任选取代的芳基-C 0 -C 6 - 烷基，任选取代的C 3 -C 8 - 环烷基-C 0 -C 6 - 烷基或任选取代的杂环-Co-C 6 - 烷基; 其制备方法和这些化合物作为药物的使用，特别是用作治疗高血压的肾素抑制剂。

27. 发明授权

US07790715B2 Organic compounds 失效
公开(公告)号：US07790715B2
公开(公告)日：2010-09-07
申请号：US10574108
申请日：2004-09-30
申请人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
发明人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
IPC分类号： C07D401/12 , A61K31/4427
CPC分类号： C07D211/42 , C07D401/12 , C07D413/12
摘要： Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.

28. 发明授权

US07786307B2 Amino alcohol derivatives and their activity as renin inhibitors 失效
标题翻译：氨基醇衍生物及其作为肾素抑制剂的活性
公开(公告)号：US07786307B2
公开(公告)日：2010-08-31
申请号：US10587150
申请日：2005-01-21
申请人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
发明人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
IPC分类号： C07D211/26 , A61K31/445
CPC分类号： C07D471/10 , C07C235/60 , C07C237/06 , C07C237/10 , C07C237/22 , C07C237/24 , C07C243/28 , C07C275/14 , C07C311/05 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/18 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/06 , C07C2602/22 , C07C2603/74 , C07D211/76 , C07D295/13 , C07D311/00
摘要： The application relates to novel amino alcohols of general formula (I) where R, R1, R2, R3, R4, R5, X1 and X2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5，X 1和X 2各自具有在说明书中详细说明的定义，其制备方法和用途的这些化合物作为药物，特别是作为肾素抑制剂。

29. 发明授权

US07718675B2 Diamino alcohols and their use as renin inhibitor 失效
标题翻译：二氨基醇及其作为肾素抑制剂的用途
公开(公告)号：US07718675B2
公开(公告)日：2010-05-18
申请号：US10586814
申请日：2005-01-21
申请人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
发明人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D207/27 , C07C233/36 , C07C233/78 , C07C311/05 , C07D205/04 , C07D207/12 , C07D207/273 , C07D209/18 , C07D211/34 , C07D211/76 , C07D213/56 , C07D223/10 , C07D239/10 , C07D277/42 , C07D295/13 , C07D295/15 , C07D303/48 , C07D309/04 , C07D333/34 , C07D413/06 , C07D471/10
摘要： The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法和用途的这些化合物作为药物，特别是作为肾素抑制剂。

30. 发明申请

US20090270380A1 3,4,5-Substituted Piperidines as Renin Inhibitors 审中-公开
标题翻译： 3,4,5-取代哌啶酮作为肾素抑制剂
公开(公告)号：US20090270380A1
公开(公告)日：2009-10-29
申请号：US11887354
申请日：2006-03-30
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Nathalie Jotterand , Dirk Behnke , Aleksandar Stojanovic , Stefan Stuz , Michael Quirmbach , Stjepan Jelakovic
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Nathalie Jotterand , Dirk Behnke , Aleksandar Stojanovic , Stefan Stuz , Michael Quirmbach , Stjepan Jelakovic
IPC分类号： A61K31/538 , C07D265/36 , A61P9/00 , A61P9/12 , A61P13/12
CPC分类号： C07D413/14 , C07D413/12
摘要： The application relates to novel substituted piperidines of the general formula (II) in which R1, R2′, R2″, R4′, X, Z, m and n have the meanings defined in the description, to a process for the preparation thereof and to the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译：本申请涉及其中R1，R2'，R2“，R4”，X，Z，m和n具有本说明书中定义的含义的通式（II）的新型取代哌啶与其制备方法以及使用这些化合物作为药物，特别是作为肾素抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式