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21. 发明授权

US07642268B2 Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament 有权
标题翻译：结晶微米酸盐，其制备方法及其用于制备药物的用途
公开(公告)号：US07642268B2
公开(公告)日：2010-01-05
申请号：US11532716
申请日：2006-09-18
申请人： Helmut Bender , Hagen Graebner , Konrad Schindler , Michael Trunk , Michael Walz
发明人： Helmut Bender , Hagen Graebner , Konrad Schindler , Michael Trunk , Michael Walz
IPC分类号： C07D491/08 , A61K31/4745
CPC分类号： A61K9/0075
摘要： The invention relates to a crystalline micronisate of (1 α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide, processes for preparing it and its use for preparing a pharmaceutical composition, particularly for preparing a pharmaceutical composition with an anticholinergic activity.
摘要翻译：本发明涉及（1α，2beta，4beta，5α，7beta）-7 - [（羟基二-2-噻吩基乙酰基）氧基] -9,9-二甲基-3-氧杂-9-氮杂三环[3.3.2]的微晶硅酸盐。 1.02,4]壬烷溴化物，其制备方法及其用于制备药物组合物的用途，特别是用于制备具有抗胆碱能活性的药物组合物。

22. 发明申请

US20070231272A1 Process for Preparing Inhalable Powders 审中-公开
标题翻译：制备可吸入粉末的方法
公开(公告)号：US20070231272A1
公开(公告)日：2007-10-04
申请号：US11762252
申请日：2007-06-13
申请人： Georg Boeck , Michael Walz
发明人： Georg Boeck , Michael Walz
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K31/46
摘要： The invention relates to a new process for producing powdered preparations for inhalation comprising a substance having a smaller particle size distribution and a substance having a larger particle size distribution, wherein a substance having a smaller particle size distribution and a substance having a larger particle size distribution are continuously metered into a suitable mixing container such that the quotient N of the delivery speed for the metering of the substance having the smaller particle size distribution and the delivery speed for the metering of the substance having the larger particle size distribution is at least as great as the quotient M of the total mass of the substance having the smaller particle size distribution and the total mass of the substance having the larger particle size distribution.
摘要翻译：本发明涉及一种用于生产粉末吸入制剂的新方法，其包括具有较小粒度分布的物质和具有较大粒度分布的物质，其中具有较小粒度分布的物质和具有较大粒度分布的物质连续地计量到合适的混合容器中，使得具有较小粒度分布的物质计量的输送速度的商N和具有较大粒度分布的物质计量的输送速度至少为作为具有较小粒度分布的物质和具有较大粒度分布的物质的总质量的总质量的商M。

23. 发明授权

US07244414B2 Process for preparing inhalable powders 有权
标题翻译：制备可吸入粉末的方法
公开(公告)号：US07244414B2
公开(公告)日：2007-07-17
申请号：US10225781
申请日：2002-08-22
申请人： Georg Boeck , Michael Walz
发明人： Georg Boeck , Michael Walz
IPC分类号： A61K9/12 , A61K9/14 , A61K13/02 , A61K9/48 , A61K9/64
CPC分类号： A61K9/0075 , A61K31/46
摘要： The invention relates to a new process for producing powdered preparations for inhalation comprising a substance having a smaller particle size distribution and a substance having a larger particle size distribution, wherein a substance having a smaller particle size distribution and a substance having a larger particle size distribution are continuously metered into a suitable mixing container such that the quotient N of the delivery speed for the metering of the substance having the smaller particle size distribution and the delivery speed for the metering of the substance having the larger particle size distribution is at least as great as the quotient M of the total mass of the substance having the smaller particle size distribution and the total mass of the substance having the larger particle size distribution.
摘要翻译：本发明涉及一种用于生产粉末吸入制剂的新方法，其包括具有较小粒度分布的物质和具有较大粒度分布的物质，其中具有较小粒度分布的物质和具有较大粒度分布的物质连续地计量到合适的混合容器中，使得具有较小粒度分布的物质计量的输送速度的商N和具有较大粒度分布的物质计量的输送速度至少为作为具有较小粒度分布的物质和具有较大粒度分布的物质的总质量的总质量的商M。

24. 发明申请

US20070031347A1 Powdered Medicaments Containing A Tiotropium Salt and Salmeterol Xinafoate 审中-公开
标题翻译：含有噻托铵盐和沙美特罗昔萘酸盐的粉末药剂
公开(公告)号：US20070031347A1
公开(公告)日：2007-02-08
申请号：US11537674
申请日：2006-10-02
申请人： Mareke Hartig , Michael Trunk , Rainer Soyka , Peter Sieger , Hagen Graebner , Michael Walz
发明人： Mareke Hartig , Michael Trunk , Rainer Soyka , Peter Sieger , Hagen Graebner , Michael Walz
IPC分类号： A61K9/14 , A61K9/48 , A61K9/20 , A61L9/04
CPC分类号： A61K9/0075 , A61K31/137 , A61K31/205 , A61K31/439 , A61K31/4745 , A61K2300/00
摘要： The invention relates to powdered preparations for inhalation containing a tiotropium salt and salmeterol xinafoate, processes for preparing them and their use in the preparation of a pharmaceutical composition for treating respiratory diseases, particularly for treating COPD (chronic obstructive pulmonary disease) and asthma.
摘要翻译：本发明涉及含有噻托铵盐和沙美特罗昔萘酸盐的吸入粉剂，其制备方法及其在制备用于治疗呼吸系统疾病，特别是治疗COPD（慢性阻塞性肺病）和哮喘的药物组合物中的用途。

25. 发明申请

US20060132267A1 SHAPE MEMORY ALLOY TRIP MECHANISM FOR ARC/GROUND FAULT CIRCUIT INTERRUPTION 有权
标题翻译：用于电弧/接地故障电路中断的形状记忆合金跳闸机制
公开(公告)号：US20060132267A1
公开(公告)日：2006-06-22
申请号：US11016950
申请日：2004-12-20
申请人： Michael Walz , Patrick Mills , Richard Benshoff , Peter Nerstrom
发明人： Michael Walz , Patrick Mills , Richard Benshoff , Peter Nerstrom
IPC分类号： H01H75/12
CPC分类号： H01H83/20 , H01H73/30 , H01H2083/201
摘要： A miniature circuit breaker comprising a non-conductive housing assembly; a pair of separable contacts including a first, fixed contact coupled to said housing assembly and having a terminal extending outside said housing assembly, and a second, movable contact having a terminal extending outside said housing assembly; an operating mechanism coupled to, and structured to move, said movable contact between a first position, wherein said movable contact engages said fixed contact, and a second position, wherein said movable contact is spaced from said fixed contact; a trip device coupled to said operating mechanism and structured to actuate said operating mechanism to separate said separable contacts upon the occurrence of a trip condition; an arc fault trip mechanism having an arc fault detector and a shape memory alloy element; said arc fault detector structured to detect an arc fault on the load side of said separable contacts and to provide an electrical pulse; said shape memory alloy element structured to transform between a first shape and a second shape during the application of an electrical pulse, said shape memory alloy element having a first end and a second end, said shape memory alloy element first end coupled to said housing assembly, said shape memory alloy element coupled to said trip device; said arc fault detector further coupled to said shape memory alloy element and structured to provide an electrical pulse to said shape memory alloy element sufficient to transform said shape memory alloy element from said first shape and said second shape; and wherein when said shape memory alloy element is in said second shape, said trip device is actuated and said operating mechanism separates said separable contacts.
摘要翻译：一种包括非导电壳体组件的微型断路器; 一对可分离触点，包括耦合到所述壳体组件的第一固定触点，并且具有延伸到所述壳体组件外部的端子;以及第二可移动触点，其具有延伸到所述壳体组件外部的端子; 操作机构，其联接到第一位置并且构造成在所述可动触头与所述固定触点接合的第一位置和第二位置之间联接并构造成移动所述可动触头，其中所述可动触头与所述固定触点间隔开; 耦合到所述操作机构并被构造成致动所述操作机构以在发生跳闸状态时分离所述可分离触点的跳闸装置; 具有电弧故障检测器和形状记忆合金元件的电弧故障跳闸机构; 所述电弧故障检测器被构造成检测所述可分离触点的负载侧上的电弧故障并提供电脉冲; 所述形状记忆合金元件构造成在施加电脉冲期间在第一形状和第二形状之间转变，所述形状记忆合金元件具有第一端和第二端，所述形状记忆合金元件第一端联接到所述壳体组件，所述形状记忆合金元件耦合到所述跳闸装置; 所述电弧故障检测器还耦合到所述形状记忆合金元件并且被构造为向所述形状记忆合金元件提供足以将所述形状记忆合金元件从所述第一形状和所述第二形状变换的电脉冲; 并且其中当所述形状记忆合金元件处于所述第二形状时，所述跳闸装置被致动，并且所述操作机构分离所述可分离触点。

26. 发明授权

US06585959B2 Process for preparing powder formulations 有权
标题翻译：粉末制剂的制备方法
公开(公告)号：US06585959B2
公开(公告)日：2003-07-01
申请号：US09977911
申请日：2001-10-11
申请人： Michael Walz , Georg Boeck
发明人： Michael Walz , Georg Boeck
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/14 , A61K9/145 , A61K31/439
摘要： The invention relates to a new process for producing powdered preparations for inhalation.
摘要翻译：本发明涉及一种生产用于吸入的粉末制剂的新方法。

27. 发明申请

US20110298587A1 SAFETY SYSTEM FOR AVOIDING WRONG USE OF MEDICINE 审中-公开
标题翻译：避免药物使用不当的安全系统
公开(公告)号：US20110298587A1
公开(公告)日：2011-12-08
申请号：US12999140
申请日：2009-07-03
申请人： Michael Walz
发明人： Michael Walz
IPC分类号： G06K7/01
CPC分类号： A61M15/0045 , A61J7/0427 , A61J2205/60 , A61J2205/70 , A61M15/0028 , A61M2202/04 , A61M2202/064 , A61M2205/276 , A61M2205/581 , A61M2205/583 , A61M2205/6054
摘要： A safety system (1) for avoiding wrong use of a medicine (2) with the aid of an applicator device (4) consisting of an RFID system of reader (5) and transponder (3) which are alternately assigned to the applicator device (4) and to the medicine (2). A use of the applicator device (4) or the removal of the medicine (2) from the package for use with the applicator device (4) is only possible when clearance is granted by the RFID system.
摘要翻译：一种用于避免错误使用药物（2）的安全系统（1），所述安全系统（1）借助于由读取器（5）和应答器（3）的RFID系统组成的施加器装置（4），所述RFID系统交替地分配给所述施加器装置 4）和药物（2）。只有当RFID系统允许间隙时，才能使用涂抹器装置（4）或将药物（2）从包装中移除以与涂抹器装置（4）一起使用。

28. 发明申请

US20100189780A1 Novel Powderous Medicaments Comprising Tiotropium and Salmeterol and Lactose as Carrier 审中-公开
标题翻译：含有噻托溴铵和沙美特罗和乳糖作为载体的新型药物
公开(公告)号：US20100189780A1
公开(公告)日：2010-07-29
申请号：US12670001
申请日：2008-07-18
申请人： Michael Walz , Stephanie Ossadnik , Michael Trunk , Christoph Kreher
发明人： Michael Walz , Stephanie Ossadnik , Michael Trunk , Christoph Kreher
IPC分类号： A61K9/48 , A61K31/46 , A61K9/14 , A61P11/00 , B65D81/26 , B65D85/00 , B65B31/00 , A61M15/00
CPC分类号： A61K31/137 , A61K9/0075 , A61K9/14 , A61K31/439 , A61M11/003 , A61M15/0026 , A61M15/0028 , A61M2202/064 , A61K2300/00
摘要： The invention relates to stable preparations in powder form for inhalation comprising a tiotropium salt and salmeterol xinafoate, process for the production thereof, and the use thereof for manufacturing a medicament for the treatment of respiratory disorders, especially for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
摘要翻译：本发明涉及用于吸入的粉末形式的稳定制剂，其包含噻托铵盐和沙美特罗昔萘酸盐，其制备方法及其用于制备用于治疗呼吸系统疾病的药物的用途，特别是用于治疗COPD（慢性阻塞性肺疾病）和哮喘。

29. 发明申请

US20090277446A1 INHALER 有权
标题翻译：吸入器
公开(公告)号：US20090277446A1
公开(公告)日：2009-11-12
申请号：US12296774
申请日：2007-04-04
申请人： Michael Walz
发明人： Michael Walz
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/003 , A61M15/0021 , A61M15/0026 , A61M15/0035 , A61M15/0041 , A61M2202/064 , A61M2205/583 , A61M2205/6045
摘要： Disclosed is an inhaler, especially a powder inhaler, for administering a medicament in the form of inhalable substances, substance formulations, or substance mixtures. Said inhaler comprises a housing that is provided with a chamber (4) for accommodating the substances. The chamber (4) is replaceably disposed inside the housing.
摘要翻译：公开了一种用于施用可吸入物质，物质制剂或物质混合物形式的药物的吸入器，特别是粉末吸入器。所述吸入器包括设置有用于容纳物质的室（4）的壳体。腔室（4）可更换地设置在壳体内。

30. 发明申请

US20080244181A1 Dynamic run-time cache size management 审中-公开
标题翻译：动态运行时缓存大小管理
公开(公告)号：US20080244181A1
公开(公告)日：2008-10-02
申请号：US11731110
申请日：2007-03-30
申请人： Michael Walz , Venkat Ramana Yalla
发明人： Michael Walz , Venkat Ramana Yalla
IPC分类号： G06F12/00
CPC分类号： G06F12/0864 , G06F2212/601 , Y02D10/13
摘要： Methods and apparatus relating to dynamic management of cache sizes during run-time are described. In one embodiment, the size of an active portion of a cache may be adjusted (e.g., increased or decreased) based on a cache busyness metric. Other embodiments are also disclosed.
摘要翻译：描述与运行期间的高速缓存大小的动态管理有关的方法和设备。在一个实施例中，高速缓存的活动部分的大小可以基于高速缓存繁忙度量来调整（例如，增加或减少）。还公开了其他实施例。

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