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21. 发明授权

US06726701B2 Embolic protection device 有权
标题翻译：栓塞保护装置
公开(公告)号：US06726701B2
公开(公告)日：2004-04-27
申请号：US09986064
申请日：2001-11-07
申请人： Paul Gilson , Eamon Brady , Michael Gilvarry
发明人： Paul Gilson , Eamon Brady , Michael Gilvarry
IPC分类号： A61M2900
CPC分类号： A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A collapsible filter element for a transcatheter embolic protection device, the filter element comprises a collapsible filter body of polymeric material which is movable between a collapsed stored position for movement through a vascular system and an expanded position for extension across a blood vessel such that blood passing through the blood vessel is delivered through the filer element. A proximal inlet portion of the filter body has one or more inlet openings sized to allow blood and embolic material enter the filter body. A distal outlet portion of the filter body has a plurality of generally circular outlet openings sized to allow through-passage of blood, but to retain embolic material within the filter body. The distal outlet portion of the filter body in the region of the outlet openings has means for reducing shear stress on blood passing through the outlet openings. The shear stress reducing means includes lead-in and lead-out radiussed portioins of the filter body leading to the outlet holes. The porosity of the distal portion of the filter body decreases towards the distal end. A blind portion extends for at least 5% of the length of the body. Preferably there are between 200 and 300 outlet opening with an average diameter of approximately 150 microns.
摘要翻译：一种用于经导管栓塞保护装置的可折叠过滤器元件，所述过滤元件包括聚合材料的可折叠过滤体，其可在通过血管系统移动的折叠存储位置和用于延伸穿过血管的扩张位置之间移动，使得血液通过通过血管通过滤器元件输送。过滤器本体的近端入口部分具有一个或多个入口开口，其大小允许血液和栓塞物质进入过滤器主体。过滤器主体的远端出口部分具有多个大致圆形的出口开口，其尺寸允许血液通过，但是将栓塞材料保持在过滤器本体内。在出口开口区域中的过滤器本体的远端出口部分具有减少通过出口开口的血液的剪切应力的装置。剪切应力减小装置包括通向出口孔的过滤体的引入和引出辐射孔。过滤器主体的远端部分的孔隙朝向远端减小。盲部延伸至身体长度的至少5％。优选地，具有200至300个出口开口，平均直径约为150微米。

22. 发明授权

US09433429B2 Clot retrieval devices 有权
标题翻译：凝块检索装置
公开(公告)号：US09433429B2
公开(公告)日：2016-09-06
申请号：US13829684
申请日：2013-03-14
申请人： David Vale , Eamon Brady , Michael Gilvarry , Mahmood Ravazi
发明人： David Vale , Eamon Brady , Michael Gilvarry , Mahmood Ravazi
IPC分类号： A61B17/221 , A61B17/22
CPC分类号： A61B17/221 , A61B2017/22034 , A61B2017/22061 , A61B2017/22094 , A61B2017/2215
摘要： A self-expandable mechanical clot retrieval device is designed variously to dislodge, engage and retract blood clot from extremely small and tortuous vasculature. The retrieval device comprises an elongate member and a plurality of ring elements. The ring elements may comprise a plurality of struts and crowns interconnected by a tether formed at a distal end of the elongate member or may be a separate component attached thereto. At least one tether may connect each ring element to the elongate member to restrain the ring element in a collapsed configuration during delivery of the retrieval device through an intravascular microcatheter. The tether connecting the ring element to the elongate member disengages when the retrieval device is positioned at the occluded site and the microcatheter is retracted to allow the self-expandable ring elements to reach an expanded configuration.
摘要翻译：可自动扩张的机械凝块取出装置被设计成不同程度地从非常小且弯曲的脉管系统中移出，接合和收回血块。检索装置包括细长构件和多个环形元件。环形元件可以包括通过形成在细长构件的远端处的系绳互连的多个支柱和冠部，或者可以是附接到其上的单独部件。至少一个系绳可以将每个环形元件连接到细长构件，以在通过血管内微导管递送检索装置期间将环形元件限制在折叠构型。当拾取装置定位在闭塞位置并且微导管缩回以允许自扩张环元件达到扩张构型时，将环形元件连接到细长构件的系绳脱离。

23. 发明授权

US09402707B2 Clot capture systems and associated methods 有权
标题翻译：凝块捕获系统及相关方法
公开(公告)号：US09402707B2
公开(公告)日：2016-08-02
申请号：US13662299
申请日：2012-10-26
申请人： Eamon Brady , David Vale , Michael Gilvarry , Mahmood Razavi , John O'Shaughnessy
发明人： Eamon Brady , David Vale , Michael Gilvarry , Mahmood Razavi , John O'Shaughnessy
IPC分类号： A61M29/00 , A61F2/01 , A61B17/221
CPC分类号： A61B17/221 , A61B2017/2212 , A61F2/01 , A61F2/013 , A61F2230/0006 , A61F2230/0008 , A61F2230/001 , A61F2230/005 , A61F2230/0058
摘要： A clot capture system for disengaging a clot from a vessel wall and removing the clot from the vessel. The system may include a clot capture device for placement on a distal side of a clot. The clot capture device may have a retracted delivery configuration and an expanded deployed configuration. The clot removal device may have a proximal support frame, and a distal fiber net. The support frame may have a retracted delivery configuration and an expanded deployed configuration. The proximal support frame in the expanded configuration may define a proximal inlet mouth for engaging a clot and a net for confining the clot. An elongate member may facilitate capture and/or withdrawal of a clot from a vessel.
摘要翻译：凝块捕获系统，用于使血块与血管壁脱离并从血管中除去凝块。该系统可以包括用于放置在凝块远端的凝块捕获装置。血块捕获装置可以具有缩回的输送配置和扩展的部署配置。凝块去除装置可以具有近端支撑框架和远端纤维网。支撑框架可以具有缩回的传送配置和扩展的部署配置。膨胀构型中的近侧支撑框架可以限定用于接合凝块和用于限制凝块的网的近端入口。细长构件可以有利于从血管捕获和/或取出凝块。

24. 发明授权

US08038697B2 Embolic protection device 有权
标题翻译：栓塞保护装置
公开(公告)号：US08038697B2
公开(公告)日：2011-10-18
申请号：US11529525
申请日：2006-09-29
申请人： Paul Gilson , Eamon Brady , Michael Gilvarry
发明人： Paul Gilson , Eamon Brady , Michael Gilvarry
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A collapsible filter element for a transcatheter embolic protection device, the filter element comprises a collapsible filter body of polymeric material which is movable between a collapsed stored position for movement through a vascular system and an expanded position for extension across a blood vessel such that blood passing through the blood vessel is delivered through the filer element. A proximal inlet portion of the filter body has one or more inlet openings sized to allow blood and embolic material enter the filter body. A distal outlet portion of the filter body has a plurality of generally circular outlet openings sized to allow through-passage of blood, but to retain embolic material within the filter body. The distal outlet portion of the filter body in the region of the outlet openings has means for reducing shear stress on blood passing through the outlet openings. The shear stress reducing means includes lead-in and lead-out radiussed portions of the filter body leading to the outlet holes. The porosity of the distal portion of the filter body decreases towards the distal end. A blind portion extends for at least 5% of the length of the body. Preferably there are between 200 and 300 outlet opening with an average diameter of approximately 150 microns.
摘要翻译：一种用于经导管栓塞保护装置的可折叠过滤器元件，所述过滤元件包括聚合材料的可折叠过滤体，其可在通过血管系统移动的折叠存储位置和用于延伸穿过血管的扩张位置之间移动，使得血液通过通过血管通过滤器元件输送。过滤器本体的近端入口部分具有一个或多个入口开口，其大小允许血液和栓塞物质进入过滤器主体。过滤器主体的远端出口部分具有多个大致圆形的出口开口，其尺寸允许血液通过，但是将栓塞材料保持在过滤器本体内。在出口开口区域中的过滤器本体的远端出口部分具有减少通过出口开口的血液的剪切应力的装置。剪切应力减小装置包括通向出口孔的过滤体的引入和引出半径部分。过滤器主体的远端部分的孔隙朝向远端减小。盲部延伸至身体长度的至少5％。优选地，具有200至300个出口开口，平均直径约为150微米。

25. 发明申请

US20130345739A1 CLOT RETRIEVAL DEVICE FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 有权
标题翻译：用于从血液容器中移除堵塞的衣服的衣服检索装置
公开(公告)号：US20130345739A1
公开(公告)日：2013-12-26
申请号：US13823060
申请日：2012-03-09
申请人： Eamon Brady , Michael Gilvarry , Mahmood K. Razavi , David Vale , Patrick Griffin , Brendan Casey , Jason McNamara
发明人： Eamon Brady , Michael Gilvarry , Mahmood K. Razavi , David Vale , Patrick Griffin , Brendan Casey , Jason McNamara
IPC分类号： A61B17/22
CPC分类号： A61B17/221 , A61B17/22031 , A61B17/320725 , A61B2017/00292 , A61B2017/00526 , A61B2017/00867 , A61B2017/22034 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61F2/013 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0069 , A61F2230/008 , A61F2230/0091 , A61F2230/0093
摘要： A clot retrieval device (9501) for removing occlusive clot from a blood vessel comprises an inner elongate body (9503) and an outer elongate body (9504) at least partially overlying the inner elongate body (9503). The device also comprises an elongate member or shaft (9502) having a proximal end which extends exterior of a patient so that a user can retrieve the stent-basket device and captured clot by retracting the shaft (9502). The outer elongate body (9504) and the inner elongate body (9503) are connected to the distal end of the shaft (9502) and are expandable relative to the shaft (9502) from a collapsed delivery configuration to an expanded deployed configuration. The outer elongate body (9504) is expandable relative to the inner elongate body (9503) to a radial extent which is greater than the radial extent of the inner body (9503) in the deployed configuration.
摘要翻译：用于从血管去除闭塞凝块的凝块取出装置（9501）包括至少部分地覆盖内部细长体（9503）的内部细长体（9503）和外部细长体（9504）。所述装置还包括细长构件或轴（9502），所述细长构件或轴（9502）具有延伸到患者外部的近端，使得使用者可以通过缩回所述轴（9502）来收回所述支架筐装置和所述血块。外部细长主体（9504）和内部细长主体（9503）连接到轴（9502）的远端并且可相对于轴（9502）从折叠的输送配置可扩展到展开的展开配置。外部细长体9504可相对于内部细长体9503扩张到在展开构型中大于内部主体9503的径向范围的径向程度。

26. 发明申请

US20130144326A1 CLOT CAPTURE SYSTEMS AND ASSOCIATED METHODS 有权
标题翻译：收集系统和相关方法
公开(公告)号：US20130144326A1
公开(公告)日：2013-06-06
申请号：US13662299
申请日：2012-10-26
申请人： Eamon Brady , David Vale , Michael Gilvarry , Mahmood Razavi , John O'Shaughnessy
发明人： Eamon Brady , David Vale , Michael Gilvarry , Mahmood Razavi , John O'Shaughnessy
IPC分类号： A61F2/01
CPC分类号： A61B17/221 , A61B2017/2212 , A61F2/01 , A61F2/013 , A61F2230/0006 , A61F2230/0008 , A61F2230/001 , A61F2230/005 , A61F2230/0058
摘要： A clot capture system for disengaging a clot from a vessel wall and removing the clot from the vessel, comprises a clot capture device for placement on a distal side of a clot. The clot capture device has a retracted delivery configuration and an expanded deployed configuration. The clot removal device has a proximal support frame, and a distal fibre net. The support frame has a retracted delivery configuration and an expanded deployed configuration. The proximal support frame in the expanded configuration defines a proximal inlet mouth for engaging a clot and a net for confining the clot. An elongate member facilitates capture and/or withdrawal of a clot from a vessel.
摘要翻译：一种凝块捕获系统，用于使凝块与容器壁分离并从血管中除去凝块，包括用于放置在凝块远侧的凝块捕获装置。血块捕获装置具有缩回的递送配置和扩展的部署配置。凝块去除装置具有近端支撑框架和远端纤维网。支撑框架具有缩回的传送配置和扩展的部署配置。在扩展构型中的近侧支撑框架限定了用于接合凝块的近端入口和用于限制凝块的网。细长构件便于从血管捕获和/或撤出凝块。

27. 发明申请

US20070060945A1 Embolic protection device 有权
标题翻译：栓塞保护装置
公开(公告)号：US20070060945A1
公开(公告)日：2007-03-15
申请号：US11529525
申请日：2006-09-29
申请人： Paul Gilson , Eamon Brady , Michael Gilvarry
发明人： Paul Gilson , Eamon Brady , Michael Gilvarry
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A collapsible filter element for a transcatheter embolic protection device, the filter element comprises a collapsible filter body of polymeric material which is movable between a collapsed stored position for movement through a vascular system and an expanded position for extension across a blood vessel such that blood passing through the blood vessel is delivered through the filer element. A proximal inlet portion of the filter body has one or more inlet openings sized to allow blood and embolic material enter the filter body. A distal outlet portion of the filter body has a plurality of generally circular outlet openings sized to allow through-passage of blood, but to retain embolic material within the filter body. The distal outlet portion of the filter body in the region of the outlet openings has means for reducing shear stress on blood passing through the outlet openings. The shear stress reducing means includes lead-in and lead-out radiussed portions of the filter body leading to the outlet holes. The porosity of the distal portion of the filter body decreases towards the distal end. A blind portion extends for at least 5% of the length of the body. Preferably there are between 200 and 300 outlet opening with an average diameter of approximately 150 microns.
摘要翻译：一种用于经导管栓塞保护装置的可折叠过滤器元件，所述过滤元件包括聚合材料的可折叠过滤体，其可在通过血管系统移动的折叠存储位置和用于延伸穿过血管的扩张位置之间移动，使得血液通过通过血管通过滤器元件输送。过滤器本体的近端入口部分具有一个或多个入口开口，其大小允许血液和栓塞物质进入过滤器主体。过滤器主体的远端出口部分具有多个大致圆形的出口开口，其尺寸允许血液通过，但是将栓塞材料保持在过滤器本体内。在出口开口区域中的过滤器本体的远端出口部分具有减少通过出口开口的血液的剪切应力的装置。剪切应力减小装置包括通向出口孔的过滤体的引入和引出半径部分。过滤器主体的远端部分的孔隙朝向远端减小。盲部延伸至身体长度的至少5％。优选地，具有200至300个出口开口，平均直径约为150微米。

28. 发明授权

US09301769B2 Clot retrieval device for removing clot from a blood vessel 有权
标题翻译：用于从血管中去除凝块的凝块取出装置
公开(公告)号：US09301769B2
公开(公告)日：2016-04-05
申请号：US13823060
申请日：2012-03-09
申请人： Eamon Brady , Michael Gilvarry , Mahmood K. Razavi , David Vale , Patrick Griffin , Brendan Casey , Jason McNamara
发明人： Eamon Brady , Michael Gilvarry , Mahmood K. Razavi , David Vale , Patrick Griffin , Brendan Casey , Jason McNamara
IPC分类号： A61B17/22 , A61B17/221 , A61F2/01 , A61B17/3207
CPC分类号： A61B17/221 , A61B17/22031 , A61B17/320725 , A61B2017/00292 , A61B2017/00526 , A61B2017/00867 , A61B2017/22034 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61F2/013 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0069 , A61F2230/008 , A61F2230/0091 , A61F2230/0093
摘要： A clot retrieval device (9501) for removing occlusive clot from a blood vessel comprises an inner elongate body (9503) and an outer elongate body (9504) at least partially overlying the inner elongate body (9503). The device also comprises an elongate member or shaft (9502) having a proximal end which extends exterior of a patient so that a user can retrieve the stent-basket device and captured clot by retracting the shaft (9502). The outer elongate body (9504) and the inner elongate body (9503) are connected to the distal end of the shaft (9502) and are expandable relative to the shaft (9502) from a collapsed delivery configuration to an expanded deployed configuration. The outer elongate body (9504) is expandable relative to the inner elongate body (9503) to a radial extent which is greater than the radial extent of the inner body (9503) in the deployed configuration.
摘要翻译：用于从血管去除闭塞凝块的凝块取出装置（9501）包括至少部分地覆盖内部细长体（9503）的内部细长体（9503）和外部细长体（9504）。所述装置还包括细长构件或轴（9502），所述细长构件或轴（9502）具有延伸到患者外部的近端，使得使用者可以通过缩回所述轴（9502）来收回所述支架筐装置和所述血块。外部细长主体（9504）和内部细长主体（9503）连接到轴（9502）的远端并且可相对于轴（9502）从折叠的输送配置可扩展到展开的展开配置。外部细长体9504可相对于内部细长体9503扩张到在展开构型中大于内部主体9503的径向范围的径向程度。

29. 发明申请

US20140277079A1 CLOT RETRIEVAL DEVICES 有权
标题翻译：衣服检索设备
公开(公告)号：US20140277079A1
公开(公告)日：2014-09-18
申请号：US13829684
申请日：2013-03-14
申请人： David Vale , Eamon Brady , Michael Gilvarry , Mahmood Ravazi
发明人： David Vale , Eamon Brady , Michael Gilvarry , Mahmood Ravazi
IPC分类号： A61B17/221
CPC分类号： A61B17/221 , A61B2017/22034 , A61B2017/22061 , A61B2017/22094 , A61B2017/2215
摘要： A self-expandable mechanical clot retrieval device is designed variously to dislodge, engage and retract blood clot from extremely small and tortuous vasculature. The retrieval device comprises an elongate member and a plurality of ring elements. The ring elements may comprise a plurality of struts and crowns interconnected by a tether formed at a distal end of the elongate member or may be a separate component attached thereto. At least one tether may connect each ring element to the elongate member to restrain the ring element in a collapsed configuration during delivery of the retrieval device through an intravascular microcatheter. The tether connecting the ring element to the elongate member disengages when the retrieval device is positioned at the occluded site and the microcatheter is retracted to allow the self-expandable ring elements to reach an expanded configuration.
摘要翻译：可自动扩张的机械凝块取出装置被设计成不同程度地从非常小且弯曲的脉管系统中移出，接合和收回血块。检索装置包括细长构件和多个环形元件。环形元件可以包括通过形成在细长构件的远端处的系绳互连的多个支柱和冠部，或者可以是附接到其上的单独部件。至少一个系绳可以将每个环形元件连接到细长构件，以在通过血管内微导管递送检索装置期间将环形元件限制在折叠构型。当拾取装置定位在闭塞位置并且微导管缩回以允许自扩张环元件达到扩张构型时，将环形元件连接到细长构件的系绳脱离。

30. 发明申请

US20130184739A1 CLOT ENGAGEMENT AND REMOVAL SYSTEMS 审中-公开
标题翻译：衣服接合和拆卸系统
公开(公告)号：US20130184739A1
公开(公告)日：2013-07-18
申请号：US13643970
申请日：2011-04-28
申请人： Eamon Brady , David Vale , Michael Gilvarry , Mahmood Razavi
发明人： Eamon Brady , David Vale , Michael Gilvarry , Mahmood Razavi
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61B17/221 , A61B17/32056 , A61B2017/00287 , A61B2017/2212
摘要： A device for the removal of clot obstructing the flow of blood through an arterial vessel comprises an elongate member, a clot engaging element and a capture basket. The elongate member extends in use from a point adjacent a target treatment site interior of the patient to a point exterior of the patient. The capture basket comprises a frame and a net, and has an expanded and a collapsed configuration. The clot engaging element comprises a plurality of struts having an expanded and a collapsed configuration. The plurality of struts form a first section and a second section, the first section tapering outward and distally from the elongate member and connected to the second section. The second section comprises a plurality of cells defined by a plurality of struts and arranged around at least a portion of the circumference of an axis substantially parallel to that of the elongate member. The clot engaging element and the capture basket are restrained in the collapsed configuration for delivery to the target site. The clot engaging element is located adjacent the distal end of the elongate member and proximal of the capture basket.
摘要翻译：用于去除阻塞血液通过动脉血管的血块的装置包括细长构件，凝块接合元件和捕获篮。细长构件在使用中从邻近患者的目标治疗部位内部的点延伸到患者外部的点。捕获篮包括框架和网，并且具有展开和折叠构造。凝块接合元件包括具有膨胀和收缩构型的多个支柱。多个支柱形成第一部分和第二部分，第一部分从细长部件向外和远端逐渐变细并连接到第二部分。第二部分包括由多个支柱限定并且围绕基本上平行于细长构件的轴线的圆周的至少一部分布置的多个单元。凝块接合元件和捕获筐被限制在折叠构型中以输送到目标位置。凝块接合元件位于细长构件的远端和捕获篮的近侧附近。

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