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21. 发明申请

US20110027757A1 MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：医疗装置及其制造方法
公开(公告)号：US20110027757A1
公开(公告)日：2011-02-03
申请号：US12809690
申请日：2008-12-19
申请人： Masayuki Kyomoto , Kazuhiko Ishihara , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Toru Moro
发明人： Masayuki Kyomoto , Kazuhiko Ishihara , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Toru Moro
IPC分类号： A61C8/00 , B32B3/00 , B32B13/12 , B05D1/18 , B05D3/06
CPC分类号： A61L33/0076 , A61K6/033 , A61K6/04 , A61L27/34 , A61L31/10 , Y10T428/31667 , A61K6/0023 , C08L33/08 , C08L33/10
摘要： An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
摘要翻译：本发明的目的是提供具有优异的抗血栓形成和滑动特性的医疗装置，其能够发挥细胞粘附抑制作用。一种医疗装置，包括：能够形成羟基的基材; 以及在适当位置层叠在基材上的生物相容性材料层，其中通过表面处理在至少所需位置上在基材的表面上形成羟基，同时生物相容性材料层由含有磷酸胆碱基团的聚合物形成，并且其中所述基材和所述生物相容性材料层通过分别与所述羟基和所述生物相容性材料共价键合的由二氧化硅形成的粘合剂层连接。

22. 发明申请

US20100262237A1 Biomaterial, Joint Prosthesis Using the Biomaterial and Method of Producing the Same 有权
标题翻译：生物材料，使用生物材料的联合假体及其生产方法
公开(公告)号：US20100262237A1
公开(公告)日：2010-10-14
申请号：US12225758
申请日：2007-03-26
申请人： Masayuki Kyomoto , Kazuhiko Ishihara , Yasuhiko Iwasaki , Toru Moro , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Tomohiro Konno , Noboru Yamawaki
发明人： Masayuki Kyomoto , Kazuhiko Ishihara , Yasuhiko Iwasaki , Toru Moro , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Tomohiro Konno , Noboru Yamawaki
IPC分类号： A61F2/02 , B32B3/10 , B05D3/06
CPC分类号： A61L27/34 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2002/30685 , A61F2002/30934 , A61F2002/3611 , A61F2310/00011 , A61F2310/00179 , A61L27/42 , B05D1/18 , B05D3/067 , B23K35/3618 , C22F1/11 , C22F1/183 , Y10T428/24917 , Y10T428/24926 , Y10T428/31536
摘要： The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
摘要翻译：本发明的目的是提供一种关节假体，轴承材料及其制造方法，其抑制滑动部分的磨损，并且即使在重复的日常操作中也抑制磨料粉末的生产。为了实现该目的，提供了一种生物材料，包括：由金属，合金或陶瓷制成的基底; 以及层叠在基材上的生物相容性材料层，其中通过表面处理在基材上形成羟基，而生物相容性材料层包含含有磷酸胆碱基团的聚合物，基材和生物相容性材料层通过粘合剂层结合，与基材的羟基和生物相容性材料层结合。

23. 发明申请

US20050008497A1 Droplet discharging head and microarray manufacturing method 有权
标题翻译：滴液喷头和微阵列制造方法
公开(公告)号：US20050008497A1
公开(公告)日：2005-01-13
申请号：US10850056
申请日：2004-05-20
申请人： Fumio Takagi , Kazuhiko Ishihara
发明人： Fumio Takagi , Kazuhiko Ishihara
IPC分类号： G01N33/53 , B01L3/02 , B41J2/14 , B41J2/16 , G01N35/10 , G01N37/00 , F04F11/00 , F04B37/02
CPC分类号： B01L3/0268 , B01L2200/021 , B01L2300/0809 , B01L2300/0819 , B01L2300/163 , B01L2400/0415 , B01L2400/0439 , B41J2/14314 , B41J2/1433 , B41J2/1606
摘要： It is an object of the present invention to provide a droplet discharging head suited to the discharge of a sample solution, and particularly one that contains a bio-related substance. This object is achieved by a droplet discharging head 1 for discharging a sample solution, wherein the portion of the inner walls of the droplet discharging head 1 that comes into contact with the sample solution is covered with a polymer composed of phosphorylcholine group-containing unsaturated compound units, or a copolymer including same. The droplet discharging head is preferably an electrostatic drive or piezoelectric drive type.
摘要翻译：本发明的目的是提供一种适于排出样品溶液的液滴喷射头，特别是含有生物相关物质的液滴喷射头。该目的通过用于排出样品溶液的液滴喷射头1来实现，其中与样品溶液接触的液滴喷射头1的内壁部分用由含磷酰胆碱基团的不饱和化合物单元或包含其的共聚物。液滴喷射头优选为静电驱动或压电驱动型。

24. 发明授权

US4933412A Method of imparting flame resistance to polyester fiber substrates 失效
标题翻译：赋予聚酯纤维基材耐火性的方法
公开(公告)号：US4933412A
公开(公告)日：1990-06-12
申请号：US309526
申请日：1989-02-10
申请人： Etsuo Ito , Masanari Matsumura , Kazuhiko Ishihara , Toshiaki Doyama
发明人： Etsuo Ito , Masanari Matsumura , Kazuhiko Ishihara , Toshiaki Doyama
IPC分类号： C09K21/08 , D06M13/02 , D06M13/08 , D06M101/00 , D06M101/16
CPC分类号： D06M13/08
摘要： This invention relates to a flame retardant for synthetic fiber substrates and a method of imparting flame resistance to such substrates using the flame retardant. The flame retardant of this invention comprises 75 to 95 weight parts of a hexabromocyclododecane compound having a melting point not less than 195.degree. C. and 25 to 5 weight parts of a hexabromocyclododecane compound having a melting point less than 160.degree. C., which hexabromocyclododecane compounds are available on bromination of trans-trans-cis-cyclododecatriene. This flame retardant imparts excellent flame resistance to synthetic fiber substrates. Moreover, when a synthetic fiber substrate is dyed using a dye bath containing this flame retardant and a dye, the soiling of the substrate and dyeing equipment is kept at the minimum.
摘要翻译：本发明涉及合成纤维基材用阻燃剂和使用阻燃剂赋予这种基材的阻燃性的方法。本发明的阻燃剂包含75至95重量份的熔点不低于195℃的六溴环十二烷化合物和25-5重量份熔点小于160℃的六溴环十二烷化合物，该六溴环十二烷化合物可用于反式 - 反 - 顺 - 环十二碳三烯的溴化反应。该阻燃剂对合成纤维基材赋予优异的阻燃性。此外，当使用含有该阻燃剂和染料的染浴将合成纤维基材染色时，将基材和染色设备的污染保持在最低限度。

25. 发明授权

US4666991A Fluorine-containing graft copolymer and adhesive and composite membrane made thereof 失效
标题翻译：含氟接枝共聚物及其制成的粘合剂和复合膜
公开(公告)号：US4666991A
公开(公告)日：1987-05-19
申请号：US792842
申请日：1985-10-30
申请人： Kiyohide Matsui , Kazuhiko Ishihara
发明人： Kiyohide Matsui , Kazuhiko Ishihara
IPC分类号： B01D69/12 , B01D71/78 , C08F291/00 , C09J151/00 , C08F291/04 , C08F291/06
CPC分类号： C09J151/00 , B01D69/12 , B01D71/78 , C08F291/00 , Y10S525/905 , Y10S525/906
摘要： A graft copolymer consisting essentially of a main chain polymer having a glass transition temperature (Tg) of at least 30.degree. C. and a graft chain fluorine-containing polymer having a repreating unit of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group, and R.sup.2 is a polyfluoroalkyl group.
摘要翻译：一种接枝共聚物，主要由玻璃化转变温度（Tg）至少为30℃的主链聚合物和具有下式表示的改性单元的接枝链含氟聚合物组成：其中R1为氢原子或低级烷基，R2为多氟烷基。

26. 发明授权

US09216241B2 Medical device and method for producing the same 有权
标题翻译：医疗器械及其制造方法
公开(公告)号：US09216241B2
公开(公告)日：2015-12-22
申请号：US12809690
申请日：2008-12-19
申请人： Masayuki Kyomoto , Kazuhiko Ishihara , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Toru Moro
发明人： Masayuki Kyomoto , Kazuhiko Ishihara , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Toru Moro
IPC分类号： A61L33/00 , A61L27/34 , A61L31/10 , A61K6/04 , A61K6/033
CPC分类号： A61L33/0076 , A61K6/033 , A61K6/04 , A61L27/34 , A61L31/10 , Y10T428/31667 , A61K6/0023 , C08L33/08 , C08L33/10
摘要： An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
摘要翻译：本发明的目的是提供具有优异的抗血栓形成和滑动特性的医疗装置，其能够发挥细胞粘附抑制作用。一种医疗装置，包括：能够形成羟基的基材; 以及在适当位置层叠在基材上的生物相容性材料层，其中通过表面处理在至少所需位置上在基材的表面上形成羟基，同时生物相容性材料层由含有磷酸胆碱基团的聚合物形成，并且其中所述基材和所述生物相容性材料层通过分别与所述羟基和所述生物相容性材料共价键合的由二氧化硅形成的粘合剂层连接。

27. 发明授权

US09192694B2 Biocompatible and low-abrasion member, and artificial joint using the same and method of producing the same 有权
标题翻译：生物相容性和低磨损性构件，以及使用其的人造接头及其制造方法
公开(公告)号：US09192694B2
公开(公告)日：2015-11-24
申请号：US12733976
申请日：2008-10-02
申请人： Masayuki Kyomoto , Kazuhiko Ishihara , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Toru Moro
发明人： Masayuki Kyomoto , Kazuhiko Ishihara , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Toru Moro
IPC分类号： A61F2/30 , A61L27/34 , A61L27/50 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44
CPC分类号： A61L27/34 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2002/30003 , A61F2002/30026 , A61F2002/30065 , A61F2002/30673 , A61F2002/30685 , A61F2002/30934 , A61F2002/30971 , A61F2310/00011 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00389 , A61F2310/00916 , A61F2310/00976 , A61L27/50 , A61L2400/18 , A61L2430/24
摘要： The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
摘要翻译：本发明的目的是提供一种滑动构件，假体和滑动构件的制造方法，其可以通过抑制滑动部的摩擦来抑制磨损残渣的产生，并且还可以在体内保持令人满意的机械特性。一种滑动构件，包括：能够形成羟基的基底1; 以及层叠在基板1的适当部分上的生物相容性材料层4，其中通过表面处理在基材1的表面的至少所需部分上形成羟基以形成表面处理层2，同时生物相容性材料层 4由含有磷酸胆碱基团的聚合物形成，并且其中基材1和生物相容性材料层4分别通过由与由羟基和生物相容性材料共价键合的二氧化硅形成的粘合剂层3而接合。

28. 发明授权

US08765265B2 Polymer sliding material, artificial joint member, medical appliance, and manufacturing method therefor 有权
标题翻译：聚合物滑动材料，人造关节构件，医疗器具及其制造方法
公开(公告)号：US08765265B2
公开(公告)日：2014-07-01
申请号：US13142058
申请日：2009-12-25
申请人： Masayuki Kyomoto , Kazuhiko Ishihara
发明人： Masayuki Kyomoto , Kazuhiko Ishihara
IPC分类号： B32B27/00 , F16C33/20
CPC分类号： A61L27/18 , C08F2/48 , C08F291/18 , Y10T428/31855 , C08L71/00
摘要： Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.
摘要翻译：公开了具有优异的耐久性并能够长时间保持耐磨性的滑动构件。进一步公开了一种减少聚合物基材的膜厚度的人造接头构件。进一步公开了能够在引入身体后显示高润滑性，生物相容性和耐位错性的人造关节。进一步公开了表现出优异的生物相容性的医疗器具材料和医疗器械。滑动材料或医疗用具材料由聚合物层或生物相容性材料层（B）形成，所述聚合物层或生物相容性材料层（B）通过涂覆聚合物基材（A）的至少一部分表面而提供，所述聚合物基材（A）的表面具有酮基聚合物基材（A）浸渍在含有单体（C），聚合物基材（A）的反应体系中，聚合物基材（A）暴露于光，并且单体的聚合从聚合物基材（A）的表面引发。使用滑动材料或医疗器具材料制造人造关节构件，人造关节，医疗器具材料和医疗器具。

29. 发明授权

US08697238B2 Biomaterial, joint prosthesis using the biomaterial and method of producing the same 有权
标题翻译：生物材料，使用生物材料的关节假体及其生产方法
公开(公告)号：US08697238B2
公开(公告)日：2014-04-15
申请号：US12225758
申请日：2007-03-26
申请人： Masayuki Kyomoto , Kazuhiko Ishihara , Yasuhiko Iwasaki , Toru Moro , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Tomohiro Konno , Noboru Yamawaki
发明人： Masayuki Kyomoto , Kazuhiko Ishihara , Yasuhiko Iwasaki , Toru Moro , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Tomohiro Konno , Noboru Yamawaki
IPC分类号： B32B29/00
CPC分类号： A61L27/34 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2002/30685 , A61F2002/30934 , A61F2002/3611 , A61F2310/00011 , A61F2310/00179 , A61L27/42 , B05D1/18 , B05D3/067 , B23K35/3618 , C22F1/11 , C22F1/183 , Y10T428/24917 , Y10T428/24926 , Y10T428/31536
摘要： The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
摘要翻译：本发明的目的是提供一种关节假体，轴承材料及其制造方法，其抑制滑动部分的磨损，并且即使在重复的日常操作中也抑制磨料粉末的生产。为了实现该目的，提供了一种生物材料，包括：由金属，合金或陶瓷制成的基底; 以及层叠在基材上的生物相容性材料层，其中通过表面处理在基材上形成羟基，而生物相容性材料层包含含有磷酸胆碱基团的聚合物，基材和生物相容性材料层通过粘合剂层结合，与基材的羟基和生物相容性材料层结合。

30. 发明申请

US20140011957A1 BIOABSORBABLE BLEND FOR TEMPORARY SCAFFOLDING OF THE BLOOD VESSEL WALL 有权
标题翻译：生物可溶性混合物用于血管壁的临时消毒
公开(公告)号：US20140011957A1
公开(公告)日：2014-01-09
申请号：US14023784
申请日：2013-09-11
申请人： Hyung-Il Kim , Kazuhiko Ishihara , Suntech Co., Ltd.
发明人： Hyung-Il Kim , Kazuhiko Ishihara
IPC分类号： A61L31/04
CPC分类号： A61L31/041 , A61F2/82 , A61F2210/0004 , A61L27/14 , A61L27/26 , A61L27/507 , A61L31/148 , A61L2300/80 , C08L101/02 , C08L67/04
摘要： A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
摘要翻译：开发了能够耐受血管壁的机械强度并适用于制造心血管装置的包含聚（L-丙交酯）（PLLA）和含磷酸胆碱基团的共聚物（PPCP）的生物可吸收混合物。混合物作为支架，用于在血管愈合期间支持血管壁，并且在血管愈合完成后在体内经历生物降解。此外，共混物可以防止血栓的形成和吸附。

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