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21. 发明授权

US07253180B2 Pre-organized tricyclic integrase inhibitor compounds 失效
标题翻译：预先组织的三环整合酶抑制剂化合物
公开(公告)号：US07253180B2
公开(公告)日：2007-08-07
申请号：US10687373
申请日：2003-10-16
申请人： James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
发明人： James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
IPC分类号： A01N43/42 , A61K31/44 , C07D471/00 , C07D491/00 , C07D498/00
CPC分类号： C07D207/404 , C07D471/04 , C07D487/04
摘要： Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
摘要翻译：公开了根据以下结构的三环化合物，其受保护的中间体和用于抑制HIV整合酶的方法。 A 1和A 2是形成五，六或七元环的部分。 L是连接Ar与N的环原子的键或连接体.X是O，S或取代的氮。 Ar是芳基或杂芳基。 Q是N，^{+ NR，或CR 4。芳基碳可以独立地被除氢以外的取代基取代。化合物可以包括共价连接在任何位点的前药部分。}

22. 发明授权

US06825354B2 Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and TACE inhibitors 失效
标题翻译：含有异羟肟酸的炔基作为基质金属蛋白酶和TACE抑制剂
公开(公告)号：US06825354B2
公开(公告)日：2004-11-30
申请号：US10055502
申请日：2001-11-13
申请人： Jeremy I. Levin , Aranapakam M. Venkatesan , Derek C. Cole , James M. Chen , Jamie M. Davis , George T. Grosu
发明人： Jeremy I. Levin , Aranapakam M. Venkatesan , Derek C. Cole , James M. Chen , Jamie M. Davis , George T. Grosu
IPC分类号： C07D21172
CPC分类号： C07D209/48 , C07C317/44 , C07C317/50 , C07C323/60 , C07C2601/14 , C07D207/34 , C07D213/56 , C07D215/48 , C07D215/54 , C07D217/26 , C07D295/088 , C07D309/04 , C07D311/84 , C07D333/20 , C07D333/60 , C07D335/02
摘要： Compounds of the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
摘要翻译：该化合物可用于治疗由TNF-α介导的疾病状况，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。

23. 发明授权

US06313123B1 Acetylenic sulfonamide thiol tace inhibitors 失效
标题翻译：乙酰磺胺硫胺止痛剂
公开(公告)号：US06313123B1
公开(公告)日：2001-11-06
申请号：US09492974
申请日：2000-01-27
申请人： Jeremy I. Levin , James M. Chen
发明人： Jeremy I. Levin , James M. Chen
IPC分类号： A61K315375
CPC分类号： C07D295/13 , A61K31/5375 , C07C323/49
摘要： The compounds of formula B: which are useful in disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss
摘要翻译：式B化合物，其可用于由TNF-α介导的疾病状态，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失

24. 发明授权

US06200996B1 Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors 失效
标题翻译：杂芳基炔基磺酰胺和次膦酸酰胺异羟肟酸抑制剂
公开(公告)号：US06200996B1
公开(公告)日：2001-03-13
申请号：US09492976
申请日：2000-01-27
申请人： Jeremy I. Levin , James M. Chen , Frances C. Nelson
发明人： Jeremy I. Levin , James M. Chen , Frances C. Nelson
IPC分类号： A61K3144
CPC分类号： A61K31/44
摘要： Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr; such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
摘要翻译：式的化合物可用于治疗由TNF-α介导的疾病状况，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。

25. 发明授权

US5643545A Catalytic method and device for controlling VOC, CO and halogenated organic emissions 失效
标题翻译：用于控制VOC，CO和卤化有机物排放的催化方法和装置
公开(公告)号：US5643545A
公开(公告)日：1997-07-01
申请号：US482464
申请日：1995-06-08
申请人： James M. Chen , Pascaline Nguyen
发明人： James M. Chen , Pascaline Nguyen
IPC分类号： B01D53/86 , B01J23/56 , B01J35/00 , B01D53/72
CPC分类号： B01D53/864 , B01D53/8662 , B01D53/8668 , B01J35/0006
摘要： A method and device for treating a gas stream comprising at least one non-halogenated carbonaceous compound and optionally at least one halogenated organic compound. The gas stream, at 100.degree. C. to 650.degree. C. and in the presence of oxygen is contacted with a first catalyst in a first catalyst zone. The first catalyst comprises a first catalytic material deposited on a low acidity support material. In this zone, the non-halogenated compound is selectively reacted to form innocuous materials such as water and carbon monoxide. This can be followed by contacting the gas stream with a second catalyst in a second catalyst zone. The second catalyst comprises a second catalytic material deposited on a high acidity support material. In this zone, the halogenated organic compounds are reacted.
摘要翻译：一种用于处理包含至少一种非卤化碳质化合物和任选的至少一种卤化有机化合物的气流的方法和装置。在100℃至650℃和氧气存在下，气流与第一催化剂区中的第一催化剂接触。第一催化剂包含沉积在低酸度载体材料上的第一催化材料。在该区域中，非卤化化合物选择性地反应以形成无害物质，例如水和一氧化碳。这可以在第二催化剂区域中使气流与第二催化剂接触。第二催化剂包含沉积在高酸性载体材料上的第二催化材料。在该区域中，卤化有机化合物反应。

26. 发明授权

US4545890A Coal liquefaction and hydrogenation 失效
标题翻译：煤液化和氢化
公开(公告)号：US4545890A
公开(公告)日：1985-10-08
申请号：US605764
申请日：1984-04-30
申请人： Harvey D. Schindler , James M. Chen
发明人： Harvey D. Schindler , James M. Chen
IPC分类号： C10G1/00 , C10G1/06
CPC分类号： C10G1/002
摘要： Disclosed is a coal liquefaction process using two stages. The first stage liquefies the coal and maximizes the product while the second stage hydrocracks the remainder of the coal liquid to produce solvent.
摘要翻译：公开了使用两个阶段的煤液化过程。第一阶段液化煤并使产品最大化，而第二阶段加氢裂解剩余的煤液体产生溶剂。

27. 发明授权

US4343776A Ozone abatement catalyst having improved durability and low temperature performance 失效
标题翻译：臭氧消除催化剂具有改善的耐久性和低温性能
公开(公告)号：US4343776A
公开(公告)日：1982-08-10
申请号：US218374
申请日：1980-12-22
申请人： William F. Carr , James M. Chen
发明人： William F. Carr , James M. Chen
IPC分类号： B01D53/86 , B01J23/89 , B01J35/04 , C01B13/00 , B01D53/36
CPC分类号： B01D53/8675 , B01J23/89 , B01J35/04
摘要： Precious metal ozone decomposition catalyst, its stabilization and method for decomposing ozone for purification and detoxification purposes by contacting with a decomposition catalyst containing a platinum group metal and a nonprecious Group VIII metal oxide or aluminate on a support, favoring exposure to ozone of the platinum group metal over the nonprecious metal oxide or aluminate, the arrangement favoring maximum conversion per unit volume and system pressure drop by catalytic element configuration within a given catalyst volume.
摘要翻译：贵金属臭氧分解催化剂，其稳定性和分解臭氧用于纯化和解毒的目的是通过与载体上含有铂族金属和非贵重的第VIII族金属氧化物或铝酸盐的分解催化剂接触，有利于暴露于铂族的臭氧在非贵重的金属氧化物或铝酸盐上的金属，这种排列有利于每单位体积的最大转化率和在给定催化剂体积内的催化元件构型的体系压降。

28. 发明授权

US08324179B2 Nucleoside analogs for antiviral treatment 有权
标题翻译：用于抗病毒治疗的核苷类似物
公开(公告)号：US08324179B2
公开(公告)日：2012-12-04
申请号：US12524545
申请日：2008-02-08
申请人： James M. Chen , Alan X. Huang , Richard L. Mackman , Jay Parrish , Jason K. Perry , Oliver L. Saunders , David Sperandio
发明人： James M. Chen , Alan X. Huang , Richard L. Mackman , Jay Parrish , Jason K. Perry , Oliver L. Saunders , David Sperandio
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07F9/65586 , C07F9/6561 , C07F9/65616 , C07H19/00
摘要： The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically acceptable salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans).
摘要翻译：本发明提供了本文所述的式I的不饱和膦酸酯或其互变异构体或其药学上可接受的盐，以及包含该化合物的药物组合物，以及包括施用化合物的治疗方法。所述化合物具有抗病毒性质，并且可用于治疗动物（例如人）中的病毒感染（例如HCV）。

29. 发明申请

US20100104532A1 NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT 有权
标题翻译：用于抗病毒治疗的核苷类似物
公开(公告)号：US20100104532A1
公开(公告)日：2010-04-29
申请号：US12524545
申请日：2008-02-08
申请人： James M. Chen , Alan X. Huang , Richard L. Mackman , Jay Parrish , Jason K. Perry , Oliver L. Saunders , David Sperandio
发明人： James M. Chen , Alan X. Huang , Richard L. Mackman , Jay Parrish , Jason K. Perry , Oliver L. Saunders , David Sperandio
IPC分类号： A61K38/21 , C07H19/23 , C07H19/16 , C07H19/06 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K31/7056 , A61K31/708 , A61K31/7072 , A61K31/7068 , A61P31/14 , A61P1/16
CPC分类号： C07F9/65586 , C07F9/6561 , C07F9/65616 , C07H19/00
摘要： The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically accepatble salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans).
摘要翻译：本发明提供如本文所述的式I的不饱和膦酸酯或其互变异构体或药学上可接受的盐，以及包含该化合物的药物组合物，以及包括施用化合物的治疗方法。所述化合物具有抗病毒性质，并且可用于治疗动物（例如人）中的病毒感染（例如HCV）。

30. 发明申请

US20100022467A1 ANTI-CANCER PHOSPHONATE ANALOGS 审中-公开
标题翻译：抗癌剂磷酸酯类似物
公开(公告)号：US20100022467A1
公开(公告)日：2010-01-28
申请号：US12202719
申请日：2008-09-02
申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
IPC分类号： A61K31/7076 , C07H19/20 , A61P35/00
CPC分类号： A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04
摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

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