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21. 发明申请

US20110152229A1 BETULINIC ACID DERIVATIVES AS ANTI-HIV AGENTS 审中-公开
标题翻译：作为抗艾滋病毒药物的白蛋白酸衍生物
公开(公告)号：US20110152229A1
公开(公告)日：2011-06-23
申请号：US11943956
申请日：2007-11-21
申请人： Chin Ho Chen , Li Huang , Kuo-Hsiung Lee
发明人： Chin Ho Chen , Li Huang , Kuo-Hsiung Lee
IPC分类号： A61K31/56 , C07J53/00 , A61P31/18
CPC分类号： C07J63/008
摘要： The present invention provides compounds of the general structure: which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of treating viral infections employing the same.
摘要翻译：本发明提供了一般结构的化合物：其在3和28位被取代，以及含有该化合物的药物制剂以及使用其的治疗病毒感染的方法。

22. 发明授权

US07957461B2 Calibrating automatic test equipment 有权
标题翻译：校准自动测试设备
公开(公告)号：US07957461B2
公开(公告)日：2011-06-07
申请号：US11095755
申请日：2005-03-31
申请人： Li Huang , Timothy Derksen , Xiaoxi Zhang , Charles Evans Crapuchettes , Stephen Hauptman
发明人： Li Huang , Timothy Derksen , Xiaoxi Zhang , Charles Evans Crapuchettes , Stephen Hauptman
IPC分类号： H04B3/46
CPC分类号： G01R31/3191
摘要： Calibrating automatic test equipment (ATE) includes determining an offset between a reference timing event and a channel event, where the channel event is associated with a communication channel of the ATE, and adjusting signal transmission over the communication channel based on the offset. Determining the offset may include obtaining a first time at which a reference timing signal is received at a device associated with a reference timing source, obtaining a second time at which the reference timing signal is received at a device associated with the communication channel, obtaining a third time at which a channel signal is received at the device associated with the communication channel, obtaining a fourth time at which the channel signal is received at the device associated with the reference timing source, and calculating the offset using the first time, the second time, the third time, and the fourth time.
摘要翻译：校准自动测试设备（ATE）包括确定参考定时事件和信道事件之间的偏移，其中信道事件与ATE的通信信道相关联，并且基于偏移调整通过通信信道的信号传输。确定偏移可以包括获得在与参考定时源相关联的设备处接收参考定时信号的第一时间，获得在与通信信道相关联的设备处接收参考定时信号的第二时间，获得在与通信信道相关联的设备处接收信道信号的第三次，获得在与参考定时源相关联的设备处接收信道信号的第四时间，并且使用第一次来计算偏移量，第二时间时间，第三次，第四次。

23. 发明申请

US20110053852A1 USE OF PODOCAN PROTEIN IN TREATING CARDIOVASCULAR DISEASES 审中-公开
标题翻译： PODOCAN蛋白在治疗心血管疾病中的应用
公开(公告)号：US20110053852A1
公开(公告)日：2011-03-03
申请号：US12809899
申请日：2008-12-19
申请人： Paul Klotman , Randolph Hutter , Li Huang
发明人： Paul Klotman , Randolph Hutter , Li Huang
IPC分类号： A61K38/02 , A61P9/12 , A61P9/00
CPC分类号： A61K38/39 , A61K9/0019 , A61K38/1709 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/45 , A61L2400/06 , C08L89/00
摘要： The present invention relates to compositions and methods for the treatment of intimal smooth muscle cell hyperplasia, restenosis following percutaneous coronary intervention, post-transplant vasculopathy, and pulmonary hypertension More particularly, the present invention relates to methods and pharmaceutical compositions for delivering podocan or podocan inhibitors to the arterial system of an animal, thus resulting in the down-regulation or up-regulation, respectively, of smooth muscle cell (SMC) functions such as SMC proliferation and migration Up-regulation of vascular smooth muscle cell proliferation and/or migration by podocan inhibition results in the treatment of vulnerable plaques, while down-regulation of vascular smooth muscle cell proliferation and/or migration via podocan delivery and/or up-regulation results in the treatment of intimal smooth muscle cell hyperplasia, restenosis following percutaneous coronary intervention, post-transplant or graft vasculopathy and pulmonary hypertension.
摘要翻译：本发明涉及用于治疗内膜平滑肌细胞增生，经皮冠状动脉介入治疗后再狭窄，移植后血管病变和肺动脉高压的组合物和方法。更具体地，本发明涉及用于递送podocan或podocan抑制剂的方法和药物组合物到动物的动脉系统，从而导致平滑肌细胞（SMC）功能的下调或上调，例如SMC增殖和迁移血管平滑肌细胞增殖和/或迁移的上调 podocan抑制导致治疗易感斑块，而通过podocan递送和/或上调导致血管平滑肌细胞增殖和/或迁移的下调导致治疗内膜平滑肌细胞增生，经皮冠状动脉介入治疗后的再狭窄，移植后或移植物血管病变和肺血管病高血压

24. 发明授权

US07668113B2 Method for implementing distribution of link state information in an optical network 有权
标题翻译：实现光网络链路状态信息分配的方法
公开(公告)号：US07668113B2
公开(公告)日：2010-02-23
申请号：US10593934
申请日：2006-02-21
申请人： Min Zhao , Junjie Feng , Li Huang
发明人： Min Zhao , Junjie Feng , Li Huang
IPC分类号： H04L12/28
CPC分类号： H04J3/14 , H04L45/00 , H04L45/125 , H04L45/62
摘要： A method for implementing distribution of link state information in an optical network includes: determining information of each link protection attribute section included in a Traffic Engineering (TE) link; carrying the information of each link protection attribute section in a customized TLV, respectively; distributing the TLV in the optical network via Traffic Engineering Link State Advertisement (TE LSA). With this invention, all the link state information such as multiple kinds of protection types included in one TE link can be carried in the customized TLV to distribute. Therefore, in the implementation of this invention, one TE link corresponding to one optical fiber can be configured with multiple kinds of protection types.
摘要翻译：一种用于实现光网络中链路状态信息分配的方法包括：确定包括在流量工程（TE）链路中的每个链路保护属性部分的信息; 分别在定制的TLV中携带每个链路保护属性部分的信息; 通过流量工程链路状态广播（TE LSA）在光网络中分配TLV。利用本发明，可以在定制的TLV中携带包括在一个TE链路中的多种保护类型的所有链路状态信息以进行分发。因此，在本发明的实现中，对应于一根光纤的一个TE链路可以配置有多种类型的保护类型。

25. 发明申请

US20090269258A1 A CATALYTIC REACTION DEVISE 有权
标题翻译：催化反应法
公开(公告)号：US20090269258A1
公开(公告)日：2009-10-29
申请号：US12097684
申请日：2006-12-13
申请人： Jangping Yi , Li Huang , Wensheng Li , Xiao Ping Zhou
发明人： Jangping Yi , Li Huang , Wensheng Li , Xiao Ping Zhou
IPC分类号： B01J8/02
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00423 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00698 , B01J2219/00747 , C40B60/12
摘要： A catalytic reaction device for fluid-solid heterogeneous catalytic reactions including a distributor, flow controllers, parallel reactors, temperature controllers, coolers and product receivers with reactive fluids flowing into the flow controllers to control the total flow of a fluid is provided.
摘要翻译：提供了一种用于流体 - 固体多相催化反应的催化反应装置，包括分配器，流量控制器，并联反应器，温度控制器，冷却器和具有流入流量控制器中的反应流体以控制流体总流量的产品接收器。

26. 发明申请

US20090163749A1 CONVERSION OF METHANE INTO C3˜C13 HYDROCARBONS 审中-公开
标题翻译：甲烷转化为C3〜C13烃
公开(公告)号：US20090163749A1
公开(公告)日：2009-06-25
申请号：US12346381
申请日：2008-12-30
申请人： Wensheng Li , Li Huang , Yanqun Ren , Xiaoping Zhou
发明人： Wensheng Li , Li Huang , Yanqun Ren , Xiaoping Zhou
IPC分类号： C07C2/00
CPC分类号： C07C9/10 , C07C1/26 , C07C9/14 , C07C17/154 , C07C2521/06 , C07C2523/02 , C07C2523/10 , C07C2523/14 , C07C2523/16 , C07C2523/20 , C07C2523/26 , C07C2523/34 , C07C2523/50 , C07C2523/72 , C07C2523/745 , C07C2523/75 , C07C2529/40 , C07C19/075
摘要： A process for converting methane into C3˜C13 hydrocarbons is provided including the steps of reacting methane with oxygen and HBr/H2O over a first catalyst in a first reactor to methane bromides and converting the methane bromides into C3˜C13 hydrocarbons and HBr over a second catalyst in a second reactor. The process may further include recovering HBr produced in the second reactor and recylcing it into the first reactor.
摘要翻译：提供了将甲烷转化为C3〜C13烃的方法，包括使甲烷与氧气和HBr / H 2 O在第一反应器中的第一催化剂上反应生成甲烷溴化物并将甲烷溴化物转化成C3〜C13烃和HBr的步骤催化剂在第二反应器中。该方法可以进一步包括回收在第二反应器中产生的HBr并将其还原成第一反应器。

27. 发明授权

US07523007B2 Calibration device 有权
标题翻译：校准装置
公开(公告)号：US07523007B2
公开(公告)日：2009-04-21
申请号：US11771389
申请日：2007-06-29
申请人： Li Huang , George W. Conner
发明人： Li Huang , George W. Conner
IPC分类号： G01R35/00
CPC分类号： G01R31/3191
摘要： A calibration device is provided for use with automatic test equipment (ATE). The calibration device includes circuitry having a fanout circuit. The compare-side fanout circuit has an input connected to a first channel of the ATE and outputs connected to N (N>1) channels of the ATE, where the N channels do not include the first channel. The ATE propagates an edge on the first channel, and the fanout circuit transmits the edge to the N channels. Optionally, a calibration device for use with automatic test equipment includes a drive-side circuit. The drive-side circuit includes circuitry having multiple inputs connected to N (N>1) channels of the ATE and an output connected to a second channel of the ATE that is not one of the N channels. The ATE propagates an edge on each of the N-channels and the circuitry propagates each edge to the second channel of the ATE.
摘要翻译：提供校准装置用于自动测试设备（ATE）。校准装置包括具有扇出电路的电路。比较侧扇出电路具有连接到ATE的第一通道的输入和连接到ATE的N（N> 1）个通道的输出，其中N个通道不包括第一通道。 ATE在第一个通道上传播边缘，扇出电路将边缘传输到N个通道。可选地，与自动测试设备一起使用的校准装置包括驱动侧电路。驱动侧电路包括具有连接到ATE的N（N> 1）个通道的多个输入的电路，以及连接到不是N个通道中的一个的ATE的第二通道的输出。 ATE在每个N通道上传播边缘，电路将每个边沿传播到ATE的第二个通道。

28. 发明授权

US07381717B2 Anti-HIV agents with dual sites of action 有权
标题翻译：具有双重作用地点的抗艾滋病毒药物
公开(公告)号：US07381717B2
公开(公告)日：2008-06-03
申请号：US11348052
申请日：2006-02-06
申请人： Chin Ho Chen , Li Huang
发明人： Chin Ho Chen , Li Huang
IPC分类号： A61K31/56 , C07J53/00
CPC分类号： A61K31/56 , C07J53/00
摘要： The present invention provides compounds of the general structure: which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of treating viral infections employing the same.
摘要翻译：本发明提供了一般结构的化合物：其在3和28位被取代，以及含有该化合物的药物制剂以及使用其的治疗病毒感染的方法。

29. 发明授权

US5726204A Suksdorfin analogs, compositions thereof, and methods for making and using thereof 失效
标题翻译：苏斯多芬类似物，其组合物，及其制备和使用方法
公开(公告)号：US5726204A
公开(公告)日：1998-03-10
申请号：US462280
申请日：1995-06-05
申请人： Kuo-Hsiung Lee , Yoshiki Kashiwada , Li Huang , Thomas Tung-Ying Lee , Mark Cosentino , Jim Snider , Mark Manak , Lan Xie
发明人： Kuo-Hsiung Lee , Yoshiki Kashiwada , Li Huang , Thomas Tung-Ying Lee , Mark Cosentino , Jim Snider , Mark Manak , Lan Xie
IPC分类号： C07D491/04 , C07D491/052 , C07D493/04 , A61K31/365 , C07D311/94 , C07D493/06
CPC分类号： C07D491/04 , C07D493/04
摘要： The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein. The invention is also directed to methods of making these compounds, pharmaceutical compositions including these compounds and methods of using the compounds to inhibit retroviral infections in cells and tissues of animals. A method for stereoselectively preparing compounds within the scope of the invention by catalytic asymmetric dihydroxylation is also disclosed.
摘要翻译：本发明涉及作为天然产物suksdorfin的类似物的化合物。本发明的化合物包括具有式I的那些：其中R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。本发明还涉及制备这些化合物的方法，包括这些化合物的药物组合物和使用该化合物抑制动物细胞和组织中的逆转录病毒感染的方法。还公开了通过催化不对称二羟基化来立体选择性地制备本发明范围内的化合物的方法。

30. 发明授权

US5637589A Suksdorfin, analogs, compositions thereof, and methods for making and using thereof 失效
标题翻译：苏科多芬类似物，其组合物，及其制备和使用方法
公开(公告)号：US5637589A
公开(公告)日：1997-06-10
申请号：US392558
申请日：1995-02-21
申请人： Kuo-Hsiung Lee , Yoshiki Kashiwada , Li Huang , Thomas T. Lee , Mark Cosentino , Jim Snider , Mark Manax , Lan Xie
发明人： Kuo-Hsiung Lee , Yoshiki Kashiwada , Li Huang , Thomas T. Lee , Mark Cosentino , Jim Snider , Mark Manax , Lan Xie
IPC分类号： C07D491/04 , C07D491/052 , C07D493/04 , A61K31/435
CPC分类号： C07D491/04 , C07D493/04
摘要： Compounds, including compositions and methods of making and using these compounds for treating retroviral infections, are provided according to formula (G-1): ##STR1## wherein M is O or NH; Z is O, NH or S; R.sup.240, and R.sup.250 are each H, C.sub.1-10 alkyl, C.sub.1-10 aryl, alkyl, amide, or CH.sub.2 COOR.sup.260, where R.sup.260 is C.sub.1-10 alkyl or acyl; R.sup.200, R.sup.210, R.sup.220 and R.sup.230 are each H, halogen, hydroxyl, NH.sub.2, NH-alkyl, N-(alkyl).sub.2, O-alkyl, O-acyl, COCF.sub.3, OCF.sub.3 or CH.sub.2 COO NH-alkyl; or R.sup.200 and R.sup.210 form C.sub.5 -C.sub.10 cyclo or heterocyclo optionally substituted with one or more of halogen, hydroxyl, NH.sub.2, NH-alkyl, N-(alkyl).sup.2, O-acyl, O-alkyl, CO, CF.sub.3, OCF.sub.3 or CH.sub.2 COONH-alkyl; wherein C3 and C4 can be bound by a single or double bond; configurations at 3' or 4' can be (R) or (S); and R.sup.240 and R.sup.250 are either cis-.beta. or cis.alpha., or trans-3'-.alpha. or trans-3'-.beta. oriented.Stereoselectivity can be enhanced by preparing these compounds by catalytic asymmetric dihyroxylation.
摘要翻译：根据式（G-1）：其中M为O或NH的化合物，包括制备和使用这些化合物用于治疗逆转录病毒感染的组合物和方法：其中M为O或NH; Z是O，NH或S; R240和R250各自为H，C1-10烷基，C1-10芳基，烷基，酰胺或CH2COOR260，其中R260为C1-10烷基或酰基; R200，R210，R220和R230各自为H，卤素，羟基，NH2，NH-烷基，N-（烷基）2，O-烷基，O-酰基，COCF3，OCF3或CH2COO NH-烷基; 或R200和R210形成任选被一个或多个卤素，羟基，NH 2，NH-烷基，N-（烷基）2，O-酰基，O-烷基，CO，CF 3，OCF 3或CH 2 仲烷基; 其中C3和C4可以被单键或双键结合; 3'或4'的构型可以是（R）或（S）; R240和R250是顺式-β或顺式α或反式-3'-α或反式-3'-β取向的。通过催化不对称二羟基化制备这些化合物可以提高立体选择性。

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