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21. 发明授权

US06531575B1 ATP synthase subunits 失效
标题翻译： ATP合酶亚基
公开(公告)号：US06531575B1
公开(公告)日：2003-03-11
申请号：US09546306
申请日：2000-04-10
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07K100
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.
摘要翻译：本发明提供两个ATP合成酶亚单位（分别命名为Asy-1和Asy-2，统称为Asy）和识别和编码Asy的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码Asy的核酸序列和产生Asy的方法。本发明还提供了用于预防和治疗与Asy表达相关的疾病的Asy和特异性结合Asy的激动剂，抗体或拮抗剂。另外，本发明提供反义分子用于编码Asy的多核苷酸用于治疗与Asy表达相关的疾病。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合Asy的抗体的诊断测定法。

22. 发明授权

US6156523A Serine/threonine protein kinases 失效
标题翻译：丝氨酸/苏氨酸蛋白激酶
公开(公告)号：US6156523A
公开(公告)日：2000-12-05
申请号：US153939
申请日：1998-09-16
申请人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
发明人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/68 , A61K38/43 , C07K14/00 , C12N9/00 , C12N15/52 , G01N23/53
CPC分类号： C12N9/1205 , C12Y207/01037 , A61K38/00
摘要： The invention provides human serine/threonine protein kinases (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HSTK.
摘要翻译：本发明提供人丝氨酸/苏氨酸蛋白激酶（HSTK）和识别和编码HSTK的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSTK表达相关的病症的方法。

23. 发明授权

US6103874A Human KDEL receptor 失效
标题翻译：人类KDEL受体
公开(公告)号：US6103874A
公开(公告)日：2000-08-15
申请号：US133735
申请日：1998-08-13
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P5/14 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , C07K14/00 , A61K38/16 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.
摘要翻译：本发明提供了一种新的人KDEL受体（NHKR）和识别并编码NHKR的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NHKR的核酸序列和生产NHKR的方法。本发明还提供了特异性结合NHKR的激动剂，抗体或拮抗剂及其在预防和治疗与NHKR表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NHKR的多核苷酸用于治疗与NHKR表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHKR的抗体的诊断测定法。

24. 发明授权

US5863898A Human lim proteins 失效
标题翻译：人体蛋白质
公开(公告)号：US5863898A
公开(公告)日：1999-01-26
申请号：US739485
申请日：1996-10-28
申请人： Surya K. Goli , Jennifer L. Hillman , Olga Bandman
发明人： Surya K. Goli , Jennifer L. Hillman , Olga Bandman
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides three human LIM proteins (designated individually as HLIM-1, HLIM-2, and HLIM-3, and collectively as HLIM) and polynucleotides which identify and encode HLIM. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HLIM and a method for producing HLIM. The invention also provides for use of HLIM and agonists, antibodies, or antagonists specifically binding HLIM, in the prevention and treatment of diseases associated with expression of HLIM. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HLIM for the treatment of diseases associated with the expression of HLIM. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HLIM.
摘要翻译：本发明提供了三种人LIM蛋白（分别命名为HLIM-1，HLIM-2和HLIM-3，并且共同称为HLIM）和鉴定和编码HLIM的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码HLIM的核酸序列的宿主细胞和生产HLIM的方法。本发明还提供了用于预防和治疗与HLIM表达相关的疾病的HLIM和特异性结合HLIM的激动剂，抗体或拮抗剂。另外，本发明提供反义分子用于编码HLIM的多核苷酸用于治疗与HLIM表达相关的疾病。本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合HLIM的抗体的诊断测定法。

25. 发明授权

US06485933B1 B cell receptor associated proteins 失效
标题翻译： B细胞受体相关蛋白
公开(公告)号：US06485933B1
公开(公告)日：2002-11-26
申请号：US08851971
申请日：1997-05-07
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli , Sherry A. Capitant
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli , Sherry A. Capitant
IPC分类号： C07H2102
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides B cell receptor associated proteins (BCRP) and polynucleotides which identify and encode BCRP. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of BCRP.
摘要翻译：本发明提供鉴定和编码BCRP的B细胞受体相关蛋白（BCRP）和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与BCRP表达相关的疾病的方法。

26. 发明授权

US6043343A Tumor proteins 失效
标题翻译：肿瘤蛋白
公开(公告)号：US6043343A
公开(公告)日：2000-03-28
申请号：US162597
申请日：1998-09-29
申请人： Olga Bandman , Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C07K14/47 , A61K38/17 , C07K16/30 , G01N33/53
CPC分类号： C07K14/82 , A61K38/00
摘要： The present invention provides novel human tumor proteins (collectively called TUPRO) and polynucleotides which identify and encode TUPRO. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TUPRO. The invention also provides pharmaceutical compositions containing TUPRO or antagonists to TUPRO, and in the use of these compositions for the treatment of diseases associated with the expression of TUPRO. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TUPRO for the treatment of diseases associated with the expression of TUPRO. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding TUPRO or anti-TUPRO antibodies which specifically bind to TUPRO.
摘要翻译：本发明提供新型人肿瘤蛋白（统称为TUPRO）和识别和编码TUPRO的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码TUPRO的核酸序列的宿主细胞。本发明还提供含有TUPRO或TUPRO拮抗剂的药物组合物，以及这些组合物用于治疗与TUPRO表达相关的疾病的药物组合物。另外，本发明提供了将反义分子用于编码TUPRO的多核苷酸用于治疗与TUPRO表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补序列与编码特异性结合TUPRO的TUPRO或抗TUPRO抗体的多核苷酸的基因组序列或转录物进行杂交的诊断测定。

27. 发明授权

US6018028A Human proteasome subunit proteins 失效
标题翻译：人类蛋白酶体亚基蛋白
公开(公告)号：US6018028A
公开(公告)日：2000-01-25
申请号：US134591
申请日：1998-08-13
申请人： Olga Bandman , Janice Au-Young , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Janice Au-Young , Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N1/21 , C12N9/64 , C07K14/47
CPC分类号： C12N9/6421 , C12Y304/25001 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode novel human proteasome subunit proteins. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PSUB. The invention also provides for the use of substantially purified PSUB, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of PSUB. Additionally, the invention provides for the use of antisense molecules to PSUB in pharmaceutical compositions for treatment of diseases associated with the expression of PSUB. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding PSUB or anti-PSUB antibodies which specifically bind to PSUB.
摘要翻译：本发明提供鉴定和编码新的人蛋白酶体亚基蛋白的多核苷酸。本发明提供了包含编码PSUB的核酸序列的基因工程表达载体和宿主细胞。本发明还提供使用基本上纯化的PSUB，拮抗剂和药物组合物来治疗与PSUB表达相关的疾病。另外，本发明提供了用于治疗与PSUB表达相关的疾病的药物组合物中PSUB的反义分子的用途。本发明还描述了使用包含多核苷酸，其片段或其互补体的诊断组合物的诊断测定法，其与编码与PSUB特异性结合的PSUB或抗PSUB抗体的多核苷酸的基因组序列或转录物杂交。

28. 发明授权

US5824500A Nucleic acid encoding novel human KDEL receptor 失效
标题翻译：编码新型人类KDEL受体的核酸
公开(公告)号：US5824500A
公开(公告)日：1998-10-20
申请号：US753159
申请日：1996-11-21
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P5/14 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.
摘要翻译：本发明提供了一种新的人KDEL受体（NHKR）和识别和编码NHKR的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NHKR的核酸序列和生产NHKR的方法。本发明还提供了特异性结合NHKR的激动剂，抗体或拮抗剂及其在预防和治疗与NHKR表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NHKR的多核苷酸用于治疗与NHKR表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHKR的抗体的诊断测定法。

29. 发明申请

US20110053217A1 Polynucleotides encoding signal peptide-containing molecules 有权
标题翻译：编码含有信号肽的分子的多核苷酸
公开(公告)号：US20110053217A1
公开(公告)日：2011-03-03
申请号：US12457389
申请日：2009-06-09
申请人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
IPC分类号： C12P21/00 , C07H21/04 , C12N1/21 , C07H21/02 , C07K14/435
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译：本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。

30. 发明授权

US6096308A Human protein kinase and kinase inhibitors 失效
标题翻译：人类蛋白激酶和激酶抑制剂
公开(公告)号：US6096308A
公开(公告)日：2000-08-01
申请号：US231529
申请日：1999-01-14
申请人： Preeti Lal , Jennifer L. Hillman , Olga Bandman , Neil C. Corley , Purvi Shah
发明人： Preeti Lal , Jennifer L. Hillman , Olga Bandman , Neil C. Corley , Purvi Shah
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K39/395 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/47 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12P21/02 , C12Q1/68 , A61K38/51
CPC分类号： C12N9/1205 , C07K14/4703 , C12Q1/6883 , A61K38/00
摘要： The invention provides a human protein kinase (PK) and kinase inhibitors (PKI) and polynucleotides which identify and encode PK and PKI. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of PK and PKI.
摘要翻译：本发明提供了鉴定和编码PK和PKI的人蛋白激酶（PK）和激酶抑制剂（PKI）和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供用于诊断，治疗或预防与PK和PKI的表达相关的障碍的方法。

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