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21. 发明授权

US5324280A Osmotic dosage system for delivering a formulation comprising liquid carrier and drug 失效
标题翻译：用于递送包含液体载体和药物的制剂的渗透剂量系统
公开(公告)号：US5324280A
公开(公告)日：1994-06-28
申请号：US502705
申请日：1990-04-02
申请人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
发明人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译：公开了用于将有益剂制剂递送到使用环境的渗透系统。渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。

22. 发明授权

US4892778A Juxtaposed laminated arrangement 失效
标题翻译：并置层叠布置
公开(公告)号：US4892778A
公开(公告)日：1990-01-09
申请号：US054714
申请日：1987-05-27
申请人： Felix Theeuwes , Patrick S. L. Wong , Richard Cortese , James B. Eckenhoff
发明人： Felix Theeuwes , Patrick S. L. Wong , Richard Cortese , James B. Eckenhoff
IPC分类号： A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61M31/002 , A61K9/0004 , Y10S428/913 , Y10T428/24992 , Y10T428/31504 , Y10T428/31511 , Y10T428/31909 , Y10T428/31978
摘要： A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.

23. 发明授权

US4837111A Dosage form for dispensing drug for human therapy 失效
标题翻译：药物用于人体治疗的剂型
公开(公告)号：US4837111A
公开(公告)日：1989-06-06
申请号：US173524
申请日：1988-03-21
申请人： Joseph C. Deters , Patrick S. L. Wong , Brian L. Barclay , Felix Theeuwes , David R. Swanson
发明人： Joseph C. Deters , Patrick S. L. Wong , Brian L. Barclay , Felix Theeuwes , David R. Swanson
IPC分类号： A61K9/00 , A61K9/22 , A61K9/36 , A61K31/505 , A61P25/02
CPC分类号： A61K9/0004 , A61K31/505
摘要： An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.

24. 发明授权

US4824675A Dispenser with movable matrix comprising a plurality of tiny pills 失效
标题翻译：具有可移动矩阵的分配器，包括多个微小的药丸
公开(公告)号：US4824675A
公开(公告)日：1989-04-25
申请号：US72506
申请日：1987-07-13
申请人： Patrick S. L. Wong , Felix Theeuwes , Richard Cortese , James B. Eckenhoff
发明人： Patrick S. L. Wong , Felix Theeuwes , Richard Cortese , James B. Eckenhoff
IPC分类号： A61K9/00 , A61K9/22 , A61K9/26
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.

25. 发明授权

US4587117A Medical device for delivering drug to pH environments greater than 3.5 失效
标题翻译：将药物输送到大于3.5的pH环境的医疗设备
公开(公告)号：US4587117A
公开(公告)日：1986-05-06
申请号：US693649
申请日：1985-01-22
申请人： David Edgren , Patrick S. L. Wong , Felix Theeuwes
发明人： David Edgren , Patrick S. L. Wong , Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/32 , A61K9/36
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering a beneficial agent to a first environment having a pH of 1.0 to 3.5 inclusive and to a second environment having a pH of greater than 3.5 to 8.0. The device maintains its integrity in the first environment and loses its integrity in the second environment.
摘要翻译：公开了一种渗透装置，用于将有益剂递送至pH为1.0至3.5的第一环境，以及pH大于3.5至8.0的第二环境。该设备在第一个环境中保持其完整性，并在第二个环境中失去其完整性。

26. 发明授权

US4503030A Device for delivering drug to certain pH environments 失效
标题翻译：将药物输送到某些pH环境的装置
公开(公告)号：US4503030A
公开(公告)日：1985-03-05
申请号：US501573
申请日：1983-06-06
申请人： David Edgren , Patrick S. L. Wong , Felix Theeuwes
发明人： David Edgren , Patrick S. L. Wong , Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/24 , A61K9/22 , A61K9/32 , A61K9/36
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering a beneficial agent to a first environment having a pH of 1.0 to 3.5 inclusive and to a second environment having a pH of greater than 3.5 to 8.0. The device maintains its integrity in the first environment and loses its integrity in the second environment.
摘要翻译：公开了一种渗透装置，用于将有益剂递送至pH为1.0至3.5的第一环境，以及pH大于3.5至8.0的第二环境。该设备在第一个环境中保持其完整性，并在第二个环境中失去其完整性。

27. 发明授权

US5443459A Osmotic device for delayed delivery of agent 失效
标题翻译：用于延迟递送药剂的渗透装置
公开(公告)号：US5443459A
公开(公告)日：1995-08-22
申请号：US109120
申请日：1993-08-19
申请人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen , Liang C. Dong
发明人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen , Liang C. Dong
IPC分类号： A61K9/00 , A61K9/22 , A61K9/48
CPC分类号： A61K9/0004 , A61K9/4808
摘要： The present invention is directed to a fluid-imbibing dispensing device for the initially delayed delivery of an active agent to a fluid environment of use and to a method of using the dispensing device. The dispenser comprises a housing having a first wall section and a second wall section in reversibly sliding telescopic arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; at least one active agent formulation in the compartment; and expansion means and a push plate in the compartment for separating apart the first and second wall sections of the housing after exposure to the environment of use to expose the active agent formulation to the environment of use.
摘要翻译：本发明涉及用于将活性剂最初延迟递送到使用的流体环境的流体吸入分配装置以及使用分配装置的方法。所述分配器包括壳体，所述壳体具有彼此可逆地滑动伸缩布置的第一壁部分和第二壁部分，所述壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 隔室中的至少一种活性剂制剂; 以及膨胀装置和隔室中的推板，用于在暴露于使用环境之后将壳体的第一和第二壁部分分开以将活性剂制剂暴露于使用环境。

28. 发明授权

US5340590A Delivery system with bilayer osmotic engine 失效
标题翻译：交付系统与双层渗透引擎
公开(公告)号：US5340590A
公开(公告)日：1994-08-23
申请号：US88931
申请日：1993-07-08
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00 , A61K9/24
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

29. 发明授权

US5236689A Multi-unit delivery system 失效
标题翻译：多单元交货系统
公开(公告)号：US5236689A
公开(公告)日：1993-08-17
申请号：US873901
申请日：1992-04-24
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/4808
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

30. 发明授权

US5030216A Osmotically driven syringe 失效
标题翻译：渗透式注射器
公开(公告)号：US5030216A
公开(公告)日：1991-07-09
申请号：US451476
申请日：1989-12-15
申请人： Felix Theeuwes , Patrick S. L. Wong
发明人： Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22 , A61M5/145
CPC分类号： A61K9/0024 , A61K9/0004 , A61M5/145 , A61M2005/14513
摘要： An implantable osmotically driven syringe is disclosed which can be used to deliver a beneficial agent, such as a drug, at a predetermined rate over an extended period of time. A movable piston divides the syringe into a beneficial agent-containing compartment and a driving compartment. The piston is movable into a position wherein the driving compartment has a volume of essentially zero. The syringe is driven by an osmotic engine which has a shaped wall surrounding, and in contact with, an osmotic solute. The wall is comprised of a semipermeable and/or microporous material which is permeable to the external fluid (e.g., water) but is impermeable to the solute. The engine also has a passageway forming a fluid flow path between the osmotic solute and the driving compartment. A portion of the wall is exposed to a fluid-containing external environment. At least about 30% of the wall which contacts the solute also is exposed to the fluid in the external environment. In operation, water from the external environment is imbided through the semipermeable wall forming a solution of the solvent in the osmotic engine. As fresh incoming fluid from the external environment is imbided by the engine, the solution is pumped through the passageway into the driving compartment. The pumping action drives the piston which causes the beneficial agent to be delivered by the syringe.
摘要翻译：公开了一种可植入的渗透驱动的注射器，其可以用于在延长的时间段内以预定的速率递送诸如药物的有益剂。可移动活塞将注射器分成含有益剂的隔室和驱动室。活塞可移动到驱动室具有基本为零的体积的位置。注射器由渗透引擎驱动，渗透引擎具有围绕并与渗透性溶质接触的成形壁。该壁由半透性和/或微孔材料构成，其可渗透外部流体（例如水），但对溶质是不可渗透的。发动机还具有在渗透性溶质和驱动室之间形成流体流路的通路。壁的一部分暴露于含流体的外部环境中。接触溶质的壁的至少约30％也暴露于外部环境中的流体。在操作中，来自外部环境的水通过形成溶剂在渗透引擎中的溶液的半透壁渗透。当来自外部环境的新鲜流体被发动机吸入时，溶液被泵送通过通道进入驱动室。抽吸作用驱动活塞，其导致有益剂被注射器递送。

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